LOCUS       NM_007826               5466 bp    mRNA    linear   ROD 18-JUL-2023
DEFINITION  Mus musculus dachshund family transcription factor 1 (Dach1),
            transcript variant 1, mRNA.
ACCESSION   NM_007826
VERSION     NM_007826.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5466)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   2  (bases 1 to 5466)
  AUTHORS   Puelles L and Hidalgo-Sanchez M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5466)
  AUTHORS   Li Z, Jiao X, Robertson AG, Di Sante G, Ashton AW, DiRocco A, Wang
            M, Zhao J, Addya S, Wang C, McCue PA, South AP, Cordon-Cardo C, Liu
            R, Patel K, Hamid R, Parmar J, DuHadaway JB, Jones SJM, Casimiro
            MC, Schultz N, Kossenkov A, Phoon LY, Chen H, Lan L, Sun Y,
            Iczkowski KA, Rui H and Pestell RG.
  TITLE     The DACH1 gene is frequently deleted in prostate cancer, restrains
            prostatic intraepithelial neoplasia, decreases DNA damage repair,
            and predicts therapy responses
  JOURNAL   Oncogene 42 (22), 1857-1873 (2023)
   PUBMED   37095257
REFERENCE   4  (bases 1 to 5466)
  AUTHORS   Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo
            MM, Trowe MO and Kispert A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   5  (bases 1 to 5466)
  AUTHORS   Thomson E, Tran M, Robevska G, Ayers K, van der Bergen J,
            Gopalakrishnan Bhaskaran P, Haan E, Cereghini S, Vash-Margita A,
            Margetts M, Hensley A, Nguyen Q, Sinclair A, Koopman P and Pelosi
            E.
  TITLE     Functional genomics analysis identifies loss of HNF1B function as a
            cause of Mayer-Rokitansky-Kuster-Hauser syndrome
  JOURNAL   Hum Mol Genet 32 (6), 1032-1047 (2023)
   PUBMED   36282544
REFERENCE   6  (bases 1 to 5466)
  AUTHORS   Davis RJ, Shen W, Heanue TA and Mardon G.
  TITLE     Mouse Dach, a homologue of Drosophila dachshund, is expressed in
            the developing retina, brain and limbs
  JOURNAL   Dev Genes Evol 209 (9), 526-536 (1999)
   PUBMED   10502109
REFERENCE   7  (bases 1 to 5466)
  AUTHORS   Hammond KL, Lettice LA, Hill RE, Lee M, Boyle S and Hanson IM.
  TITLE     Human (DACH) and mouse (Dach) homologues of Drosophila dachshund
            map to chromosomes 13q22 and 14E3, respectively
  JOURNAL   Genomics 55 (2), 252-253 (1999)
   PUBMED   9933575
REFERENCE   8  (bases 1 to 5466)
  AUTHORS   Caubit X, Thangarajah R, Theil T, Wirth J, Nothwang HG, Ruther U
            and Krauss S.
  TITLE     Mouse Dac, a novel nuclear factor with homology to Drosophila
            dachshund shows a dynamic expression in the neural crest, the eye,
            the neocortex, and the limb bud
  JOURNAL   Dev Dyn 214 (1), 66-80 (1999)
   PUBMED   9915577
REFERENCE   9  (bases 1 to 5466)
  AUTHORS   Hammond KL, Hanson IM, Brown AG, Lettice LA and Hill RE.
  TITLE     Mammalian and Drosophila dachshund genes are related to the Ski
            proto-oncogene and are expressed in eye and limb
  JOURNAL   Mech Dev 74 (1-2), 121-131 (1998)
   PUBMED   9651501
  REMARK    GeneRIF: The mouse dachshund gene is related to the Ski
            proto-oncogene and is expressed in eye and limb.
REFERENCE   10 (bases 1 to 5466)
  AUTHORS   Stewart GJ, Savioz A and Davies RW.
  TITLE     Sequence analysis of 497 mouse brain ESTs expressed in the
            substantia nigra
  JOURNAL   Genomics 39 (2), 147-153 (1997)
   PUBMED   9027501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139060.1, BC059934.1, AC126264.3 and BC052005.1.
