LOCUS       NM_023118               4520 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus disabled 2, mitogen-responsive phosphoprotein (Dab2),
            transcript variant 1, mRNA.
ACCESSION   NM_023118
VERSION     NM_023118.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4520)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   2  (bases 1 to 4520)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (bases 1 to 4520)
  AUTHORS   Roy,S., Mehta,D., Paradkar,A., Chovatiya,G. and Waghmare,S.K.
  TITLE     Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of
            hair follicle stem cells
  JOURNAL   Commun Biol 7 (1), 525 (2024)
   PUBMED   38702433
  REMARK    GeneRIF: Dab2 (Disabled-2), an adaptor protein, regulates
            self-renewal of hair follicle stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4520)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4520)
  AUTHORS   Rbaibi,Y., Long,K.R., Shipman,K.E., Ren,Q., Baty,C.J., Kashlan,O.B.
            and Weisz,O.A.
  TITLE     Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal
            tubule cells
  JOURNAL   Mol Biol Cell 34 (7), ar74 (2023)
   PUBMED   37126375
  REMARK    GeneRIF: Megalin, cubilin, and Dab2 drive endocytic flux in kidney
            proximal tubule cells.
REFERENCE   6  (bases 1 to 4520)
  AUTHORS   Duncan,R.R., Betz,A., Shipston,M.J., Brose,N. and Chow,R.H.
  TITLE     Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo
  JOURNAL   J Biol Chem 274 (39), 27347-27350 (1999)
   PUBMED   10488064
  REMARK    Erratum:[J Biol Chem 2000 Jan 21;275(3):2246]
REFERENCE   7  (bases 1 to 4520)
  AUTHORS   Cho,S.Y., Cho,S.Y., Lee,S.H. and Park,S.S.
  TITLE     Differential expression of mouse Disabled 2 gene in retinoic
            acid-treated F9 embryonal carcinoma cells and early mouse embryos
  JOURNAL   Mol Cells 9 (2), 179-184 (1999)
   PUBMED   10340473
REFERENCE   8  (bases 1 to 4520)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 4520)
  AUTHORS   Xu,X.X., Yi,T., Tang,B. and Lambeth,J.D.
  TITLE     Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
  JOURNAL   Oncogene 16 (12), 1561-1569 (1998)
   PUBMED   9569023
REFERENCE   10 (bases 1 to 4520)
  AUTHORS   Xu,X.X., Yang,W., Jackowski,S. and Rock,C.O.
  TITLE     Cloning of a novel phosphoprotein regulated by colony-stimulating
            factor 1 shares a domain with the Drosophila disabled gene product
  JOURNAL   J Biol Chem 270 (23), 14184-14191 (1995)
   PUBMED   7775479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856968.1, CB952492.1, CD348957.1, CB598046.1, AK165519.1,
            AK162851.1 and AC105324.11.
            
            On Aug 22, 2007 this sequence version replaced NM_023118.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154716.1, U18869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BB856968.1         2-85
            85-613              CB952492.1         74-602
            614-1144            CD348957.1         137-667
            1145-1602           CB598046.1         186-643
            1603-1699           CB598046.1         645-741
            1700-2519           AK165519.1         930-1749
            2520-3436           AK162851.1         1837-2753
            3437-4520           AC105324.11        29718-30801         c
FEATURES             Location/Qualifiers
     source          1..4520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 2.15 cM"
     gene            1..4520
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /note="disabled 2, mitogen-responsive phosphoprotein"
                     /db_xref="GeneID:13132"
                     /db_xref="MGI:MGI:109175"
     exon            1..185
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            186..374
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..2584
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /note="isoform a is encoded by transcript variant 1;
                     mitogen-responsive phosphoprotein; disabled homolog 2;
                     adaptor molecule disabled-2; differentially expressed in
                     ovarian carcinoma 2"
                     /codon_start=1
                     /product="disabled homolog 2 isoform a"
                     /protein_id="NP_075607.2"
