LOCUS       NM_133720               5327 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus cysteinyl leukotriene receptor 2 (Cysltr2), transcript
            variant 1, mRNA.
ACCESSION   NM_133720
VERSION     NM_133720.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5327)
  AUTHORS   Qi,L., Iskols,M., Shi,D., Reddy,P., Walker,C., Lezgiyeva,K.,
            Voisin,T., Pawlak,M., Kuchroo,V.K., Chiu,I.M., Ginty,D.D. and
            Sharma,N.
  TITLE     A mouse DRG genetic toolkit reveals morphological and physiological
            diversity of somatosensory neuron subtypes
  JOURNAL   Cell 187 (6), 1508-1526 (2024)
   PUBMED   38442711
REFERENCE   2  (bases 1 to 5327)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5327)
  AUTHORS   Florsheim,E.B., Bachtel,N.D., Cullen,J.L., Lima,B.G.C.,
            Godazgar,M., Carvalho,F., Chatain,C.P., Zimmer,M.R., Zhang,C.,
            Gautier,G., Launay,P., Wang,A., Dietrich,M.O. and Medzhitov,R.
  TITLE     Immune sensing of food allergens promotes avoidance behaviour
  JOURNAL   Nature 620 (7974), 643-650 (2023)
   PUBMED   37437602
REFERENCE   4  (bases 1 to 5327)
  AUTHORS   Cao,Z., Huang,C., Lu,F., Jiang,X., Hu,Y., Cao,C. and Liu,Z.
  TITLE     Meis1 Regulates Nociceptor Development and Behavioral Response to
            Tactile Stimuli
  JOURNAL   Front Mol Neurosci 15, 901466 (2022)
   PUBMED   35875660
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5327)
  AUTHORS   Ualiyeva,S., Lemire,E., Aviles,E.C., Wong,C., Boyd,A.A., Lai,J.,
            Liu,T., Matsumoto,I., Barrett,N.A., Boyce,J.A., Haber,A.L. and
            Bankova,L.G.
  TITLE     Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically
            initiate lung type 2 inflammation
  JOURNAL   Sci Immunol 6 (66), eabj0474 (2021)
   PUBMED   34932383
REFERENCE   6  (bases 1 to 5327)
  AUTHORS   Jiang,Y., Kanaoka,Y., Feng,C., Nocka,K., Rao,S. and Boyce,J.A.
  TITLE     Cutting edge: Interleukin 4-dependent mast cell proliferation
            requires autocrine/intracrine cysteinyl leukotriene-induced
            signaling
  JOURNAL   J Immunol 177 (5), 2755-2759 (2006)
   PUBMED   16920908
REFERENCE   7  (bases 1 to 5327)
  AUTHORS   Sheng,W.W., Li,C.T., Zhang,W.P., Yuan,Y.M., Hu,H., Fang,S.H.,
            Zhang,L. and Wei,E.Q.
  TITLE     Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose
            deprivation-induced PC12 cell death
  JOURNAL   Biochem Biophys Res Commun 346 (1), 19-25 (2006)
   PUBMED   16756959
  REMARK    GeneRIF: findings show that CysLT1 receptor attenuates while CysLT2
            receptor facilitates oxygen glucose deprivation -induced PC12 cell
            death
REFERENCE   8  (bases 1 to 5327)
  AUTHORS   Beller,T.C., Maekawa,A., Friend,D.S., Austen,K.F. and Kanaoka,Y.
  TITLE     Targeted gene disruption reveals the role of the cysteinyl
            leukotriene 2 receptor in increased vascular permeability and in
            bleomycin-induced pulmonary fibrosis in mice
  JOURNAL   J Biol Chem 279 (44), 46129-46134 (2004)
   PUBMED   15328359
REFERENCE   9  (bases 1 to 5327)
  AUTHORS   Ogasawara,H., Ishii,S., Yokomizo,T., Kakinuma,T., Komine,M.,
            Tamaki,K., Shimizu,T. and Izumi,T.
