LOCUS       NM_001081655            2828 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus dishevelled-binding antagonist of beta-catenin 3
            (Dact3), mRNA.
ACCESSION   NM_001081655 XM_914665 XM_984413 XM_985316
VERSION     NM_001081655.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2828)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2828)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2828)
  AUTHORS   Lenoir,M., Martin,R., Torres-Maravilla,E., Chadi,S.,
            Gonzalez-Davila,P., Sokol,H., Langella,P., Chain,F. and
            Bermudez-Humaran,L.G.
  TITLE     Butyrate mediates anti-inflammatory effects of Faecalibacterium
            prausnitzii in intestinal epithelial cells through Dact3
  JOURNAL   Gut Microbes 12 (1), 1-16 (2020)
   PUBMED   33054518
  REMARK    GeneRIF: Butyrate mediates anti-inflammatory effects of
            Faecalibacterium prausnitzii in intestinal epithelial cells through
            Dact3.
REFERENCE   4  (bases 1 to 2828)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2828)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2828)
  AUTHORS   Xue,H., Xiao,Z., Zhang,J., Wen,J., Wang,Y., Chang,Z., Zhao,J.,
            Gao,X., Du,J. and Chen,Y.G.
  TITLE     Disruption of the Dapper3 gene aggravates ureteral
            obstruction-mediated renal fibrosis by amplifying Wnt/beta-catenin
            signaling
  JOURNAL   J Biol Chem 288 (21), 15006-15014 (2013)
   PUBMED   23580654
  REMARK    GeneRIF: Dapper3 antagonizes the fibrotic actions of Wnt signaling
            in kidney.
REFERENCE   7  (bases 1 to 2828)
  AUTHORS   Kivimae,S., Yang,X.Y. and Cheyette,B.N.
  TITLE     All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit
            conserved interactions with Vangl, Dvl, and serine/threonine
            kinases
  JOURNAL   BMC Biochem 12, 33 (2011)
   PUBMED   21718540
  REMARK    GeneRIF: conserved role for Dact3 protein in kinase-regulated
            biochemistry involving Vangl and Dvl.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2828)
  AUTHORS   Kettunen,P., Kivimae,S., Keshari,P., Klein,O.D., Cheyette,B.N. and
            Luukko,K.
  TITLE     Dact1-3 mRNAs exhibit distinct expression domains during tooth
            development
  JOURNAL   Gene Expr Patterns 10 (2-3), 140-143 (2010)
   PUBMED   20170752
  REMARK    GeneRIF: Dact3 may contribute to early tooth formation by
            modulation of Wnt signaling pathways in the mesenchyme, including
            preodontoblasts
REFERENCE   9  (bases 1 to 2828)
  AUTHORS   Fisher,D.A., Kivimae,S., Hoshino,J., Suriben,R., Martin,P.M.,
            Baxter,N. and Cheyette,B.N.
  TITLE     Three Dact gene family members are expressed during embryonic
            development and in the adult brains of mice
  JOURNAL   Dev Dyn 235 (9), 2620-2630 (2006)
   PUBMED   16881060
  REMARK    GeneRIF: Dact3, not previously described in any organism, is
            expressed in the ventral region of maturing somites, limb bud and
            branchial arch mesenchyme, and in the embryonic CNS
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ832319.1 and AC148981.7.
