LOCUS       NM_001081106             974 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus cytokine-like 1 (Cytl1), mRNA.
ACCESSION   NM_001081106 XM_132070
VERSION     NM_001081106.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Zhu W, Yang X, Liu S, Wang M, Ye S, Luo H and Cui S.
  TITLE     The involvement of cytokine-like 1 (Cytl1) in chondrogenesis and
            cartilage metabolism
  JOURNAL   Biochem Biophys Res Commun 529 (3), 608-614 (2020)
   PUBMED   32736681
  REMARK    GeneRIF: The involvement of cytokine-like 1 (Cytl1) in
            chondrogenesis and cartilage metabolism.
REFERENCE   2  (bases 1 to 974)
  AUTHORS   Xue H, Li S, Zhao X, Guo F, Jiang L, Wang Y and Zhu F.
  TITLE     CYTL1 Promotes the Activation of Neutrophils in a Sepsis Model
  JOURNAL   Inflammation 43 (1), 274-285 (2020)
   PUBMED   31823178
  REMARK    GeneRIF: CYTL1 Promotes the Activation of Neutrophils in a Sepsis
            Model.
REFERENCE   3  (bases 1 to 974)
  AUTHORS   Shin Y, Won Y, Yang JI and Chun JS.
  TITLE     CYTL1 regulates bone homeostasis in mice by modulating osteogenesis
            of mesenchymal stem cells and osteoclastogenesis of bone
            marrow-derived macrophages
  JOURNAL   Cell Death Dis 10 (2), 47 (2019)
   PUBMED   30718470
  REMARK    GeneRIF: Results collectively suggest that CYTL1 negatively
            regulates the osteogenesis of MSCs and positively regulates
            osteoclastogenesis to modulate bone mass.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 974)
  AUTHORS   Kim J, Kim J, Lee SH, Kepreotis SV, Yoo J, Chun JS, Hajjar RJ,
            Jeong D and Park WJ.
  TITLE     Cytokine-Like 1 Regulates Cardiac Fibrosis via Modulation of
            TGF-beta Signaling
  JOURNAL   PLoS One 11 (11), e0166480 (2016)
   PUBMED   27835665
  REMARK    GeneRIF: Collectively, the data suggest that Cytl1 plays an
            essential role in cardiac fibrosis likely through activating the
            TGF-beta-SMAD signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 974)
  AUTHORS   Brommage R, Liu J, Hansen GM, Kirkpatrick LL, Potter DG, Sands AT,
            Zambrowicz B, Powell DR and Vogel P.
  TITLE     High-throughput screening of mouse gene knockouts identifies
            established and novel skeletal phenotypes
  JOURNAL   Bone Res 2, 14034 (2014)
   PUBMED   26273529
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 974)
  AUTHORS   Jeon J, Oh H, Lee G, Ryu JH, Rhee J, Kim JH, Chung KH, Song WK,
            Chun CH and Chun JS.
  TITLE     Cytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and
            bone development but exhibit augmented osteoarthritic cartilage
            destruction
  JOURNAL   J Biol Chem 286 (31), 27206-27213 (2011)
   PUBMED   21652695
  REMARK    GeneRIF: results suggest that, rather than regulating cartilage and
            bone development, Cytl1 is required for the maintenance of
            cartilage homeostasis, and loss of Cytl1 function is associated
            with experimental OA cartilage destruction in mice
REFERENCE   7  (bases 1 to 974)
  AUTHORS   Lu CC, Appler JM, Houseman EA and Goodrich LV.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   8  (bases 1 to 974)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 974)
  AUTHORS   Kim JS, Ryoo ZY and Chun JS.
  TITLE     Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal
            cells
  JOURNAL   J Biol Chem 282 (40), 29359-29367 (2007)
   PUBMED   17644814
  REMARK    GeneRIF: chondrocyte-specific Cytl1 regulates chondrogenesis as a
            novel autocrine factor, but not hypertrophic maturation of
            chondrocytes during cartilage development
REFERENCE   10 (bases 1 to 974)
  AUTHORS   Ficker M, Powles N, Warr N, Pirvola U and Maconochie M.
