LOCUS       NM_021476               2979 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus cysteinyl leukotriene receptor 1 (Cysltr1), transcript
            variant 1, mRNA.
ACCESSION   NM_021476
VERSION     NM_021476.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2979)
  AUTHORS   Mosala,P., Mpotje,T., Abdel Aziz,N., Ndlovu,H., Musaigwa,F.,
            Nono,J.K. and Brombacher,F.
  TITLE     Cysteinyl leukotriene receptor-1 as a potential target for
            host-directed therapy during chronic schistosomiasis in murine
            model
  JOURNAL   Front Immunol 15, 1279043 (2024)
   PUBMED   38840916
  REMARK    GeneRIF: Cysteinyl leukotriene receptor-1 as a potential target for
            host-directed therapy during chronic schistosomiasis in murine
            model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2979)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2979)
  AUTHORS   Liu,X., Tang,S.S., Liu,S.M., Zeng,J., Chen,Z.G., Liu,C.H., Mu,R.H.,
            Yuan,D.H., Zhao,J.J., Hong,H. and Wang,H.
  TITLE     Deficiency of astrocyte CysLT1R ameliorates depression-like
            behaviors in mice by modulating glutamate synaptic transmission
  JOURNAL   Neurobiol Dis 175, 105922 (2022)
   PUBMED   36371059
  REMARK    GeneRIF: Deficiency of astrocyte CysLT1R ameliorates
            depression-like behaviors in mice by modulating glutamate synaptic
            transmission.
REFERENCE   4  (bases 1 to 2979)
  AUTHORS   Fujita,H., Ando,A., Mizusawa,Y., Ono,M., Hattori,T., Habuta,M.,
            Oohashi,T., Kubota,S. and Ohuchi,H.
  TITLE     Cysteinyl leukotriene receptor 1 is dispensable for osteoclast
            differentiation and bone resorption
  JOURNAL   PLoS One 17 (11), e0277307 (2022)
   PUBMED   36395281
  REMARK    GeneRIF: Cysteinyl leukotriene receptor 1 is dispensable for
            osteoclast differentiation and bone resorption.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2979)
  AUTHORS   Badrani,J.H., Strohm,A.N., Lacasa,L., Civello,B., Cavagnero,K.,
            Haung,Y.A., Amadeo,M., Naji,L.H., Lund,S.J., Leng,A., Kim,H.,
            Baum,R.E., Khorram,N., Mondal,M., Seumois,G., Pilotte,J.,
            Vanderklish,P.W., McGee,H.M. and Doherty,T.A.
  TITLE     RNA-binding protein RBM3 intrinsically suppresses lung innate
            lymphoid cell activation and inflammation partially through CysLT1R
  JOURNAL   Nat Commun 13 (1), 4435 (2022)
   PUBMED   35908044
  REMARK    GeneRIF: RNA-binding protein RBM3 intrinsically suppresses lung
            innate lymphoid cell activation and inflammation partially through
            CysLT1R.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2979)
  AUTHORS   Maekawa,A., Austen,K.F. and Kanaoka,Y.
  TITLE     Targeted gene disruption reveals the role of cysteinyl leukotriene
            1 receptor in the enhanced vascular permeability of mice undergoing
            acute inflammatory responses
  JOURNAL   J Biol Chem 277 (23), 20820-20824 (2002)
   PUBMED   11932261
  REMARK    GeneRIF: determination of role in enhanced vascular permeability of
            mice undergoing acute inflammatory responses
REFERENCE   7  (bases 1 to 2979)
  AUTHORS   Ogasawara,H., Ishii,S., Yokomizo,T., Kakinuma,T., Komine,M.,
            Tamaki,K., Shimizu,T. and Izumi,T.
  TITLE     Characterization of mouse cysteinyl leukotriene receptors mCysLT1
            and mCysLT2: differential pharmacological properties and tissue
            distribution
  JOURNAL   J Biol Chem 277 (21), 18763-18768 (2002)
   PUBMED   11854273
REFERENCE   8  (bases 1 to 2979)
  AUTHORS   Martin,V., Sawyer,N., Stocco,R., Unett,D., Lerner,M.R.,
            Abramovitz,M. and Funk,C.D.