            
            [WARNING] On Sep 25, 2023 this sequence was replaced by
            NM_007826.4.
            
            On Sep 27, 2013 this sequence version replaced NM_007826.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF102547.1, AF090436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AK139060.1         2-223
            223-1561            BC059934.1         1-1339
            1562-1717           AC126264.3         87094-87249
            1718-5441           BC059934.1         1340-5063
            5442-5466           BC052005.1         2619-2643
FEATURES             Location/Qualifiers
     source          1..5466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 48.25 cM"
     gene            1..5466
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /note="dachshund family transcription factor 1"
                     /db_xref="GeneID:13134"
                     /db_xref="MGI:MGI:1277991"
     exon            1..1283
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..2712
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dachshund homolog 1; dachshund 1"
                     /codon_start=1
                     /product="dachshund homolog 1 isoform 1"
                     /protein_id="NP_031852.1"
                     /db_xref="CCDS:CCDS36994.1"
                     /db_xref="GeneID:13134"
                     /db_xref="MGI:MGI:1277991"
                     /translation="MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSI
                     GPPASSGPTLFRPEPIASSASSSAAATVTSPGGGGGGSGGGGGSGGNGGGGGSNCNPS
                     LAAGSSGGGVSAGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPL
                     PGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGG
                     LHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNAS
                     SRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAATNAAIAEA
                     MKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGSSGGSWDKETLHSPPSQGSQAPV
                     AHARMPAAFSLPVSHPLNHLQHSHLPPNGLELPFMMMPHPLIPVSLPPASVTMAMSQM
                     NHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSS
                     VSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLAGHDMGHESKRIHI
                     EKDETPLSTPTARDSIDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQGLLKV
                     AIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAK
                     RKLQEALEFETKRREQAEQTLKQAASADSLRVLNDSLTPEIEADRSGGRADAERTIQD
                     GRLYLKTTVMY"
     exon            1284..1399
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1561
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1717
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1890
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2026
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2161
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2313
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2461
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2605
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2674
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..5448
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctctcaat ctttgatcaa tgtacttgcc agggagaacc caagtccctc aaccctcctc
       61 cttttcacct tcatccttaa ctttgtgcta gagcgggacc cacacaccac cagccgaccc