            
            On or before Feb 24, 2007 this sequence version replaced
            XM_985316.1, XM_914665.2, XM_984413.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ832319.1, AB073971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1968              DQ832319.1         1-1968
            1969-2828           AC148981.7         24208-25067         c
FEATURES             Location/Qualifiers
     source          1..2828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..2828
                     /gene="Dact3"
                     /gene_synonym="EG666671; naa-3"
                     /note="dishevelled-binding antagonist of beta-catenin 3"
                     /db_xref="GeneID:629378"
                     /db_xref="MGI:MGI:3654828"
     exon            1..357
                     /gene="Dact3"
                     /gene_synonym="EG666671; naa-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1941
                     /gene="Dact3"
                     /gene_synonym="EG666671; naa-3"
                     /note="dact 3; dapper antagonist of catenin 3; dapper
                     homolog 3, antagonist of beta-catenin"
                     /codon_start=1
                     /product="dapper homolog 3"
                     /protein_id="NP_001075124.1"
                     /db_xref="CCDS:CCDS39788.1"
                     /db_xref="GeneID:629378"
                     /db_xref="MGI:MGI:3654828"
                     /translation="MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQA
                     LRLAQPGMGGAEAEDEEDAEEDEDAAAARRAAAALEEQLEALPGLIWDLGQQLGDLSL
                     ESGGLDQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSGSYGRLGPSDPRGIYAS
                     ERPKSLGDASPSAPESVGARVAVPRSFSAPYPTAAAGAETCSSAERRARAGPFLTPSP
                     LHAVALRSPRPSGRVPCGSPDGAASRPLDGYISALLRRRRRRGAGQPRTSPGGADGGA
                     RRQNGARPRPPEASPPPGGARPAREPSTERAWAAAWEAEVPPEPAPPAAASPPSSPAE
                     GRLVKAQYIPGAPAASRGLPGRAARRRAPPLTRGRSVEQSPPRERPRAAGRRGRLAEP
                     SGRRGSPRARKAARSQSETSLLGRAHAAPPPKYPTAERDEPRPPRPRRGPAPTPTVQA
                     CRRWRSTAEIDAPDGRRPRARVPAPRGPAPSPSAPPRRLLYGCAGSDSECSAVGRPVP
                     LGRRMPSGCAPGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAAAGASPSG
                     PGGAAGGGTPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV"
     exon            358..454
                     /gene="Dact3"
                     /gene_synonym="EG666671; naa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..607
                     /gene="Dact3"
                     /gene_synonym="EG666671; naa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            608..2828
                     /gene="Dact3"
                     /gene_synonym="EG666671; naa-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dact3"
                     /gene_synonym="EG666671; naa-3"
                     /note="hexamer: AATAAA"
     polyA_site      2821
                     /gene="Dact3"
                     /gene_synonym="EG666671; naa-3"
                     /note="major polyA site"
ORIGIN      
        1 acggtgacag cccggccagc gggcgggcgg gctgctgggg cggggaggtg ggaccggcga
       61 gaggggcggc cgtggggccc ggccgggctg gggcgggggg ccgcagccat gatccgggcc
      121 ttctcgttcc cggtgagccc ggagcggggt cggctgcggg gatggttgga aggcagcctg
