LOCUS       NM_033077               3212 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus DNA segment, Chr 1, Pasteur Institute 1 (D1Pas1),
            mRNA.
ACCESSION   NM_033077
VERSION     NM_033077.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3212)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3212)
  AUTHORS   Ogonuki,N., Kyogoku,H., Hino,T., Osawa,Y., Fujiwara,Y., Inoue,K.,
            Kunieda,T., Mizuno,S., Tateno,H., Sugiyama,F., Kitajima,T.S. and
            Ogura,A.
  TITLE     Birth of mice from meiotically arrested spermatocytes following
            biparental meiosis in halved oocytes
  JOURNAL   EMBO Rep 23 (7), e54992 (2022)
   PUBMED   35587095
REFERENCE   3  (bases 1 to 3212)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3212)
  AUTHORS   Inoue,H., Ogonuki,N., Hirose,M., Hatanaka,Y., Matoba,S., Chuma,S.,
            Kobayashi,K., Wakana,S., Noguchi,J., Inoue,K., Tanemura,K. and
            Ogura,A.
  TITLE     Mouse D1Pas1, a DEAD-box RNA helicase, is required for the
            completion of first meiotic prophase in male germ cells
  JOURNAL   Biochem Biophys Res Commun 478 (2), 592-598 (2016)
   PUBMED   27473657
  REMARK    GeneRIF: Deletion of D1Pas1 did not cause noticeable embryonic
            defects or death, indicating that D1Pas1 is not essential for
            embryogenesis. Whereas homozygous knockout female mice showed
            normal reproductive performance, homozygous knockout male mice were
            completely sterile. mouse D1Pas1 is the first-identified DEAD-box
            RNA helicase that plays critical roles in the final step of the
            first meiotic prophase in male germ cells.
REFERENCE   5  (bases 1 to 3212)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3212)
  AUTHORS   Vong,Q.P., Li,Y., Lau,Y.F., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Structural characterization and expression studies of Dby and its
            homologs in the mouse
  JOURNAL   J Androl 27 (5), 653-661 (2006)
   PUBMED   16728723
  REMARK    GeneRIF: unlike DBY in humans, the role of Dby in spermatogenesis
            is less obvious in the mouse and its biologic activity may be
            replaced by that of Ddx3 and D1Pas1.
REFERENCE   7  (bases 1 to 3212)
  AUTHORS   Session,D.R., Lee,G.S. and Wolgemuth,D.J.
  TITLE     Characterization of D1Pas1, a mouse autosomal homologue of the
            human AZFa region DBY, as a nuclear protein in spermatogenic cells
  JOURNAL   Fertil Steril 76 (4), 804-811 (2001)
   PUBMED   11591417
REFERENCE   8  (bases 1 to 3212)
  AUTHORS   Leroy,P., Alzari,P., Sassoon,D., Wolgemuth,D. and Fellous,M.
  TITLE     The protein encoded by a murine male germ cell-specific transcript
            is a putative ATP-dependent RNA helicase
  JOURNAL   Cell 57 (4), 549-559 (1989)
   PUBMED   2720782
REFERENCE   9  (bases 1 to 3212)
  AUTHORS   Leroy,P., Seboun,E., Mattei,M.G., Fellous,M. and Bishop,C.E.
  TITLE     Testis-specific transcripts detected by a human Y-DNA-derived probe
  JOURNAL   Development 101 Suppl, 177-183 (1987)
   PUBMED   3503717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029542.1 and BG070553.2.