      121 tccccgcccc acccccgcct ctcccccccc aagagcagcc cgcgatccca gccccgagag
      181 aggactcgca tttcgacttg cgggacactt ttgtgcgttt ctctctcgag cgcctctcgc
      241 gctcgcccct cctgcgctcg ctctttctta acctcacctc ctttttctcc tcttctctcc
      301 ctctctccaa ctaaggttcc ttcctagagt gcttgttgtc tctgcccccc cccccacctc
      361 gatccttgtc cccctttctc ccccttcccc tttggggggt gtgtggcaac ttttccccct
      421 cgcttctcct ccttctgttt ccccttatat gtgaccatgg cagtgccggc ggctttgatc
      481 cctccgaccc agctggtccc ccctcaaccc ccgatctcta cttctgcttc ctcctcgggc
      541 accaccacct ccacctcctc ggcgacctcg tctccggctc catccatcgg acccccggcg
      601 tcgtctgggc caactctgtt ccggccggag cccattgcct cttctgcttc ttcttcagcc
      661 gcggccacag tcacctctcc tggtggcggc ggcggcggca gcggaggcgg cggtggcagc
      721 ggcggcaacg gaggcggcgg cgggagcaac tgcaacccca gcctggcggc cgggagcagc
      781 ggcggcggcg ttagcgctgg cggcggcggc gcctccagca cccccatcac cgcgagcacc
      841 ggcagcagca gcagtagcag cagcagcagc agcagtagca gcagcagcag cagtagcagc
      901 agcagcagca gtagcagcag cagctgcggc cccctccctg ggaaacccgt gtactcaacc
      961 ccgtccccag tggaaaacac cccccagaat aatgagtgca aaatggtgga tctgagaggg
     1021 gccaaagtgg cttcctttac ggtggagggc tgcgagctga tctgcctgcc ccaggctttc
     1081 gacctgttcc tgaagcactt ggtggggggc ttgcacaccg tctacaccaa gctgaagcgg
     1141 ttggagatca cgccggtggt gtgcaatgtg gaacaggttc gcatcctgag gggactgggg
     1201 gccatccagc ccggagtgaa ccgctgcaaa ctcatctcca ggaaggactt cgagaccctc
     1261 tacaatgact gcaccaacgc cagttccaga cctggaaggc ctcctaagag gactcaaagt
     1321 gtcacttccc cagagaactc tcacatcatg ccgcattctg tccctggcct catgtctcct
     1381 ggaatcattc caccaacagg tctgactgca gctgctgcag ctgctgcagc tgctaccaat
     1441 gcagctattg ctgaagcaat gaaggtgaaa aaaataaaat tagaagctat gagcaactat
     1501 catgccagta acaaccaaca tggagcagat tctgaaaacg gggacatgaa ttcaagtgtt
     1561 ggcagcagtg gtggttcttg ggataaggaa acactgcact ctcccccatc ccagggatcc
     1621 caggctcctg ttgcacatgc ccgcatgcct gcagcgttta gccttccagt tagccatcct
     1681 ctcaaccatc tgcagcacag ccaccttccg ccaaatggac tggaacttcc ttttatgatg
     1741 atgccccacc ctctcattcc tgtcagccta cctccagcat ctgtcaccat ggcaatgagt
     1801 cagatgaacc accttagcac cattgcaaat atggcggcgg cagcacaagt tcagagtcct
     1861 ccatccaggg tggagacatc tgttattaag gagcgtgttc ccgacagtcc ctcgcctgct
     1921 ccatctctgg aggagggccg gaggcccggc agccacccat cctcacaccg cagcagcagt
     1981 gtgtccagct ccccggcgcg gactgagagt tcttccgaca gaatccctgt ccatcagaat
     2041 ggcctgtcca tgaaccagat gcttatgggt ttatccccaa atgtgcttcc tgggccaaag
     2101 gagggggatt tggctggtca tgacatgggg catgagtcaa aacggatcca cattgaaaaa
     2161 gatgagaccc cactttccac accaaccgca agagacagca tcgacaaact ttctctaact
     2221 gggcatggac aaccactacc tcccggcttc ccatctccct ttctgtttcc tgatggcctg
     2281 tcctccatag agactcttct cactaacata cagggcctct tgaaagttgc catagacaat
     2341 gccagagctc aagaaaagca ggtccaactg gaaaaaacag agctgaagat ggatttttta
     2401 agagaaagag aactaagaga aacactggag aagcagctgg ccatggaaca aaagaacaga
     2461 gccatagttc aaaagaggct aaagaaggaa aagaaagcaa agagaaaact gcaggaggca
     2521 ctagaatttg agacaaaacg ccgtgagcaa gcggagcaga cactgaaaca ggcagcttca
     2581 gcggacagtc tccgggtctt aaatgactcc ctgacccctg agatagaagc tgaccgcagc
     2641 ggagggagag cagatgctga aaggacaata caagatggaa gactgtattt gaaaactact
     2701 gtcatgtact gaatattcct tgttgaagaa acacgtcatc tactagagaa ctctggaggc
     2761 agaccttcat cgtcggaaag ttcaggaaaa aaacaaagtc catataaaag accttcttca
