LOCUS       NM_021532               3650 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus dishevelled-binding antagonist of beta-catenin 1
            (Dact1), transcript variant 2, mRNA.
ACCESSION   NM_021532
VERSION     NM_021532.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3650)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3650)
  AUTHORS   Knupp,D., Cooper,D.A., Saito,Y., Darnell,R.B. and Miura,P.
  TITLE     NOVA2 regulates neural circRNA biogenesis
  JOURNAL   Nucleic Acids Res 49 (12), 6849-6862 (2021)
   PUBMED   34157123
REFERENCE   3  (bases 1 to 3650)
  AUTHORS   Zhao,C., Gao,J., Li,S., Liu,Q., Hou,X., Xing,X., Wang,D., Sun,M.,
            Wang,S. and Luo,Y.
  TITLE     Cyclin G2 regulates canonical Wnt signalling via interaction with
            Dapper1 to attenuate tubulointerstitial fibrosis in diabetic
            nephropathy
  JOURNAL   J Cell Mol Med 24 (5), 2749-2760 (2020)
   PUBMED   31978940
  REMARK    GeneRIF: Cyclin G2 regulates canonical Wnt signalling via
            interaction with Dapper1 to attenuate tubulointerstitial fibrosis
            in diabetic nephropathy.
REFERENCE   4  (bases 1 to 3650)
  AUTHORS   Yu,C.Y., Yang,C.Y. and Rui,Z.L.
  TITLE     MicroRNA-125b-5p improves pancreatic beta-cell function through
            inhibiting JNK signaling pathway by targeting DACT1 in mice with
            type 2 diabetes mellitus
  JOURNAL   Life Sci 224, 67-75 (2019)
   PUBMED   30684546
  REMARK    GeneRIF: High DACT1 expression is associated with type 2 diabetes
            mellitus.
REFERENCE   5  (bases 1 to 3650)
  AUTHORS   Zhang,K., Zhang,Y., Gu,L., Lan,M., Liu,C., Wang,M., Su,Y., Ge,M.,
            Wang,T., Yu,Y., Liu,C., Li,L., Li,Q., Zhao,Y., Yu,Z., Wang,F.,
            Li,N. and Meng,Q.
  TITLE     Islr regulates canonical Wnt signaling-mediated skeletal muscle
            regeneration by stabilizing Dishevelled-2 and preventing autophagy
  JOURNAL   Nat Commun 9 (1), 5129 (2018)
   PUBMED   30510196
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3650)
  AUTHORS   Hunter,N.L., Hikasa,H., Dymecki,S.M. and Sokol,S.Y.
  TITLE     Vertebrate homologues of Frodo are dynamically expressed during
            embryonic development in tissues undergoing extensive morphogenetic
            movements
  JOURNAL   Dev Dyn 235 (1), 279-284 (2006)
   PUBMED   16278878
  REMARK    GeneRIF: Frodo is expressed in primitive streak mesoderm,
            neuroectoderm, neural crest, presomitic mesoderm, and somites. In
            many cases, Frodo expression is confined to tissues undergoing
            extensive morphogenesis
REFERENCE   7  (bases 1 to 3650)
  AUTHORS   Brott,B.K. and Sokol,S.Y.
  TITLE     Frodo proteins: modulators of Wnt signaling in vertebrate
            development
  JOURNAL   Differentiation 73 (7), 323-329 (2005)
   PUBMED   16219036
  REMARK    Review article
REFERENCE   8  (bases 1 to 3650)
  AUTHORS   Wong,H.C., Bourdelas,A., Krauss,A., Lee,H.J., Shao,Y., Wu,D.,
            Mlodzik,M., Shi,D.L. and Zheng,J.
  TITLE     Direct binding of the PDZ domain of Dishevelled to a conserved
            internal sequence in the C-terminal region of Frizzled
  JOURNAL   Mol Cell 12 (5), 1251-1260 (2003)
   PUBMED   14636582
REFERENCE   9  (bases 1 to 3650)
  AUTHORS   Gloy,J., Hikasa,H. and Sokol,S.Y.