            
            On Oct 12, 2012 this sequence version replaced NM_033077.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK029542.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3188              AK029542.1         1-3188
            3189-3212           BG070553.2         275-298             c
FEATURES             Location/Qualifiers
     source          1..3212
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 90.09 cM"
     gene            1..3212
                     /gene="D1Pas1"
                     /gene_synonym="DDX3XL; Pl10"
                     /note="DNA segment, Chr 1, Pasteur Institute 1"
                     /db_xref="GeneID:110957"
                     /db_xref="MGI:MGI:91842"
     exon            1..3212
                     /gene="D1Pas1"
                     /gene_synonym="DDX3XL; Pl10"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..2443
                     /gene="D1Pas1"
                     /gene_synonym="DDX3XL; Pl10"
                     /EC_number="3.6.4.13"
                     /codon_start=1
                     /product="putative ATP-dependent RNA helicase Pl10"
                     /protein_id="NP_149068.1"
                     /db_xref="CCDS:CCDS15603.1"
                     /db_xref="GeneID:110957"
                     /db_xref="MGI:MGI:91842"
                     /translation="MSHVAEEDELGLDQQLAGLDLTSRDSQSGGSTASKGRYIPPHLR
                     NREAAKAFYDKDGSRWSKDKDAYSSFGSRSDTRAKSSFFSDRGGSGSRGRFDERGRSD
                     YESVGSRGGRSGFGKFERGGNSRWCDKADEDDWSKPLPPSERLEQELFSGGNTGINFE
                     KYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRD
                     LMACAQTGSGKTAAFLLPILSQIYTDGPGEALRAMKENGKYGRRKQYPISLVLAPTRE
                     LAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGK
                     IGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLA
                     RDFLDEYIFLAVGRVGSTSENITQKVVWVEEADKRSFLLDLLNATGKDSLILVFVETK
                     KGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISN
                     VKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEV
                     PSWLENMAFEHHYKGGSRGRSKSRFSGGFGARDYRQSSGASSSSFSSGRASNSRSGGG
                     SHGSSRGFGGGSYGGFYNSDGYGGNYSSQGVDWWGN"
     regulatory      2818..2823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="D1Pas1"
                     /gene_synonym="DDX3XL; Pl10"
                     /note="hexamer: AATAAA"
     polyA_site      2847
                     /gene="D1Pas1"
                     /gene_synonym="DDX3XL; Pl10"
                     /note="major polyA site"
ORIGIN      
        1 acgcacggag gaaatcgcgg attagaggga aggtgaagtt caagccaaac aggacagcgg
       61 tcgggttgat cgacgttccg ggggctccgg gctgccgtgt acatctaact ccattatgaa
      121 ctcaaccgag tgctgttccg ccgctgtaag tctgacaggg cggcgggccc tgtgaccgca
      181 tcgcgggcga tggcgcgcta ggcctgacca ggaagtctcg cgagattaga aatcggcgcg
      241 caggagctgc ggcgggcaga agccatagcg ttagcttgga gagaggccgt gagagggacg
      301 ggaggcccgc ggcgctggca gagcgggctt tgggggaatc aggtcggcca ctggacggac
      361 agacggacgg acggacgcgc cgttcacccc acagaggacc tctgaggtga aaccatagct
      421 cagcagaggc aagccccaga gttctccgta ctcttcaggg atgagtcatg tggcagagga
      481 agatgagctc gggctggacc agcagttggc tggcctagac ctgacgtctc gggacagcca
      541 gagcgggggc agcacagcca gcaaagggcg ctacatcccc cctcacctgc ggaaccggga
