LOCUS       NM_001199941            2559 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus DNA segment, Chr 7, ERATO Doi 443, expressed
            (D7Ertd443e), transcript variant 1, mRNA.
ACCESSION   NM_001199941
VERSION     NM_001199941.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Zhang,L., Zhang,K., Zhang,J., Zhu,J., Xi,Q., Wang,H., Zhang,Z.,
            Cheng,Y., Yang,G., Liu,H., Guo,X., Zhou,D., Xue,Z., Li,Y.,
            Zhang,Q., Da,Y., Liu,L., Yin,Z., Yao,Z. and Zhang,R.
  TITLE     Loss of fragile site-associated tumor suppressor promotes antitumor
            immunity via macrophage polarization
  JOURNAL   Nat Commun 12 (1), 4300 (2021)
   PUBMED   34262035
  REMARK    GeneRIF: Loss of fragile site-associated tumor suppressor promotes
            antitumor immunity via macrophage polarization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2559)
  AUTHORS   Yan,S., Qiu,L., Ma,K., Zhang,X., Zhao,Y., Zhang,J., Li,X., Hao,X.
            and Li,Z.
  TITLE     FATS is an E2-independent ubiquitin ligase that stabilizes p53 and
            promotes its activation in response to DNA damage
  JOURNAL   Oncogene 33 (47), 5424-5433 (2014)
   PUBMED   24240685
REFERENCE   5  (bases 1 to 2559)
  AUTHORS   Zhang,X., Zhang,Q., Zhang,J., Qiu,L., Yan,S.S., Feng,J., Sun,Y.,
            Huang,X., Lu,K.H. and Li,Z.
  TITLE     FATS is a transcriptional target of p53 and associated with
            antitumor activity
  JOURNAL   Mol Cancer 9, 244 (2010)
   PUBMED   20843368
  REMARK    GeneRIF: FATS expression was silent or downregulated in human
            cancers, and overexpression of FATS suppressed tumorigenicity in
            vivo independently of p53. Results reveal FATS as a p53-regulated
            gene to monitor genomic stability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2559)
  AUTHORS   Li,Z., Zhang,Q., Mao,J.H., Weise,A., Mrasek,K., Fan,X., Zhang,X.,
            Liehr,T., Lu,K.H., Balmain,A. and Cai,W.W.
  TITLE     An HDAC1-binding domain within FATS bridges p21 turnover to
            radiation-induced tumorigenesis
  JOURNAL   Oncogene 29 (18), 2659-2671 (2010)
   PUBMED   20154723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            GQ499374.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ499374.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2559              GQ499374.1         1-2559
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 78.4 cM"
     gene            1..2559
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /note="DNA segment, Chr 7, ERATO Doi 443, expressed"
                     /db_xref="GeneID:71007"
                     /db_xref="MGI:MGI:1196431"
     exon            1..154
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     exon            155..246
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     exon            247..1363
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1648
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1827
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2005
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2069
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2169
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2559
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2547
                     /gene="D7Ertd443e"
