LOCUS       NM_001379372            5874 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus dishevelled associated activator of morphogenesis 2
            (Daam2), transcript variant 3, mRNA.
ACCESSION   NM_001379372 XM_006525091
VERSION     NM_001379372.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5874)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5874)
  AUTHORS   Colozza,G., Lee,H., Merenda,A., Wu,S.S., Catala-Bordes,A.,
            Radaszkiewicz,T.W., Jordens,I., Lee,J.H., Bamford,A.D.,
            Farnhammer,F., Low,T.Y., Maurice,M.M., Bryja,V., Kim,J. and
            Koo,B.K.
  TITLE     Intestinal Paneth cell differentiation relies on asymmetric
            regulation of Wnt signaling by Daam1/2
  JOURNAL   Sci Adv 9 (47), eadh9673 (2023)
   PUBMED   38000028
REFERENCE   3  (bases 1 to 5874)
  AUTHORS   Wang,C.Y., Zuo,Z., Jo,J., Kim,K.I., Madamba,C., Ye,Q., Jung,S.Y.,
            Bellen,H.J. and Lee,H.K.
  TITLE     Daam2 phosphorylation by CK2alpha negatively regulates Wnt activity
            during white matter development and injury
  JOURNAL   Proc Natl Acad Sci U S A 120 (35), e2304112120 (2023)
   PUBMED   37607236
REFERENCE   4  (bases 1 to 5874)
  AUTHORS   Cristobal,C.D., Wang,C.Y., Zuo,Z., Smith,J.A., Lindeke-Myers,A.,
            Bellen,H.J. and Lee,H.K.
  TITLE     Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin
            Cytoskeleton through Rac1 and Gelsolin
  JOURNAL   J Neurosci 42 (9), 1679-1691 (2022)
   PUBMED   35101966
  REMARK    GeneRIF: Daam2 Regulates Myelin Structure and the Oligodendrocyte
            Actin Cytoskeleton through Rac1 and Gelsolin.
REFERENCE   5  (bases 1 to 5874)
  AUTHORS   Jo,J., Woo,J., Cristobal,C.D., Choi,J.M., Wang,C.Y., Ye,Q.,
            Smith,J.A., Ung,K., Liu,G., Cortes,D., Jung,S.Y., Arenkiel,B.R. and
            Lee,H.K.
  TITLE     Regional heterogeneity of astrocyte morphogenesis dictated by the
            formin protein, Daam2, modifies circuit function
  JOURNAL   EMBO Rep 22 (12), e53200 (2021)
   PUBMED   34633730
REFERENCE   6  (bases 1 to 5874)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
REFERENCE   7  (bases 1 to 5874)
  AUTHORS   Nakaya,M.A., Habas,R., Biris,K., Dunty,W.C. Jr., Kato,Y., He,X. and
            Yamaguchi,T.P.
  TITLE     Identification and comparative expression analyses of Daam genes in
            mouse and Xenopus
  JOURNAL   Gene Expr Patterns 5 (1), 97-105 (2004)
   PUBMED   15533824
  REMARK    GeneRIF: Daams are expressed in tissues known to require Wnts, so
            effectors of Wnt signaling during vertebrate development.
REFERENCE   8  (bases 1 to 5874)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   9  (bases 1 to 5874)
  AUTHORS   Kida,Y., Shiraishi,T. and Ogura,T.
  TITLE     Identification of chick and mouse Daam1 and Daam2 genes and their
            expression patterns in the central nervous system
  JOURNAL   Brain Res Dev Brain Res 153 (1), 143-150 (2004)
   PUBMED   15464228
  REMARK    GeneRIF: involved in pivotal steps in neuronal cell differentiation
            and movement
REFERENCE   10 (bases 1 to 5874)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124748.5 and AC165258.2.