  TITLE     Molecular cloning and functional characterization of murine
            cysteinyl-leukotriene 1 (CysLT(1)) receptors
  JOURNAL   Biochem Pharmacol 62 (9), 1193-1200 (2001)
   PUBMED   11705452
REFERENCE   9  (bases 1 to 2979)
  AUTHORS   Maekawa,A., Kanaoka,Y., Lam,B.K. and Austen,K.F.
  TITLE     Identification in mice of two isoforms of the cysteinyl leukotriene
            1 receptor that result from alternative splicing
  JOURNAL   Proc Natl Acad Sci U S A 98 (5), 2256-2261 (2001)
   PUBMED   11226226
REFERENCE   10 (bases 1 to 2979)
  AUTHORS   Mollerup,J., Jorgensen,S.T., Hougaard,C. and Hoffmann,E.K.
  TITLE     Identification of a murine cysteinyl leukotriene receptor by
            expression in Xenopus laevis oocytes
  JOURNAL   Biochim Biophys Acta 1517 (3), 455-459 (2001)
   PUBMED   11342226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732460.7 and AK033476.1.
            
            On Aug 9, 2013 this sequence version replaced NM_021476.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Both variants 1 and
            2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033476.1, BC027102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AL732460.7         47516-47732         c
            218-2939            AK033476.1         2-2723
            2940-2979           AL732460.7         20562-20601         c
FEATURES             Location/Qualifiers
     source          1..2979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.36 cM"
     gene            1..2979
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1; CysLT1R"
                     /note="cysteinyl leukotriene receptor 1"
                     /db_xref="GeneID:58861"
                     /db_xref="MGI:MGI:1926218"
     exon            1..445
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1; CysLT1R"
                     /inference="alignment:Splign:2.1.0"
     exon            446..532
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1; CysLT1R"
                     /inference="alignment:Splign:2.1.0"
     exon            533..622
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1; CysLT1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             610..1668
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1; CysLT1R"
                     /note="isoform a is encoded by transcript variant 1;
                     cysteinyl leukotriene D4 receptor; LTD4 receptor"
                     /codon_start=1
                     /product="cysteinyl leukotriene receptor 1 isoform a"
                     /protein_id="NP_067451.2"
                     /db_xref="CCDS:CCDS41098.1"
                     /db_xref="GeneID:58861"
                     /db_xref="MGI:MGI:1926218"
                     /translation="MYLQGTKQTFLENMNGTENLTTSLINNTCHDTIDEFRNQVYSTM
                     YSVISVVGFFGNSFVLYVLIKTYHEKSAFQVYMINLAIADLLCVCTLPLRVVYYVHKG
                     KWLFGDFLCRLTTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNINLVTQKKARFVCI
                     GIWIFVILTSSPFLMYKSYQDEKNNTKCFEPPQNNQAKKYVLILHYVSLFFGFIIPFV
                     TIIVCYTMIILTLLKNTMKKNMPSRRKAIGMIIVVTAAFLVSFMPYHIQRTIHLHLLH
                     SETRPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTFRKHSLSSMTY
                     VPKKKASLPEKGEEICNE"
     exon            623..2979
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1; CysLT1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2948..2953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1; CysLT1R"
                     /note="hexamer: AATAAA"
     polyA_site      2976
                     /gene="Cysltr1"
                     /gene_synonym="Cyslt1; CysLT1R"
                     /note="major polyA site"
ORIGIN      
