LOCUS       NM_001310767            3506 bp    mRNA    linear   ROD 11-MAR-2023
DEFINITION  Mus musculus D-2-hydroxyglutarate dehydrogenase (D2hgdh),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001310767 XM_006529969
VERSION     NM_001310767.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3506)
  AUTHORS   Liu Y, Wang M, Guo Y, Wang L and Guo W.
  TITLE     D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell
            activation and promotes histone acetylation via ATP-citrate lyase
  JOURNAL   Cell Rep 42 (2), 112067 (2023)
   PUBMED   36724076
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3506)
  AUTHORS   Achouri Y, Noel G, Vertommen D, Rider MH, Veiga-Da-Cunha M and Van
            Schaftingen E.
  TITLE     Identification of a dehydrogenase acting on D-2-hydroxyglutarate
  JOURNAL   Biochem J 381 (Pt 1), 35-42 (2004)
   PUBMED   15070399
REFERENCE   3  (bases 1 to 3506)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ104853.1, AK141691.1 and AC167139.9.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_001310767.2.
            
            On Jul 18, 2015 this sequence version replaced XM_006529969.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141691.1, SRR7345562.2825143.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CJ104853.1         2-35
            35-333              AK141691.1         2-300
            334-779             AK141691.1         302-747
            780-1887            AK141691.1         749-1856
            1888-3506           AC167139.9         77453-79071
FEATURES             Location/Qualifiers
     source          1..3506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..3506
                     /gene="D2hgdh"
                     /note="D-2-hydroxyglutarate dehydrogenase"
                     /db_xref="GeneID:98314"
                     /db_xref="MGI:MGI:2138209"
     exon            1..341
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1971
                     /gene="D2hgdh"
                     /EC_number="1.1.99.39"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; D-2-hydroxyglutarate dehydrogenase,
                     mitochondrial"
                     /codon_start=1
                     /product="D-2-hydroxyglutarate dehydrogenase,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_001297696.1"
                     /db_xref="CCDS:CCDS78658.1"
                     /db_xref="GeneID:98314"
                     /db_xref="MGI:MGI:2138209"
                     /translation="MRMLCACRVVFFRLSPLSRAGTMVLPLVSRWSARVLWASPGWRR
                     TYTQRACVGLKRLGCPRGVYSPLAHRAYSVVAGGPEVTLTPERYPVQRLPFSTVSEED
                     LAAFECIIPGRVITDPEQLQTCNVDWLKTVRGCSKVLLRPQTSEEVSQILRHCYKRNL
                     AVNPQGGNTGMVGGSVPVFDEVILSTALMNQVISFHDVSGILVCQAGCVLEELSRYVQ
                     ERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLRGTVLGLEVVLADGTILNCLT
                     SLRKDNTGYDLKQMFIGSEGTLGVITAVSIVCPPRPKAVNVAFLGCPGFAEVLQTFRT
                     CRGMLGEILSAFEFMDTECMQLVGQHLQLTNPVQESPFYVLVETSGSSAGHDAEKLTN
                     VLEQVLNSGLVTDGTMATDQRKVQMLWALRERITEALSRDGYVFKYDLSLPVERLYDL
                     VIDLRTRLGPRAKHVVGYGHLGDGNLHLNVTAEAFSRELLGALEPYVYAWTAEQRGSV
                     SAEHGLGFKKKDVLGYSKPPVAVTLMQQLKAMLDPEGILNPYKTLPAQA"
     exon            342..697
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            698..755
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            756..895
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1089
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1258
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1402
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1545
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1711
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..3506
                     /gene="D2hgdh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcaggcc tacggttctg caggggtggg aagcagggtg cgggtgcgga ctcggtcttt
       61 gcactcggac ggaagctagg gtgcgtagtg ggctagctgt agttcctggg tggagggtgc
      121 tggtgtctga gtctgtgcag tccgggctgt ggcctgtcaa gtgattgcac aggtcaggtg
      181 tgagttggga ttgccggcag ggcgaaccta gtcgcatcgc ttctcactta cacccacggg