  TITLE     Characterization of mouse cysteinyl leukotriene receptors mCysLT1
            and mCysLT2: differential pharmacological properties and tissue
            distribution
  JOURNAL   J Biol Chem 277 (21), 18763-18768 (2002)
   PUBMED   11854273
REFERENCE   10 (bases 1 to 5327)
  AUTHORS   Hui,Y., Yang,G., Galczenski,H., Figueroa,D.J., Austin,C.P.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Funk,C.D.
  TITLE     The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and
            genomic cloning, alternative splicing, and in vitro
            characterization
  JOURNAL   J Biol Chem 276 (50), 47489-47495 (2001)
   PUBMED   11591709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571265.12 and AC155237.2.
            
            On Sep 13, 2022 this sequence version replaced NM_133720.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF331658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415134 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                CT571265.12        24821-24899         c
            80-184              CT571265.12        24309-24413         c
            185-241             CT571265.12        23994-24050         c
            242-312             AC155237.2         170518-170588       c
            313-450             AC155237.2         168542-168679       c
            451-5327            AC155237.2         161743-166619       c
FEATURES             Location/Qualifiers
     source          1..5327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 38.54 cM"
     gene            1..5327
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /note="cysteinyl leukotriene receptor 2"
                     /db_xref="GeneID:70086"
                     /db_xref="MGI:MGI:1917336"
     exon            1..79
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /inference="alignment:Splign:2.1.0"
     exon            80..184
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /inference="alignment:Splign:2.1.0"
     exon            185..241
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /inference="alignment:Splign:2.1.0"
     exon            242..312
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /inference="alignment:Splign:2.1.0"
     exon            313..450
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /inference="alignment:Splign:2.1.0"
     exon            451..5327
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /note="hexamer: AATAAA"
     polyA_site      1811
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /note="major polyA site"
     regulatory      5302..5307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /note="hexamer: AATGAA"
     regulatory      5308..5313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /note="hexamer: ATTAAA"
     polyA_site      5319
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
                     /note="major polyA site"
     polyA_site      5327
                     /gene="Cysltr2"
                     /gene_synonym="2300001H05Rik; Cltr2; Cyslt2; CYSLT2R"
ORIGIN      
        1 aaataaacaa gctgcattct atggggcgag aagcctggag tcagagcaga cgccagggcg
       61 accgaaggca gaggcacaga ttcggtcatt ttattctgta agaccttttt ctactccgaa
      121 gctttgcttt tggaagagag aagagtccat ctgagaaggc atacttcagt gatttggttc
