LOCUS       NM_144853               7942 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus cysteine and tyrosine-rich protein 1 (Cyyr1), mRNA.
ACCESSION   NM_144853 XM_917513
VERSION     NM_144853.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7942)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   2  (bases 1 to 7942)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   3  (bases 1 to 7942)
  AUTHORS   Reymond,A., Camargo,A.A., Deutsch,S., Stevenson,B.J.,
            Parmigiani,R.B., Ucla,C., Bettoni,F., Rossier,C., Lyle,R.,
            Guipponi,M., de Souza,S., Iseli,C., Jongeneel,C.V., Bucher,P.,
            Simpson,A.J. and Antonarakis,S.E.
  TITLE     Nineteen additional unpredicted transcripts from human chromosome
            21
  JOURNAL   Genomics 79 (6), 824-832 (2002)
   PUBMED   12036297
REFERENCE   4  (bases 1 to 7942)
  AUTHORS   Vitale,L., Casadei,R., Canaider,S., Lenzi,L., Strippoli,P.,
            D'Addabbo,P., Giannone,S., Carinci,P. and Zannotti,M.
  TITLE     Cysteine and tyrosine-rich 1 (CYYR1), a novel unpredicted gene on
            human chromosome 21 (21q21.2), encodes a cysteine and tyrosine-rich
            protein and defines a new family of highly conserved
            vertebrate-specific genes
  JOURNAL   Gene 290 (1-2), 141-151 (2002)
   PUBMED   12062809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025589.9.
            
            On Jan 23, 2023 this sequence version replaced NM_144853.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY061854.1, AK031840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               CT025589.9         37351-37709
            360-462             CT025589.9         42822-42924
            463-617             CT025589.9         122054-122208
            618-7942            CT025589.9         130064-137388
FEATURES             Location/Qualifiers
     source          1..7942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 47.45 cM"
     gene            1..7942
                     /gene="Cyyr1"
                     /note="cysteine and tyrosine-rich protein 1"
                     /db_xref="GeneID:224405"
                     /db_xref="MGI:MGI:2152187"
     exon            1..359
                     /gene="Cyyr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..784
                     /gene="Cyyr1"
                     /note="proline-rich domain-containing protein"
                     /codon_start=1
                     /product="cysteine and tyrosine-rich protein 1 precursor"
                     /protein_id="NP_659102.1"
                     /db_xref="CCDS:CCDS28286.1"
                     /db_xref="GeneID:224405"
                     /db_xref="MGI:MGI:2152187"
                     /translation="MDALRLPRRPGVLLPKLILLFVYAGDCLAQCGKECHSYCCDGST
                     PYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRAA
                     HINAISYPMAPPPYTYDHEMEYRTDLPPPYSAAPQASAQRSPPPPYPGNPRKYSSSQN
                     RIRDN"
     exon            360..462
                     /gene="Cyyr1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..617
                     /gene="Cyyr1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..7942
                     /gene="Cyyr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyyr1"
                     /note="hexamer: AATAAA"
     polyA_site      2788
                     /gene="Cyyr1"
