LOCUS       NM_001360036            3851 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus CYFIP related Rac1 interactor B (Cyrib), transcript
            variant 3, mRNA.
ACCESSION   NM_001360036 XM_011245563
VERSION     NM_001360036.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3851)
  AUTHORS   Park,C.S., Guan,J., Rhee,P., Gonzalez,F., Lee,H.S., Park,J.H.,
            Coscoy,L., Robey,E.A., Shastri,N. and Sadegh-Nasseri,S.
  TITLE     Fam49b dampens TCR signal strength to regulate survival of
            positively selected thymocytes and peripheral T cells
  JOURNAL   Elife 13, e76940 (2024)
   PUBMED   39158947
  REMARK    GeneRIF: Fam49b dampens TCR signal strength to regulate survival of
            positively selected thymocytes and peripheral T cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3851)
  AUTHORS   Nikolaou,S., Juin,A., Whitelaw,J.A., Paul,N.R., Fort,L., Nixon,C.,
            Spence,H.J., Bryson,S. and Machesky,L.M.
  TITLE     CYRI-B-mediated macropinocytosis drives metastasis via
            lysophosphatidic acid receptor uptake
  JOURNAL   Elife 13, e83712 (2024)
   PUBMED   38712822
  REMARK    GeneRIF: CYRI-B-mediated macropinocytosis drives metastasis via
            lysophosphatidic acid receptor uptake.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3851)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3851)
  AUTHORS   Sisario,D., Spindler,M., Ermer,K.J., Grutz,N., Nicolai,L.,
            Gaertner,F., Machesky,L.M. and Bender,M.
  TITLE     Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and
            CYFIP1 in Platelets
  JOURNAL   Cells 13 (4), 299 (2024)
   PUBMED   38391912
  REMARK    GeneRIF: Differential Role of the RAC1-Binding Proteins FAM49b
            (CYRI-B) and CYFIP1 in Platelets.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3851)
  AUTHORS   Huang,Z., Pu,J., Luo,Y., Fan,J., Li,K., Peng,D., Zong,K., Zhou,B.,
            Guan,X. and Zhou,F.
  TITLE     FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion
            injury by inhibiting TRAF6/IKK signaling pathway in a
            Rac1-dependent manner
  JOURNAL   Mol Immunol 143, 135-146 (2022)
   PUBMED   35131594
  REMARK    GeneRIF: FAM49B, restrained by miR-22, relieved hepatic
            ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling
            pathway in a Rac1-dependent manner.
REFERENCE   6  (bases 1 to 3851)
  AUTHORS   Uslu,V.V., Petretich,M., Ruf,S., Langenfeld,K., Fonseca,N.A.,
            Marioni,J.C. and Spitz,F.
  TITLE     Long-range enhancers regulating Myc expression are required for
            normal facial morphogenesis
  JOURNAL   Nat Genet 46 (7), 753-758 (2014)
   PUBMED   24859337
REFERENCE   7  (bases 1 to 3851)
  AUTHORS   Nagarajan,N.A., Gonzalez,F. and Shastri,N.
  TITLE     Nonclassical MHC class Ib-restricted cytotoxic T cells monitor
            antigen processing in the endoplasmic reticulum
  JOURNAL   Nat Immunol 13 (6), 579-586 (2012)
   PUBMED   22522492
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3851)
  AUTHORS   Ishikawa,H., Thompson,J., Yates,J.R. 3rd and Marshall,W.F.
  TITLE     Proteomic analysis of mammalian primary cilia
  JOURNAL   Curr Biol 22 (5), 414-419 (2012)
   PUBMED   22326026
REFERENCE   9  (bases 1 to 3851)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   10 (bases 1 to 3851)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156573.3 and AC140673.4.