                     /gene_synonym="4933400E14Rik; FATS; Gm497"
                     /note="major polyA site"
ORIGIN      
        1 tgggagtttg actcattctg agagtagcag cctgtgcaga ctgtggccat gttccttgat
       61 ttagcaaggc acatctttgt ccttagatgg tctttgaaat gaagtaagat gtctttgaaa
      121 catcagtgag acatgattaa actgtctggg gaaggattac tgcacacgtg ctatagtaca
      181 aatgatcaaa tcgcccttaa aaacctgcag tctgatgtta cagagaggaa gttggacttc
      241 tccaaggaga cactggcatc acagaacaca agaatgatat cacctgtggt catttcccgg
      301 ctgattgatg aaaagaaatc tatggaaaat ggagcaatat tgccacaagc cattgctcag
      361 cctcagctgt gtcccacaaa gccagctttg gccaggcgcg atggagtgag catgcacagg
      421 cgatttgctt tatctccaga cagactggga attttgactc catcagatga tcaaggactg
      481 gagacagaac cgctgtctac aggggacaat ctaggcaaag gttcccacag cggtttctcg
      541 tctatcacca ttactgcccg acgtgtgggc cctccagcca gcagcttggt atgggacact
      601 tttagggacc cactgtgtcc caagtgcaaa gccaaggatg ctctgttcca agagccccca
      661 gttctggctg gtgatgccca tctctgtcag cacaatagac ccttcacctg tacagagtcc
      721 cccagcaatg gctccgtaga ggggatgaag gttttccagg ctcactcaag gctgagtgca
      781 aggcaggact actgggtcac ccacacgaat gacaatgagg acagtttttc ttcagacaat
      841 tcaccatcga gaaaagtccc actggtgttc agttcttgtg tccacttccg ggtgtctcag
      901 cagtgtccca atgccattta ctatttggac aagtctcttt ctgttcccct tgagcgacct
      961 caaattgcta gccccaaaat gcacaggtct gtcctgtctc tcagcctccg ctgtagttcc
     1021 caccagttaa cagcagatgg agtagacagc tcagctaatg gagagccaat cagcacagct
     1081 ctatcacagg aactctcgga gggaaagcag gacctcctag gtccacaatg gggccagcca
     1141 caaggtggtc actggaagga gagcccagca ttggtgccag tacatttggg gagtggcaca
     1201 tgccctcgga ctggctcccc tccactggaa aatgtcaaat ttgcagacgt gggaaggaac
     1261 caggtcccag tacgaaagga gaaagaggac catgcaacat gtaccagtag cagccacacc
     1321 aaccaactct ccatccatat tcccggctgg agttacaggg ctgaaacaaa agtactttct
     1381 ggaagcaaga agcagcagca agaagcacaa agaactcttc ctgctttccc agtgggacag
     1441 aagaccatta aacacttccc tcctgaaggg gacagttcac caagcagtga tggtcaacct
     1501 agcatccttt cagagtccaa tgagaggcaa cacccatact tcatgatacc cagagtccct
     1561 ctgcctgggt tttattgccc tttacaaact gggtgtgcct ctctgcagga agatggtgct
     1621 gttcagatag aaacacactt ccccaaagat tacacgtgct gtgacttggt tgtaaaacta
     1681 aaggaatgtg agaagaacga agaccccact gtcacccctg agccctcacc agcaaccccc
     1741 tctccatcaa ccccagaggg agcacagagc tctgacccat cagaagatag ttacgagcct
     1801 ctgctggcaa gttctatgac tttgcaggaa gcactggaag tccatagacc tcagttcatt
     1861 tctcgctcac aagaacggct gcaaaagctt aagcgcatgg tacagcaaag gaaaacccaa
     1921 caaaaggaga gcctggggca gaagcagagc ctacttcctg tccgcgccaa caagaagcag
     1981 ttcaccattc cccatcctct tagtgataac ttgttcaaac ccaaagaaag atgcatttca
     2041 gagaaggaga tgcatatgag atctaaaaga atctataata atttgccgga agttaaaaag
     2101 aaaaaagaag agcagaagaa aagaatgatc ttacagagta accggctccg agcagaagtc
     2161 ttcaaaaagc aattactgga ccagctcctt caaaggaatg cagtttgatc ccaggtggct
     2221 ctgctagccc tggatctggg aacacttctg acgacgacgc tggatggatg aaccattaca
     2281 tttaacacta tctccacacg tgcaagacac ctttacttta ctcctgattt ttctttttcc
     2341 cacaaaggaa atgtcacttt ctgaatgtcc caaacagaag caacagtccg gcaggcaatg
     2401 gatcagcagt ccattgctgg gacttcaaca cctcgggacc taccagattt agtcccttcc
     2461 aacttccttg gcttgtgaat tttacccatt gcttctgaag tttccattgt accaattcca
     2521 cccaagcagg aaagcttcat atactcacgt gtgcttgga
//
