LOCUS       NM_172826               2849 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus dishevelled-binding antagonist of beta-catenin 2
            (Dact2), mRNA.
ACCESSION   NM_172826
VERSION     NM_172826.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2849)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2849)
  AUTHORS   Kim,C., Kwak,W., Won,D.H., Kim,J., Hwang,D.B., Kim,N., Kang,M.,
            Jeon,Y., Park,Y.I., Park,J.W. and Yun,J.W.
  TITLE     Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through
            regulation of the Igfl-MAPK pathway axis
  JOURNAL   Cell Biol Toxicol 39 (6), 3197-3217 (2023)
   PUBMED   37603122
  REMARK    GeneRIF: Loss of Dact2 alleviates cisplatin-induced nephrotoxicity
            through regulation of the Igfl-MAPK pathway axis.
REFERENCE   3  (bases 1 to 2849)
  AUTHORS   Lu,L., Wang,Y., Ou,R., Feng,Q., Ji,L., Zheng,H., Guo,Y., Qi,X.,
            Kong,A.N. and Liu,Z.
  TITLE     DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal
            Cancer Prevention and Treatment
  JOURNAL   Pharmacol Res 129, 318-328 (2018)
   PUBMED   29199082
  REMARK    GeneRIF: Our findings provide a novel DACT2 demethylating
            stimulator to verify and expand previously established link between
            DACT2 and colorectal cancer (CRC), suggesting DACT2 demethylation
            is strongly correlated with CRC prognosis.
REFERENCE   4  (bases 1 to 2849)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2849)
  AUTHORS   Naillat,F., Yan,W., Karjalainen,R., Liakhovitskaia,A.,
            Samoylenko,A., Xu,Q., Sun,Z., Shen,B., Medvinsky,A., Quaggin,S. and
            Vainio,S.J.
  TITLE     Identification of the genes regulated by Wnt-4, a critical signal
            for commitment of the ovary
  JOURNAL   Exp Cell Res 332 (2), 163-178 (2015)
   PUBMED   25645944
REFERENCE   6  (bases 1 to 2849)
  AUTHORS   Dequeant,M.L., Glynn,E., Gaudenz,K., Wahl,M., Chen,J., Mushegian,A.
            and Pourquie,O.
  TITLE     A complex oscillating network of signaling genes underlies the
            mouse segmentation clock
  JOURNAL   Science 314 (5805), 1595-1598 (2006)
   PUBMED   17095659
REFERENCE   7  (bases 1 to 2849)
  AUTHORS   Fisher,D.A., Kivimae,S., Hoshino,J., Suriben,R., Martin,P.M.,
            Baxter,N. and Cheyette,B.N.
  TITLE     Three Dact gene family members are expressed during embryonic
            development and in the adult brains of mice
  JOURNAL   Dev Dyn 235 (9), 2620-2630 (2006)
   PUBMED   16881060
  REMARK    GeneRIF: Dact2 expression is most prominent during organogenesis of
            the thymus, kidneys, and salivary glands, with much lower levels in
            the somites and in the developing CNS.
REFERENCE   8  (bases 1 to 2849)
  AUTHORS   Brott,B.K. and Sokol,S.Y.
  TITLE     Frodo proteins: modulators of Wnt signaling in vertebrate
            development
  JOURNAL   Differentiation 73 (7), 323-329 (2005)
   PUBMED   16219036
  REMARK    Review article
REFERENCE   9  (bases 1 to 2849)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   10 (bases 1 to 2849)
  AUTHORS   Cheyette,B.N., Waxman,J.S., Miller,J.R., Takemaru,K.,
            Sheldahl,L.C., Khlebtsova,N., Fox,E.P., Earnest,T. and Moon,R.T.
  TITLE     Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK
            signaling, is required for notochord formation
  JOURNAL   Dev Cell 2 (4), 449-461 (2002)
   PUBMED   11970895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151292.2 and BC058740.1.
