LOCUS       NP_035311                400 aa            linear   ROD 02-JUN-2024
DEFINITION  cytohesin-2 isoform 1 [Mus musculus].
ACCESSION   NP_035311
VERSION     NP_035311.1
DBSOURCE    REFSEQ: accession NM_011181.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 400)
  AUTHORS   London,N.R. Jr., Tharakan,A., Smith,A., Thomas,K.R., Zhu,W.,
            Odelberg,S.J., Ramanathan,M. Jr. and Lane,A.P.
  TITLE     Deletion of Arno Reduces Eosinophilic Inflammation and
            Interleukin-5 Expression in a Murine Model of Rhinitis
  JOURNAL   Ear Nose Throat J 101 (2_suppl), 1S-7S (2022)
   PUBMED   33393815
  REMARK    GeneRIF: Deletion of Arno Reduces Eosinophilic Inflammation and
            Interleukin-5 Expression in a Murine Model of Rhinitis.
REFERENCE   2  (residues 1 to 400)
  AUTHORS   Miyamoto,Y., Torii,T., Homma,K., Oizumi,H., Ohbuchi,K.,
            Mizoguchi,K., Takashima,S. and Yamauchi,J.
  TITLE     The adaptor SH2B1 and the phosphatase PTP4A1 regulate the
            phosphorylation of cytohesin-2 in myelinating Schwann cells in mice
  JOURNAL   Sci Signal 15 (718), eabi5276 (2022)
   PUBMED   35077201
  REMARK    GeneRIF: The adaptor SH2B1 and the phosphatase PTP4A1 regulate the
            phosphorylation of cytohesin-2 in myelinating Schwann cells in
            mice.
REFERENCE   3  (residues 1 to 400)
  AUTHORS   Wang,Y., Cil,C., Harnett,M.M. and Pineda,M.A.
  TITLE     Cytohesin-2/ARNO: A Novel Bridge Between Cell Migration and
            Immunoregulation in Synovial Fibroblasts
  JOURNAL   Front Immunol 12, 809896 (2022)
   PUBMED   35095899
  REMARK    GeneRIF: Cytohesin-2/ARNO: A Novel Bridge Between Cell Migration
            and Immunoregulation in Synovial Fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 400)
  AUTHORS   Ito,H., Morishita,R., Noda,M., Ishiguro,T., Nishikawa,M. and
            Nagata,K.I.
  TITLE     The synaptic scaffolding protein CNKSR2 interacts with CYTH2 to
            mediate hippocampal granule cell development
  JOURNAL   J Biol Chem 297 (6), 101427 (2021)
   PUBMED   34800437
  REMARK    GeneRIF: The synaptic scaffolding protein CNKSR2 interacts with
            CYTH2 to mediate hippocampal granule cell development.
REFERENCE   5  (residues 1 to 400)
  AUTHORS   Ito,A., Fukaya,M., Sugawara,T., Hara,Y., Okamoto,H., Yamauchi,J.
            and Sakagami,H.
  TITLE     Cytohesin-2 mediates group I metabotropic glutamate
            receptor-dependent mechanical allodynia through the activation of
            ADP ribosylation factor 6 in the spinal cord
  JOURNAL   Neurobiol Dis 159, 105466 (2021)
   PUBMED   34390832
  REMARK    GeneRIF: Cytohesin-2 mediates group I metabotropic glutamate
            receptor-dependent mechanical allodynia through the activation of
            ADP ribosylation factor 6 in the spinal cord.
REFERENCE   6  (residues 1 to 400)
  AUTHORS   Cronin,T.C., DiNitto,J.P., Czech,M.P. and Lambright,D.G.
  TITLE     Structural determinants of phosphoinositide selectivity in splice
            variants of Grp1 family PH domains
  JOURNAL   EMBO J 23 (19), 3711-3720 (2004)
   PUBMED   15359279
REFERENCE   7  (residues 1 to 400)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 400)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
REFERENCE   9  (residues 1 to 400)
  AUTHORS   Nair,S., Guerra,C. and Satir,P.
  TITLE     A Sec7-related protein in Paramecium
  JOURNAL   FASEB J 13 (10), 1249-1257 (1999)
   PUBMED   10385615
REFERENCE   10 (residues 1 to 400)
  AUTHORS   Kim,H.S., Chen,Y. and Lonai,P.
  TITLE     Complex regulation of multiple cytohesin-like genes in murine
            tissues and cells
  JOURNAL   FEBS Lett 433 (3), 312-316 (1998)
   PUBMED   9744817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143829.1, AK045451.1, BE983477.1, BY470655.1 and AC149053.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.52 cM"
     Protein         1..400
                     /product="cytohesin-2 isoform 1"
                     /note="pleckstrin homology, Sec7 and coiled-coil domains
                     2; mSec7-2; SEC7 homolog B; PH, SEC7 and coiled-coil
                     domain-containing protein 2; ARF nucleotide-binding site
                     opener"
                     /calculated_mol_wt=46440
     Region          61..243
                     /region_name="Sec7"
                     /note="Sec7 domain; pfam01369"
                     /db_xref="CDD:460178"
     Region          258..378
                     /region_name="PH_GRP1-like"
                     /note="General Receptor for Phosphoinositides-1-like
                     Pleckstrin homology (PH) domain; cd01252"
                     /db_xref="CDD:269954"
     Site            order(258,286,288,290,300,303,305,336..338,340,343..348,
                     378)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269954"
     Site            order(268,271,276,278,280,291,301,339,350..351)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269954"
     Region          387..395
                     /region_name="C-terminal autoinhibitory region.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P63034.3)"
     CDS             1..400
                     /gene="Cyth2"
                     /gene_synonym="ARNO; CLM2; Pscd2"
                     /coded_by="NM_011181.4:141..1343"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:19158"
                     /db_xref="MGI:MGI:1334255"
ORIGIN      
        1 medgvyeppd ltpeermele nirrrkqell veiqrlreel seamsevegl eanegsktlq
       61 rnrkmamgrk kfnmdpkkgi qflvehellq ntpeeiarfl ykgeglnkta igdylgeree
      121 lnlsvlhafv dlheftdlnl vqalrqflws frlpgeaqki drmmeafaqr yclcnpgvfq
      181 stdtcyvlsf avimlntslh npnvrdkpgl erfvamnrgi neggdlpedl lrnlydsirn
      241 epfkipeddg ndlthtffnp dregwllklg ggrvktwkrr wfiltdncly yfeyttdkep
      301 rgiiplenls irevddprkp ncfelyipnn kgqlikackt eadgrvvegn hmvyrisapt
      361 qeekdewiks iqaavsvdpf yemlaarkkr isvkkkqeqp
//