  TITLE     Frodo interacts with Dishevelled to transduce Wnt signals
  JOURNAL   Nat Cell Biol 4 (5), 351-357 (2002)
   PUBMED   11941372
REFERENCE   10 (bases 1 to 3650)
  AUTHORS   Cheyette,B.N., Waxman,J.S., Miller,J.R., Takemaru,K.,
            Sheldahl,L.C., Khlebtsova,N., Fox,E.P., Earnest,T. and Moon,R.T.
  TITLE     Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK
            signaling, is required for notochord formation
  JOURNAL   Dev Cell 2 (4), 449-461 (2002)
   PUBMED   11970895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110521.14.
            
            On Jun 26, 2010 this sequence version replaced NM_021532.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077691.1, BC145833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-424               AC110521.14        97697-98120
            425-557             AC110521.14        100499-100631
            558-713             AC110521.14        101598-101753
            714-3650            AC110521.14        104984-107920
FEATURES             Location/Qualifiers
     source          1..3650
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 29.39 cM"
     gene            1..3650
                     /gene="Dact1"
                     /gene_synonym="4921528D17Rik; DAPPER; DAPPER1; Frd1;
                     FRODO; Frodo1; MDpr1; MTNG3; THYEX3"
                     /note="dishevelled-binding antagonist of beta-catenin 1"
                     /db_xref="GeneID:59036"
                     /db_xref="MGI:MGI:1891740"
     exon            1..424
                     /gene="Dact1"
                     /gene_synonym="4921528D17Rik; DAPPER; DAPPER1; Frd1;
                     FRODO; Frodo1; MDpr1; MTNG3; THYEX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2437
                     /gene="Dact1"
                     /gene_synonym="4921528D17Rik; DAPPER; DAPPER1; Frd1;
                     FRODO; Frodo1; MDpr1; MTNG3; THYEX3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dapper 1; thymus-expressed novel gene 3 protein; thymus
                     expressed gene 3; frodo homolog; dapper antagonist of
                     catenin 1; dapper homolog 1, antagonist of beta-catenin"
                     /codon_start=1
                     /product="dapper homolog 1 isoform 2"
                     /protein_id="NP_067507.2"
                     /db_xref="CCDS:CCDS25963.1"
                     /db_xref="GeneID:59036"
                     /db_xref="MGI:MGI:1891740"
                     /translation="MKPDAAREPEPLSPGRGAEAEGRWRERGEADTERQRTRERQEAT
                     LAGLAELGYLRQRQELLVRGALRCSGTVGTVAPRSGELRGDAAQRSRLEEKFLEENIL
                     LLRRQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSGFYELSDG
                     ASGSLSNSSNSVFSECLSSCHSSTCFCSPLEAALTISDGCPKSADVNPKYQCDLVSKN
                     GNDVYRYPSPLHAVAVQSPMFLLCLTGNTLREEEGLGSHASDICIGSELNATKTDNSL
                     PSPSSLWSASHPASSKKMDGYILSLVQKKTHPVRTNKPRTSVNADPTKGLLRNGSVCV
                     RAPSGVPPGSSVNFKNTKQMCLPAGGITSLENGPFSPPKQRSKDSKTDQLESKRLALP
                     ESCSAGAAMEPQSKHVPKAAKAASQELTRCQAGLGESMKESNQASAVSPKTSPGRGPV
