LOCUS       NM_010014               1209 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus disabled 1 (Dab1), transcript variant 1, mRNA.
ACCESSION   NM_010014 XR_104874 XR_107606
VERSION     NM_010014.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1209)
  AUTHORS   Skelin,L., Racetin,A., Kelam,N., Ogorevc,M., Znaor,L.,
            Saraga-Babic,M., Filipovic,N., Katsuyama,Y., Pogorelic,Z. and
            Vukojevic,K.
  TITLE     Connexin Expression Is Altered in the Eye Development of Yotari
            Mice: A Preliminary Study
  JOURNAL   Biomolecules 14 (9), 1174 (2024)
   PUBMED   39334940
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1209)
  AUTHORS   Honda,T., Hirota,Y. and Nakajima,K.
  TITLE     Heterozygous Dab1 Null Mutation Disrupts Neocortical and
            Hippocampal Development
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   36941061
  REMARK    GeneRIF: Heterozygous Dab1 Null Mutation Disrupts Neocortical and
            Hippocampal Development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1209)
  AUTHORS   Ishii,K., Kohno,T., Sakai,K. and Hattori,M.
  TITLE     Reelin regulates the migration of late-born hippocampal CA1 neurons
            via cofilin phosphorylation
  JOURNAL   Mol Cell Neurosci 124, 103794 (2023)
   PUBMED   36435394
REFERENCE   4  (bases 1 to 1209)
  AUTHORS   Maglica,M., Kelam,N., Haque,E., Perutina,I., Racetin,A.,
            Filipovic,N., Katsuyama,Y. and Vukojevic,K.
  TITLE     Immunoexpression Pattern of Autophagy Markers in Developing and
            Postnatal Kidneys of Dab1-/-(yotari) Mice
  JOURNAL   Biomolecules 13 (3), 402 (2023)
   PUBMED   36979337
  REMARK    GeneRIF: Immunoexpression Pattern of Autophagy Markers in
            Developing and Postnatal Kidneys of Dab1[-/-](yotari) Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1209)
  AUTHORS   Kelam,N., Racetin,A., Katsuyama,Y., Vukojevic,K. and Kostic,S.
  TITLE     Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and
            HIP2 in Developing and Postnatal Kidneys of Dab1-/- (yotari) Mice
  JOURNAL   Int J Mol Sci 23 (4), 2025 (2022)
   PUBMED   35216141
  REMARK    GeneRIF: Immunohistochemical Expression Pattern of FGFR1, FGFR2,
            RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-)
            (yotari) Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1209)
  AUTHORS   Howell,B.W., Hawkes,R., Soriano,P. and Cooper,J.A.
  TITLE     Neuronal position in the developing brain is regulated by mouse
            disabled-1
  JOURNAL   Nature 389 (6652), 733-737 (1997)
   PUBMED   9338785
REFERENCE   7  (bases 1 to 1209)
  AUTHORS   Sheldon,M., Rice,D.S., D'Arcangelo,G., Yoneshima,H., Nakajima,K.,
            Mikoshiba,K., Howell,B.W., Cooper,J.A., Goldowitz,D. and Curran,T.
  TITLE     Scrambler and yotari disrupt the disabled gene and produce a
            reeler-like phenotype in mice
  JOURNAL   Nature 389 (6652), 730-733 (1997)
   PUBMED   9338784
REFERENCE   8  (bases 1 to 1209)
  AUTHORS   Ware,M.L., Fox,J.W., Gonzalez,J.L., Davis,N.M., Lambert de
            Rouvroit,C., Russo,C.J., Chua,S.C. Jr., Goffinet,A.M. and
            Walsh,C.A.
  TITLE     Aberrant splicing of a mouse disabled homolog, mdab1, in the
            scrambler mouse
  JOURNAL   Neuron 19 (2), 239-249 (1997)
   PUBMED   9292716
REFERENCE   9  (bases 1 to 1209)
  AUTHORS   Howell,B.W., Gertler,F.B. and Cooper,J.A.