                     /db_xref="CCDS:CCDS37029.1"
                     /db_xref="GeneID:13132"
                     /db_xref="MGI:MGI:109175"
                     /translation="MSNEVETSTTNGQPDQQAAPKAPSKKEKKKGSEKTDEYLLARFK
                     GDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGI
                     KIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVV
                     DLKDLFQVIYNVKKKEEDKKKVEEANKAEENGSEALMTLDDQANKLKLGVDQMDLFGD
                     MSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGVTSCSLPRPKPQASFLP
                     ENAFSANLNFFPTPNPDPFRDDPFAQPDQSAPSSFDSLTSPDQKKASLSSSSTPQSKG
                     PLNGDTDYFGQQFDQLSNRTGKPEAQGGPWPYPSSQTQQAVRTQNGVSEREQNGFHIK
                     SSPNPFVGSPPKGLSVPNGVKQDLESSVQSSAHDSIAIIPPPQSTKPGRGRRTAKSSA
                     NDLLASDIFASEPPGQMSPTGQPAVPQSNFLDLFKGNAPAPVGPLVGLGTVPVTPPQA
                     GPWTPVVYSPSTTVVPGAIISGQPPSFGQPLVFGTTPAVQVWNQSPSFATPASPPPPT
                     VWCPTTSVAPNAWSSTSPLGNPFQSNNIFPPPTMSTQSSPQPMMSSVLATPPQPPPRN
                     GPLKDIPSDAFTGLDPLGDKEVKEVKEMFKDFQLRQPPLVPSRKGETPPSGTSSAFSS
                     YFNNKVGIPQEHVDHDDFDANQLLNKINEPPKPAPRQGVLLGTKSADNSLENPFSKGF
                     SSSNPSVVSQPASSDPHRSPFGNPFA"
     exon            375..514
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            515..613
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            614..745
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            746..826
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            827..853
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            854..907
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            908..970
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1624
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1778
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..2414
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2521
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2589
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..4520
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /note="hexamer: AATAAA"
     polyA_site      3417
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /note="major polyA site"
     regulatory      3419..3424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /note="hexamer: AATAAA"
     polyA_site      3439
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
     regulatory      4500..4505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /note="hexamer: AATAAA"
     polyA_site      4520
                     /gene="Dab2"
                     /gene_synonym="5730435J12Rik; D15Wsu122e; D630005B22Rik;
                     Doc-2; Doc2; p96"
                     /note="major polyA site"
ORIGIN      
        1 agcaaaaaca tcccgccgcc acattcctgg agagtcctca gagccagcat ctgattagaa
       61 ccatatctct accgggagtg gccgcgcggc tatttaagtg gcgttctccg cgtcctcggc
      121 gctgcagcct tgaggcttcg ggcgcgggga agtcatgctg gctccacaga agcactagct
      181 agtccgtgta ctttgtgggt tctgtccttt tgagacctgc ccgtcgggga ttggctggta
      241 tcagtgactg tctactgctg gattttctgc ttgccttccc gtcatgtcta acgaagtaga
      301 aacaagcaca accaatggcc agcctgacca acaggctgcc ccgaaagcgc catcaaagaa
      361 ggagaagaag aaaggttctg aaaagacaga cgagtacttg ttggccaggt tcaaaggtga
      421 tggtgtaaaa tacaaggcca agctaatcgg tattgatgat gtgcctgatg ctcgaggaga
      481 caaaatgagt caggattcta tgatgaaact caagggaatg gcagcagctg gtcgctctca
      541 gggacaacac aagcaaagaa tctgggtcaa catttccttg tctggcataa aaatcattga
      601 tgagaaaact ggggtaattg aacatgaaca tccagtaaat aagatttcct tcattgctcg
      661 tgatgtgaca gacaacagag catttggtta tgtgtgtgga ggtgaaggcc agcatcaatt
      721 ttttgctata aaaacagggc aacaggctga accattagtc gtcgatctta aagacctttt
      781 tcaagttatc tataatgtaa agaaaaagga agaagataag aaaaaggttg aagaagccaa
      841 caaagcagaa gagaatggaa gtgaggccct aatgaccctt gatgatcaag ctaacaaatt
      901 gaagctgggt gttgaccaga tggatttgtt tggggacatg tctacacctc ctgacctaaa
      961 tagtccaaca gaaagcaaag atatcctgtt agtggatcta aactctgaaa tcgacaccaa
     1021 tcagaactct ttaagagaaa atccattctt aacaaatgga gtcacctcct gttctctccc
     1081 tcgaccaaag cctcaggcat ccttcttgcc tgagaacgcc ttttctgcca atctcaactt