                     /note="major polyA site"
ORIGIN      
        1 agagaagctg ccgtttgctt gccagggcac agcacctttg ggcagaacat aaagcccctg
       61 cggcagctca cccgggctag gaccaccagc gcccagctgc cctgcagccg gccggattcg
      121 ccaaggctgg ggtcatggcc agggcggctt tggaccctgc tctcaggacc acatccctgt
      181 tctcctgacc gccctgtatc ctccgcatcg ctgctggggt tcactccagt cgctcccagg
      241 tctaccggtc tctgtcctag agagcagctt ggggccaccg gcttggatgg acgcgctgag
      301 gctgccccgg cgtccagggg tcctgcttcc gaagttgatc ctgctctttg tttatgcagg
      361 ggattgcctg gcgcagtgtg gcaaagagtg ccactcttac tgctgcgacg gtagcacgcc
      421 ctactgctgc tcctactacg cctatattgg gaacattctc tcgggcacgg cgattgctgg
      481 catcgtgttt ggaatcgtgt tcatcatggg ggtcattgca ggaatcgcca tctgcatctg
      541 catgtgcatg aagaacaacc gggggacccg cgtgggggtc atcagagcag cacacatcaa
      601 cgccatctcc tatcccatgg caccaccccc ctatacttat gaccacgaga tggaatatcg
      661 cacagacctg ccacctccat actctgcagc cccacaggct tcggcccagc gctctccacc
      721 ccctccgtat cctggaaatc caaggaaata ttcctcctcc cagaacagaa tacgtgacaa
      781 ttagcaattt tacccagaac aaaatgcctc aacttagaaa catgcacaaa aatgattgtc
      841 tactggctag ggtccgataa tatctcaggc agaatgtaca cgtggagcag gctctttccc
      901 tgctcagagc taggtggaga attatgcttg gttttctgaa gtcatggatt aagtgatctg
      961 cggatccacc caggcacagt cagatcaaag cgttgcaatt ggcaggctcc tgataaccat
     1021 gctgctttag gacgagatga agacaaagtc aatattgaac ccggaataaa gacgaacaga
     1081 gcgtagtccg atctacatca gggaagagct acattccata cagccttagg agaactagaa
     1141 cagatcgtta tttcatttat ccacaaatat gtatcaagtg ccttagagcc cactctgtgc
     1201 ctcgcaacat gaggggccct ggatagaagt aaccaggggg aactttggtt ctggcacagg
     1261 catacctcat cctgttgcac tttgaccttt tgcactttgc aggtgatgca ttttttacaa
     1321 gttgaaggtt tgtggtaacc ctgcaccaaa cagtgtcatt tacccaccac taggagtgta
     1381 cttttcctat ccttgtatca catgttggtc atcctcaaca gtattccaaa cattctcatc
     1441 attgctatta ttatgtctgt tatggtgatc tgtgttcagc aatagtggtg ttgttacagt
     1501 agccttttgg gggggggggt gtcatgaact ctgcacatat agaacagtga gattaataga
     1561 ctggtaaata ttatgtgtgc catatctgct ccactagaaa gctccctccc tccctccctc
     1621 cctccctccc tccctccctc cctccttccc tccctccctc tctctttccc tccttctctc
     1681 tctctctctc cctccctccc tccctttctc tctctccctc cctccctccc tccctctctc
     1741 tccctccctc cctctctccc tccctccctc ccttcctccc cgcccccaac tcagggaaca
     1801 gtattgaaat taagccaatt aataagtcaa caatgacctc taagtgttca agctacaaga
     1861 atcatatagt tcttgctttt cttgctttaa cccaaaactg gaaatacttc atcttggtga
     1921 caaaagcatg ttcaaatcca ggagaggctg aaaggccagc atctatgcca gctcgttagt
     1981 taagccataa acacagatgc ggctttccca aaggaagcta aaactgtctc tctccaaaca
     2041 cacaaatgat agaaaagaaa gaaaacagcg acctcatcgt ttataagaac tcttcagtgg
     2101 tgtgtgcagc catcaaaaca gccacattcc ctcaagtcat aaagcttgat tcagagctaa
     2161 gacctaactc ttcattctac aaaggttggc agaggcaaag aggaatcata gcttgcatgc
     2221 tataagagaa agattgtgag gagcagagat caggtcctga agtgaaggaa aggagctgac
     2281 ccctgtagta tcaaagggga aagcgaagcc tcaggcactg caatggaagt tgctgcctgt
     2341 tctcccaaag acctcaatag gatcacacat aagatggctg cctggtgcaa atgaaagacc
     2401 ctcctgtgga aagacttgtc ttctagaact tccccaacca gagaaaagaa gctatcttaa
     2461 ccccacacct caaaagacag cctgggtttc ttgttagtgt ctattccaca actttcacat
     2521 gaagccaatg ttcaatgttc attttctagt caaaactcct agtcctctta agcatatgca
     2581 aagtttgctc tgcccatagt ctataaatag aacaaccagg tctatttttg atgtcactta