                     APAESKALQLPKKMSQKNSLQAVPALDRPALDFKSEGSSQSLEEGHLVKAQFIPGQQA
                     AARPHRAHRNPGVARSATLKARGQAAMEHGLPTVREKPRAAGKKCRFPDDSDTNKKFR
                     KTSAKGRRSGGLQDAGLPGRALGTGGHRAGSRAHAHGREPVVAKPKHKRTDYRRWKSS
                     AEVSYEEALRRARRARREHGAAYRVAVALPYASPYAYVPSDSEYSAECESLFHSTVVD
                     TSEDEQSNYTTNCFGDSESSVSEGDFVGESTTTSDSEESGGLIWSQFVQTLPIQTVTA
                     PDLHTRPTKTFVKIKASHNLKKKILRFRSGSLKLMTTV"
     exon            425..557
                     /gene="Dact1"
                     /gene_synonym="4921528D17Rik; DAPPER; DAPPER1; Frd1;
                     FRODO; Frodo1; MDpr1; MTNG3; THYEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..713
                     /gene="Dact1"
                     /gene_synonym="4921528D17Rik; DAPPER; DAPPER1; Frd1;
                     FRODO; Frodo1; MDpr1; MTNG3; THYEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..3650
                     /gene="Dact1"
                     /gene_synonym="4921528D17Rik; DAPPER; DAPPER1; Frd1;
                     FRODO; Frodo1; MDpr1; MTNG3; THYEX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3610..3615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dact1"
                     /gene_synonym="4921528D17Rik; DAPPER; DAPPER1; Frd1;
                     FRODO; Frodo1; MDpr1; MTNG3; THYEX3"
                     /note="hexamer: TATAAA"
     polyA_site      3638
                     /gene="Dact1"
                     /gene_synonym="4921528D17Rik; DAPPER; DAPPER1; Frd1;
                     FRODO; Frodo1; MDpr1; MTNG3; THYEX3"
                     /note="major polyA site"
ORIGIN      
        1 agacgggagc agcgcgggat gcgagtgcgg gcggcatgag ctcgcggccg gggccctagc
       61 gtgtgctgct gctcccgggc tggcggggcc tcggggggtc atgaagccgg acgcagcgcg
      121 cgagccggag ccgctgagcc ccggccgggg cgcggaggcc gaggggcgct ggcgcgagag
      181 gggcgaggcg gacacggagc ggcagcgtac ccgcgagcgc caggaggcca cgctggcggg
      241 gctggcggag ctggggtacc tgcggcaacg ccaagagctg ctggtgcgcg gtgcgctgcg
      301 ctgctccggg accgtgggga ccgtcgcgcc gcgctccggg gagctgcggg gagacgcggc
      361 gcagcgcagc cgcctggagg agaagttcct ggaagagaac atcttgctgc tgcgaaggca
      421 gttgaattgt ttgaggagaa gagatgccgg tttgttgaat cagttgcaag aacttgacaa
      481 gcagataagt gacctgagac tggatgtgga gaagacatct gaagagcacc tggagacaga
      541 cagccggcct agctcagggt tttatgagct gagtgatgga gcttcgggct ccctctctaa
      601 ctcctccaac tccgtgttca gtgagtgttt gtccagttgc cattccagca cctgcttctg
      661 cagccccttg gaggcggcct tgaccatctc agacggttgc cccaaatctg cagatgtgaa
      721 tcctaaatac cagtgtgatc ttgtgtctaa aaacgggaat gacgtatatc gctaccccag
      781 tccacttcat gctgtggctg tgcagagccc aatgtttctc ctttgtctga cgggcaacac
      841 tctgagggaa gaggaggggc ttgggagcca tgccagcgac atctgcattg gatctgaact
      901 gaacgccacc aaaacagaca attccctgcc atctccaagc agtttgtggt ccgcttccca
      961 tcctgcatcc agtaagaaaa tggatgggta tattttgagc ctcgtgcaga agaaaacaca
     1021 ccctgtaagg accaataaac ctagaaccag tgtgaacgct gaccctacca agggccttct
     1081 gaggaatgga agtgtgtgtg tcagggcccc tagtggcgtc ccaccgggca gtagtgtgaa
     1141 ctttaagaat acaaaacaga tgtgtttgcc cgctggggga ataacctctt tggaaaacgg
