LOCUS       NM_139200               5735 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytohesin 1 interacting protein (Cytip), mRNA.
ACCESSION   NM_139200
VERSION     NM_139200.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5735)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5735)
  AUTHORS   Martinez-Garcia,M., Naharro,P.R., Skinner,M.W., Baran,K.A.,
            Lascarez-Lagunas,L.I., Nadarajan,S., Shin,N., Silva-Garcia,C.G.,
            Saito,T.T., Beese-Sims,S., Diaz-Pacheco,B.N., Berson,E.,
            Castaner,A.B., Pacheco,S., Martinez-Perez,E., Jordan,P.W. and
            Colaiacovo,M.P.
  TITLE     GRAS-1 is a novel regulator of early meiotic chromosome dynamics in
            C. elegans
  JOURNAL   PLoS Genet 19 (2), e1010666 (2023)
   PUBMED   36809245
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5735)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 5735)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 5735)
  AUTHORS   Heib,V., Sparber,F., Tripp,C.H., Ortner,D., Stoitzner,P. and
            Heufler,C.
  TITLE     Cytip regulates dendritic-cell function in contact hypersensitivity
  JOURNAL   Eur J Immunol 42 (3), 589-597 (2012)
   PUBMED   22488362
  REMARK    GeneRIF: Data suggest a suppressive function for Cytip in mouse
            dendritic cells in limiting immune responses.
REFERENCE   6  (bases 1 to 5735)
  AUTHORS   Watford,W.T., Li,D., Agnello,D., Durant,L., Yamaoka,K., Yao,Z.J.,
            Ahn,H.J., Cheng,T.P., Hofmann,S.R., Cogliati,T., Chen,A.,
            Hissong,B.D., Husa,M.R., Schwartzberg,P., O'Shea,J.J. and Gadina,M.
  TITLE     Cytohesin binder and regulator (cybr) is not essential for T- and
            dendritic-cell activation and differentiation
  JOURNAL   Mol Cell Biol 26 (17), 6623-6632 (2006)
   PUBMED   16914744
  REMARK    GeneRIF: These data suggest that Cybr is not absolutely required
            for hematopoietic cell development or function, but stem cells
            lacking Cybr are at a developmental disadvantage compared to
            wild-type cells.
REFERENCE   7  (bases 1 to 5735)
  AUTHORS   Coppola,V., Barrick,C.A., Bobisse,S., Rodriguez-Galan,M.C.,
            Pivetta,M., Reynolds,D., Howard,O.M., Palko,M.E., Esteban,P.F.,
            Young,H.A., Rosato,A. and Tessarollo,L.
  TITLE     The scaffold protein Cybr is required for cytokine-modulated
            trafficking of leukocytes in vivo
  JOURNAL   Mol Cell Biol 26 (14), 5249-5258 (2006)
   PUBMED   16809763
  REMARK    GeneRIF: expression in vivo is differentially modulated by type 1
            cytokines during lymphocyte maturation
REFERENCE   8  (bases 1 to 5735)
  AUTHORS   Gorski,K.S., Shin,T., Crafton,E., Otsuji,M., Rattis,F.M., Huang,X.,
            Kelleher,E., Francisco,L., Pardoll,D. and Tsuchiya,H.
  TITLE     A set of genes selectively expressed in murine dendritic cells:
            utility of related cis-acting sequences for lentiviral gene
            transfer
  JOURNAL   Mol Immunol 40 (1), 35-47 (2003)
   PUBMED   12909129
REFERENCE   9  (bases 1 to 5735)
  AUTHORS   Boehm,T., Hofer,S., Winklehner,P., Kellersch,B., Geiger,C.,
            Trockenbacher,A., Neyer,S., Fiegl,H., Ebner,S., Ivarsson,L.,
            Schneider,R., Kremmer,E., Heufler,C. and Kolanus,W.
  TITLE     Attenuation of cell adhesion in lymphocytes is regulated by CYTIP,
            a protein which mediates signal complex sequestration
  JOURNAL   EMBO J 22 (5), 1014-1024 (2003)
   PUBMED   12606567
REFERENCE   10 (bases 1 to 5735)
  AUTHORS   Kitano,J., Kimura,K., Yamazaki,Y., Soda,T., Shigemoto,R.,
            Nakajima,Y. and Nakanishi,S.
  TITLE     Tamalin, a PDZ domain-containing protein, links a protein complex
            formation of group 1 metabotropic glutamate receptors and the
            guanine nucleotide exchange factor cytohesins
  JOURNAL   J Neurosci 22 (4), 1280-1289 (2002)
   PUBMED   11850456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157859.1, AK152784.1 and AL928564.8.
