LOCUS       NM_011181               2470 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus cytohesin 2 (Cyth2), transcript variant 1, mRNA.
ACCESSION   NM_011181
VERSION     NM_011181.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2470)
  AUTHORS   London,N.R. Jr., Tharakan,A., Smith,A., Thomas,K.R., Zhu,W.,
            Odelberg,S.J., Ramanathan,M. Jr. and Lane,A.P.
  TITLE     Deletion of Arno Reduces Eosinophilic Inflammation and
            Interleukin-5 Expression in a Murine Model of Rhinitis
  JOURNAL   Ear Nose Throat J 101 (2_suppl), 1S-7S (2022)
   PUBMED   33393815
  REMARK    GeneRIF: Deletion of Arno Reduces Eosinophilic Inflammation and
            Interleukin-5 Expression in a Murine Model of Rhinitis.
REFERENCE   2  (bases 1 to 2470)
  AUTHORS   Miyamoto,Y., Torii,T., Homma,K., Oizumi,H., Ohbuchi,K.,
            Mizoguchi,K., Takashima,S. and Yamauchi,J.
  TITLE     The adaptor SH2B1 and the phosphatase PTP4A1 regulate the
            phosphorylation of cytohesin-2 in myelinating Schwann cells in mice
  JOURNAL   Sci Signal 15 (718), eabi5276 (2022)
   PUBMED   35077201
  REMARK    GeneRIF: The adaptor SH2B1 and the phosphatase PTP4A1 regulate the
            phosphorylation of cytohesin-2 in myelinating Schwann cells in
            mice.
REFERENCE   3  (bases 1 to 2470)
  AUTHORS   Wang,Y., Cil,C., Harnett,M.M. and Pineda,M.A.
  TITLE     Cytohesin-2/ARNO: A Novel Bridge Between Cell Migration and
            Immunoregulation in Synovial Fibroblasts
  JOURNAL   Front Immunol 12, 809896 (2022)
   PUBMED   35095899
  REMARK    GeneRIF: Cytohesin-2/ARNO: A Novel Bridge Between Cell Migration
            and Immunoregulation in Synovial Fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2470)
  AUTHORS   Ito,H., Morishita,R., Noda,M., Ishiguro,T., Nishikawa,M. and
            Nagata,K.I.
  TITLE     The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to
            mediate hippocampal granule cell development
  JOURNAL   J Biol Chem 297 (6), 101427 (2021)
   PUBMED   34800437
  REMARK    GeneRIF: The synaptic scaffolding protein CNKSR2 interacts with
            CYTH2 to mediate hippocampal granule cell development.
REFERENCE   5  (bases 1 to 2470)
  AUTHORS   Ito,A., Fukaya,M., Sugawara,T., Hara,Y., Okamoto,H., Yamauchi,J.
            and Sakagami,H.
  TITLE     Cytohesin-2 mediates group I metabotropic glutamate
            receptor-dependent mechanical allodynia through the activation of
            ADP ribosylation factor 6 in the spinal cord
  JOURNAL   Neurobiol Dis 159, 105466 (2021)
   PUBMED   34390832
  REMARK    GeneRIF: Cytohesin-2 mediates group I metabotropic glutamate
            receptor-dependent mechanical allodynia through the activation of
            ADP ribosylation factor 6 in the spinal cord.
REFERENCE   6  (bases 1 to 2470)
  AUTHORS   Cronin,T.C., DiNitto,J.P., Czech,M.P. and Lambright,D.G.
  TITLE     Structural determinants of phosphoinositide selectivity in splice
            variants of Grp1 family PH domains
  JOURNAL   EMBO J 23 (19), 3711-3720 (2004)
   PUBMED   15359279
REFERENCE   7  (bases 1 to 2470)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2470)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
REFERENCE   9  (bases 1 to 2470)
  AUTHORS   Nair,S., Guerra,C. and Satir,P.
  TITLE     A Sec7-related protein in Paramecium
  JOURNAL   FASEB J 13 (10), 1249-1257 (1999)
   PUBMED   10385615
REFERENCE   10 (bases 1 to 2470)
  AUTHORS   Kim,H.S., Chen,Y. and Lonai,P.
  TITLE     Complex regulation of multiple cytohesin-like genes in murine
            tissues and cells
  JOURNAL   FEBS Lett 433 (3), 312-316 (1998)
   PUBMED   9744817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143829.1, AK045451.1, BE983477.1, BY470655.1 and AC149053.3.