      181 gccgggctct gcgagttgca ttggctccga gagaggcagg agtaccgcgt gcagcaggcg
      241 ctgcggctgg cccagcccgg gatggggggc gccgaggctg aggacgagga ggacgccgag
      301 gaggacgagg atgcggcagc ggcgcgcagg gccgcagcag ccctggagga gcagctggag
      361 gccctgcctg ggctcatctg ggacctgggc cagcagctgg gagacctgag tctggagtct
      421 ggtggcctgg accaggagag tgggcgcagc tcaggcttct atgaagaccc cagttctact
      481 ggaggcccag attcaccacc ctccaccttc tgcggggaca gtggcttctc cggatctggc
      541 tcctatggac gcctgggtcc ctcggacccc cggggcatct atgccagtga gagacccaag
      601 tccttaggcg acgccagtcc cagcgcccca gagtcggtgg gtgcccgggt tgcagtgcct
      661 cgatccttct cagctcccta tccgacggca gcagccggag ctgagacctg ctcatccgcg
      721 gaacggcggg ctcgtgccgg gcccttcctg acacctagcc cactgcacgc ggtggctctg
      781 cgcagcccaa ggccaagtgg acgcgtaccg tgcggctcgc cggacggggc ggccagccgg
      841 ccccttgacg gctacatctc ggcgctcctg cgcaggcgcc gccgccgggg ggcgggccaa
      901 ccgcgcacaa gtcccggggg cgcggacggg ggcgcgcggc gccagaacgg cgcgcgcccg
      961 cggccgcctg aagcgtcccc gccccccgga ggcgcgcgac ccgcgcggga accgtcgaca
     1021 gagcgcgcct gggctgcggc gtgggaggcg gaggttccac ccgaacccgc gcctccggcc
     1081 gccgcgtcgc cgccctccag tccggcagag ggccgcctcg tgaaggcaca gtacatcccg
     1141 ggcgcgcccg cggcctccag gggcctcccg ggccgcgccg cgcgccgccg ggctccgccg
     1201 cttacgcgag gtcgcagtgt ggagcagtcc ccgccaaggg aacggccgcg cgctgcgggc
     1261 cgtcggggcc gcctggcaga gccgtcgggg cgtcggggat cgccgagggc gcgcaaagcg
     1321 gcgcgctcgc agtctgagac cagtctactg ggccgcgcgc acgccgctcc gccacccaag
     1381 taccccacgg ccgagcgaga cgaaccccga ccgccccggc cccgtcgtgg cccagcgccc
     1441 acgccgacgg tccaggcctg ccgtcggtgg cgttccaccg ctgagatcga cgcaccggat
     1501 ggccgccgcc cccgagcccg cgtgcccgcg ccacgaggcc ccgcaccctc gccatctgcg
     1561 cccccgcgcc ggctgttgta cggttgcgca ggcagcgact ccgagtgctc agcggtaggg
     1621 cggccggtgc cgctcggccg tcggatgccg tctggatgcg ctccaggagg ctatggcgaa
     1681 agcgagtcga gcgccagcga gggcgagtcg cccgccttca gctctgcctc tagcgactcc
     1741 gacggcagcg gaggcctcgt gtggccgcag caactggtgg cggccgccgg ggcctcgccg
     1801 tcggggcccg ggggtgctgc tggtggaggg acgcctgcgg gccccgccaa ggtcttcgtg
     1861 aagatcaagg catcgcacgc gctgaagaaa aagatccttc gttttcggtc gggttctctg
     1921 aaggtcatga cgactgtgtg agttggggcg ggatgggctt gaacttcact tcacctccat
     1981 ggcctccgca cccccacact tctcatcctc caaccctctc cacacccacc ttccaaagac
     2041 caccagtttt ctctgcttcc aaagaccctc ctcactcact gcccgccgtc catagccgtc
     2101 ctggagaggc cgcccctctc cccccacggg gaggcgccca gattgtccca cgacagctgg
     2161 ttttcaaagc cttgaaccag aaggcacccc tccgtgggcc acactctccc catctgtaca
     2221 atgggtgtac gcaaatgcag taattctgtt cgggtctctc ctccttcacc cccgttttaa
     2281 ttttagaagc ttagtctgtt ctccacttct ctgacatagc cttctcattc ctcttttcct
     2341 tgcccagata gggtcccctt ctcattcaca aagtgccccc tccatgtccc tggaccctta
     2401 ggataccccc tggggccccc aagtcagaga ctgtctgact caggttatgc ctacagagtg
     2461 ccatgccctg gaagaggaag tggcactgtc ttaggggctt tgagggtcaa gtaggagttg
     2521 ccaacacctg gaaaggactc tttctgctcc atccttggac agtcatgggg aattgggagg
     2581 ttagagagag gaaggaagat ggtttcaatc tcgtgcctct ccccacgggg ggtgggggac
     2641 gctgaatgac cctcagctgt tccaatccag tgggtttttt tgatttgttt gtttttgttt
     2701 tttttttttt attaaagaaa ttactgtatt tattatgaca atggtgactc cccggtgcat
     2761 ggggggccag attctgtgtg tttctctaac ctctttgtaa ataaatgcac agtgttacat
     2821 acccctgg
//