            
            On Feb 2, 2007 this sequence version replaced NM_139200.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152784.1, AK089364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK157859.1         2-20
            20-2433             AK152784.1         2-2415
            2434-2539           AK152784.1         2417-2522
            2540-5735           AL928564.8         112469-115664       c
FEATURES             Location/Qualifiers
     source          1..5735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.05 cM"
     gene            1..5735
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /note="cytohesin 1 interacting protein"
                     /db_xref="GeneID:227929"
                     /db_xref="MGI:MGI:2183535"
     exon            1..241
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1147
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /note="pleckstrin homology, Sec7 and coiled-coil domains,
                     binding protein; tamalin; cbp HE; cytohesin-binding
                     protein HE; cytohesin binding protein"
                     /codon_start=1
                     /product="cytohesin-interacting protein"
                     /protein_id="NP_631939.1"
                     /db_xref="CCDS:CCDS16048.1"
                     /db_xref="GeneID:227929"
                     /db_xref="MGI:MGI:2183535"
                     /translation="MSLQRFLQRQGSNGNLEYCADSAYGSYSVLTGQLTMEDNRRIQV
                     LADTVATLPRGRKQLALARSSSLGDFSWSQRKVVTVEKQDNGTFGFEIQTYRLQNQNI
                     CSSEVCTMICKVQEDSPAHCAGLQVGDIFANVNGVSTEGFTHKQVVDLIRSSGNLLTI
                     ETLNGTMIHRRAELEAKLQTLKQTLKKKWVELRSLHLQEQRLLHGDTANSPNLENMDL
                     DESSLFGNLLGPSPALLDRHRLSSESSCKSWLSSLTVDSEDGYRSSMSEDSIRGAFSR
                     QTSTDDECFHSKDGDEILRNASSRRNRSISVTSSGSFSPLWESNYSSVFGTLPRKSRR
                     GSVRKQILKFIPGLHRAVEEEESRF"
     exon            242..291
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            292..346
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            347..449
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            450..543
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            544..613
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            614..680
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /inference="alignment:Splign:2.1.0"
     exon            681..5735
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2087..2092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /note="hexamer: ATTAAA"
     polyA_site      2106
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /note="major polyA site"
     regulatory      2149..2154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /note="hexamer: GATAAA"
     polyA_site      2172
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
                     /note="hexamer: ATTAAA"
     polyA_site      3396
                     /gene="Cytip"
                     /gene_synonym="A130053M09Rik; Cbp; Cybr; Pscdbp"
ORIGIN      
        1 gcatttcgct tcctccctcc tgcaaggcca gggaaccatg tgttggcggg attaatcttt
       61 gcccacaatg tctctgcaaa ggtttctgca gcggcagggc agcaatggca atttggagta
      121 ctgtgctgac tctgcctacg gctcctactc cgtcctcacg ggccagctca cgatggaaga
      181 caaccgaagg attcaagtgc tggcagacac tgtagctact ttgccccggg gacgaaagca
      241 gcttgcgttg gccagatcaa gctctttggg tgatttttcc tggtctcaaa ggaaggttgt
