LOCUS       NM_033605               3014 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus dachshund family transcription factor 2 (Dach2),
            transcript variant 2, mRNA.
ACCESSION   NM_033605
VERSION     NM_033605.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Satta,J.P., Lan,Q., Taketo,M.M. and Mikkola,M.L.
  TITLE     Stabilization of Epithelial beta-Catenin Compromises Mammary Cell
            Fate Acquisition and Branching Morphogenesis
  JOURNAL   J Invest Dermatol 144 (6), 1223-1237 (2024)
   PUBMED   38159590
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Thomson,E., Tran,M., Robevska,G., Ayers,K., van der Bergen,J.,
            Gopalakrishnan Bhaskaran,P., Haan,E., Cereghini,S.,
            Vash-Margita,A., Margetts,M., Hensley,A., Nguyen,Q., Sinclair,A.,
            Koopman,P. and Pelosi,E.
  TITLE     Functional genomics analysis identifies loss of HNF1B function as a
            cause of Mayer-Rokitansky-Kuster-Hauser syndrome
  JOURNAL   Hum Mol Genet 32 (6), 1032-1047 (2023)
   PUBMED   36282544
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Su-Feher,L., Rubin,A.N., Silberberg,S.N., Catta-Preta,R., Lim,K.J.,
            Ypsilanti,A.R., Zdilar,I., McGinnis,C.S., McKinsey,G.L.,
            Rubino,T.E. Jr., Hawrylycz,M.J., Thompson,C., Gartner,Z.J.,
            Puelles,L., Zeng,H., Rubenstein,J.L.R. and Nord,A.S.
  TITLE     Single cell enhancer activity distinguishes GABAergic and
            cholinergic lineages in embryonic mouse basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2108760119 (2022)
   PUBMED   35377797
REFERENCE   5  (bases 1 to 3014)
  AUTHORS   Weiss,A.C., Bohnenpoll,T., Kurz,J., Blank,P., Airik,R.,
            Ludtke,T.H., Kleppa,M.J., Deuper,L., Kaiser,M., Mamo,T.M.,
            Costa,R., von Hahn,T., Trowe,M.O. and Kispert,A.
  TITLE     Delayed onset of smooth muscle cell differentiation leads to
            hydroureter formation in mice with conditional loss of the zinc
            finger transcription factor gene Gata2 in the ureteric mesenchyme
  JOURNAL   J Pathol 248 (4), 452-463 (2019)
   PUBMED   30916783
REFERENCE   6  (bases 1 to 3014)
  AUTHORS   Ozaki,H., Nakamura,K., Funahashi,J., Ikeda,K., Yamada,G.,
            Tokano,H., Okamura,H.O., Kitamura,K., Muto,S., Kotaki,H., Sudo,K.,
            Horai,R., Iwakura,Y. and Kawakami,K.
  TITLE     Six1 controls patterning of the mouse otic vesicle
  JOURNAL   Development 131 (3), 551-562 (2004)
   PUBMED   14695375
REFERENCE   7  (bases 1 to 3014)
  AUTHORS   Backman,M., Machon,O., Van Den Bout,C.J. and Krauss,S.
  TITLE     Targeted disruption of mouse Dach1 results in postnatal lethality
  JOURNAL   Dev Dyn 226 (1), 139-144 (2003)
   PUBMED   12508235
REFERENCE   8  (bases 1 to 3014)
  AUTHORS   Li,X., Perissi,V., Liu,F., Rose,D.W. and Rosenfeld,M.G.
  TITLE     Tissue-specific regulation of retinal and pituitary precursor cell
            proliferation
  JOURNAL   Science 297 (5584), 1180-1183 (2002)
   PUBMED   12130660
REFERENCE   9  (bases 1 to 3014)
  AUTHORS   Kardon,G., Heanue,T.A. and Tabin,C.J.
  TITLE     Pax3 and Dach2 positive regulation in the developing somite
  JOURNAL   Dev Dyn 224 (3), 350-355 (2002)
   PUBMED   12112464
REFERENCE   10 (bases 1 to 3014)
  AUTHORS   Davis,R.J., Shen,W., Sandler,Y.I., Heanue,T.A. and Mardon,G.