     1141 ctttcccacc cctaaccctg atcctttccg tgatgatccc tttgcacagc cagaccaatc
     1201 ggcaccctct tcgtttgatt ctctcacatc tccagatcag aagaaagcga gtctgagtag
     1261 ctcgtctact ccacagagta aagggcccct gaacggtgat actgattact ttggtcagca
     1321 atttgaccag ctctctaacc ggactggcaa accggaagct cagggaggcc cgtggcccta
     1381 cccaagttcg cagacccagc aagcagtgag aactcaaaat ggggtatctg aaagagaaca
     1441 gaacggcttc catatcaaat cttccccgaa cccttttgtg ggaagccctc ccaaaggact
     1501 atcggtaccg aatggcgtaa agcaggactt ggaaagttct gtccagtcct cagcacatga
     1561 ctccatagcc attatcccac ctccacaaag taccaaacca ggaagaggca gaaggactgc
     1621 taagtcttca gcaaacgact tgcttgcttc agacatcttt gcctcagaac ctccaggcca
     1681 gatgtccccc acaggacaac ctgcagtccc gcagtcgaac tttctggatc tcttcaaagg
     1741 caatgctcct gccccagtgg ggccccttgt aggtctaggt acggtcccag taacaccccc
     1801 ccaagcagga ccctggacgc ctgttgtcta cagtccttcg acaactgtgg tcccaggagc
     1861 cataataagt ggccagcctc ccagttttgg ccagccactc gtttttggta caaccccagc
     1921 agtacaagtc tggaatcagt ctccatcatt tgcaacccca gcttcccctc caccccccac
     1981 agtttggtgt cctaccacat ctgtggcgcc caacgcttgg tcatccacaa gccctctggg
     2041 gaatcctttt cagagtaata atatctttcc acctcccacc atgtccactc agtcctctcc
     2101 tcagcctatg atgtcctctg ttctggccac accgcctcaa ccacctcccc gaaatggccc
     2161 actaaaggac attcccagtg acgctttcac tggcttagac ccccttgggg ataaagaggt
     2221 caaggaagtg aaagaaatgt ttaaggactt ccagctgcgg cagccacctc ttgttccctc
     2281 aaggaagggg gagacgcctc cctctgggac ttcaagcgcc ttctccagtt acttcaacaa
     2341 taaagttggc attcctcagg agcatgtaga ccatgatgat tttgatgcca atcaactgtt
     2401 gaacaagatt aatgaaccac caaagccagc cccgagacaa ggtgtcctct tgggtaccaa
     2461 gtctgctgac aattcactcg agaacccttt ctccaaaggg ttcagctcat caaacccctc
     2521 tgtggtttct cagcctgcat cttctgatcc ccacaggagc cctttcggaa atccttttgc
     2581 ctagcttctg aagttgtaat gatgactatc cagatgagca aaagactggc tttggtcaag
     2641 aatgaagcag acagccagaa acatgttgac ctctgtcctc gctccagctt tgacgtatta
     2701 tctgttaccc tatttgtttt ggcctcttgt acttgtaaaa tgcctttcat tttcctgtct
     2761 aggctaaagc taaacttaaa ctatggcttt acgtaaatta agctcctaaa ctctctagct
     2821 ccaatataaa tgaagtagct tccctatcaa atccttgtct gttgtgcccc cttgaaactt
     2881 ccagaatatt ctccattcta ccctccattt gggaggagcg gctaccttta cccttaatat
     2941 cacactgcct tgagtcaatg tccaaatact catagctctc aaagtcattt ggggttcctg
     3001 gtgtgcggcc taaacctaaa gcatcctatt aatagggaag taagacacct tgcttcctat
     3061 gtccactcag aaagaatttt atttaataaa atgaaagcaa gactaacttc tcaaatccac
     3121 ccaaggacca ttttgagatg gtcgtttctc agctaactgc accatttacc aatcctgccc
     3181 caagtggtgc ttacatttga cttgaagaag agaaagagct aactcaaaac acaaggcatt
     3241 attcaaagct aataaaacaa tttctccctg gggccccaca ttgttttcat tccagatacg
     3301 ttgcagctgt ttgaccctga tgacattatg ccctacattt tccttgaaga tcctgatttt
     3361 atttcatgtg atttttgttt ctcaataaag atgattattg tgtgcattac taaaaaataa
     3421 taaagtataa tttctctcat tctggtgatc tctcccagga cctaggctgt tccattttca
     3481 atctcttgct ggctgtttta aatgagagga aagcattctt tatctctccc tgtctttctc
     3541 tctttctctt tcagttcatt ttgctcctgg gtttatataa acagtgcctc ccttttacca
     3601 ggaatggatt tttcacgggg caaaaagcat taaatgtttc acagatctga agtgcacgca
     3661 cccactccag tcattgttag tccaggggct agacttctgg aaggtgcacc ttcttcattc
     3721 tccctatggc ttgggggact tagactgaag tttcatagag caatttaaca cagtagggga
     3781 actggattct gctcagcagt gaaggactgt attctgaaag ctaaatgtga ctatgctaga
     3841 cacactgggt ccttactgga tgactaggcc tttatcaagt aactggaaaa ctttcttgaa
     3901 gccacaatca tggacaaata tttggggtta tcattgaaaa atctgcctga aatatattcc
     3961 tcatagcctt ggaaacctac acagtacatt ttcatttcca ggctttttgt tatacagagc
     4021 tgaagggttt gttcctgcca agttgtgttt ttttttttag tttatgttga gtattttttt
     4081 ttcaatgtta tctcttgacc caaaatgctc aggtccttgt gggtgttagt ccaatcttac
     4141 cttttgttgg aagagaatga ctgctcaggt tttaaacaag gcgctagcct tgtgagcctc
     4201 tgttaattag ccccaagtga tccaagctga agtcctgtgg gtttctgttt aatgctagtg
     4261 gttaattatc tatgatatgt gtttcttttt tcctgtctga cttcctactc agtcattatg
     4321 aacagacttg aaatcatact ttaaaaattt caaatacctg aagatgtgct aaagtgaagg
     4381 taactctttc tagatagtcg agtttttgaa agtaatgatc agccacacaa ctgttttgta
     4441 tgtacttgtc ttcttgtgca cttttctgta tgcaaacaaa tctataaatt tacgcattca
     4501 ataaactgga atgacaaaaa
//