            
            On Jul 29, 2020 this sequence version replaced NM_011181.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1496              AK143829.1         3-1498
            1497-2184           AK045451.1         1526-2213
            2185-2464           BE983477.1         17-296              c
            2465-2467           BY470655.1         428-430
            2468-2470           AC149053.3         155070-155072
FEATURES             Location/Qualifiers
     source          1..2470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.52 cM"
     gene            1..2470
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /note="cytohesin 2"
                     /db_xref="GeneID:19158"
                     /db_xref="MGI:MGI:1334255"
     exon            1..159
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1343
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pleckstrin homology, Sec7 and coiled-coil domains 2;
                     mSec7-2; SEC7 homolog B; PH, SEC7 and coiled-coil
                     domain-containing protein 2; ARF nucleotide-binding site
                     opener"
                     /codon_start=1
                     /product="cytohesin-2 isoform 1"
                     /protein_id="NP_035311.1"
                     /db_xref="GeneID:19158"
                     /db_xref="MGI:MGI:1334255"
                     /translation="MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAM
                     SEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEIARFLYK
                     GEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKI
                     DRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNR
                     GINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKT
                     WKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQL
                     IKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRIS
                     VKKKQEQP"
     exon            160..307
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..374
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..493
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..574
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..687
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..836
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..948
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..951
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1028
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1100
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1255
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..2470
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1516
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /note="major polyA site"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /note="hexamer: AATAAA"
     polyA_site      2470
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
ORIGIN      
        1 cggcgctgag gacgggcgct gaggaggcgg cggtggctcc tggggcgttt gagcgggctc
       61 actcgagccc gcgggccgac gcggacgcag gcccagccgg cggaaccgcc ccggactccc
      121 cgcgggcctt cctagccgcc atggaggacg gtgtctacga gcccccagac ttgactccag
      181 aggagcgcat ggagttggag aacatccggc ggcgcaagca ggagctgctg gtggagatcc
      241 agcgcctgcg agaagagcta agtgaagcta tgagcgaggt ggagggtctg gaggccaatg
      301 agggcagtaa gaccttgcag cggaaccgga agatggcaat gggcaggaag aaattcaaca
      361 tggaccccaa aaaggggatc caattcttgg tggagcatga acttctgcag aacacgcctg
      421 aggaaattgc ccgcttcctg tacaagggcg aggggctgaa caagacagcc attggggact
      481 acctagggga aagggaagag ctgaacctgt ctgtgctcca tgcttttgtg gatctccatg
      541 agttcaccga cctcaacctg gtgcaggccc tccggcaatt cctatggagc tttcgcctcc
      601 ctggagaggc tcagaaaatt gatcgaatga tggaggcctt tgcccagaga tactgcttat
      661 gcaaccctgg ggtcttccag tctacagaca cctgctacgt gttgtccttt gccgtgatca
      721 tgctgaacac cagccttcac aatcccaatg tcagggacaa gccgggcctg gagcgctttg
      781 tggccatgaa ccggggcatc aacgagggtg gggatctgcc tgaggatctt ctcaggaacc
      841 tctacgacag catccggaac gagcccttca aaatcccaga ggatgatggg aatgatctca
      901 cccacacctt cttcaaccca gaccgagagg gctggctcct aaagctggga gggggccggg
      961 tgaagacttg gaagcggcgc tggttcatcc ttacagacaa ctgcctctac tactttgaat
     1021 acactacgga caaggagccc cgagggatta tccccctaga gaacctgagc atccgggagg
     1081 tggacgatcc tcggaagccg aactgctttg agctttacat tcccaacaat aagggacagc
     1141 tcatcaaagc ctgcaaaaca gaggctgacg gccgggtagt ggaggggaac cacatggtgt
     1201 accgaatctc agcacccacc caggaggaga aagatgagtg gatcaaatcc atccaggctg
     1261 ctgtaagtgt ggaccccttc tatgagatgt tggcagcaag aaagaagcga atttctgtga
     1321 agaagaagca agaacaaccc tgacccctgt ccccaactcc attatttatt ttggagctgc
     1381 cccgcctggg tggcaggacc cctgggccct ggggctgtgg atcctggttc cccatttgga
     1441 aaatcaccac ctctagctcc tgactcctta tttgtaatta acatgttggt aatcttatta
     1501 attatttaat cccttgcgcc tgcagatgcc ctcatttctt gggtttggga gagctgagga
     1561 cccatcccct tgacatttac caggatgctg ggctgcatat agggtgcaga caggcacatc
     1621 ccagacaagt cactcaagcc ctgtgggtgc tgagtgcaga gagagtttac tgtctcagtg
     1681 tggtatttag gcacagcata ctctccatgt gctctgccca ccatgttaat gttggacctg
     1741 tgctcattgg agacctagcc tagcacagga gactaagact aaaacaacaa aggactggct
     1801 caggagggag caagtcctga gaaggccccg agtcggtcac taggaactgg ctgtgctgtc
     1861 catgagtacc ccagagtgta ctagaggagg gggcacagcg ctatcaggag gtacctggga
     1921 tgccattgtg acagtggcct cttctaaccc cagatctagc ctcctgtgga ggtgtgtgtt
     1981 tctgactcat gagaggggat ctcggtgaag gaataatgca gagaccccaa tggtcttgtg
     2041 ctcctgtgct gctgggggaa tagtctgccc acatttagcc tggaagcttt tttgttactc
     2101 ttcctggcct gtggtgagct taaagtctga atcctgcctg cttcttccca gcatgcttta
     2161 gcatgcaggc ttgactggga agaatgaatg ctgtcccgga gccttctggg aattaagatt
     2221 ccagaacgtg tgtattggat ttgcaaaccc ctgtgggtgt gtaccccaac agcactgatc
     2281 tgggtaaggg ggagcatcca ggctctattt taggtgggct ttggctcagg ctacgtgtca
     2341 atagacagtg gcagtcttca cagtggccgt cttgtctcct aggaaaaggt catgaattac
     2401 tattcccctg cccccagggg ctgctgtgaa atggagattc ccaaataaaa caacatgagt
     2461 gtcacccaaa
//