      181 agagtctttt acatgtacct gagagtaata tgaatgaaga aataagaaga tgcaatcaaa
      241 gttgtcctgg ggaaggatgt gtatcattgg ctaaagagaa gacttggaac ttcttgagtt
      301 gagaggataa aagatgaaga agatgatctg ttagagacca cttgtagcaa tggtttgaac
      361 tccaaaggac atataatggc attttaattc tgatctgggg cctgaatttg ggaaaggaag
      421 agtgaagaat agttgtccaa gagataagat gtccatcatg tgtatgcctg atgtctacca
      481 aggtcacaag agggtgtcgg aaaaacttgc ttctctccat ggtgagactg agtacggcaa
      541 atgtttgatc agtaatcagg aagaaaagta gagttgtatg aagtaacttt tgggatttat
      601 ttctttaata taaagagaaa actttgaatt agtcctcgcc tctgtcaact ccacatcaga
      661 aatggaagta actgggaccc ccagcagtta tagtaacagg aactgtacaa tagaaaactt
      721 taagaaggaa ttttacccca tcatatacct gataatattt ttctggggag ccttgggaaa
      781 tggcttttcc atatatgtct ttctacagac ttgcaagaag tccacatctg taaatgtttt
      841 catgctcaac ctggccactt ccgattttct attcatcagc accttgccct tcagggctga
      901 ctattatttc agaggttcca attggatatt tggggacttg gcctgcagag tcatgtctta
      961 ttccttatat gtcaacatgt atactagcat ttatttccta actgtgctga gtgtggtgcg
     1021 tttcctggcc acagtccacc ccttccggat gttccatgtc accagtgtca ggagtgcctg
     1081 gatcctctgt gggatcatat gggttttcat catggcttcc tcagccctgc ttctggtgaa
     1141 cggccaagag gagaaagata acattatatc atgcttggag ctgagtcctc aaaagtttaa
     1201 aagtctcctg atcatgaacc acattgcagt agcggtaggc ttcttgctcc catttctcac
     1261 gctcaccgtc tgctacctgc tgatcatccg gatcttgtta aaggctgaga ttccagaatc
     1321 aggtccacgt gctgctcata ggaaggcgct gaccaccatt gtcattgcca tgatcacctt
     1381 cctcctctgt tttctgccat accatgcact gcggaccctc cacttggtca catgggataa
     1441 agattcatgt ggggatgtgc tacataaggc cacagtcatc acactgacca tggctgcagc
     1501 caatagctgc ttcaatccct ttctctatta ttttgctggg gagaatttca aagctcgatt
     1561 aagggctata ttcagcaaag ttcatctata gaaattaaag tcaaagtgca gccttcctgt
     1621 ttgtgagtag ctgaagaaca gaattaagag tataaggagc tgttctgcag gcatgctcat
     1681 gaacattggt gtccaccttc attcactcag agtctccaac ttactttata tttgcatcct
     1741 aaccaacaag ttggttcctg acatttaatt gaccacaaca tttgctaata aagtctattt
     1801 cagaaatttc attagatata tttttagtgg ttggaactaa atgggaagtg taagaaaaaa
     1861 tatttctact ggaatcttgc atgctgaaat gtgacattgg gaagacttgt caaacactgt
     1921 agggccatgt tttgcatcag atcctatgtt agctctctgg cccagacatt ctaaattcct
     1981 aacttgaaga catccttaag caccccagct tctccaaatc ctttcctcat taaagccttt
     2041 gagacacagt caaacctact gggagcttct gtgcatcgag gagagcatcc caagggctct
     2101 ggagcaggct ttgatttgaa gaggaaaact gtcctttaat aattcaagtc aaggtccaga
     2161 caaggttggc aagagaaaaa ggaggagaag aattaaagca aaagagagtg aataataagt
     2221 agaggtaaag agtaatttcc tctttgcctc caagagatgg gttctagcaa ccaaatggaa
     2281 ggatgtgcct gtagtgcctt ttttaccagg agttaggaaa actgaggagt gaggctgtgt
     2341 ggggatcact tccctatggg attcaggaat tgtgtgtaga atagggacaa ggaatagtca
     2401 cggacatgta tctcatgaca cttgggtctg aagtgatgtc attgtagtca ttgacccctc
     2461 ctagtaaccc acagagatga caactgaagg aagtgggcct ttggaaaagg gctgggcaga
     2521 atgtgagaag tgttataaaa aaatctttaa tattagtttc tatccacaga aactgactac
     2581 agatactacc aattattcac atgaccattg tgttgacccc aacaatcaag tggcatccct
     2641 gtgctgagcc ttcagaaatg ctggagaaag cacagagatt tcatgggtgg agaacttaaa
     2701 aagtatgtcc tagtctacac agctagtgag cagtttaaaa gctctgcaga aatgttgact