  TITLE     Mouse disabled (mDab1): a Src binding protein implicated in
            neuronal development
  JOURNAL   EMBO J 16 (1), 121-132 (1997)
   PUBMED   9009273
REFERENCE   10 (bases 1 to 1209)
  AUTHORS   Sweet,H.O., Bronson,R.T., Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Scrambler, a new neurological mutation of the mouse with
            abnormalities of neuronal migration
  JOURNAL   Mamm Genome 7 (11), 798-802 (1996)
   PUBMED   8875886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY264959.1, Y08381.1 and BE947086.1.
            
            On Oct 30, 2013 this sequence version replaced NM_010014.2.
            
            Transcript Variant: This variant (1) lacks several exons and
            includes an alternate 3' terminal exon, compared to variant 2. It
            encodes isoform 1 which is shorter and has a distinct C-terminus,
            compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08381.1, SRR7345562.4028447.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY264959.1         2-53
            53-1178             Y08381.1           1-1126
            1179-1209           BE947086.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..1209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 47.79 cM"
     gene            1..1209
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /note="disabled 1"
                     /db_xref="GeneID:13131"
                     /db_xref="MGI:MGI:108554"
     exon            1..180
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /inference="alignment:Splign:2.1.0"
     exon            181..382
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..969
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /note="isoform 1 is encoded by transcript variant 1;
                     yotari; disabled homolog 1"
                     /codon_start=1
                     /product="disabled homolog 1 isoform 1"
                     /protein_id="NP_034144.1"
                     /db_xref="GeneID:13131"
                     /db_xref="MGI:MGI:108554"
                     /translation="MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKA
                     KLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTG
                     ALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQL
                     IYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQVISEPRQGFACSCEGSFD"
     exon            383..522
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /inference="alignment:Splign:2.1.0"
     exon            523..621
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /inference="alignment:Splign:2.1.0"
     exon            622..753
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /inference="alignment:Splign:2.1.0"
     exon            754..873
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1193
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1167..1172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /note="hexamer: AATAAA"
     polyA_site      1186
                     /gene="Dab1"
                     /gene_synonym="C630028C02Rik; mDab1; scm; scr; scrambler;
                     yot"
                     /note="major polyA site"
ORIGIN      
        1 ggtctcctcc ccctgctctg acgcgcgccc gtcgcttccc ggggaggatg gacccagctc
       61 ggcgctcacc cgggcttccc cgggctggag agcgcgtttg agtgcggccg cccgcagggc
      121 atggagagcc gtgtcccggg cggctgcggc agccaaggag gatgctccgg gggagccgag
      181 cactccgcca gagtgaatga catgcacggt gttgggtgtc ctttctgaag ggaggagcct
      241 ttctcttgga gaggatcctc gatgagcctg gccgaggccc ggggtctgtg tgaagaggac
      301 taaggattaa gtaggatgtc aactgagaca gaacttcaag tagctgtgaa aaccagcgcc
      361 aagaaagact ccaggaagaa aggtcaggat cgcagcgaag ccactttgat aaagaggttt
      421 aaaggcgaag gggtccggta caaagccaag ctgattggga ttgatgaagt gtccgcagct
      481 cggggagaca agttatgtca agattccatg atgaagctca agggtgttgt tgctggcgca
      541 cgttccaagg gagaacacaa acagaaaatc tttttaacca tctcctttgg aggaatcaaa
      601 atctttgatg agaagacggg ggcccttcag catcaccatg ctgttcatga aatttcctac
      661 attgcgaagg acatcacaga tcatcgggct ttcggatacg tttgcgggaa ggaagggaat
      721 cacagatttg tggccatcaa aacagcccag gcggctgaac ctgttatcct ggacttgaga
      781 gatctctttc aactcatcta tgagctgaag caaagagaag aattggaaaa aaaggcacaa
      841 aaggataagc agtgtgaaca agctgtgtac cagaccattt tggaagagga tgtggaagat
      901 cccgtgtacc aggtaatttc tgaaccacgt cagggttttg catgcagctg tgaaggctct
      961 tttgactgaa acttgaggat tctgttgaac gcagaacctg cagaagaatt aagatgattt
     1021 ctgaaggcca gggttgccag cctctgcagg gagagaattt ttccacacta agaagccagc
     1081 agccgtgatg ggagatctag aaatccactt ccttcttcgt acccttgctt cagacccctc
     1141 cccaatctgg aaagttttat cctagaaata aatgtttttc agtggtctct tgaaaaaaaa
     1201 aaaaaaaaa
//