            
            On Jan 26, 2018 this sequence version replaced XM_011245563.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1. 2, 3, and 4 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075613.1, SRR7652917.324319.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AC156573.3         76307-76560         c
            255-305             AC156573.3         38682-38732         c
            306-344             AC140673.4         174428-174466       c
            345-427             AC140673.4         160098-160180       c
            428-549             AC140673.4         153504-153625       c
            550-655             AC140673.4         147821-147926       c
            656-792             AC140673.4         146682-146818       c
            793-870             AC140673.4         145429-145506       c
            871-987             AC140673.4         143143-143259       c
            988-1067            AC140673.4         142162-142241       c
            1068-1194           AC140673.4         140796-140922       c
            1195-1265           AC140673.4         139077-139147       c
            1266-3851           AC140673.4         132592-135177       c
FEATURES             Location/Qualifiers
     source          1..3851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 28.16 cM"
     gene            1..3851
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /note="CYFIP related Rac1 interactor B"
                     /db_xref="GeneID:223601"
                     /db_xref="MGI:MGI:1923520"
     exon            1..254
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            255..305
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            306..344
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            345..427
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1329
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /note="isoform 1 is encoded by transcript variant 3;
                     protein FAM49B; family with sequence similarity 49, member
                     B"
                     /codon_start=1
                     /product="CYFIP-related Rac1 interactor B isoform 1"
                     /protein_id="NP_001346965.1"
                     /db_xref="CCDS:CCDS27505.1"
                     /db_xref="GeneID:223601"
                     /db_xref="MGI:MGI:1923520"
                     /translation="MGNLLKVLTCTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLK
                     DAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEA
                     ALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYR
                     RTLSRMRINNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIE
                     NTTDCLSTMASVCRVMLETPEYRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKT
                     SKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIRSMLQ"
     exon            428..549
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            550..655
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            656..792
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            793..870
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            871..987
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1067
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1194
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1265
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..3851
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1977..1982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /note="hexamer: AATAAA"
     polyA_site      2003
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /note="major polyA site"
     regulatory      3831..3836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
                     /note="hexamer: AATAAA"
     polyA_site      3851
                     /gene="Cyrib"
                     /gene_synonym="0910001A06Rik; Fam49b"
ORIGIN      
        1 ggcgccgggc tgggctgcga aggtaaacag cgcttcctct tcctcctcgc cgcctcttcc
       61 ttttatagcg atttctggcc gcgccggggc cgggccgctg ctgctgccgt ttgctgctgc
      121 tgctgtcgct tgctgccgcg gcggggccgc tcgcgaacct gcggcgggga cgcgcgagcc
      181 gccgacccgg aagcggcgtg tgtgcaccgc aggctcccgc cgccagctcg cccgcccgcc
      241 cgtcgggccg ccaggagaag acgccgaggc ccgggatctg agatcctttc aaggctactg
      301 cattgataga aggacaagga caaaatcacc agcactggct gaaggtacct taacatgggg