     2761 ggatgctctt ccccacccac caccccctgt gaacctccag aaagtctgca tggaaaccca
     2821 tggtcaaaag tctacatgga gactttctct cttgtcagac acatatgcct ttctcatcct
     2881 tgcaaggaaa ccaaggtctg ggggctggag agatgctttg gggtgaatag tacttgttgc
     2941 ttttatagag gatccaagca ctgacatgga gcctcacagt catctttcac tccagttcca
     3001 caggacctga tgctctcttg tggctctgtg ggcatgcaca cagtgtgcag acatatgtac
     3061 agataagaca ctcgtacatg taaaaactct taacaacaat gacaacaaca ctgaaaaaaa
     3121 tagcaatttt tggcctctgg cacccttgag tgtggaaggg agattgtctt tgcagttgga
     3181 gagcactata gtattgttta tataaaacga cgactctgtc tgtaaccttc cttatttagc
     3241 tactagaatg atagagagat atcagaggaa gaccctagta catctgccta cagggaactc
     3301 ctctatccta gggaaaaggc taacagatac ttgggaatcc tccaacccca aatctgagtg
     3361 tctgctcttt gatttatctg acagcgaagc ctacaatctg atccactcct tccagtccca
     3421 gagagcatct agccaccttg gtctagttcc actcttgatt ataagcaatt taatgaccac
     3481 acaattttca atggaaaaaa cccttaatat tcaaggcact aacaattaag agcacagaag
     3541 aagacatctt caataggaaa ggtctcaatg ttttttgttt ttgtttttta aacttgtatc
     3601 agaaagcact gggatactgt tcaaaacaaa caaacaaaca aacacaagca gacaggcaac
     3661 caaaacaact atagcacaat gcagtcatta gtttgtttga gtagtaactg gagcccacta
     3721 catagttgaa tatttacaca gagcttgaca catagaaaca ctactatgga gtcttaggaa
     3781 atgagtggaa agggtgcaca tgggggtggg ggcagaggca caggaagctt gggtttccat
     3841 cttcaaccag agagaattca tgttaaccag agttggggag caataaacag ctacgcagca
     3901 tcttgtttag tgagagggag tgaatgggag aagggtggtg gtgcaaaaag acctggagga
     3961 gattacctct ggacagggat ttgagagtgg gatacacaca cacacacaca cacacacaca
     4021 cacacacaca cacacacaca tatctcaatc aaagaggatg aatgttttat ttgtttctca
     4081 gtgttgcaaa gccggtgctt cactgtggga aaacaacagc caacacagca catggtgaaa
     4141 caaagacagt attctcccgc ctctgacatt gtagaatact tccctgcatt tccaatgaga
     4201 agacactaag tctctgaccc aaatccagtg gtggatatgg gcaagtaaca aaattatcta
     4261 agataattta tatatcttag atatattatt atattgactt atgaaagtct tataaccagt
     4321 aggtagggtc tcaccatgta gcagtggctg gtttagaact tgttgtgtag accaaccttg
     4381 aactaacatc tgcctgttga gtgctgggat tagaaggtgg tctgtcacca aacccagcct
     4441 cataaccact tttcaccgca gatgatctta agaattctaa acaccagggc ttaactccta
     4501 gtctaaatac ttagtatggc aattatcaaa aatctgtaca ctgtgtttat ctgcatcctt
     4561 taggaagttg ggggtggctc ttaagtagca ctgtcaagaa cagtttcttt ccatcagtat
     4621 tgctaaaagt tatttcaagt cctctactct ccactagttt aagacaagca tgctggagca
     4681 ggtcacatcc agtttgatct ggagtggagg ggtgccatgg tcttcacata tttctcatat
     4741 gcttcttcac tcatcattca tctagctctg aagggtcgct cagtgtcatc ttgatcagcc
     4801 aaccatcttt gtaacaggat ttgttgacga gccctgggtc ttcggcaatg gcttcactga
     4861 cttcagttac ctctcctgac aaaggtgagg agagctcact ggcagccttc acactctcca
     4921 aagcaccaaa ctcctcttgt tttttttctc aattttgtcc caacttcagg cagactacag
     4981 taaacaacat cttccaaagc ttcctgtgca aaattgctga ttcccactgt tccaatacct
     5041 tcctctgttg ttatccattc atgtttctct gtgaatttac gcactgacag caaagcagat
     5101 ccggtgcgca gtgagcagag gccagggcgg tgcgcaggct gtaggccaca acccgaaagc
     5161 tcctcgaccc ttgcagcgac atgatcagag gtccggagtg ggtaactgtg cttcgcctcc
     5221 gccaccaggc cagcggggtg ggatatttgt tattgagaat tgttaaactg agtgatttgt
     5281 gaatgtatgc tgctgaaata aaatgaaatt aaatagaaac ctttaaa
//