  TITLE     Analysis of genes from inner ear developmental-stage cDNA
            subtraction reveals molecular regionalization of the otic capsule
  JOURNAL   Dev Biol 268 (1), 7-23 (2004)
   PUBMED   15031101
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC158588.3.
            
            On Feb 6, 2007 this sequence version replaced XM_132070.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063103.1, CB566234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC158588.3         173956-174146
            192-236             AC158588.3         175799-175843
            237-365             AC158588.3         176019-176147
            366-974             AC158588.3         177649-178257
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.21 cM"
     gene            1..974
                     /gene="Cytl1"
                     /gene_synonym="4930443F05Rik; 4Cytl1; C17; Cyt1; Gm147"
                     /note="cytokine-like 1"
                     /db_xref="GeneID:231162"
                     /db_xref="MGI:MGI:2684993"
     exon            1..191
                     /gene="Cytl1"
                     /gene_synonym="4930443F05Rik; 4Cytl1; C17; Cyt1; Gm147"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..449
                     /gene="Cytl1"
                     /gene_synonym="4930443F05Rik; 4Cytl1; C17; Cyt1; Gm147"
                     /codon_start=1
                     /product="cytokine-like protein 1 precursor"
                     /protein_id="NP_001074575.1"
                     /db_xref="CCDS:CCDS39077.1"
                     /db_xref="GeneID:231162"
                     /db_xref="MGI:MGI:2684993"
                     /translation="MSPKTLPLLLLLVVVVIAWPLAVQSAPPTCYSRMLTLSREIMAD
                     FQSLQASEPEDSCVRYLPRLYLDIHNYCVLAKLRDFVASPQCWKMAEVDTLKDRVRKL
                     YTIMNSFCRRDLVFLSDDCSALEDPIPEATGPPDWQS"
     exon            192..236
                     /gene="Cytl1"
                     /gene_synonym="4930443F05Rik; 4Cytl1; C17; Cyt1; Gm147"
                     /inference="alignment:Splign:2.1.0"
     exon            237..365
                     /gene="Cytl1"
                     /gene_synonym="4930443F05Rik; 4Cytl1; C17; Cyt1; Gm147"
                     /inference="alignment:Splign:2.1.0"
     exon            366..974
                     /gene="Cytl1"
                     /gene_synonym="4930443F05Rik; 4Cytl1; C17; Cyt1; Gm147"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgaccca gcagtaggca ccaggcacca tgtcaccaaa gacactacct ctgttgctgc
       61 tgctggtggt ggtggtgata gcctggcctc tggcagtaca gtccgcgccc cccacctgct
      121 actctcggat gctgaccctg agccgtgaga tcatggcaga cttccagagc ctgcaggctt
      181 cagagcctga ggattcctgt gtgaggtact tgccccggct ttacctggac atccataact
      241 actgtgtgct ggccaagctg agagacttcg tggcttctcc tcagtgctgg aagatggccg
      301 aagtggacac tctgaaggac agagtgcgga agctgtatac catcatgaac tccttctgca
      361 ggcgggactt ggtattcctc tcagatgact gcagtgcctt agaagaccca attcccgagg
      421 ccacgggtcc tccagactgg cagagctaag caggtggacc agaagaacaa cccagaggtc
      481 tgaagctggg ccagttgtcc agagttacac cccccacaca cacacccagg tctactttta
      541 gtgccactgt tagacctgcc acatgtctct agcttctgaa acaccagtga gggtcctacc
      601 tctgagcatg ctttgtgcac aggttggaag ctcagctcag ctcctaggtg tctcattgga
      661 atgtaagagg cacaaagagg aaagtgcaca ctggcttcgc tttggagagc aagcacctta
      721 ggaacagcaa aatctcatgc ctttgtgact gttttaatga actaatggga ccactcttct
      781 ttctggtctc tgcttacacc tacaggggct tcaactttat gcttccttct tcctgtgcaa
      841 gctttcctgc ctctctctca ttttaaagtg tttttactgc ttttgcgata catttacaag
      901 gcttttatgt agtgtaaacg agccaccctt tcgctgaagg gtgatgaaaa ccaaataaac
      961 ctctgtcgtg agaa
//