            
            On Apr 3, 2009 this sequence version replaced NM_172826.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058740.1, AK041604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC151292.2         196189-196260       c
            73-2849             BC058740.1         1-2777
FEATURES             Location/Qualifiers
     source          1..2849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..2849
                     /gene="Dact2"
                     /gene_synonym="2900084M21Rik; A630024E20; dapper2; Dpr2;
                     Frd2"
                     /note="dishevelled-binding antagonist of beta-catenin 2"
                     /db_xref="GeneID:240025"
                     /db_xref="MGI:MGI:1920347"
     exon            1..318
                     /gene="Dact2"
                     /gene_synonym="2900084M21Rik; A630024E20; dapper2; Dpr2;
                     Frd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2376
                     /gene="Dact2"
                     /gene_synonym="2900084M21Rik; A630024E20; dapper2; Dpr2;
                     Frd2"
                     /note="dapper, antagonist of beta-catenin, homolog 2;
                     mDpr2; dapper antagonist of catenin 2; dapper homolog 2,
                     antagonist of beta-catenin"
                     /codon_start=1
                     /product="dapper homolog 2"
                     /protein_id="NP_766414.3"
                     /db_xref="CCDS:CCDS28406.1"
                     /db_xref="GeneID:240025"
                     /db_xref="MGI:MGI:1920347"
                     /translation="MWAPSGQGPAGWDRRRVGARLRAALAGLQELQGLRATQQARVRG
                     ALGLHPAPGPRGQELRLEAALTALREQLSRLRRQDAGLKTHLDQLDQQISELQLDVSR
                     SSCEALDSDSRPSSGFYELSDAGSCSLSTSCASVCSDRLSPSLGSWLPVFQPSKSRSG
                     IGDWRPRSADETTVPAWSPQLTEDSRLLHGAEGTGRLTGMFRPRPVSTGDLERVLPAD
                     VGLQRAGTDAAHLLGQGIEIPAHALDPTYQRDLVARGGQEVYPYPSPLHAVALQSPLF
                     ALPKEAPCFDICSPPQEPPLVPVDENRTQPEPIRELGSAEAYIHRLLHLRGQELPLRD
                     VGQEQGGDTAAFPPKPCGQRSESTCQLEKQACGADRGGLKLGRGAAKDSLKQHGPVSL
                     VGAEPLSSPLKEETIPWNPCVHGDNTVGSSPCSQAQQPLNDCGQGPVLSPSRVLGTES
                     PPLAPEPFAYTSCTTGETSPVKLRMGFSQNKAVKVRRRVSEKVPRLGKQLPPQPERQR
                     VTERDPSRPHQGGLSRRPTLAREPPGRSCSESTLYPVPFLVPVVVAQRESYPTSPQAF
                     FPMEAALLSSAARRKQRRWQSTMEISAKAGSVSQPGPSMGLPRSPAKRGSGPRAQSRP
                     TLARQDACARCESDPSEHSADCTSLYHSTIAETSEDEEASDHTANRFGDESSSNDSEG
                     CFRGSRRRLAIGSAEAGQGGWAWPRVPPQQPSRAPGNTRPPLPPVPKLCRIKASKALK
                     KKIRRFQPAALKVMTMV"
     exon            319..451
                     /gene="Dact2"
                     /gene_synonym="2900084M21Rik; A630024E20; dapper2; Dpr2;
                     Frd2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..727
                     /gene="Dact2"
                     /gene_synonym="2900084M21Rik; A630024E20; dapper2; Dpr2;
                     Frd2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..2809
                     /gene="Dact2"
                     /gene_synonym="2900084M21Rik; A630024E20; dapper2; Dpr2;
                     Frd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2780..2785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dact2"
                     /gene_synonym="2900084M21Rik; A630024E20; dapper2; Dpr2;
                     Frd2"
                     /note="hexamer: AATAAA"
     polyA_site      2809
                     /gene="Dact2"
                     /gene_synonym="2900084M21Rik; A630024E20; dapper2; Dpr2;
                     Frd2"