      301 tactgtggaa aagcaggaca atggaacatt tggatttgaa attcagacct acagactcca
      361 gaaccagaac atctgttcct cagaagtgtg cactatgatc tgcaaagtgc aggaagacag
      421 ccccgctcac tgtgctggcc tgcaagttgg tgacatcttt gcaaatgtca atggtgtgag
      481 cacagaaggc tttactcaca aacaagtggt tgacctgatc cgatcatcag gaaatctgct
      541 aacgatagag actcttaatg gaacaatgat tcacagaaga gcagaacttg aagcaaaact
      601 gcagacttta aagcaaacct tgaagaaaaa atgggtggag ctcaggtctc tgcacttaca
      661 ggaacagcgc ctgttgcatg gagacacagc aaactcccca aatttggaaa acatggacct
      721 cgacgagtcg tccttgtttg gaaatctgct ggggccgagt ccagccctcc tggaccggca
      781 tcgactgtcc agtgagagca gttgtaagag ttggctgagc tccctcacag tggacagtga
      841 ggacggctac cggagcagta tgtctgagga ctccatccgg ggtgccttca gccggcagac
      901 cagcaccgac gatgagtgct ttcactctaa ggatggagac gagattctgc ggaatgcttc
      961 ttccaggaga aaccggagca tcagtgtcac tagtagtggg tccttttctc ccttgtggga
     1021 gagcaattac tcaagcgtgt ttgggaccct gccccggaaa agcagacggg gtagtgtccg
     1081 gaaacaaatt ttgaaattca tccctggcct tcatcgtgca gtggaagagg aagagagtcg
     1141 cttttgatgg gctgctgcag accttttgaa ttggcttgtt tcacaatcct ctctctaccc
     1201 gccaagatga acccctggct tagtgggaaa gtacagatag actgtgaagc tcacatccca
     1261 tctcacagca gcagtgacct ttaagttctt atattgttat ttttggggtc ttatatcaga
     1321 ggtttgtttt tgttcgtttg tttgtttcaa tcagtagtgt tcaacttcta aacagacatc
     1381 acaagaggaa agtaataggt taaataatgt aataatatgt ctgctcattc taatgctggc
     1441 caggaaagta caaaaatatt tattatactg accatgcatg taaaaagtgg agaattctta
     1501 gatcaagtaa gaatatagac cgacagaata taattattgg gttgctttta atatgttaat
     1561 ttgatagact acaaaacctc ctatttgctt catttactct gtagcctctg ggagcttgcc
     1621 caagagagaa ttaaaattgt tttcaaacca ttaaaggatc ataaaacata gcatcatacg
     1681 catcttctca cttcagcagt gacagtgagg cgggagagat gcctagtatt ggtgcagagg
     1741 agagctcttg gtgctgggat cctatgccac tccccactcc atctctaaac agagtgagtg
     1801 agactctcat tattttcgcc catttcaatt tttattttct gcctgaacat tcatgccaag
     1861 gccagaaatc tcaggatcaa atctatagat ctgtgattgt attttctgca aatgtctaaa
     1921 attctaaaaa tgagaatggg gaaggaacat ttcttctgta tgtttatctc ctgctacacc
     1981 tcattaaaca ttccacatag gtatcacctc agctcgaagt tccttgttag ctgtgcttgt
     2041 attgtactct cacctgtcaa tcatgctcta tgttatttca acatccatta aactctgttc
     2101 tggtgataca gctgttcatt acctgtatgc tcaagtaaat aaccatgtga taaagactta
     2161 ggttgattcc aagcacactc tctccctcca ccctttcggg gtgtgtgtgt gtgtgtgtgt
     2221 gtgtgtgtgt gtgtgtatgt gtttgtgtgt cttcaacaga gctgatacat ttaagtgaat
     2281 ttctagttgg tctatagaaa gcaattttga tttttaaaaa agtgaagtaa agtctgtagg
     2341 ataataagta gtaaaattta tctaagtggg acctgctgcc tataaactct ttgaactaag
     2401 acacatgttt tttttgtttt gttttgtttt tttccgtgtg tgttattcgg cacacttctc
     2461 aggtatacca gcagtgctgt ctcccaaata tggagtgtaa ggcagtctaa aagcacctta
     2521 gaacaactgg agacaggata caaaaaaaaa aaaaaaagaa agaaagaaag aaggaaagat
     2581 agaggggagg ggagaggaga gagagagaga gagagagaga gagagagaga gagagagaga
     2641 gagagagaga gagagagaga tcagggatgc agagcctgtg gtcatggctt gtcagtgttg
     2701 tcctggctag aagtgaaagc catttcttct tggatgtagc caatactctt ggcttcttta
     2761 ggaatcgtta ctcttttgct ggttctggtg gagttatatt agaacaactg gagctttctc
     2821 atcagggttg tgtatgatac agggacttaa aatgtctgaa actcaactct caccaaaaaa
     2881 atcaacagtg gcttttgagt tgtctcagat gaatagtaat ggcacagact catgtgggag
     2941 taaaactaac aagctttatt gtggaaagat ggggaaaggt gacaaatcaa aggggaaact
