LOCUS       NM_001310461             663 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus cysteine-rich perinuclear theca 1 (Cypt1), transcript
            variant 2, mRNA.
ACCESSION   NM_001310461 XM_006527692
VERSION     NM_001310461.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 663)
  AUTHORS   Hansen,M.A., Nielsen,J.E., Retelska,D., Larsen,N. and Leffers,H.
  TITLE     A shared promoter region suggests a common ancestor for the human
            VCX/Y, SPANX, and CSAG gene families and the murine CYPT family
  JOURNAL   Mol Reprod Dev 75 (2), 219-229 (2008)
   PUBMED   17342728
  REMARK    GeneRIF: Human VCX/Y, SPANX, and CSAG2 gene families together with
            the murine SPANX gene and the CYPT family may share a common
            ancestor.
REFERENCE   2  (bases 1 to 663)
  AUTHORS   Hansen,M.A., Nielsen,J.E., Tanaka,M., Almstrup,K., Skakkebaek,N.E.
            and Leffers,H.
  TITLE     Identification and expression profiling of 10 novel spermatid
            expressed CYPT genes
  JOURNAL   Mol Reprod Dev 73 (5), 568-579 (2006)
   PUBMED   16477651
REFERENCE   3  (bases 1 to 663)
  AUTHORS   Kitamura,K., Iguchi,N., Kaneko,Y., Tanaka,H. and Nishimune,Y.
  TITLE     Characterization of a novel postacrosomal perinuclear
            theca-specific protein, CYPT1
  JOURNAL   Biol Reprod 71 (6), 1927-1935 (2004)
   PUBMED   15286030
  REMARK    GeneRIF: CYPT1 and the proteins of the paralogous genes constitute
            a novel, basic cysteine-rich sperm protein family that may
            contribute to the function of the postacrosomal PT during nuclear
            shaping.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006892.1 and AL805907.5.
            
            On Jul 14, 2015 this sequence version replaced XM_006527692.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006892.1, CN842310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AK006892.1         1-234
            235-235             AL805907.5         61847-61847
            236-655             AK006892.1         236-655
            656-663             AL805907.5         62428-62435
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 11.68 cM"
     gene            1..663
                     /gene="Cypt1"
                     /gene_synonym="4931420D14Rik; Ckt1r3; Cypt5; Cypt6;
                     TISP55"
                     /note="cysteine-rich perinuclear theca 1"
                     /db_xref="GeneID:66742"
                     /db_xref="MGI:MGI:3616441"
     exon            1..300
                     /gene="Cypt1"
                     /gene_synonym="4931420D14Rik; Ckt1r3; Cypt5; Cypt6;
                     TISP55"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..531
                     /gene="Cypt1"
                     /gene_synonym="4931420D14Rik; Ckt1r3; Cypt5; Cypt6;
                     TISP55"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cysteine-rich postacrosomal PT protein; cysteine-rich
                     postacrosomal perinuclear theca protein; basic protein
                     CKT1R3; cysteine-rich perinuclear theca 5; cysteine-rich
                     perinuclear theca 6; cysteine-rich perinuclear theca
                     protein 1"
                     /codon_start=1
                     /product="cysteine-rich perinuclear theca protein 1
                     isoform 2"
                     /protein_id="NP_001297390.1"
                     /db_xref="CCDS:CCDS81101.1"
                     /db_xref="GeneID:66742"
                     /db_xref="MGI:MGI:3616441"
                     /translation="MAQMAKKVHWSSAAAGAAAAAKISKLEKTTKRFKLIKKRNPSSK
                     LPKRSSHSLLCSLSRSCCCCRCRCCCYCRCCRCCCSRSRRFRSRTTLKFFQITEKGEQ
                     SLQRRIRRQLTRSQLELIEPEPTMALEPSEITVAFFSHKNANVSDPEEVPPCLDSDPF
                     PNGDLASS"
     exon            301..663
                     /gene="Cypt1"
                     /gene_synonym="4931420D14Rik; Ckt1r3; Cypt5; Cypt6;
                     TISP55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      642..647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cypt1"
                     /gene_synonym="4931420D14Rik; Ckt1r3; Cypt5; Cypt6;
                     TISP55"
                     /note="hexamer: AATAAT"
     polyA_site      661
                     /gene="Cypt1"
                     /gene_synonym="4931420D14Rik; Ckt1r3; Cypt5; Cypt6;
                     TISP55"
                     /note="major polyA site"
ORIGIN      
        1 ggccagtctc tggagagctc tgctatggct cagatggcca agaaagtcca ctggtctagc
       61 gcagcagcag gagcagccgc tgctgccaaa atttcgaagc ttgagaagac caccaaaaga
      121 ttcaaactta ttaagaagcg aaaccctagt tctaagcttc ccaagagatc ttcacactct
      181 ttactttgtt ctctttctcg ttcctgttgt tgctgtcgct gtcgttgttg ctgttactgt
      241 cgttgctgtc gttgttgctg tagtcgttct cgtcgttttc gtagcagaac tacattaaag
      301 ttctttcaga ttacggagaa gggggagcaa tcacttcaaa gaagaattag gagacaattg
      361 acgcggagcc aactggagct gatcgaaccg gaaccgacca tggctttgga gccaagcgag
      421 attacagtgg cattcttctc tcataagaat gccaatgtgt ctgatccaga ggaagttcca
      481 ccatgccttg acagtgaccc atttccgaat ggagacttgg ccagttccta gaccccgaac
      541 gggtccaaag tcccatgaaa catcagtgga cgggtctggg agctgagctg tggtcctgtc
      601 aaggaaactc ttcaccacaa actaatttga atgatggtga aaataatcag atgtgaaaat
      661 atg
//
