LOCUS       NM_001135611            3400 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cell cycle regulator of NHEJ (Cyren), transcript
            variant 2, mRNA.
ACCESSION   NM_001135611
VERSION     NM_001135611.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3400)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3400)
  AUTHORS   Castaneda-Zegarra,S., Zhang,Q., Alirezaylavasani,A.,
            Fernandez-Berrocal,M., Yao,R. and Oksenych,V.
  TITLE     Leaky severe combined immunodeficiency in mice lacking
            non-homologous end joining factors XLF and MRI
  JOURNAL   Aging (Albany NY) 12 (23), 23578-23597 (2020)
   PUBMED   33289702
  REMARK    GeneRIF: Leaky severe combined immunodeficiency in mice lacking
            non-homologous end joining factors XLF and MRI.
REFERENCE   3  (bases 1 to 3400)
  AUTHORS   Castaneda-Zegarra,S., Huse,C., Rosand,O., Sarno,A., Xing,M.,
            Gago-Fuentes,R., Zhang,Q., Alirezaylavasani,A., Werner,J., Ji,P.,
            Liabakk,N.B., Wang,W., Bjoras,M. and Oksenych,V.
  TITLE     Generation of a Mouse Model Lacking the Non-Homologous End-Joining
            Factor Mri/Cyren
  JOURNAL   Biomolecules 9 (12), 798 (2019)
   PUBMED   31795137
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3400)
  AUTHORS   Hung,P.J., Johnson,B., Chen,B.R., Byrum,A.K., Bredemeyer,A.L.,
            Yewdell,W.T., Johnson,T.E., Lee,B.J., Deivasigamani,S., Hindi,I.,
            Amatya,P., Gross,M.L., Paull,T.T., Pisapia,D.J., Chaudhuri,J.,
            Petrini,J.J.H., Mosammaparast,N., Amarasinghe,G.K., Zha,S.,
            Tyler,J.K. and Sleckman,B.P.
  TITLE     MRI Is a DNA Damage Response Adaptor during Classical
            Non-homologous End Joining
  JOURNAL   Mol Cell 71 (2), 332-342 (2018)
   PUBMED   30017584
REFERENCE   5  (bases 1 to 3400)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3400)
  AUTHORS   Agarwal,S., Harada,J., Schreifels,J., Lech,P., Nikolai,B.,
            Yamaguchi,T., Chanda,S.K. and Somia,N.V.
  TITLE     Isolation, characterization, and genetic complementation of a
            cellular mutant resistant to retroviral infection
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15933-15938 (2006)
   PUBMED   17043244
  REMARK    GeneRIF: Characterizes the hamster ortholog and suggests that it
            may modulate the ability of the proteasome to degrade retroviral
            cores upon cellular infection.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611813.1, AK083365.1 and AK042380.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR compared to variant 1. Both variants 1 and 2 encode
            the same protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083365.1, AK170119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BB611813.1         2-35
            35-515              AK083365.1         2-482
            516-3400            AK042380.1         797-3681
FEATURES             Location/Qualifiers
     source          1..3400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.18 cM"
     gene            1..3400
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /note="cell cycle regulator of NHEJ"
                     /db_xref="GeneID:78412"
                     /db_xref="MGI:MGI:1925662"
     exon            1..166
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /inference="alignment:Splign:2.1.0"
     exon            167..399
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..727
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /note="isoform 1 is encoded by transcript variant 2;
                     modulator of retrovirus infection homolog; cell cycle
                     regulator of non-homologous end joining"
                     /codon_start=1
                     /product="cell cycle regulator of non-homologous end
                     joining isoform 1"
                     /protein_id="NP_001129083.1"
                     /db_xref="CCDS:CCDS19997.1"
                     /db_xref="GeneID:78412"
                     /db_xref="MGI:MGI:1925662"
                     /translation="METLKSKTKTRVLPSWMTAPVDERKVVSVKTATRKQTAAWAQRV
                     GAATRAPATETVYCMNEAEMVDVALGILIEGRKQEKPWEQRSLEATDKLQLSPPCSSS
                     PGSSSEEEDSRISSLAPGLSPPRGPEASDSPCSRSPEEEKEEEDALKYVREIFFS"
     exon            400..475
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /inference="alignment:Splign:2.1.0"
     exon            476..3400
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1421..1426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /note="hexamer: AATAAA"
     polyA_site      1487
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /note="major polyA site"