                     /note="major polyA site"
ORIGIN      
        1 cctccgcggc cagcgatagg tcccaaccca cctaagcgac ctgcagccgg gggcggggag
       61 acgcgacggg gacgcgcggc gcggcggttg agcgtccggg agatgtgggc accgagcggc
      121 caggggcccg cgggttggga ccgccgcagg gtgggcgcgc gactacgagc cgcactggcc
      181 gggctgcagg agcttcaggg gctgcgagcc acgcagcaag cacgcgtgcg gggagctctg
      241 ggcctgcacc ctgcgccagg gccccgcggc caggagctgc gtctggaggc ggcgctgacc
      301 gcgctacggg agcagctgtc acggctaagg agacaggatg ctggcctgaa gacacacttg
      361 gaccagctgg atcagcagat aagtgaacta cagctggatg tgagcaggtc ttcttgcgag
      421 gccttggata gtgacagcag acccagctca ggtttctatg agctgagcga tgctggttcc
      481 tgttctctgt ccacctcctg cgcatctgtt tgcagcgacc gtctatcccc ctccctgggt
      541 agctggctgc ctgtgttcca gccctccaag tccaggtctg gcatcgggga ctggcgacca
      601 cgctctgctg atgagaccac tgtccctgca tggagcccac agctcacaga agatagcagg
      661 ctcctgcatg gtgcagaggg cacaggccgg ctgacgggca tgttccggcc cagaccagta
      721 tctacaggtg atctcgaaag agtccttcca gctgacgtgg ggctccagag agctggtact
      781 gatgctgcac atctcctggg ccaggggata gagatcccag cccacgccct ggaccccacg
      841 taccagcgtg acctggtggc caggggaggc caggaggtgt acccatatcc cagccccctc
      901 catgcggtgg ccctgcagag tcccctcttc gctctgccca aagaagcccc gtgttttgac
      961 atctgctcac ctccccagga gcctcctctg gtccctgttg atgagaacag gactcaacct
     1021 gagccgatcc gtgagctggg ctcagccgaa gcctacatcc acaggctgtt gcatctgcgg
     1081 ggccaagagc tccccctgag agatgtgggg caggagcagg gaggtgacac agctgctttt
     1141 ccaccgaagc cctgtggcca gaggtcggag agcacatgtc agctggagaa gcaggcctgt
     1201 ggagctgaca ggggaggact gaaactaggt aggggtgctg ccaaggacag cctcaagcaa
     1261 catgggcctg tgtcccttgt gggtgctgag cccctcagca gccccctaaa ggaagaaacc
     1321 attccttgga atccctgtgt ccatggagac aatactgttg gttcctcacc ctgctcccag
     1381 gcccaacagc ctcttaatga ctgtggccaa ggaccagtcc tgtcaccatc cagggtgttg
     1441 ggcactgaga gcccacctct ggccccggag ccctttgcct atacatcctg caccactggt
     1501 gaaacctctc ccgtgaagct gaggatgggc ttttcccaaa acaaggccgt gaaggtcaga
     1561 agaagagtta gtgagaaagt cccgaggcta gggaagcagc tccctccaca accagagagg
     1621 cagcgggtca cagagcggga cccctccagg ccccatcagg gaggtctcag caggaggccc
     1681 acactggccc gggagcctcc tggacgctcc tgctctgagt ccaccctcta ccccgtgccc
     1741 ttccttgtcc ccgtagtggt ggcccagagg gaaagttacc caacgtcacc ccaagcgttc
     1801 ttcccaatgg aggcagctct cctcagctca gcagccaggc ggaagcagcg caggtggcag
     1861 tccaccatgg agatctcagc caaagccggt tcagtcagcc aacctgggcc cagcatgggg
     1921 ctccctaggt ccccagccaa gagaggaagt ggtcccaggg cccagagtag gcccacactt
     1981 gcccgtcagg atgcctgtgc gaggtgtgag tcggacccct cggagcactc tgcagactgc
     2041 acctcactct accactccac cattgccgag accagcgagg acgaggaggc gagtgaccac
     2101 actgccaacc gctttgggga cgagtccagc agcaacgatt cagaagggtg tttccggggc
     2161 agccgccgtc gcctggcaat aggcagtgca gaggctgggc aaggggggtg ggcctggcct
     2221 cgggtgcccc cccagcagcc ctcacgggcc ccaggaaaca ccaggccacc cttgccccct
     2281 gtgcccaaac tgtgccgcat caaggcctcc aaggccctga agaagaagat ccgaaggttt
     2341 cagccagcag ccctgaaggt catgaccatg gtgtgatggc agtgtttcag gacaagccta
     2401 ggaccccaga aggtgccata tgatgtggta ccccgtgcca tgtgatgagc cgggggaggg
     2461 tggtatcaac ctgctattgc gcttagtttt ctcagccacc ctcactgtgg ttgggagtcg
     2521 tctggggtca cattccctcc agccattttc attgcatgac cgcagtcaca actttgctcc
     2581 tcaccatcct ctgcctgatt tgtggggaga ggtctctaat aagacacttc tccccagaga
     2641 catgaaagaa acatggcatc ctttgcgggc gggggggggg ggggggggag aacgggacga
     2701 cggggacgga ccagatttgc atttaactcc atattgcagt tgtatgaaca aacacctaca
     2761 ccatgctggt atagttccaa ataaaagagc cacatttcct ttctcctcaa aaaaaaaaaa
     2821 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
