LOCUS       NP_001366301            1067 aa            linear   ROD 30-APR-2025
DEFINITION  disheveled-associated activator of morphogenesis 2 isoform 3 [Mus
            musculus].
ACCESSION   NP_001366301 XP_006525154
VERSION     NP_001366301.1
DBSOURCE    REFSEQ: accession NM_001379372.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1067)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1067)
  AUTHORS   Colozza,G., Lee,H., Merenda,A., Wu,S.S., Catala-Bordes,A.,
            Radaszkiewicz,T.W., Jordens,I., Lee,J.H., Bamford,A.D.,
            Farnhammer,F., Low,T.Y., Maurice,M.M., Bryja,V., Kim,J. and
            Koo,B.K.
  TITLE     Intestinal Paneth cell differentiation relies on asymmetric
            regulation of Wnt signaling by Daam1/2
  JOURNAL   Sci Adv 9 (47), eadh9673 (2023)
   PUBMED   38000028
REFERENCE   3  (residues 1 to 1067)
  AUTHORS   Wang,C.Y., Zuo,Z., Jo,J., Kim,K.I., Madamba,C., Ye,Q., Jung,S.Y.,
            Bellen,H.J. and Lee,H.K.
  TITLE     Daam2 phosphorylation by CK2alpha negatively regulates Wnt activity
            during white matter development and injury
  JOURNAL   Proc Natl Acad Sci U S A 120 (35), e2304112120 (2023)
   PUBMED   37607236
REFERENCE   4  (residues 1 to 1067)
  AUTHORS   Cristobal,C.D., Wang,C.Y., Zuo,Z., Smith,J.A., Lindeke-Myers,A.,
            Bellen,H.J. and Lee,H.K.
  TITLE     Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin
            Cytoskeleton through Rac1 and Gelsolin
  JOURNAL   J Neurosci 42 (9), 1679-1691 (2022)
   PUBMED   35101966
  REMARK    GeneRIF: Daam2 Regulates Myelin Structure and the Oligodendrocyte
            Actin Cytoskeleton through Rac1 and Gelsolin.
REFERENCE   5  (residues 1 to 1067)
  AUTHORS   Jo,J., Woo,J., Cristobal,C.D., Choi,J.M., Wang,C.Y., Ye,Q.,
            Smith,J.A., Ung,K., Liu,G., Cortes,D., Jung,S.Y., Arenkiel,B.R. and
            Lee,H.K.
  TITLE     Regional heterogeneity of astrocyte morphogenesis dictated by the
            formin protein, Daam2, modifies circuit function
  JOURNAL   EMBO Rep 22 (12), e53200 (2021)
   PUBMED   34633730
REFERENCE   6  (residues 1 to 1067)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
REFERENCE   7  (residues 1 to 1067)
  AUTHORS   Nakaya,M.A., Habas,R., Biris,K., Dunty,W.C. Jr., Kato,Y., He,X. and
            Yamaguchi,T.P.
  TITLE     Identification and comparative expression analyses of Daam genes in
            mouse and Xenopus
  JOURNAL   Gene Expr Patterns 5 (1), 97-105 (2004)
   PUBMED   15533824
  REMARK    GeneRIF: Daams are expressed in tissues known to require Wnts, so
            effectors of Wnt signaling during vertebrate development.
REFERENCE   8  (residues 1 to 1067)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   9  (residues 1 to 1067)
  AUTHORS   Kida,Y., Shiraishi,T. and Ogura,T.
  TITLE     Identification of chick and mouse Daam1 and Daam2 genes and their
            expression patterns in the central nervous system
  JOURNAL   Brain Res Dev Brain Res 153 (1), 143-150 (2004)
   PUBMED   15464228
  REMARK    GeneRIF: involved in pivotal steps in neuronal cell differentiation
            and movement
REFERENCE   10 (residues 1 to 1067)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124748.5 and AC165258.2.
            
            On Apr 1, 2020 this sequence version replaced XP_006525154.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.19360.1,
                                           SRR10223969.17852.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1067
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 25.5 cM"
     Protein         1..1067
                     /product="disheveled-associated activator of morphogenesis
                     2 isoform 3"
                     /note="disheveled-associated activator of morphogenesis 2"
                     /calculated_mol_wt=123277
     Region          41..228
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          231..435
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          595..968
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; pfam02181"
                     /db_xref="CDD:396655"
     CDS             1..1067
                     /gene="Daam2"
                     /gene_synonym="2310016D11Rik"
                     /coded_by="NM_001379372.1:167..3370"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:76441"
                     /db_xref="MGI:MGI:1923691"
ORIGIN      
        1 malrkrsphg lgflccfggs dlpeidlrds hplqylefsg pipnpeelnv rfaelvdeld
       61 ltdknreavf alppekkwqi ycskrkeqed pnklatswpe yyidrinama amqnlyeted
      121 eetdkrnqvv edlktalrtq pmrfvtrfid legltcllnf lrgmdhttce srihtsligc
      181 ikalmnnsqg rahvlaqpea isiiaqslrt ensktkvavl eilgavclvp gghkkvlqam
      241 lhyqayaaer trfqtllnel drslgryrde vnlktaimsf inavlnagag ednlefrlhl
      301 ryeflmlgiq pvidklrqhe naildkhldf femvrneddl elarrfdmvh idtksasqmf
      361 elihkklkht eaypcllsvl hhclqmpykr nggyfqqwql ldrilqqivl qdergvdpdl
      421 aplenfnvkn ivnmlinene vkqwrdqaek frkehmelms rlerkerece tktlekeemm
      481 rtlnkmkdkl aresqelrqa rgqvaelvar hnesstgpvs sppppggplt lsssrttndl
      541 pppppplpfd scppppappl ppggppippg appcfssgpp pshdpfssne aplrkkripq
      601 pshplksfnw vklneervsg tvwneiddsq vfrildledf ekmfsayqrh qkelgstedi
      661 yitsrkvkel svidgrraqn ciillsklkl sndeirqail rmdeqedlak dmleqllkfi
      721 peksdidlle ehkheierma radrflyems ridhyqqrlq alffkkkfqe rlaeakpkve
      781 aillasrelt lsqrlkqmle vvlaignfmn kgqrggaygf rvaslnkiad tkssidrnis
      841 llhylimile khfpdilnmp selkhlseaa kvnlaeleke vsilrrglra veveleyqrh
      901 qardpndkfv pvmsdfitvs sfsfseledq lneardkfak althfgeqes kmqpdeffgi
      961 fdtflqafle arqdleamrr rkeederrar mefmlkeqre kerwqrqrkv laggaleesg
     1021 efddlvsalr sgevfdkdls kfkrnrkrpg sqvpevtrer ainrlny
//