     2641 atgaatgttt taaaccaagt gttgagactg ctcagggaaa aaacaaggtt tctttcaaaa
     2701 ccttactgct ccttgacaat gcactgttca tctgttcatc taagagctct gatggagatg
     2761 gacaaagaaa taaaccatgt ttctcatatt tatgagtgat tccagtccca ctctgtgtcc
     2821 cttagactat gattaaactc aacttctatg tctcattatt taataaccac ctttttaaag
     2881 gtcataacgg acacagaaat gggaacttct gggggcttgg caaagtcctg gaaagaaccc
     2941 acatctgtag atccatgact cacaagaaga agtcaagagg tcagtattaa taaacatttg
     3001 gaggaagtag atttttgccc tcatacacaa tgctgccttt gttagggctt tggtggggga
     3061 agtacctaca gatatggtaa acccacaaag gtgctgaagg tgcagttcag ttactatgtc
     3121 ttatgatatc actatgagag gaacaattgc ttcttttttt tttttttttt ttaacaattg
     3181 cttcttatgg taagcaatga aaggaggttt tggttcttct ggtgaaacat gctcctggtg
     3241 aaaggtgctg tgggcaaaga tgaggtgaca gcagagggtt tagagtattt ataagtgact
     3301 tgagaagtca gcaaccagat tggagaaaat tacaattttc aaggaagaaa cactgtgcat
     3361 taaaagccac caaacagcat cacatgccac cggaaactct ttcatgaaga gaagtttcat
     3421 gaaacccatc tatcagactt cagtgtcata ttatttgaag gaactcacag tcttccaaaa
     3481 tgagcaacca ccaacctaat cgccagtaac tctcacccca ctgctaccaa taagatttag
     3541 acctgctgaa agctcgagtg ctagttgcca ttttttagca caaaatattt taatgagggt
     3601 atacacattg ctttgaagac acttaacaaa ctatagtata gtataaactt gaatgtgctc
     3661 tggaaagcta aaaagtattt gtgtgattct cttgtgagac ttgctttaca agagagacaa
     3721 gcaacttcat agatgacatc gaagtgttac tggtacgggt atatcaaaca catgccatct
     3781 ctaaagtatg taaaacaaaa caaagcaagc caacaacgaa aagcagttgc agctttcctg
     3841 ttgactagct aactttgtga agcccgtcca tcaagattcc atacaaaagg tgttggtgtg
     3901 gtaaagaaat atgctagaaa gaatgtctaa aatgaataac ggatcaaact ttctgctttt
     3961 gtcttaggta ggtgtgtcca gctgtgtctg cagcaatgaa tgcagccaat caatcttatc
     4021 cattatcttt gacaatttaa acaagatcaa aggtacccaa agggttctgg gagctaagat
     4081 ctccatagtc attactaacc cctcctaaaa acccacatgg tgttagtcac tggtatatga
     4141 gggttgctcc aactgtagaa tgaatggtga gaaaccaaaa attctcaggg ttttatatca
     4201 gtaataaaat gtgtcatttg actgtagatg aaagaccttt ttaaagggga aaataaatgc
     4261 tcaaatatag tagccatttc ttccatttta ttaactttta tcttttagac aagttatata
     4321 attaatggga aaggcaagaa ggcacagggt tgccttttgc ctgaatacta gtttttgtga
     4381 agtacttcct ttaaatgtaa aagcaattaa tgaaatcttc caatatgtca tgttctacaa
     4441 taagtggccc tagcattcat atttttacgt gggtcttttt gtgtactttt aactgtttgt
     4501 cgaaaactag agatagatga tcagacctta atgccacttt aaaagaaaac ctaaaacact
     4561 caatccagta tcatgattat aattcagtga cattccaaaa tgacactaag acactccata
     4621 aataaccaaa agaaatatct tacaatataa gttatggaat atgagcttgt agttgaggaa
     4681 gttaatatga acaaatagtg ccttttattg tatcagatat ctacagttga aatgtgtagg
     4741 tctgactgaa catggtctcc tgaaggtatt aaggctagat ttgttttgag tgacttgctt
     4801 ggctttggaa agaataatct tagcttcgaa gatgtgaagc cttcaggggt cctgtttgtt
     4861 ccagaaagag acttcctgcc tggcatgaaa tattagcata gtgttcacag tacatgagct
     4921 ttgatttatt tttcttccac caatgtgatt agtttccact actctcaagc aagagtccgc
     4981 aatgccaaag tcatggtggt ctgagaatgt tgtcggtcgg caaatccact acacatttct
     5041 aaagaaaaat agagaggcat gaccataaaa attaaatgct cttcttggca ataatgtata
     5101 tttaccacgt gcctctgaca ttctataaat attgcctgca ccggaaccat ttctgtccat
     5161 actatctctc cttgagtttt ttatggctca ccctgaggca tagcatgaat ctatataatc
     5221 accatagatg aaggatttta ctgtttttat tagtatcata ataacagaaa taaacatatc