            
            On Apr 1, 2020 this sequence version replaced XM_006525091.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.19360.1,
                                           SRR10223969.17852.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC124748.5         160054-160161
            109-334             AC165258.2         62869-63094
            335-424             AC165258.2         65586-65675
            425-499             AC165258.2         67351-67425
            500-594             AC165258.2         67885-67979
            595-928             AC165258.2         71473-71806
            929-1039            AC165258.2         72745-72855
            1040-1143           AC165258.2         73510-73613
            1144-1210           AC165258.2         75290-75356
            1211-1328           AC165258.2         76306-76423
            1329-1467           AC165258.2         78735-78873
            1468-1526           AC165258.2         81018-81076
            1527-1711           AC165258.2         81186-81370
            1712-2011           AC165258.2         81835-82134
            2012-2119           AC165258.2         85245-85352
            2120-2226           AC165258.2         88408-88514
            2227-2311           AC165258.2         89753-89837
            2312-2418           AC165258.2         92034-92140
            2419-2507           AC165258.2         92339-92427
            2508-2676           AC165258.2         97169-97337
            2677-2784           AC165258.2         97767-97874
            2785-2845           AC165258.2         99599-99659
            2846-2977           AC165258.2         101062-101193
            2978-3148           AC165258.2         102577-102747
            3149-5874           AC165258.2         103053-105778
FEATURES             Location/Qualifiers
     source          1..5874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 25.5 cM"
     gene            1..5874
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /note="dishevelled associated activator of morphogenesis
                     2"
                     /db_xref="GeneID:76441"
                     /db_xref="MGI:MGI:1923691"
     exon            1..108
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            109..334
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..3370
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /note="isoform 3 is encoded by transcript variant 3;
                     disheveled-associated activator of morphogenesis 2"
                     /codon_start=1
                     /product="disheveled-associated activator of morphogenesis
                     2 isoform 3"
                     /protein_id="NP_001366301.1"
                     /db_xref="GeneID:76441"
                     /db_xref="MGI:MGI:1923691"
                     /translation="MALRKRSPHGLGFLCCFGGSDLPEIDLRDSHPLQYLEFSGPIPN
                     PEELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQEDPNKLATSWPEYY
                     IDRINAMAAMQNLYETEDEETDKRNQVVEDLKTALRTQPMRFVTRFIDLEGLTCLLNF
                     LRGMDHTTCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVA
                     VLEILGAVCLVPGGHKKVLQAMLHYQAYAAERTRFQTLLNELDRSLGRYRDEVNLKTA
                     IMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMV
                     RNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNG
                     GYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEK
                     FRKEHMELMSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELV
                     ARHNESSTGPVSSPPPPGGPLTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPGGPP
                     IPPGAPPCFSSGPPPSHDPFSSNEAPLRKKRIPQPSHPLKSFNWVKLNEERVSGTVWN
                     EIDDSQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYITSRKVKELSVIDGRRAQNCI
                     ILLSKLKLSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMA
                     RADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELTLSQRLKQM
                     LEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDI
                     LNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDKFVPVMS
                     DFITVSSFSFSELEDQLNEARDKFAKALTHFGEQESKMQPDEFFGIFDTFLQAFLEAR
                     QDLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKVLAGGALEESGEFDDLVSALR
                     SGEVFDKDLSKFKRNRKRPGSQVPEVTRERAINRLNY"
     exon            335..424