     2821 attttgtgtg ttagtgctct ctttcattta agtattccac aaaggcagaa aagtttcctc
     2881 cattgatttt tttttcaccc gtggttcata ccagagactg agaatgtttg taaatgtaca
     2941 catatcaaag ttcttacagt taatagctcc cctgtgctgc tggacacttg tgtagagagc
     3001 taaagacagg tctgaggaag accgagctct ggtttgtttt ctttttcttc ttaatggaat
     3061 gaactttttt tccctcttct gacagttctg taactgagca catcagcaga ctttgtagca
     3121 gctcacccag acttacagaa ttgtgtccca cagaaaccag caagaatcta tgggataaac
     3181 tttgaagggt catagaggat tctgggaggg ggaaatgaga gaagtgagag tattctgtta
     3241 catacaattt taaactctat aactgcaggt tttgtcctga agaccttttt catatacttt
     3301 ctgaaagtcc aacaaacaga tgctaacaac tcaatgaaat tacattttgc atatctgaaa
     3361 aagaagcatt gaatataagc caaacggttt cactggtggt ctctttttct taaagataaa
     3421 aatatataaa aaatatatat aaatataaca tgttttcatt ccaaactggt agcggtatat
     3481 aggattaaaa ataataatgt tgcttcttat tcaaactgtt ggtcatatgt acagtatata
     3541 aacataaaac tcacaggaag gtattatgta tgcagtagta tactagcgtt taggaaatga
     3601 aaattttaga aaatatgttt tgtcaccctg ttggtcagaa agatgtcttt ctggttttaa
     3661 cgcatgcagg catgtaaata tttgtctgga gtcacagtat taatgaatga gatcttatac
     3721 atctggtgac atcagaattc tgtcagccat ttttatttgt atattgatcc ctagtgagta
     3781 ccccaaactc cactacagag ggtgaattgt ggctgaccag taaatcaaaa caccagagat
     3841 atttttatat gttaatgtca tattatgtta atgttgctga aaaacaaaac ttaataagcc
     3901 cttggtgtat tggtccaagg ccatgtagcc ccaggtgatg aagttaaact gtgctgtgat
     3961 tcccagctca ttcagaggga acgggggcgg gggggctacg tgctattttc actgtctttt
     4021 tgaaagttac agtatgcgtt ttcatatttg tgcgtataac tggaagtaaa gctgcaaaca
     4081 gtgcttatca tatgctgacg ttaagtttgt ttttaaacat tgggagtaac ccttctaaag
     4141 actttcatga acccatgcag ttgctctaca ctttatgatt ttctgtcata ttaaagtttt
     4201 gtcattatag tatttttatt accattaaaa acaaagtgat aaatctaaag cagctagcat
     4261 cagtgtgttt aaagatagtt ttgattgggt aattattatt tggttaagac aaaaaaaaag
     4321 ttcctattat ggattctgtg tcactgagct cctgtcattt ttaggtcttc ctttcagttc
     4381 tgaagcataa ctaattcttg gctgtaactt gctattaact ggttaagttc acttttttta
     4441 agaaaacaaa aggttatatg tatagttctt ttagcttgca ttaaagggga ataatatttt
     4501 aatttaaaac actgttagta actgctttgt agaaatggtt tgctgagcat aattcttcca
     4561 tggtcatgtt ttgttgtttg agcaaaagag attcaattct tacttacatg tatttttgtt
     4621 tgtttttccc tacatacatg catacatact gtaaatgatt acagttctta aaattggaag
     4681 gatttgtaga aaggtttgga gtcgtacatg ttttttaaga gactattttg tttttgcttt
     4741 tgtttttaag actacaactt acataggtag gagttgatca ttgctctgct cctggcatag
     4801 agtcacctgt taaatggggt agttttaaaa gacttatgtg aaagacctat gagaatgcat
     4861 tagtgtttgg ttcagcataa aagaaaattt taggatcgaa gacaaaaagc tatccactat
     4921 atgttaagag actcttatta acctgttgta catattacaa ttcacaaaat gttattgtaa
     4981 gtttgtaact taatttttcc ctctttttag ttaaacaggt ttatttagaa atttgtgttt
     5041 tggtgtaagc aagtaaaatt gtgcccattt tatggtcccc atgcttttgt aatcttacaa
     5101 atattaacgt ctagttgttc tatattataa ccatatttgc gctctatgca agcccttgga
     5161 acagaacata ctcatcttca tgtaggacct atgaaaattg tctattttta tctatatatt
     5221 taaagttttc taaaaatgat aaaaggttat tacgaatttt gttgtacaaa atctgtacaa
     5281 aaatctgttt ttacatcata atgcaagaat tggaaatttt tctatggtag cctagttatt
     5341 tgagcctggt ttcaatgtga gaaccacgtt tactgttatt gtatttaatt ttctttttct
     5401 tttcaacaat ctcctaataa aaatgtctga aatcgccttg cgactttaaa aaaaaaaaaa
     5461 aaaaaa
//
