LOCUS       NM_001081051            5146 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RIKEN cDNA D130043K22 gene (D130043K22Rik), transcript
            variant 1, mRNA.
ACCESSION   NM_001081051 XM_111397
VERSION     NM_001081051.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5146)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5146)
  AUTHORS   Perrino,P.A., Chasse,R.Y., Monaco,A.P., Molnar,Z., Velayos-Baeza,A.
            and Fitch,R.H.
  TITLE     Rapid auditory processing and medial geniculate nucleus anomalies
            in Kiaa0319 knockout mice
  JOURNAL   Genes Brain Behav 21 (6), e12808 (2022)
   PUBMED   35419947
REFERENCE   3  (bases 1 to 5146)
  AUTHORS   Guidi,L.G., Mattley,J., Martinez-Garay,I., Monaco,A.P.,
            Linden,J.F., Velayos-Baeza,A. and Molnar,Z.
  TITLE     Knockout Mice for Dyslexia Susceptibility Gene Homologs KIAA0319
            and KIAA0319L have Unaffected Neuronal Migration but Display
            Abnormal Auditory Processing
  JOURNAL   Cereb Cortex 27 (12), 5831-5845 (2017)
   PUBMED   29045729
  REMARK    GeneRIF: Analyses of Kiaa0319L (AU040320) and double
            Kiaa0319;AU040320 knockouts (dKO) revealed no evidence for impaired
            cortical lamination, neuronal migration, neurogenesis or other
            anatomical abnormalities. However, dKO mice displayed an auditory
            deficit in a behavioral gap-in-noise detection task. Recordings of
            click-evoked auditory brainstem responses revealed suprathreshold
            deficits in wave III amplitude in AU040320-KO mice.
REFERENCE   4  (bases 1 to 5146)
  AUTHORS   Martinez-Garay,I., Guidi,L.G., Holloway,Z.G., Bailey,M.A.,
            Lyngholm,D., Schneider,T., Donnison,T., Butt,S.J., Monaco,A.P.,
            Molnar,Z. and Velayos-Baeza,A.
  TITLE     Normal radial migration and lamination are maintained in
            dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout
            mice
  JOURNAL   Brain Struct Funct 222 (3), 1367-1384 (2017)
   PUBMED   27510895
REFERENCE   5  (bases 1 to 5146)
  AUTHORS   Franquinho,F., Nogueira-Rodrigues,J., Duarte,J.M., Esteves,S.S.,
            Carter-Su,C., Monaco,A.P., Molnar,Z., Velayos-Baeza,A., Brites,P.
            and Sousa,M.M.
  TITLE     The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth
            Through Smad2 Signaling
  JOURNAL   Cereb Cortex 27 (3), 1732-1747 (2017)
   PUBMED   28334068
  REMARK    GeneRIF: Study establishes KIAA0319 as a novel player in axon
            growth and regeneration with the ability to repress the intrinsic
            growth potential of axons; describes a novel regulatory mechanism
            operating during peripheral nervous system and central nervous
            system axon growth, and offers novel targets for the development of
            effective therapies to promote axon regeneration
REFERENCE   6  (bases 1 to 5146)
  AUTHORS   Rue,L., Banez-Coronel,M., Creus-Muncunill,J., Giralt,A.,
            Alcala-Vida,R., Mentxaka,G., Kagerbauer,B., Zomeno-Abellan,M.T.,
            Aranda,Z., Venturi,V., Perez-Navarro,E., Estivill,X. and Marti,E.
  TITLE     Targeting CAG repeat RNAs reduces Huntington's disease phenotype
            independently of huntingtin levels
  JOURNAL   J Clin Invest 126 (11), 4319-4330 (2016)
   PUBMED   27721240
REFERENCE   7  (bases 1 to 5146)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 5146)
  AUTHORS   Masuda,T., Kai,N., Sakuma,C., Kobayashi,K., Koga,H. and Yaginuma,H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   9  (bases 1 to 5146)
  AUTHORS   Paracchini,S., Thomas,A., Castro,S., Lai,C., Paramasivam,M.,
            Wang,Y., Keating,B.J., Taylor,J.M., Hacking,D.F., Scerri,T.,
            Francks,C., Richardson,A.J., Wade-Martins,R., Stein,J.F.,
            Knight,J.C., Copp,A.J., Loturco,J. and Monaco,A.P.
  TITLE     The chromosome 6p22 haplotype associated with dyslexia reduces the
            expression of KIAA0319, a novel gene involved in neuronal migration
  JOURNAL   Hum Mol Genet 15 (10), 1659-1666 (2006)
   PUBMED   16600991
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY718582.1, AK051381.1,
            AL589699.4, AK148668.1 and AV332865.1.
            
            On May 7, 2015 this sequence version replaced NM_001081051.1.