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            425..499
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            500..594
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..928
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1039
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1143
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1210
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1328
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1467
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1526
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1711
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..2011
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2119
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2226
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2311
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2418
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2507
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2676
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2784
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2845
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2977
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3148
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..5874
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5853..5858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5874
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctttctccg gagtcctgag cagccaagga ctgagctgag caagcggagc gcggtgcctg
       61 cgggaagccg ggacagcagc agcctcaccg tgccatgcgg gcctcaggat tgtgccaatg
      121 aggacctaag gtgcctgccc gccaaccatc ccagcctgca gtgaccatgg ccctccgcaa
      181 gaggagtcct catggcctgg gcttcctttg ctgctttgga ggcagtgacc ttcccgagat
      241 cgacctccgg gacagccacc cactgcagta tctggagttc tccggtccca tcccgaatcc
      301 tgaggagctc aatgtccgct ttgcagagct ggtggatgaa ttggacctca cagataaaaa
      361 ccgagaggct gtgtttgcac taccacccga gaagaaatgg cagatctact gcagcaagag
      421 gaaggagcag gaggatccca acaagctggc aaccagttgg cctgagtact acattgatcg
      481 tatcaatgcc atggccgcca tgcagaatct gtatgaaact gaagatgagg agacagacaa
      541 gaggaaccaa gttgtagaag acctgaagac agccctccgg acacaaccca tgaggtttgt
      601 gacccgcttc atcgatctgg aaggcctgac ctgtctgctg aatttcctcc ggggcatgga
      661 ccacaccacc tgtgaaagcc gcatccacac atctctcatt ggctgcatca aggctctgat
      721 gaacaactct cagggccggg cacacgtcct ggcacaacct gaggccatca gcatcatcgc
      781 tcagagcctg cgcacagaga acagcaagac caaagttgca gtgctggaga tcctgggtgc
      841 agtgtgcctt gtacccggag gccacaagaa ggttctacag gccatgctac actatcaggc
      901 gtatgcagcc gagcgcactc gtttccagac tttgctgaat gaactggatc gaagcttagg
      961 ccgctaccgg gatgaggtaa acctgaagac agccatcatg tccttcatca atgctgtcct
     1021 caatgctggc gctggagagg ataacctgga attccgcctg catctccggt atgagttcct
     1081 gatgctgggg atccagccag tgattgataa actccggcaa cacgagaatg ccatcctgga
     1141 caagcattta gacttctttg agatggtccg gaatgaggat gacctggagc tagccaggag
     1201 gtttgacatg gtccacattg acacaaaaag tgcctcccag atgtttgagc tgatccacaa
     1261 gaagctgaag cacacggaag cctatccctg cctgctctct gtcctgcacc actgcctgca
     1321 gatgccctac aagcggaatg gtggctactt ccagcagtgg cagctcctgg accgaatcct
     1381 tcaacagatt gtcctccagg atgagcgagg ggtggaccct gacctggccc cactggaaaa
     1441 ctttaatgtc aagaacatcg ttaacatgct catcaatgag aatgaggtga agcagtggag
     1501 ggaccaggca gagaagtttc ggaaagaaca catggaactc atgagccggc tggagagaaa
     1561 agagcgggaa tgtgagacaa agacactgga gaaggaggag atgatgcgga cgctcaacaa
     1621 gatgaaggac aaactggccc gcgagtccca ggagctgcgc caagctaggg gacaagtggc
     1681 agagctggta gcccgacata atgagagctc aaccggcccg gtgtcctccc cacctccccc
     1741 tggaggtcca ctcaccttgt cttcctccag gacaaccaat gatctgcctc cacccccacc
     1801 acctctcccc tttgatagct gcccaccccc acccgcacca cccctccctc ccggagggcc
     1861 tcccatcccc ccaggtgccc caccctgctt cagctcaggc ccacccccat ctcatgaccc
     1921 cttctccagc aatgaagccc cactcaggaa aaagcgcatt ccccagcctt cacacccact
     1981 gaagtccttc aactgggtca agctgaatga ggagcgtgtt tctggcaccg tgtggaatga
     2041 aattgatgac tcgcaggtat ttcggattct ggacctggaa gactttgaaa aaatgttctc
     2101 ggcatatcag aggcaccaga aagaactggg ctccacggag gacatctaca taacctcccg
     2161 caaggttaaa gagctgtcag tcatcgatgg ccggagggcc cagaactgta tcattcttct
     2221 ctccaagctg aagctttcta atgatgaaat acggcaggcc atcttgcgga tggatgaaca
     2281 agaagacctc gctaaggaca tgctggagca gcttctcaag ttcatccccg agaagagcga