     3001 cctgaaaaca ggaggggttc ccaagaatga aaaagccctg aaaatatctg tctagaagtg
     3061 tttttttttt catttttgtt tataggattt acaacagaaa ttgacaaaga ctgtgatcat
     3121 ttctattgag atggatcagt tctctagggt atcatggccc atgctaatag aggaacaaca
     3181 cactctgagc atatcttact gcttcaatca cgggaatgat catgccctgt ttgcatgctg
     3241 cccactctat ccagagtact tgcagagttc cagctttgtt catctctgag ttctgttagt
     3301 tagctactgg ccttgatttc tgtctgttag ctgatagccc tctcgtcgtt gatatcgtag
     3361 ttatattgcc agctgttaat taaattgtgg cctctatatg atcagtttgc actttaatca
     3421 tttcagaggg aaaactcaat caaagctaca aaggtgtagc tgcgactgtc cttattactt
     3481 catgttaggt ctttgcttat ggggcagtct cctttctgaa ttagatggac acttcttatt
     3541 agaagatgta ctacctacat tttagtctgt cacagttgaa acacaagcaa gactataggg
     3601 aaggacaact gccttgttta tgttcctgca gtgctgcaac ctgcaaggga ttgacctgac
     3661 tcggacactg gaatgatgta acaacagaca taggaacaga aaagctggat agagtaggtc
     3721 acgtgctttg atgaagatgt tccagcatcc agcaaactca gcatgcttgt gacatagctt
     3781 aacaaaggtg tgggttagct aatcttggta agaggtctct ttgtagagga acagtctaag
     3841 gctgcagata tcccagagga gaaagccata cttgatactt tcacacactg tcaccatcta
     3901 tattctgacc aggggaaggc cttgccattt ctgtgggtct gagacactgg ggtcttttga
     3961 catggtagca ctcatgtcaa catacacatc atctctagac tttatccatt cccccaggac
     4021 attggctgtc gggcctgcta gtcctgacct tactagccag tctatgttcc ttgtgtctag
     4081 tcaaaggttt taaccccaac ctttttattt ttaaccccag tgtctgtttt gaccttcccc
     4141 tttgtgatca acaaggaatc gtcaccatga gccccttccc cttcctacct gcagagtgat
     4201 agcaacagcc tcagctcgat gaacttccca ctgtaatact tttaattcac ctgccagaaa
     4261 atattaaaat ataaattgtt gagccaatag cgaaatatct cgtggtctct ggagagtagg
     4321 acaccaacaa tttagggtga ttcttttctt agctttcatt agcaagcttt caaatacagt
     4381 acataagtac ttagatgcta caacacatta cattttcttt acaatacatt aattaattgc
     4441 aatacattaa tgtttcctta agagttttaa aacagttatc attgagctag cacagcattt
     4501 tcttttcctc tttttaggac tatcatgcta aagatcagct tacatgaata cagcatcttg
     4561 atctccgccc atgacgtatg gggaagagat gtgcgtttat atgggtcaaa gtttcccgaa
     4621 agtgagaacc tgttgcagag ccacttcaga tcatctgaga aagcagagca taggtcaccg
     4681 gcttctcttg caaacgtctg ttagtaaatg tcaaatgcaa agtggggacc aggaagggat
     4741 ggagccagta ccaagttcat ttgtgttgag aagaattagc atcaaaaggt agacctgtgt
     4801 tcttggggtt ggaggagagg aagcaaaact ggttaaccag agcacaggaa ggaaggctat
     4861 gccatgtgct tagtgttcac aagcagttta atgtaaatgt aggggaattt cataccatgt
     4921 tttagtctgt gtctgacctg agtgggacct tagaagaagc tcctgtggca ctgtggctca
     4981 cttggatgta atttatgggg aaaatacctt aaaagccgtt ttactttttt ttttttaatt
     5041 ttttgaattc tgaagttgtc aggtatgtaa ttttggtgca ttgcactaat tgacaaatcg
     5101 ttatgaaact actgttttct agaacggtgt ctgataaacc aattctgagt catgccgatt
     5161 ctgaactgca taatcactga gctcaaagac tagggcacga aacaagtagg agagaaaaga
     5221 gttttctctt tttgatactt tatgtgtctg agtgctgtac ctgcatccat gtgtgtaccg
     5281 tgtgctggca gagatcagaa tgcatcagag tcctatagaa caagaattac agatggttgt
     5341 tagcctcggc gtagatggtt tgaactgtgt ctggtcctct gcaatggcat agccactgag
     5401 ccatccctcc agtcccagaa aagagttttt taaaaaaatt aacaacttta actcaaaaca
     5461 ttctactttt aatactttta tatcttatgt gcatgacaca aatggtaaca gaaacatcaa
     5521 tttgaatcaa agagactgaa cttaaatcta gtttatgtgc actcttgatg aagtgtgctt
     5581 ctgcatgtag acaaagtaga gtaactaata tgttactagg ctgagtcctt caggttacaa
     5641 acactgttgc ttgctgtcta cttgcataca gaattgtgga ctcccaaatg aaagtattta
     5701 tgttctgaaa taaagaatgc ttttttggct atcag
//