      601 ggccgcgaag gcgttctacg acaaagacgg ctcacggtgg agtaaagaca aggatgccta
      661 cagcagcttc gggtcccgca gcgacacgag agccaagtcc agtttcttca gtgaccgcgg
      721 cggaagcggc tccaggggaa ggtttgacga gcgcgggcgg agtgactacg agagtgttgg
      781 cagccgggga ggtagaagtg gctttggcaa atttgagcgg ggcgggaaca gtcgctggtg
      841 tgacaaagca gacgaggatg actggtcgaa accgctccca ccaagcgaac gcttggaaca
      901 ggaactcttt tccggaggca acactgggat taactttgag aaatatgatg acatcccggt
      961 tgaggcgaca gggaataact gccctccaca tattgaaagt ttcagcgatg tcgagatggg
     1021 agagattatt atgggaaaca tcgagctcac tcgttacaca cgcccaactc ctgtgcaaaa
     1081 gcatgctatt cctattatca aggagaaaag agacttgatg gcttgtgccc aaacggggtc
     1141 tggaaaaaca gcagcttttc ttctacctat cttgagtcag atctatacgg atggtccagg
     1201 tgaggctttg agggccatga aggagaatgg aaagtatggg cgtcgcaaac agtatccaat
     1261 ctccttggtc ttggctccga ccagagaatt ggccgtgcag atctatgagg aggccaggaa
     1321 attctcatac cgctctcgag ttcgtccttg tgtggtttat ggtggagctg atattgggca
     1381 gcagattcga gacttggaac gtggctgtca cttgttagta gctactccag gacggctagt
     1441 agatatgatg gagagaggaa agattggact ggacttctgc aaatacttgg tgttagatga
     1501 agcagatcga atgttggaca tgggctttga gcctcagata cgaagaatag ttgagcaaga
     1561 caccatgcct ccaaaaggtg tccgccacac tatgatgttt agtgctacct ttcctaagga
     1621 aatacagatg ctggctcggg atttcttgga tgaatatatc tttctggccg taggaagagt
     1681 tgggtctact tctgagaaca tcacacagaa agtcgtgtgg gtggaagaag cagacaagcg
     1741 gtcatttctg cttgacctcc tgaatgcaac gggcaaggat tccctgatat tggtgtttgt
     1801 ggaaaccaaa aagggtgcag attctctgga ggacttctta taccacgaag gatatgcttg
     1861 taccagtatc catggagacc gatctcagcg agatagggaa gaggcccttc accaattccg
     1921 atcaggaaaa agcccaattc tcgtggctac agcagtagct gcaagaggac tggatatttc
     1981 caatgtgaaa catgtcatca atttcgactt gcctagtgac atcgaagaat atgtgcatcg
     2041 cattggccgt acaggtcgtg ttggaaacct tggccttgcc acctcattct tcaacgagag
     2101 gaacataaat attaccaaag atttattgga tcttcttgtt gaagcaaaac aagaagtgcc
     2161 atcttggcta gaaaacatgg cttttgaaca ccattacaag ggtggcagtc gtggacggtc
     2221 caagagcaga tttagtggag gatttggtgc tagagactat cgacaaagta gcggtgccag
     2281 cagttccagc ttcagcagtg gccgtgctag caacagtcgc agcggtggag gcagccatgg
     2341 cagcagcaga gggtttggtg gaggtagcta tggaggcttt tacaacagtg atggatatgg
     2401 aggaaattat agctcccagg gggttgactg gtggggtaac tgagcctgct ttgccatagg
     2461 ccactctacc aaacaaatac agaaaacact acatgtaatg tagccagact atacctgata
     2521 tagcttcaag aaaccacaga acagtgcctc ctgtgattcc ccattgaata ctttttaagg
     2581 gagcttaaag tgacaagaag aaaggaacaa tccagaagac ccattcagaa ggtggtttaa
     2641 agacttgatt gttgtagttt ggattaactc tcctcttacc cccatcctac tctgcattta
     2701 taacttcatg actaaggatc atttgtttgt taatgtgctg tacctttact ttagacaact
     2761 tttattctga tgtcccgttg gctcagtaat gcttaagata tcaaattgtt ttagcaaaat
     2821 aaattttctg aacttgggct aagaaaacaa agggacaggt atttgttatg ggaatgggac
     2881 tgtccttaag tacaccttag gtactctaag gaaggcaggg gtgaagccca ggatgaagga
     2941 tggcatttgg gaatacataa ataacagccc aggggttcaa gagtagttat ggttgaaata
     3001 tctgtttaag tgtacagttc tagttgctaa acttagcacg gccaggaaat gcaatggcat
     3061 ttttattttc ctgtgtactt taaataatcc tttgttagta gtcatcctca atgaaatgta
     3121 gtggcagcct tgggagtcac tagtcagtat tcatgcttag tactgtgatg tagaggatct
     3181 gaatggctcc aaataaatgg tatcaggaaa cc
//