     2341 cattgatctc ctagaagagc acaaacatga gattgagagg atggcgcgtg cagatcgctt
     2401 cctctatgaa atgagcagga tcgaccatta ccagcaacgg ctacaggccc tgttcttcaa
     2461 gaagaagttc caggaacgcc tggctgaggc caagcccaaa gtagaagcca tcctgctggc
     2521 ctcccgggag ctgactctca gccagcgcct gaagcaaatg ctggaggtgg tcctagccat
     2581 cggcaacttc atgaacaagg ggcagcgtgg cggtgcctat ggcttccggg tagccagtct
     2641 caacaagatc gctgacacca agtccagcat tgacaggaac atctctctgc ttcattacct
     2701 gatcatgatc ctggagaagc acttcccaga tatcctgaac atgccctcag agctaaagca
     2761 cctatcagaa gctgccaaag tcaacctggc agagctggag aaggaggtga gcattctcag
     2821 gagaggcctc cgagcagtgg aagtggagtt ggaatatcag agacaccagg cacgagaccc
     2881 caatgacaag ttcgtccctg tcatgagtga cttcatcaca gtgtctagct tcagcttctc
     2941 agagctggag gaccagctga atgaggccag ggacaagttt gccaaggcac tgacacattt
     3001 cggagagcag gagagtaaga tgcaaccgga tgaattcttt ggcatcttcg acaccttcct
     3061 gcaggccttc ttggaggccc ggcaggacct ggaggccatg cggaggagga aggaggaaga
     3121 tgagcggaga gcacgtatgg aattcatgtt gaaggaacag cgtgagaaag agagatggca
     3181 gaggcagagg aaggtcttgg ctggcggcgc cctggaggag agcggcgagt ttgatgacct
     3241 agtgtcagcc ctgcgctctg gagaagtttt cgataaggac ttaagcaagt tcaagcgcaa
     3301 ccggaagcgg cccgggagcc aggttccgga ggtcacccgc gagcgggcca taaacaggct
     3361 aaattattga cttggagact ggggactaac cacagaccag caagcctgga gacagggatt
     3421 agaagaaagg agttgaatag taaaagcaat gacttaagtg attttggaaa actgggtgtc
     3481 ggagccctgg gctgggtcct gggtgtcgta tgcggctaga ccgggtgtct cccgcactga
     3541 aagaggggtc tttgcttgtc tcctgtatat tacccacttt catccttgtt ctgtacgtct
     3601 ctgtctgtgc ccctccccct cctggccatc cttctctaag actagcttgg gcatccctga
     3661 taggccctcc caggctgggt gacactgttc tccacacctc atgttggcac agagctgttt
     3721 aagacccagg agacattctt gtcccaacat tttgtacatt aagtatatgg tgatggagtg
     3781 gaacctgaga gccagcaagc agtaggctcc tatctgaaaa gacagctcaa cggaacatgg
     3841 atctgggatg ggaaccaggg ggttatgtgt tctagctaga taagctctag tctgttccag
     3901 aaaaacagga ccagggccag caagtgaatt agttatctgt ctgtgccttt ttcctacacc
     3961 aagtcctagg gcctcacttc ttccccggct acctccatcc catttactga tttctggtct
     4021 ccacattcct ctccgattcc cagaactctg gctcaccatc agcttatagt gtggctctgg
     4081 taaggagtgt ccaagaaaga ctgtcgtcac ctcaccagac tcaggcatag gccccaaggc
     4141 aaaccccaag gtaacctgac cactgtcttg gagagagacc tcaggtcccc accagaaggt
     4201 agcactagaa tgcttcactc gcctgagagt accccatcta ccatcgctct cagctgaccc
     4261 ttggtgtgct acagtggccc cagtctccac ctgcaggtca cagggagctc ccaacactag
     4321 gctgcagctg gccttgggaa attgttcgtg agggctagaa ctacccccca tatttaactg
     4381 tcactccgag ggagacagtt agacaggggg cctgagaaga gctcactcca gggtctgccc
     4441 ctacatttgt gctgttccct tcctcagtct cgccgcatgg ggtcattctg gccccctttt
     4501 cacactcatc ttctgtcctg tccacccatc ttcagctgtg ttgatggtat tggttgggtg
     4561 gcactgctac atctagtcac atttctaaat ggagcacggt aggatcaact ccatgtaggt
     4621 ttattgttaa atgcacccct attccctctc atcttgagac ccatcttgcc tgattaccat
     4681 ccaccagctc ctggctcttc tctctaaccc actgacttga tcaaggttgt tgctagtgac
     4741 tgtgggctgc tcggtcttgg ttctgtaact gcttgtcttc ctacaggagc ttcccagggg
     4801 gatggggcca tagtagttgt ggggaggaga gacacggggc taagctgggt gcgtgcattg
     4861 gtttgaaagg gatctcagca agtggaggcc tggccagtat ggtgtgaaga agcaagccta
     4921 agagcacaaa agacttctaa gaatggctat ggaggagggc tttaacgctc atctgcacac
     4981 tcaaagaacc tctccatcct tgcccccacc ccaccccacc cttcaggaag caagctatga
     5041 gaatgtaaag gctggtgctg gacatcttca aatcctctct gaaactggct gggatgtcag
     5101 gctaccatgc gagggccagg ggacagggat ggactatata ctgccaccgg acaggcatgg
     5161 ctgggcctag tcttcccaca cgcaccagga gaaataagga agatggaagt tgttgaaggg
     5221 acatgttggc tcttcagaaa agctgcctgg catctctcca gagcccagcc ttctcgcccc
     5281 caaagaattc tgccttctct atttattatt ttctatagct tcccagtggt tctggtactg
     5341 tgtgcctttg taaccagatt ccaacagtgc tttggaccat ggactgttgt gggtgactca
     5401 gcaggaagtg aatggtgctc agtggaggtg gataggctgg tcctcaacgt taaatgatga
     5461 agtctactcc caaatatcca cccaaccttc ctgccgccta tgggccaacc cctccagcta
     5521 gtcttgtgca caatgtaaaa ctcatagtcc agccaacaca ccctgtctca gcagcagcaa
     5581 tttccctccc aggatggaag tttgttcagg ggttggaagg acaactctcc aggtgggtgg
     5641 atacaggcat gggctctccc tatccactcc tattgccacc aactggggag ctgcaacaac
     5701 ctcccctccc caggatatct gccaaccttc atgccaaggc tgctctcacc agctgctgca
     5761 gaagacaagc aaggtctata tgtacaaaac tctacagcgt tctttttacc agcacccttt
     5821 tataagaata tattgtaata cttaaaaaaa atattaaatc catccccacc ccta
//
