LOCUS       NM_011182               3749 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus cytohesin 3 (Cyth3), transcript variant 1, mRNA.
ACCESSION   NM_011182
VERSION     NM_011182.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3749)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3749)
  AUTHORS   Das,S., Malaby,A.W., Nawrotek,A., Zhang,W., Zeghouf,M., Maslen,S.,
            Skehel,M., Chakravarthy,S., Irving,T.C., Bilsel,O., Cherfils,J. and
            Lambright,D.G.
  TITLE     Structural Organization and Dynamics of Homodimeric Cytohesin
            Family Arf GTPase Exchange Factors in Solution and on Membranes
  JOURNAL   Structure 27 (12), 1782-1797 (2019)
   PUBMED   31601460
  REMARK    GeneRIF: Structural organization and dynamics of Grp1 and
            cytohesin-2 in solution and on membranes has been described.
REFERENCE   3  (bases 1 to 3749)
  AUTHORS   Jux,B., Gosejacob,D., Tolksdorf,F., Mandel,C., Rieck,M.,
            Namislo,A., Pfeifer,A. and Kolanus,W.
  TITLE     Cytohesin-3 is required for full insulin receptor signaling and
            controls body weight via lipid excretion
  JOURNAL   Sci Rep 9 (1), 3442 (2019)
   PUBMED   30837656
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3749)
  AUTHORS   Kinoshita-Kawada,M., Hasegawa,H., Hongu,T., Yanagi,S., Kanaho,Y.,
            Masai,I., Mishima,T., Chen,X., Tsuboi,Y., Rao,Y., Yuasa-Kawada,J.
            and Wu,J.Y.
  TITLE     A crucial role for Arf6 in the response of commissural axons to
            Slit
  JOURNAL   Development 146 (3) (2019)
   PUBMED   30674481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3749)
  AUTHORS   Malaby,A.W., Das,S., Chakravarthy,S., Irving,T.C., Bilsel,O. and
            Lambright,D.G.
  TITLE     Structural Dynamics Control Allosteric Activation of Cytohesin
            Family Arf GTPase Exchange Factors
  JOURNAL   Structure 26 (1), 106-117 (2018)
   PUBMED   29276036
  REMARK    GeneRIF: Structural dynamics control allosteric activation of Grp1
            and ARF6.
REFERENCE   6  (bases 1 to 3749)
  AUTHORS   Jackson,C.L. and Casanova,J.E.
  TITLE     Turning on ARF: the Sec7 family of guanine-nucleotide-exchange
            factors
  JOURNAL   Trends Cell Biol 10 (2), 60-67 (2000)
   PUBMED   10652516
  REMARK    Review article
REFERENCE   7  (bases 1 to 3749)
  AUTHORS   Korthauer,U., Nagel,W., Davis,E.M., Le Beau,M.M., Menon,R.S.,
            Mitchell,E.O., Kozak,C.A., Kolanus,W. and Bluestone,J.A.
  TITLE     Anergic T lymphocytes selectively express an integrin regulatory
            protein of the cytohesin family
  JOURNAL   J Immunol 164 (1), 308-318 (2000)
   PUBMED   10605025
REFERENCE   8  (bases 1 to 3749)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 3749)
  AUTHORS   Kim,H.S., Chen,Y. and Lonai,P.
  TITLE     Complex regulation of multiple cytohesin-like genes in murine
            tissues and cells
  JOURNAL   FEBS Lett 433 (3), 312-316 (1998)
   PUBMED   9744817
REFERENCE   10 (bases 1 to 3749)
  AUTHORS   Klarlund,J.K., Guilherme,A., Holik,J.J., Virbasius,J.V., Chawla,A.
            and Czech,M.P.
  TITLE     Signaling by phosphoinositide-3,4,5-trisphosphate through proteins
            containing pleckstrin and Sec7 homology domains
  JOURNAL   Science 275 (5308), 1927-1930 (1997)
   PUBMED   9072969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY271755.1, AK159229.1 and AI846077.1.