        1 cttcccacct cagagcagct gcatgacttc ctgaggattc tattgcagta gccagagata
       61 aacactcatt tgtgcatatt acgtgcaagt ctccagtttc tattcttctt ccctctccgc
      121 tctttccctt cccccacttt aaaccaggga agccaaactc tggcggggtt gaagcggctt
      181 gagaagtact aagaaacagg aagaagagtc gaggtctatt ggctagcaaa tgtgccatgg
      241 cctgacctct ctcctctgga aaagaaacat tcctaaagag caggagccct gtgaatggag
      301 tggaccatcc cgaatatcca gacttatttg cagctcacca tccagggtta gctcaccagg
      361 agactagcag gttggaattt ctgaagattt ggatcttgct tcagggagca aaaggacctt
      421 aaactgtgaa gcttggaatc agcagcttga acgtactctg acactacaac ataagaacag
      481 tggccacagt aagaagggaa gtttgtgaaa ggtgctgagg taccagatag aggtctccct
      541 gtgtatccta ggctgatctt aaattcacca tcttcctgct ttggcttctc aagggctgtg
      601 attgcagaaa tgtacctcca aggcaccaag cagacattcc tggagaacat gaatggaact
      661 gaaaatctga cgacatctct cattaataac acgtgtcatg acacaattga tgaattccga
      721 aatcaagtat actccactat gtattctgtg atctctgttg tgggtttctt tggcaatagc
      781 tttgtgctct atgtcctcat aaaaacatac catgagaaat cagccttcca agtatacatg
      841 attaatctag ccatagcaga tctactctgt gtatgtacat tgcctctccg tgtggtctat
      901 tatgttcaca aaggcaagtg gctctttggt gactttttgt gccgcctcac cacctatgcc
      961 ttgtacgtta acctctattg tagcatcttc tttatgacag ccatgagctt tttccggtgt
     1021 gttgcaattg tctttccagt ccagaacatt aatttggtta cacagaaaaa agccaggttc
     1081 gtttgcattg gaatttggat ttttgtgatt ttgacaagtt ctcccttttt aatgtacaaa
     1141 tcttaccaag atgagaaaaa caatactaaa tgctttgagc ctccacagaa caatcaagct
     1201 aaaaaatacg ttttgatctt gcattatgtg tcattattct ttggtttcat catccctttt
     1261 gtcaccataa ttgtctgtta cacaatgatc attctgacct tactaaaaaa tacaatgaag
     1321 aaaaacatgc caagtcgtag gaaggctata gggatgatca tagttgtgac agctgccttt
     1381 ttagtgagct tcatgccata tcatattcaa cgaactatcc accttcacct tttacacagt
     1441 gaaactagac cctgtgattc tgtccttagg atgcagaagt cagtggtcat aaccttatct
     1501 ctagctgcat caaattgttg ctttgatcct ctgctatatt tcttttcagg tggaaacttt
     1561 aggagaaggc tatctacatt tagaaagcat tctttgtcca gtatgactta tgtacccaag
     1621 aagaaagctt ccttgccaga aaaaggagaa gaaatatgta acgaataatt caaactcatc
     1681 tacagtgcag aacaatgaaa aagaaattcc ctaacgagtg tttttctaaa tcaaaattaa
     1741 aaaaaaatgt ttcccattaa tagtttacaa ataattatat ctatttcatt tataaatact
     1801 attatttgat attttaagtg ttcaaaactc aatttataac tgtgaactaa cccatagatt
     1861 tctttttgaa gactcaccag aaacttaaga atgtttatgg ttctgaacta taaaactgag
     1921 tatgaaatca agaatataaa agggatttaa aaggctacct actagacttt tgagttcagc
     1981 ttttaaatat agttttaaaa ttagcaaata gtcatcagtc accctaacat ctccctttgc
     2041 atgcatgcca tcagatgaga cctggagatg actcgggacg tacatttggt cagccgtttc
     2101 ctttgtagta ctgactagct aggtaaagta gtgccctgtc ttccagaaga gaatgttcaa
     2161 gtaccagaac agaccaatat tcagccaaat agctccacag gctgcatgaa atttacaata
     2221 tggaaaaata aggaagataa atctgatcaa aggccagttt gtctctaatt ctcttctgcc
     2281 cttgactcaa gcaccggcaa aagaatggtg ttcttgctca cagtggttca atccctattc
     2341 tacctataat ccttccttaa taagtaaggc aactggcatt cccatatatg acagaagaag
     2401 tcaaaattca tcagaagtaa agaaaatagg cctacctttc tacatgagat ttgttggaat
     2461 caaaatttac tatgttagat agcagaagaa aatttgaata tccatgtcat taatactttt
     2521 aataagtata tgcatttata tgtatgtata taaatatatg taatctatct tgttctatga
     2581 tatgcattta ttgttagtta attatgagat ttattgttgt tttatactta tttctttttt
     2641 attagcatgt tgaaagtaat atttgtttac agtgattttt atattatagc agaagctttg
     2701 ttcttaaacc aaaccattga aaacagcttg gttgtgacta aaatatgata ttcattgaca
     2761 aagttttgct gaaggccact tttttcctaa ctatgagttt caaaagtcac atcaactcag
     2821 aagaaataaa tgatagcaga gatgggaaaa agaaaaacca tgaatggagt tgtgtcagta
     2881 tcagctacgt gaaaactttt tctatttcac ttctgctgga ccccttggga aattgtgttt
     2941 aaagcataat aaagagagga ctctaaggat gaaaaataa
//