  TITLE     Characterization of mouse Dach2, a homologue of Drosophila
            dachshund
  JOURNAL   Mech Dev 102 (1-2), 169-179 (2001)
   PUBMED   11287190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045154.1, AK041446.1 and AL672062.4.
            
            On Jul 21, 2005 this sequence version replaced NM_033605.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment in the 5' coding region and uses a different segment for
            its 3' coding region and UTR, compared to variant 1. The resulting
            protein (isoform 2) has a shorter and distinct C-terminus when it
            is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF257217.1, SRR7345562.506961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1432              AK045154.1         4-1435
            1433-2026           AK041446.1         1100-1693
            2027-3014           AL672062.4         70791-71778         c
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 49.13 cM"
     gene            1..3014
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /note="dachshund family transcription factor 2"
                     /db_xref="GeneID:93837"
                     /db_xref="MGI:MGI:1890446"
     exon            1..680
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2076
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dachshund homolog 2; dachshund 2; Dach2fiveprime;
                     Dach2threeprime"
                     /codon_start=1
                     /product="dachshund homolog 2 isoform 2"
                     /protein_id="NP_291083.1"
                     /db_xref="CCDS:CCDS30363.1"
                     /db_xref="GeneID:93837"
                     /db_xref="MGI:MGI:1890446"
                     /translation="MAVSAPPVISATSSSAGVPGGLFRAEPLYSSPGEPPRLTPNMIN
                     SFMANNHNGSVLGGGIGGGSGGSSNTNTNECRMVDMHGVKVASFLMDGQELICLPQVF
                     DLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFE
                     TLFTDCTNARRKRQMTRKQAVNSSRPGRPPKRSLGVLQDNARLLPHAVPGLLSPGLIT
                     PTGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSTTGGSESSWDKDKI
                     QSPLAASGPQHGIAHAALAGQPGLGGAPTLNPLQQNHLLSNRLDLPFMMMPHPLLPVS
                     LPPASVAMAMNQMNHLNTIANMAAAAQIHSPLSRAGASVIKERIPESPSPAPSLEESH
                     RPGSQTSSHPSSSVSSSPSQMDHHSERMVMMPNNREELIVDQDNGQSIKKFQRDNKEE
                     VPAQIPVMKSPLDKIQLAPGQALHPGFPGPFIFADSLSSVETLLTNIQGLLKVALDNA
                     RIQEKQIQQEKKELRIELFREREIRENLERQLAVELQSRSTMQKRLKKEKKAKRKLQE
                     ALEFESKRREQVEQALKQATSGDSGLRMLKDSGIPDIEIENSGTPHDSAAMQGGNYYC
                     LAMAQQLCSA"
     exon            681..719
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            720..832
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..964
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1123
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1296
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1432
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1516
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1665
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1813
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1960
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2026
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..3014
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2499..2504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2522
                     /gene="Dach2"
                     /gene_synonym="9430028N04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtggatgagc tggagccgga gccagcgcgc ttcagacttg agaacagttc agagagtcag
       61 aacgtgcctg aaagagagag agagagagtc agcgagtgag cgcaagggga cctaaaggag