            
            On Jul 28, 2009 this sequence version replaced NM_011182.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035296.1, AK142407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY271755.1         1-29
            30-3734             AK159229.1         2-3706
            3735-3749           AI846077.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..3749
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.36 cM"
     gene            1..3749
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /note="cytohesin 3"
                     /db_xref="GeneID:19159"
                     /db_xref="MGI:MGI:1335107"
     exon            1..227
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1393
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pleckstrin homology, Sec7 and coiled-coil domains 3; SEC7
                     homolog C; ARF nucleotide-binding site opener 3; general
                     receptor of phosphoinositides 1; mSec7-3; PH, SEC7 and
                     coiled-coil domain-containing protein 3"
                     /codon_start=1
                     /product="cytohesin-3 isoform 1"
                     /protein_id="NP_035312.3"
                     /db_xref="CCDS:CCDS19845.1"
                     /db_xref="GeneID:19159"
                     /db_xref="MGI:MGI:1335107"
                     /translation="MDEGGGGEGGSVPEDLSLEEREELLDIRRRKKELIDDIERLKYE
                     IAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVA
                     QFLYKGEGLNKTVIGDYLGERDDFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG
                     EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERF
                     ITMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGG
                     RVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSH
                     KGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRK
                     RRIANKK"
     exon            228..310
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            311..375
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            376..442
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            443..561
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..642
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..755
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..904
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1016
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1093
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1165
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1320
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..3738
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3712..3717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /note="hexamer: AATAAA"
     polyA_site      3738
                     /gene="Cyth3"
                     /gene_synonym="ARNO3; CLM3; Grp1; Pscd3"
                     /note="major polyA site"
ORIGIN      
        1 ggttttgtgt cacgtgatgg cgccggagca gtgaggctcc gcccggccct ccgtggaggc
       61 ccggccgcga cccgggccgc gctcgctgag gagctctccg gttctccccg cgaccacttc
      121 tcttagtccc ggcgttcagc ccagtcgctc ccgccggctc cgggctcgcc ggctggcggg
      181 gagtggcctc aaaatggacg aaggcggtgg cggtgagggc ggcagcgtgc ctgaagacct
      241 gtcattagaa gagcgagaag aacttttgga cattcgtaga agaaaaaagg aacttattga
      301 tgacattgag aggctgaaat atgaaattgc agaagtgatg acggagattg acaacctgac
      361 ttcagtggag gagagcaaaa ctactcagag gaacaagcaa atagccatgg gaaggaagaa
      421 attcaacatg gaccccaaaa agggcattca gttcctaatt gagaacgacc tgctgcagag
      481 ctccccagag gatgtcgccc agtttctgta caaaggagag ggcctgaaca agaccgtcat
      541 cggagactac ctgggtgaga gggatgactt taatatcaaa gttcttcagg cttttgttga
      601 gctgcatgag tttgctgatc tcaaccttgt ccaggcctta aggcagttcc tatggagctt
      661 cagacttcct ggagaggcac agaagatcga ccgcatgatg gaggcctttg catcccgata