      361 aatcttctta aagttttgac atgcacagac cttgagcagg ggccaaattt tttccttgat
      421 tttgaaaatg cccagcctac agagtctgag aaggaaatat ataatcaggt gaatgtagtg
      481 ttaaaagatg cagaaggcat cttggaggat ttgcagtcat acagaggagc tggccacgaa
      541 atacgagagg caatccagca tccagccgat gagaagttgc aagagaaggc gtggggtgca
      601 gtcgtgccac tagtaggcaa attaaagaag ttttacgaat tttctcagag actagaagca
      661 gcactaagag gccttctggg agccttgact agtacgccat actcgcccac ccaacatcta
      721 gagcgagagc aggctctcgc taaacagttt gcagagattc ttcacttcac actccggttt
      781 gatgagctca agatgacaaa tcctgccata caaaatgact tcagctacta cagaagaaca
      841 ttgagtcgta tgagaattaa taatgtcccg gcagaaggag aaaatgaagt aaataatgaa
      901 ttggcaaatc gaatgtcatt gttttacgct gaggccaccc caatgctgaa aaccttaagt
      961 gatgcaacaa caaaatttgt atcggagaat aaaaatttgc caatagaaaa taccacagat
     1021 tgtttaagca ccatggcaag tgtatgcaga gtcatgctgg agacaccgga atacagaagc
     1081 agatttacca atgaagagac agtatcattc tgcttgaggg taatggtggg tgtcataata
     1141 ctctatgacc acgtccatcc agtgggagca tttgccaaaa cttctaagat tgatatgaaa
     1201 ggttgtatca aagttcttaa ggaccaacct cctaatagtg tagaaggtct tctcaatgct
     1261 ctcaggtaca caacaaaaca tttgaatgat gagactacct ccaagcaaat taggtccatg
     1321 ctgcagtaag agctgtggag caagccccta ctgcagatgg agcacacagt gttcttcagt
     1381 gaccgagaat gcacagtctt agtgaatgcc atcaaatctc cttattcttg ctttggtttc
     1441 tttcctctgt tcctcttccc actttttaaa tcatgttctt gttcttaaga cttcttttct
     1501 gtgccaaaat cagtaaagtt atactttgaa agggattttg tcctttcaaa acaggccatc
     1561 taaggcagct aattacgcat tgcattgagg tctctactga gaaaagttct gtgacttgaa
     1621 ctaaatattt ttaaatgtgg attttttttg aaaactaata tttaatattg cttctcctgc
     1681 atggcgaaac tgcctattct gctatttaaa accctcataa atttattttc tactgccgct
     1741 ttttcatgtg cagccaaaat ggaaatgttt aaattaactg tgttgtacaa atggtaccca
     1801 acacaaaacc ttttttaaat tagtaagact ttgtttaaag ttttaagttt gcaggttgac
     1861 ttttttttta aggttgtatg ttgtgtgttt aacatttatt aactaacgtt aaaaactgtg
     1921 atgtgtgcgt agaatattac gtatgcatgt tcatgtttaa gaatggctgt tgataaaata
     1981 aaaatcagct ttcctttttc taagtgtggc ttggtttact gaggtttctg gaagttttcc
     2041 ctgtatatat ttctatggaa tgcatataca cattacataa tttttctttc tcttaggcaa
     2101 tagctatgtc tttttcagtt gttttgcttt actttttgtc tatgtacata agttagactg
     2161 cttttaaaac tgttgtgtat aagatgacca gtgattgtgt cgacattaac ttgacttctg
     2221 ttctgattta atctttgtga gcgtagtcat agaaggaaac ccgtactttc tcagctctcg
     2281 gtttcaggaa tgaaagggcg gtgacaggaa gcacatggtg tctcgaaggc acgaggagcc
     2341 cttgacattg gaggagagtg agcaataaga gtacttccag aggaaataaa tgaaagtccg
     2401 agatctcact ggtcgtagga agtgacatga gttacaattt aaaatcataa agcccaaggc
     2461 aaagaaatgt gtctcagttg agagaagctg cttgaaagtt gtcgaattca gccttgtcag
     2521 ggacttaatg acaaggtgac ctgaggtggg acacagttaa agtgcttaac catgggagat
     2581 gatcacaggc tgccctctgg accctctcca tcagagcgcc agattgtggt gcacacggca
     2641 cttgatggta aagttcctgt tgacctctct ggcctcctgc ttactcgtgt tccacttcct
     2701 accctgctct ccagccaagc ttaactactt gctgtttaca gattgttccg tgtggtgttg
     2761 cttcgtaact gatctggcta caacctgaac ctggtcttcc ttcttctctc cttcatgttt
     2821 gtctgaccaa caccagctgt catctttcaa aaatcagctt cttttacttc ctccaaaaac
     2881 catttagatg acattggcca tgtcttccag gaggcttcta cagtgttata atgggtttaa
     2941 tagtttactc cataaagggt aatgtctgga acctgtacat atggcctcat tttgaagaag
     3001 ggcattttca ggtgaatgta aggacctatg tatgtatggc atcgtcctgg atgagagtgg
     3061 gtcctagccc tactgacaag tccttttaag agaaaagaag gggaaacaag cagtggaggt
     3121 cctgggagga tagaggcaaa ggtaacatca tatcttgaaa tttcctggac cacagaagcc
     3181 agaagaaggt catggaacac tttccatcag agtttctaga aggaagcgac cctgttgctg
     3241 tttttatttc agacttctat tatgatgaaa aaaataagtt tctattctaa gccacctagt
     3301 ttgtggtaat ttgttacagt caacttaagc attgaataca actgtctcac aaaacagcct
     3361 gatacatcac tacactttta tatcttctct gatactcatg agaagttaca atgtctagat
     3421 gctgcagaga ctgagaacct gagaagagcc atgtcttatt ccttcagtgt ctcaagcaag
     3481 gatcttgcat agtacctaaa tatggagagc tgccaagtga gtaattgaat ggagtgagtg
     3541 aggactgata aatgaagtag atgtagtaat cctgctgtgg cctttcaggt aacatggttc
     3601 acactctgca tgttgaagat taagttggca aaaaaatctt taactctagc ctaggggtca
     3661 gtagcccagt cggtgggcca attcacctcc ctctggacct acacaacctg tgaattaaga
     3721 atgattttta aaatgtcggg agaataaagg ataacaaatg tttttctaaa agttgaaaaa
     3781 tattttgtag catgagaaaa gtatatgaaa ttcaaactcc agtgttcata aataaaattt
     3841 tattgaacat a
//