     1201 gccattctcc cctcctaagc agaggtccaa agactcaaag acagaccagt tagaaagcaa
     1261 gaggttggct ctgccggaga gctgctcggc aggcgccgcc atggaacccc aaagcaagca
     1321 tgtgcccaaa gccgccaagg cagcctctca agagctcaca aggtgtcaag ccgggctggg
     1381 ggaatccatg aaggaaagca atcaggcctc cgctgtttct cctaaaacaa gtcctggcag
     1441 aggccctgtc gcccccgcag agagcaaagc cctgcagctc ccgaaaaaga tgtcgcagaa
     1501 gaacagcctc caggctgtgc ccgcgctgga caggccggcc ttggacttca aaagcgaggg
     1561 ctcatctcaa agcctcgagg aagggcatct ggtgaaagct cagttcattc cggggcagca
     1621 ggcggccgcc aggcctcacc gtgcacacag gaacccgggt gtcgcaagga gcgccacctt
     1681 gaaggcccgc ggccaggcag ccatggaaca cggcctgccc accgtcaggg agaaaccgcg
     1741 ggcagcaggc aagaagtgcc gtttcccaga cgactcggat acaaataaga aattcaggaa
     1801 gacctccgcc aagggccggc gcagtggcgg gctgcaggac gctggccttc ccggtagggc
     1861 cctgggcacc ggcggccatc gggcgggtag cagggcgcac gcgcatggcc gggagcccgt
     1921 ggtggccaaa ccgaagcaca agcgaaccga ctaccggcgg tggaaatcgt cagccgaggt
     1981 ctcctacgaa gaagccctgc ggagggcccg gagggctcgc agggagcacg gggctgccta
     2041 ccgggtggct gtcgccctgc cttacgccag cccctatgcc tacgtgccca gcgactccga
     2101 gtactcggcg gagtgcgagt cgctcttcca ctccacggtg gtggacacca gcgaggacga
     2161 gcagagcaac tacaccacca actgcttcgg cgacagcgag tccagcgtga gcgaaggcga
     2221 cttcgtgggc gagagcacca ccaccagcga ctcagaggag agcgggggtt taatctggtc
     2281 ccagtttgtc cagactctcc cgattcaaac ggtcacggcc ccagacctcc acacccgtcc
     2341 cacaaaaacc tttgtcaaaa tcaaggcttc gcacaacctc aagaagaaga tcctccgttt
     2401 ccgctctggc tctttgaaac tgatgactac cgtttgagta gctgatgtag cgagtgtctt
     2461 ctcctccccc tagtctctga gaaaaagaaa aaggtgttgt cttaatattt gtgtcatact
     2521 taaatggaat actttccttt cactaggata aacccaagat aaattatgtc tcgcggtcat
     2581 gtatggacgc tagtgccttt aatggaaggt gaaggatgta tctctagtta gaagtgaata
     2641 ttgaggtctt agtggtggtg atagtgaatg cattttgatt atcagatgtt tcgtccgagt
     2701 gtctggccaa gtacaggtgt gtgatgttca agttttattt ggatgagacc ttttgtttcc
     2761 aaggttcgtg gataaaattt ttaagccgtg aactcgctcc ttgatccttt agggctttgt
     2821 ccctgaaagg gctttccggt tgaggggcat tgcatacaat tgtgtagagt aggtagaaaa
     2881 aacaaacaaa caaacaaaac agtcattgct ttctgtaaat tttttactat agacaacact
     2941 ctcagatgtc tctccatcct attttcttct tagaagtaca ctttttactg gatttagaac
     3001 ttagtagacc agacttttaa tctggaggtg gtaaactgga tagggagact gataggacct
     3061 taaaaggatt cacaaaaacc tttgccacct gtagtgcctc cgccttcgtt acagtagccc
     3121 tttcatgggc catatatcca gcagtttttg atgcctttct atctctctgc tcctaatttg
     3181 tagccaatac aactgtttgt cccttagagg gcttgtcttt gggataaagt gttggtcctt
     3241 tggtgcaaag aaattcaccc ttactgggct tgactccaag cccagaattg ctctcaccaa
     3301 gcactggcct gaacagtagt gcagttcaac cctcaccgga ccgctgactt atctggaagg
     3361 gcattacatt ttttaaaaaa gcttttggta aacagtattg tgtaaaatag agtttttaaa
     3421 atactgatat atgcatgttt tgtgcatgag tagtagttct ttggattcct gttttgatat
     3481 tcctgttgct gaattactgt atgatataaa cagtatgtgt tttatatata tcattgtgta
     3541 aatttaatat aacacattat atgctgtact aaatgatttg ttttattgct gttaaacttt
     3601 gttatttgtt ataaaaacca gatgtttaca cctataaatc ttgtgctggc
//