     5281 atagatgtct aaaaagttca ctgtttattt ttaggagtaa tgtatatcag aggcaaacaa
     5341 tatttgatgt aaaaatttga ttgtggttat ttaagaacta acctttgtta tggctaattt
     5401 gtttataagg aacaataaac tgaaagaact tataacaaga atgggagttt tggggttttt
     5461 tgtttgtttg tttttgcttt ttggttttgg ttttggtttt ggttttgaga caaggttttt
     5521 ctgtgtagcc ttggctgtgt ggaatctccc tttatagacc aagctagtct caaactcaca
     5581 gatatcctcc tgtctctgcc tctcctctgc ctctgcctcc tccacctccg cctcctccgc
     5641 ctctgcctcc acctctgcct ctggaaagct gtgccccact gccagagtaa caagaaccat
     5701 gttttaatta ttatgtcatt aatcctccct gctattcctc ctgaataagc cttttgtttt
     5761 actttgcaca tggaaatagt tctgtcacca tactgacttt ttaatcctgt ctctcaccta
     5821 agtgatttga agacggatac ttttcctctg atagctaaat ttccattcta tgatacatga
     5881 atgatagagt gggcctcagg ggttttctga aaactggcta aatgtgcaca atttattttt
     5941 agtctggaac ccaagacttg gaaactatcc tatccaaatg aacccaaatt aaattttcaa
     6001 aactcgtcat aaaataacaa catctagact tgtgcatata aagttaaatt aattggaact
     6061 aaattaagtt aaaaaaaaag aaaagaaaag aaaaggagag gagaggagag gagaagggag
     6121 gagaggagag gagaggagag gagaggagag gagaggagag gagaggagag gagaggagag
     6181 aagagaagag aagagaagag aagagaagag aagagaagag aagagaagag aagagaagag
     6241 aagagaagag aagagaagag aagagaaaag tgctgcaaac cgtctaggcc cctttgtctg
     6301 cgtggaaatt ccaacaacga aaagcagttg cagctttcct gttgactagc taactttgtg
     6361 aagcccgtcc atcaagattc catacaaaag gtgttggtgt ggtaaagaaa tatgctagaa
     6421 agaatgtcta aaatgaataa cggatcaaac tttctgcttt tgtcttaggt aggtgtgtcc
     6481 agctgtgtct gcagcaatga atgcagccaa tcaatcttat ccattatctt tgacaattta
     6541 aacaagatca aaggtaccca aagggttctg ggagctaaga tctccatagt cattactaac
     6601 ccctcctaaa aacccacatg gtgttagtca ctggtatatg agggttgctc caactgtaga
     6661 atgaatggtg agaaaccaaa aattctcagg gttttatatc agtaataaaa tgtgtcattt
     6721 gactgtagat gaaagacctt tttaaagggg aaaataaatg ctcaaatata gtagccattt
     6781 cttccatttt attaactttt atcttttaga caagttatat aattaatggg aaaggcaaga
     6841 aggcacaggg ttgccttttg cctgaatact agtttttgtg aagtacttcc tttaaatgta
     6901 aaagcaatta atgaaatctt ccaatatgtc atgttctaca ataagtggcc ctagcattca
     6961 tatttttacg tgggtctttt tgtgtacttt taactgtttg tcgaaaacta gagatagatg
     7021 atcagacctt aatgccactt taaaagaaaa cctaaaacac tcaatccagt atcatgatta
     7081 taattcagtg acattccaaa atgacactaa gacactccat aaataaccaa aagaaatatc
     7141 ttacaatata agttatggaa tatgagcttg tagttgagga agttaatatg aacaaatagt
     7201 gccttttatt gtatcagata tctacagttg aaatgtgtag gtctgactga acatggtctc
     7261 ctgaaggtat taaggctaga tttgttttga gtgacttgct tggctttgga aagaataatc
     7321 ttagcttcga agatgtgaag ccttcagggg tcctgtttgt tccagaaaga gacttcctgc
     7381 ctggcatgaa atattagcat agtgttcaca gtacatgagc tttgatttat ttttcttcca
     7441 ccaatgtgat tagtttccac tactctcaag caagagtccg caatgccaaa gtcatggtgg
     7501 tctgagaatg ttgtcggtcg gcaaatccac tacacatttc taaagaaaaa tagagaggca
     7561 tgaccataaa aattaaatgc tcttcttggc aataatgtat atttaccacg tgcctctgac
     7621 attctataaa tattgcctgc accggaacca tttctgtcca tactatctct ccttgagttt
     7681 tttatggctc accctgaggc atagcatgaa tctatataat caccatagat gaaggatttt
     7741 actgttttta ttagtatcat aataacagaa ataaacatat catagatgtc taaaaagttc
     7801 actgtttatt tttaggagta atgtatatca gaggcaaaca atatttgatg taaaaatttg
     7861 attgtggtta tttaagaact aacctttgtt atggctaatt tgtttataag gaacaataaa
     7921 ctgaaagaac ttataacaag aa
//