            
            Summary: This gene encodes a transmembrane protein that contains a
            large extracellular domain with multiple polycystic kidney disease
            (PKD) domains. The encoded protein may play a role in the
            development of the cerebral cortex by regulating neuronal migration
            and cell adhesion. Single nucleotide polymorphisms in a similar
            gene in human are associated with dyslexia. Alternatively spliced
            transcript variants have been identifed. [provided by RefSeq, May
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122246.1, BC115723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY718582.1         2-5
            5-1130              AK051381.1         2-1127
            1131-1131           AL589699.4         152601-152601
            1132-2579           AK051381.1         1129-2576
            2580-2718           AK148668.1         2181-2319
            2719-4970           AK051381.1         2577-4828
            4971-4977           AL589699.4         195905-195911
            4978-5053           AV332865.1         73-148
            5054-5054           AL589699.4         195988-195988
            5055-5115           AV332865.1         150-210
            5116-5116           AL589699.4         196050-196050
            5117-5146           AV332865.1         212-241
FEATURES             Location/Qualifiers
     source          1..5146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.72 cM"
     gene            1..5146
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /note="RIKEN cDNA D130043K22 gene"
                     /db_xref="GeneID:210108"
                     /db_xref="MGI:MGI:3036268"
     exon            1..169
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            170..315
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..3506
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /codon_start=1
                     /product="dyslexia-associated protein KIAA0319 homolog
                     precursor"
                     /protein_id="NP_001074520.1"
                     /db_xref="CCDS:CCDS36624.1"
                     /db_xref="GeneID:210108"
                     /db_xref="MGI:MGI:3036268"
                     /translation="MVSPPGVLSSLLLLAAMAGGSSQQCSEGRTYSDAIISPNPETIR
                     IMRVSQTFSVGDCTAACCDLLTCDLAWWFEGSCYLVKCMRSENCEPRTTGPIRSYLTF
                     VRRPVQRPGQLLDYGDMMLSRGSPSGAWGDSLEDLRKDLPFLGKDGGPEETTEYSDEY
                     KDLERGLLQPSNQQDPRGSAEYPDWSLLPSNEGGFNATATGDNSAASMEKLQDPTPHP
                     LDQEQLQALNESTWSPTPGHSSISSVWPSSASPLPTEEGLEGEETLQLQEQPSNSSGK
                     EVPMPSHNPSPASLESSPATTEKNSNFTVTPRSRKHSTPTFPTSTVLTGLTPPPWPLS
                     PTASRTVKALAVSAGDNLVLTLPDREAELKASVEPAPPADTTYSYEWSLMSHPVDFQG
                     KIKQENKPTLHLSQLSVGLYAFRVAVSSENAFGEGYVNVTVMPAARVNQPPVAVVSPQ
                     TQELSVPLTSALIDGSQSTDDTEIVSYHWEEVDGPFLGEEFPADTPILRLSNLVPGNY
                     TFRLTITDSDGATNSTTASLVIRDAVDYPPVANAGPNQTITLPQNTIILNGNQSSDDH
                     QIVLYEWFAGPGGESKEMVMQGAQTPYLHLSELQEGEYTFQLMVTDSSGQQSTALVAV
                     TVQAENNQAPVAVAGPDKELVFPVQSATLDGSRSSDDHGIVCYHWEHIRGPSAVEMEN
                     VDKAIATVTGLQVGIYHFRLTVRDQQGLSSTSTLTVAVKKENNSPPRAQAGGRHVLIL
                     PNNSITLDGSRSTDDRGIVSYLWIRDGQSPAAGDVIGGSDHRAALQLTNLVEGVYTFH
                     LLVTDSQGASDSDAATVEVLPDPKKDGLVELILQVGVEQLTEQQKETLVRQLAVLLNV
                     LDSDVKVLKIQAHTDVSTVIVFYVQSGSPFKVLRAAAVARNLHKRLSKEKEAFLLFKV
                     LRVDTAGCLLKCSGHGHCDPITKRCICSQLWMENLIQRYMWDGESNCEWSVFYVAALA
                     LTLTLLTGAVSWLCICCCRRRKRTKIRKKTKYTILDSMDEQERMELRPKYGIKHRSTE
                     HNSSLMVSESEFESDQDTLFSRERMERGVLKGSLNGCARNGVSFGYYSKDR"
     exon            316..1091
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1281