     polyA_site      1498
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /note="major polyA site"
     regulatory      3311..3316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
                     /note="hexamer: ATTAAA"
     polyA_site      3332
                     /gene="Cyren"
                     /gene_synonym="3110062M04Rik; Mri"
ORIGIN      
        1 gttctgaatc cccggaaccc acgggaagga ccgcagcgct gccctcccct cttgcccacg
       61 gttccatcct gtccccaggc ccccggctct gcgccctctg cggtagggag ggagtggcgc
      121 ggccagctcc gcgctagtgc agcgacgtcc cgcgtgtgcc ttctgggcat tgaagatcgg
      181 cacccactgg ggtcagatga gcctggtgtg acaagagagt gtgagttttg gtcctgttct
      241 agagaagcaa gccatggaaa ccctaaaatc caagaccaaa acgagggtcc tcccctcttg
      301 gatgacagcc cctgtggatg agagaaaggt tgtatcagtg aagacagcca caaggaagca
      361 gacagccgcc tgggcccaga gagtgggggc agcaacaaga gccccagcca cggagaccgt
      421 gtactgcatg aatgaagctg aaatggtaga cgtggcactg gggatcctga ttgagggccg
      481 caaacaggaa aagccctggg aacagcggtc tctggaggcc actgataagc tgcagctctc
      541 ccctccctgt tcctcgtccc ccgggagcag cagtgaggaa gaagacagca ggatcagctc
      601 tcttgctcca ggcctcagcc ctccccgggg accagaagct tcggactctc cctgtagcag
      661 aagcccggag gaggagaagg aggaggaaga cgcgttgaag tacgtcaggg aaatattttt
      721 cagttagtat gaattgttca ctgcttcagc tgagagctgt gggtgctgcc cacccctact
      781 ggcccctgcc acccacgaaa accaggcttt gctcccaact tccagtccca ggaggttgtc
      841 agtttgggtg ggactttttc tgtagcagga tgcagaaacg catcctgtta cagactttcc
      901 ctgctccacc ctcgggccct gagggatggc aatcccagcc ccgagtttca ttcacagtaa
      961 aagtgaggtc ttgggcctac ttgccagatg caaaggaaaa tagagctgcc gagaacatgg
     1021 gtattctaga caggcagcca gatctcgact taaagagacc tatgaacagt ctccctcacg
     1081 acacagtcca gcagtaagct tccaccctcc caaccaaaca ggctggcaac tgcccacagt
     1141 tccctgccag tctaggagcc tcctgctcct agactgtgag gctggtgagc cacacaggcc
     1201 ctgtctacca ccagtcacct ctcttcctcc tggggcctcc accttgaccc ctgtaaggga
     1261 gagtgggaca cgggtcgctg aggacaaaag atcacaccag agtccaggtt tctttatatt
     1321 cactttggct tttgatgagc acagaatgaa gaactcattg ccacgtaggt tttctgatat
     1381 acaggcactg aacaaaatat atactgatgc cgcgatgcat aataaagacc atgccttctg
     1441 cctttccagt tctgggtaag gtgaggggac acggtgtgtg tttgtgacga ctattcaatc
     1501 ctgttcacct tccaggagtt gacacatttt gcgtctgcat ccctgggtca cgaggatggc
     1561 ttaacagctg attcctgttt gctgtcaggt ccagggaccc cttcagggga ccctaaaaag
     1621 ccagtgaggc ttctctttgt gctgacagga ctcggtgtta aagcaggttg cttgtttgtt
     1681 tgttttttgt ttttccccta atcatcccat ttgttgccat aaccatcaca gagttctagt
     1741 ttgacacttt gccaagatag cttggaagtt tggcctctga cagactccca cctgcctggg
     1801 actataggaa tccctgtgct aatgagctac atggtaccct aagaaactgc aggtacccca
     1861 gccctccaag ccgcctctgg gttccttgac accacagccc gtctgcacag tgagtggtcc
     1921 cctctgctgt gctggagatc aacattagct atgacacagg gtgactgaga agaactactc
     1981 agcacaggtc ctctggcacc ttcttggagc acagttggaa ccgaaccctt gcaatcccat
     2041 aataagcctt tgtaagaccg gactaacagt tctcccactg gttcttgtcc tccttatccc
     2101 gtggcgggaa cctaaccgtg gccacaagca agaagatgag taacagctgg gctaggcata
     2161 gagctggcaa ggcaggcccc aggaaggaga gcctgagcca cttccacacg aaggagagga
     2221 agaggcttag tcctccggcc aacagaatgg aggatgccgc caggaagcac acggccagcc
     2281 gccactctcc ctcatctctg ttgtactggg caaggaggag aggcagaggg acgaacactg
     2341 tgaggaccag ggctccatac acaccgagcc tggccagggc tagtccaacc tgaggaatgc
     2401 ccagcacgtc cagctcggga aagttgtaac atgctaggga gcccatgtcc tccttccaca
     2461 gacagaagtt gtagaagccg attctcaggc taggtaggtc agcgaggttg ccagccttcc
     2521 agaggagagc gtagaacatc aggcacaggg ccgcggccaa gaggatcatg atgcccacga
     2581 agggcaggtg gttgttccgc cacagcctgg agaaggccat atcttctgct gttgcaggga
     2641 gacctggaaa aggtcacagc agtgaatatc tagccctttc cttgtgttta caagttccca
     2701 ttctttctgt cctcatgaag ataggaggtc ccaagtcaca gccaggtccc agtcacagtg
     2761 gtccactgct ttgaggttag aaggaactgg gcagctgtgg aaacctgaag tatcctgagc
     2821 cgcagccctc aggtaaaggg ctttcccgca gcatggatat cacaggctgt tgggggctct
     2881 ctgagagtgt ctcaggtcct cataaaggtg ggtttgcagg tgtgagggtg aagggcaagc
     2941 ctcacggtta gttgggacgg cagcttgagg taggtgcgcg aggcttgact gagcctaagc
     3001 tcagttgctg ctgacaacca cttagatgac tgcagaacta cccagctagg ctacatgaca
     3061 gtcagcccag tgtctgcagg ctgggtgtgc gtggtcagca aagctctatg gctcagttgg
     3121 ttggatgtga gcctgagtga aggatcagtg gcctgtgcct ccttccccgt ttagggaact
     3181 gaacctctcc ttgggtgaaa tcacactatt gtatgatgtt gcttttaaaa catgtctgtc
     3241 tgtcccctcc tcccataaca acagtaatct attagtctag gaaattctgg aaacttttta
     3301 aaagaaaaaa attaaaataa ccctttatcc taccaccata gtaaaaccac tgttcatatt
     3361 tcacagacat ttcccctatg tgattatatg tctttaaagc
//