      121 tcagggagag aaagctaggg ctctaagagc taggctcaag acagagtgac catggctgtc
      181 tctgcacctc cggtgatctc tgcaacttcc agcagcgccg gcgtcccggg gggtttattc
      241 cgggctgaac ccctgtattc gtctccagga gagccccctc gcctaacccc taacatgatc
      301 aacagtttca tggccaataa ccataacggc agtgtcttgg gtggcgggat tggtggtggc
      361 agcggtggca gcagcaacac caacacaaac gagtgccgga tggtcgacat gcacggggtg
      421 aaggtagctt cattcctgat ggatggccag gaactgatct gcctgccgca agtctttgac
      481 cttttcctca agcacctggt gggagggttg cacacagtgt acactaagct gaagagactc
      541 gacatatctc cggtggtgtg cactgtagag caagttcgaa tcctccgtgg gctgggggcc
      601 atccagccag gggtgaatcg ttgcaagctc atcaccagga aagactttga aactttgttc
      661 accgattgca ccaacgccag aaggaagagg caaatgacaa ggaaacaagc tgttaacagt
      721 tcaaggcctg gcaggccccc taagcgttct ttgggagtat tgcaagataa tgcccgactt
      781 ctgccccatg cagtcccagg cctcttatca ccaggactga tcactccaac aggtatcaca
      841 gctgcagcga tggctgaggc catgaagctc cagaagatga agcttatggc aatgaatact
      901 cttcagggta atggaagcca aaatgggact gagtcagagc cagatgacct taattctacg
      961 acaggtggaa gtgaatcctc ctgggataaa gataagatac aatctccact tgctgcttct
     1021 ggacctcaac atggaattgc tcatgcagca cttgctggtc agccaggcct tggaggtgct
     1081 ccgaccctta atccacttca gcagaatcac ctgctaagca atcgtctgga tctcccattt
     1141 atgatgatgc ctcatcccct acttccagtc agcttacctc ctgcatcagt tgccatggca
     1201 atgaatcaga tgaatcatct caatactatt gccaacatgg ctgctgcagc ccagattcac
     1261 agtccactct ccagagctgg tgcctctgtt ataaaggaac ggatcccaga gagtccttct
     1321 cctgctccct ctctggaaga gagtcatcgt cctgggagcc agacctcctc ccacccaagc
     1381 agcagtgtgt ccagctctcc ctcgcagatg gatcatcatt cagagagaat ggttatgatg
     1441 cccaacaatc gagaagagct tattgttgac caagataatg gacaaagcat aaaaaaattc
     1501 cagagggata ataaagaaga agtaccagct caaatcccag tcatgaagtc acccttggat
     1561 aagatccagt tggctcctgg acaggcattg catcctggat tccctggacc attcattttt
     1621 gcagatagtc tatcttctgt ggagactctg ttgaccaaca ttcagggtct actgaaagtg
     1681 gctttggata atgctcgtat ccaggagaag cagattcagc aggaaaagaa ggaactgcga
     1741 atagagctct tcagagaaag agaaattaga gaaaacctgg agcgacaact tgcagttgag
     1801 cttcaaagca gaagtacaat gcaaaagcgt ctgaaaaaag agaaaaaggc taagagaaaa
     1861 cttcaggaag ccttggaatt tgaatcaaag cgccgcgagc aagtggagca agcacttaaa
     1921 caagctacat ctggtgacag tggactgaga atgttaaaag attctggaat tccagatatt
     1981 gaaatagaaa acagtggaac gccgcatgac agtgctgcta tgcaaggagg taactattac
     2041 tgtttagcaa tggcacagca gttgtgttca gcctgaaagg tcctcgctgg ctttacatta
     2101 aagaagatac ttgtgattcc agtatatctc tgaaaatatc catcatggag ttatttcagt
     2161 tgtgtttatc agcaaagctc tgtgactgaa tcataatttc tatgttacat taagaaaaaa
     2221 aaaaggaata cgtgtatatt taaaaagcaa tgatgtgata atctttgtcc tggtattaga
     2281 ttcaccaatt taaaaacatg agctaaaccc tgatgactta agtatattga ccatatttga
     2341 tgatttttta tgctcatttc tgcttggctt tttgtccttc aaaaaaaaac atagtagtat
     2401 cttagagact agaaacttat atgtatggtt tctctgttct acaatatgtt aagttaaagt
     2461 acactttgtt taaaatgtac ttgctaaatt tcagtatgaa taaaagcatt ttgaatttgt
     2521 cagtcatttc tctgagtttt tatttccata ttgccaaatg caatcattga agtacaaagc
     2581 aaaaacatta caaatcaaaa tctagatact acaatgatgc ttgcataact ttctttagtg
     2641 ttgctctgtt gagagaatat gaatacaaat tacattccat ttcacgtgtt tagaataacc
     2701 aacattcttg ttttcagttg ttttagtgac ttatactaaa taaactcttc caaagaatac
     2761 atgcttactg attctgcttc catgatggtg tattgtagtc agaagtaaaa acttcattaa
     2821 tgaagaacta gaaaatcttc tatgtatatc tattaccaaa agtttcttct agacccactt
     2881 ccttatggaa acctatctga atatatatgt ttatgtacat atctagggaa tattttgttc
     2941 caaaatacaa aaacataaaa acttaaatct agttgagttc caataaattt tggttgccag
     3001 actggtattg tctc
//