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1380
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1478
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1566
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1659
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1792
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..2021
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2145
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2278
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2427
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2579
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2718
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2878
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3021
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3144
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3235
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3327
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..5146
                     /gene="D130043K22Rik"
                     /gene_synonym="4930451E12Rik; Kiaa0319"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggcaga aaggcgctga atcaccagcg cgggctcgca gcgtctgtct gtgcagccgc
       61 aggggtgggc aggtgtcgcc tgcaggtgtg cctcgcaggt gtctcaactg gacatcagcg
      121 gctggccagt ctggagtacc gcggagcctg gagatcgctg gggatggagt tctagaaggc
      181 tacacctggc tggctcatca accatcaaag ggagtgtttt aagtccactg ccctggaagc
      241 cgcattctgt gtgaggcaga atggtgtccc caccaggagt actgtcttca ttgctgctgc
      301 tggcagccat ggcaggaggc agttctcagc agtgctctga gggcaggact tactccgatg
      361 ccatcatttc acctaacccg gaaaccatca gaatcatgcg ggtgtctcaa accttctccg
      421 tgggagactg cacggccgct tgctgtgact tgctcacctg tgacctggcc tggtggtttg
      481 agggcagctg ctatctggtg aaatgcatgc gctcggagaa ttgcgagccc aggaccacag
      541 gccccatccg gtcttacctc actttcgtgc gcagacctgt ccagaggccc gggcagctgc
      601 tggactatgg agacatgatg ctgagcaggg gctccccctc aggagcttgg ggagactccc
      661 ttgaggacct caggaaggac ttgccctttc ttggcaaaga cgggggacca gaggagacca
      721 ctgagtactc agatgaatac aaagacctgg agcggggcct cctgcagccc tccaaccagc
      781 aagaccctag aggtagcgca gagtaccccg actggagcct gctgcccagc aacgagggag
      841 gtttcaatgc tacagctaca ggagacaact cagctgcttc catggagaag ctgcaggatc
      901 ccacgcccca cccactggac caggagcagc tgcaggccct gaatgagtcg acttggtccc
      961 ctacacccgg gcactcttca ataagcagtg tgtggccttc ctctgcgagc ccattaccta
     1021 cagaggaggg actggaagga gaagagactt tacagctcca agaacaaccg agcaatagct
     1081 ctggaaaaga ggttccaatg ccttcccata atccttcccc tgccagcctg gagtctagcc
     1141 cagccacgac ggaaaaaaac tccaacttta cagtcacgcc acggagcaga aaacacagca
     1201 ccccaacttt tcctaccagt acagtcctca ctgggctaac ccctcctccg tggcccttgt
     1261 cacctactgc ttccaggaca gtaaaggcgc ttgctgtgtc tgctggagat aacctagtac
     1321 taaccttacc ggacagagaa gcagaactga aggcctctgt tgaaccagcg ccccctgcag
     1381 atacaactta ctcctatgaa tggagtttaa tgagccaccc agtagacttc caaggtaaaa
     1441 tcaaacaaga aaacaagccg actcttcacc tctctcaatt atctgtggga ctctatgcct
     1501 tcagagtggc tgtttctagt gagaatgcat ttggagaagg ctatgtcaat gtcacggtta
     1561 tgccagctgc aagagtcaac cagccacctg tagctgttgt ttctccccag acacaagagc
     1621 tcagtgtgcc tttgacctca gccctgatcg atggcagcca aagtacagat gatactgaaa
     1681 tagtgagtta ccactgggaa gaagtcgacg ggcccttcct aggagaggag tttccagctg
     1741 acaccccaat cttacgattg tcgaacctag ttcctggtaa ctacaccttt aggttgacca
     1801 tcacagactc ggatggcgct accaactcca ccactgcatc cctcgtcatc cgtgatgccg
     1861 tggactaccc acccgttgcc aatgcagggc caaatcagac catcactttg ccccaaaaca
     1921 ccatcattct gaatgggaac cagagcagtg atgatcacca gattgttctc tatgagtggt
     1981 tcgcaggccc tggcggtgag agcaaagaga tggtcatgca gggagcgcag accccatacc
     2041 ttcacttgtc tgagctgcag gaaggagagt acacatttca gctgatggtg acggattcct