      721 ctgcctgtgc aaccctgggg tcttccagtc cacagataca tgctacgtgc tctcctttgc
      781 catcatcatg ctcaacacca gcttgcacaa ccacaacgtg cgcgacaagc ccaccgctga
      841 gcgcttcatc accatgaacc gaggcatcaa cgagggtggg gaccttcctg aggagctgct
      901 gaggaacttg tatgaaagta tcaagaatga gccgtttaag atcccagaag acgacggaaa
      961 tgacctgaca cacacgttct tcaacccaga ccgagaaggc tggctgctga agctgggggg
     1021 tcgtgtgaag acctggaaac ggcgctggtt catcctcaca gataactgcc tctactactt
     1081 tgagtacacc acggacaagg agcccagggg catcatcccc ctggagaacc tcagcatcag
     1141 ggaggtggag gacccccgga agccgaactg ctttgagctg tataacccca gtcacaaagg
     1201 tcaagtcatc aaggcctgca agacggaggc cgatggccgt gtggtggagg gcaaccacgt
     1261 tgtgtaccgg atctctgccc ccagcccgga ggaaaaggag gagtggatga agtccatcaa
     1321 agcaagcatc agtagggacc cgttctatga catgttggcc acgaggaaaa ggaggattgc
     1381 caataagaaa taggtaaatg tcaggatcca gactccagca gatacactgg cctccccagc
     1441 ggcaggaccg gggacgatgt ggtgcccacg ggccctccag aacagccagc caaggcctga
     1501 gccctcaagc ctgtgctctg ggacattggt cagctgggag tgtctccttc ctgccaccgg
     1561 cctggcattg acctttgggg acccttgtcc acaacagcac ctggtgatac agcctccaga
     1621 tctgcacagc ccacatggga ctcctgttct ggagccagag cctcacccac accatgccac
     1681 acctgctctt tggggcaaca ctagatgttc tagaagtcgc tgttttatat caaaatggga
     1741 aaggaaaacc taccactttt ttattcagaa tttttctcag atatatagga ttatagcttt
     1801 tatatgcctt tttatattct gaaaattata atgaaagata cttaatttct aacagtagta
     1861 tttttagaat ggcagctata aacttaactc ctggacacac gtatatactg tgcactgaaa
     1921 acagtctata tatgcagccc ccatgcactt ggggccagag cagctggggc acagtcatcc
     1981 tgacagagtg tcagctgggt gaagaggcat tggggtgagt gtggagagca gtgtgcttgg
     2041 gagattcagg cgtgactgcc acttcccctc acatgcttct ctaagatgaa tcagtaaggt
     2101 acagctatgg ccggggtatt tatcctgtca gtgccaaggc ctggagatgg agttccttct
     2161 ctggaaaaca ggccacttat gtgcagaacc tcctcttgtc tgaccttcat acaggacagt
     2221 ttcatgtggt ccgagtgcac atggctcatg actttggtac ttttgttgct tgctgtttca
     2281 aacttgggtt aagtgctaac acatattttg atgtagtaag caagcagaag cagccagaag
     2341 taatccacct gttctctgga gtgccatgtt ttccaacatt tgacatcctt tggaggaggt
     2401 gaaaaactga agatggcact gagggacacg tgtgacatcc agacccctaa cacacacaca
     2461 cacacacacc agtgcatgcc ttcagggcat atgtgcttgg gctgagactg ggtaagatga
     2521 gagggcccat tcatggctta tttggaaaat ggtcttcccc tgcacgtgga gctggtgttc
     2581 tgagagccct tgaaaaccgc caaccaaatg cccttacacg agactttcag tgagctgtct
     2641 taaggctttt tgcctgacct tggtggtagc tgccatctaa gatggcacag aaggatgtgc
     2701 aggccagagc tccctcgctc gtgcaccaga ctgatcactt tttggtttat tcccaagctt
     2761 ctaggctttg cttttactga tacctcaaat ctgaaaccct tgcatttgag ctgcctggct
     2821 ggtgtgtatg cagcctggct tccagtcttc catgatccct atcccctatt ccccacccca
     2881 gacctgaatt tactgctggt ggggcacctg tagggaggta ggaactggca tttttttcaa
     2941 tcaggaccat ggtgagccgg tcagatgttc aacccaggtg tggccctggg caacagagct
     3001 ctctgtggga tattgaggtc aggacgttaa gcatgaggct acctaatgtt gtctttgatg
     3061 ccatagtcat ctttgagggg accttgcctg atggctgttg gtgctaagaa tcctaagtta
     3121 ctggctcttg gagtatccac atggagtcac ttaactcagg ttatgttgtg acagtgttaa
     3181 acccaagggc atctgccact cccagagctt gtaaaggctc aggcactcct gcccttcacc
     3241 ctttgtctgc actcgtcagt gaagcattaa agccctactc tgcccaaaga cagttccctg
     3301 tcctgctggg ccctgggcat cattcctggg tttcagaaga cttgatgtgg tactgcagag
     3361 taactaggaa ccgtctgggg atgggactta ctgtgcttcc tgtcatgctg agttcagagc
     3421 tacaggtgtg ctttgctgac aagttaggtc gttacagacc agaaaccatg ttgtgatttc
     3481 tttttatctt agaaaacatt tctatttaca ataaatagtt actatgtaaa taatgtacat
     3541 atgtattaat ttcttcagtg ttatacaatg tatatactcc tacaacctgc atgaagaaat
     3601 atcctattaa tgttgatatc agaatttctg gctattttat tgcaaagcaa acagctagta
     3661 aaatggaggg ccttacggct gtcagaacta ttgcaaatac tgtgttccct aaataaaaac
     3721 atactgctaa aaccaaaaaa aaaaaaaaa
//