      241 ccgtgtgggc tgggagtgca aatagttggt cctccttgac gtcacaacac atggcgcatg
      301 cgcatgctct gcgcatgtcg tgttgtgttt tttcgtctca gccccctctc aagagcagga
      361 acaatggtgc tccctctggt gtccagatgg tctgcaaggg tcctctgggc atctccagga
      421 tggaggagga cctacaccca gagagcttgt gtggggttga agcggctggg ttgccctcgg
      481 ggtgtgtaca gccccttggc tcacagagca tactccgtgg tagctggcgg cccagaggtg
      541 acgctgaccc ctgagcgata tccggtgcaa cggctgccgt tttctactgt gtccgaggag
      601 gacctggctg catttgaatg catcatacct ggcagagtta tcacagatcc agagcaactg
      661 cagacatgca acgttgactg gctgaagacc gtccggggtt gtagtaaggt tttgctgaga
      721 ccccagacct cagaggaagt ctcccagatt cttaggcact gctataagag gaacttggct
      781 gtgaacccac agggcgggaa cactggcatg gtgggtggca gtgttcctgt ctttgacgaa
      841 gtcatcctgt ccactgccct catgaatcaa gtcatcagct ttcatgatgt atctggaatc
      901 ctggtttgcc aggcaggctg tgtgctggag gagctgagca ggtacgtgca ggagcgggac
      961 ttcatcatgc cactggactt gggagcaaag ggcagctgcc acatcggggg aaatgtggca
     1021 acaaatgctg gtggcctgcg attcctgaga tatggctccc ttcgagggac tgtcctgggc
     1081 ctggaagtgg tactcgctga tgggaccatc ctgaactgcc tgacatctct gaggaaggac
     1141 aacacaggct atgacctgaa gcagatgttc attgggtcag agggcaccct aggagtcatc
     1201 actgctgtgt ccattgtgtg cccacccagg cctaaggctg tgaatgtggc tttccttggc
     1261 tgccctgggt ttgctgaggt tctgcagacc ttccgcacct gcagggggat gctgggtgag
     1321 atcctgtctg cctttgagtt catggatact gaatgcatgc agttggttgg acagcacctc
     1381 cagctgacca acccagtaca agagagtcca ttctatgtcc tggttgagac ctcaggctcc
     1441 agtgcaggac atgatgctga gaagctgacg aacgtcctgg agcaggtgct gaactctggc
     1501 ctggtgacag atggcactat ggccaccgac cagaggaaag tccagatgct atgggccttg
     1561 cgggagagga tcacagaggc actcagccga gatggctatg tgttcaagta tgacttatct
     1621 ctccctgtgg agcggctcta cgaccttgtg atcgacctac gcacccgcct tggcccccgt
     1681 gccaagcacg tggtgggata tggacacctg ggggatggca accttcacct gaacgtgaca
     1741 gcagaggcct ttagccggga gttgctcggt gccttggaac cttatgtgta tgcctggaca
     1801 gcggagcagc ggggcagtgt cagtgcggag cacggcctgg gcttcaagaa gaaggatgta
     1861 cttggctata gcaagccacc tgtggccgtg acgcttatgc aacagctcaa ggccatgctg
     1921 gaccccgaag gcatcctgaa cccctataag actctacctg cccaggccta aatggagctt
     1981 ttcagcttgt gcaagatgct aggacctagg cgaaggaagg tttggtgggc ctggaggcct
     2041 cccagctgat gtcatccaca atagaccagg ttactgactc tcactgttag ccaggagcca
     2101 gctctgagca ccctctggac aaggttgcct ctctgtgggg gcgaacagat cagatagagc
     2161 tgccaggccc ttcttttgtg tcctgtggac agaataagtg ggtgggcaat tgccctactc
     2221 ccaaacaggc cagatctcac cagctctagg gtgggtggcc tgtggagacc tgctttgttg
     2281 catctctata gcgtgtaatt ttaaaagatc cctatttgcc tggtgactcg cgaggctgcc
     2341 accagtctct cactctcact cagcttcgct aatggccagt tggccatttt cccctggagc
     2401 tgtgattgct cccccatccc ctcatgccta gctttgtcaa actgtcgcca acaactgccc
     2461 caatggatag aaaacaccag ttttattatc ttaaaactag atagataact caatggctgg
     2521 gtgaagaatt tcttgcccta atcttatcaa ctagctccct caatcttgcc ttgccttctg
     2581 cccacagcag aagctataaa ctctacgagc cccaagacct acatgtctac agcatcctac
     2641 tcactccaaa gcctggtcca aattctgctt tcttctttct ttcttctgcc tgggacctac
     2701 aacttcaatc tttttccctt cattcaacaa ttagcttctg cctcctttat tgacacaatc
     2761 aagaaccaat tagagaacca atacctctcc ctccacatct ttgggaagag aaccatgtga
     2821 tttcttggat ggatcttact ggacagtttg ccctgtggca tgtattctct gagggctgca
     2881 gcagagttgt ctagccccag attagttacc acagtgacag agaatgccag aactcattcc
     2941 caagggcctg agtggggttt gctgtcatat caagcaggcc ttggattggt aactgtggtc
     3001 cacctggcta ggccattccc tcaggttttg tttgttttga gacaggttct ctctacgtaa
     3061 ttctgactgt tctggaactt atgatgtaga ccagatagac ctttaactca cagagctcct
     3121 ccatgcctct gcctttactt ctgccccctg agcaatggga ttaaaggcaa gtgccactac
     3181 acccagctta ccttgttctt aaagacctgt ctggttctaa gaagatgtgg agggctatga
     3241 ttgcctgcag agcctgacct ttctgggtat gggacagttc cctaattgaa tgaatagaag
     3301 cgactttcag tcatgtggtc tacacactat tctctatcac ttggcttgtc tcatgacctg
     3361 gcagtctgga aggctgaata cacctaccgt attttttttc cctgctatca gtttctggaa
     3421 aaaatttgaa ctacaacctg ctgctgctag aaaatgattc acataaagtt aattgtaaag
     3481 ttgtggctca ttacatctct ccacac
//