     2101 cgggacagca atccaccgct ttggtcgctg tgactgtcca ggctgagaac aaccaggctc
     2161 cggtggccgt ggcaggcccc gacaaggagc tggttttccc ggtgcagagt gctacactgg
     2221 atgggagccg gagcagtgac gatcacggca ttgtctgcta tcactgggag cacatcagag
     2281 gccccagtgc agtggagatg gagaatgtgg acaaagccat agccactgtc accggccttc
     2341 aggtgggtat ctaccacttc cggttaaccg tgagagacca gcagggtctg agcagcacgt
     2401 ccaccctcac tgtggctgtg aagaaggaaa ataacagccc tcccagagcc caggctggtg
     2461 gcagacatgt tcttatactt cccaataatt ccattacttt ggatggttca aggtctactg
     2521 atgaccgagg aattgtgtcc tatctgtgga tccgggatgg ccagagtcca gctgccggag
     2581 atgtcattgg aggctctgac cacagggcag ctctgcagct caccaatctg gtggaaggcg
     2641 tctacacttt tcacttgcta gtcactgaca gtcagggggc ctcggactca gacgcggcca
     2701 ctgtggaggt gctgccagac cccaagaagg atggcctggt ggagttgatc ctgcaggttg
     2761 gtgttgagca gctgacagag cagcagaagg agactctagt gaggcagctg gctgtgctcc
     2821 tgaacgtgct agactcagac gtgaaggtgt tgaagatcca ggctcacacg gatgtcagca
     2881 ctgtgattgt attttatgta cagagtggat cacctttcaa ggttctcaga gctgctgctg
     2941 tggcccggaa tctgcacaag cggctttcca aggagaagga ggctttcctg cttttcaagg
     3001 tcttgagggt agacacagca gggtgccttc tcaagtgttc aggccacggt cactgtgacc
     3061 ccatcacgaa gcgctgcatc tgctcccagc tgtggatgga gaacctcata cagcggtaca
     3121 tgtgggatgg agagagcaac tgtgagtgga gtgtattcta tgtggcagct ctggcattga
     3181 cactaacact gctaactgga gctgtgtctt ggctgtgcat ctgctgctgc aggagacgga
     3241 aaaggactaa gatccggaag aaaaccaagt ataccatcct agacagcatg gacgaacagg
     3301 aaagaatgga actgaggccc aagtacggta tcaagcacag gagcacggag cacaactcca
     3361 gtctgatggt gtcggagtct gagtttgaaa gcgaccagga cacgctattc agccgagaga
     3421 ggatggagag aggagtcctg aagggttccc tgaatggctg tgccagaaat ggagtttcct
     3481 tcggttacta ctcaaaggac agataacagg ctgctgtgga gagaccttgt gagccccccg
     3541 tggctcagta ctaggcagat ggaagttaaa acacaaaagc tgactcctgc tggtcacagt
     3601 gcagtggcaa ccctccccag ggaccttgca ctgtgctcca catagtgatg agaagacctg
     3661 agttcttgga actttcaaga cacaaaacaa aatcctgctt ctccaactga tgctcatcaa
     3721 cagagaaaag gggtgcataa aacctctggc gtctgctgaa aagttttgtg tcttctagca
     3781 gacactttgt tatatttatt gtccatgatg agattaggca aacacctgtt tctatttata
     3841 tagccctgta ggaaaggcaa gttaaggagg gttgattgct ctgtagaagc tgtgactgcc
     3901 tctaagaacc ttccagaaac ggcttctcca gaggacctgc aggatcagct tgcagttcat
     3961 ctttgaggca ggaaccttct gtgtgcagct tcctgtctgt gatgcagcca gctgtggcca
     4021 gctagacggt caggagctaa ggaagcatgg aatctaagga caggaggcaa tagagatggg
     4081 gagggggcga aggaccctca ggttaaatgt tgaaggcctt taacattttt ctcattcact
     4141 ttctctaaga aaaagaaacc acagtgggac ttctttcagc cccaatggac attcagactg
     4201 actgcttatt attgtaactt tttactaaat atgcactgta gcactgccgt ggaaaatggg
     4261 gaggattcag tgagcacaga cattcccaag ctctgaaata tgctcctaat gaggggaaag
     4321 tggtcggtca ccatgctctg acctcctaca gagacttccc attgaaataa ctggacagaa
     4381 catccaccat ttgtgcttaa aaacttattt aagggactag agaaatggct acatataaga
     4441 cctcactgct cttgcagaag actgtggttc agttcctagc gctcacagga tgacttgcaa
     4501 ctgtccagaa ctccactttc aggggtccag tgccctcttc tggcctccag cagcagcggt
     4561 ggcggcagcg gcagcggcag cgacggcagc agcagcagca gcagcagcag cagcagcagc
     4621 agcagcagca gcagcagcag caggaagaat gtacagagtt catacatgtg ggcaaaatac
     4681 tcaagcacat aaaaaggaat tatacaaggt ccaccaacaa agcaggaccc agagcaatgg
     4741 actggagcta attgcagcct gagatgttga ctgacttatg gtagttgccc aggtgcccat
     4801 ggtcccaagg ctgttggcct tgatgatgcc cttggcattt agagaatgga agagccagta
     4861 ctgtagtctt agctttggga gaggagaaca aggtggaaca ggaattcagt gctagccttg
     4921 gctatacaac aagtttgagg gcagcctgga ctatttgaga tcctatgtgt aaaaatgaaa
     4981 aaaaaaaaaa agttaggaga attagaacta caacttaaat tttagtaatt gtttgttctg
     5041 gaattttcta tttctcagct atagttaact gaaaactcaa aaaaaaatca gagggctcag
     5101 tatattataa ctttactggt ggaataatgg aattaaaatg tatagg
//
