LOCUS       NM_020010               4353 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 51 (Cyp51), mRNA.
ACCESSION   NM_020010
VERSION     NM_020010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4353)
  AUTHORS   Gamart,J., Barozzi,I., Laurent,F., Reinhardt,R., Martins,L.R.,
            Oberholzer,T., Visel,A., Zeller,R. and Zuniga,A.
  TITLE     SMAD4 target genes are part of a transcriptional network that
            integrates the response to BMP and SHH signaling during early limb
            bud patterning
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34822715
REFERENCE   2  (bases 1 to 4353)
  AUTHORS   Cokan,K.B., Urlep,Z., Lorbek,G., Matz-Soja,M., Skubic,C., Perse,M.,
            Jeruc,J., Juvan,P., Rezen,T. and Rozman,D.
  TITLE     Chronic Disruption of the Late Cholesterol Synthesis Leads to
            Female-Prevalent Liver Cancer
  JOURNAL   Cancers (Basel) 12 (11), 3302 (2020)
   PUBMED   33182326
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4353)
  AUTHORS   Mu,X., Wen,J., Chen,Q., Wang,Z., Wang,Y., Guo,M., Yang,Y., Xu,J.,
            Wei,Z., Xia,G., Yang,M. and Wang,C.
  TITLE     Retinoic acid-induced CYP51 nuclear translocation promotes meiosis
            prophase I process and is correlated to the expression of REC8 and
            STAG3 in mice
  JOURNAL   Biol Open 7 (11) (2018)
   PUBMED   30420384
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4353)
  AUTHORS   Liu,J., Tian,Y., Ding,Y., Heng,D., Xu,K., Liu,W. and Zhang,C.
  TITLE     Role of CYP51 in the Regulation of T3 and FSH-Induced
            Steroidogenesis in Female Mice
  JOURNAL   Endocrinology 158 (11), 3974-3987 (2017)
   PUBMED   28938463
  REMARK    GeneRIF: CYP51 is a mediator of T3 and FSH-induced follicular
            development.
REFERENCE   5  (bases 1 to 4353)
  AUTHORS   Araldi,E., Fernandez-Fuertes,M., Canfran-Duque,A., Tang,W.,
            Cline,G.W., Madrigal-Matute,J., Pober,J.S., Lasuncion,M.A., Wu,D.,
            Fernandez-Hernando,C. and Suarez,Y.
  TITLE     Lanosterol Modulates TLR4-Mediated Innate Immune Responses in
            Macrophages
  JOURNAL   Cell Rep 19 (13), 2743-2755 (2017)
   PUBMED   28658622
REFERENCE   6  (bases 1 to 4353)
  AUTHORS   Rozman,D., Fink,M., Fimia,G.M., Sassone-Corsi,P. and Waterman,M.R.
  TITLE     Cyclic adenosine 3',5'-monophosphate(cAMP)/cAMP-responsive element
            modulator (CREM)-dependent regulation of cholesterogenic lanosterol
            14alpha-demethylase (CYP51) in spermatids
  JOURNAL   Mol Endocrinol 13 (11), 1951-1962 (1999)
   PUBMED   10551787
REFERENCE   7  (bases 1 to 4353)
  AUTHORS   Stromstedt,M., Keeney,D.S., Waterman,M.R., Paria,B.C., Conley,A.J.
            and Dey,S.K.
  TITLE     Preimplantation mouse blastocysts fail to express CYP genes
            required for estrogen biosynthesis
  JOURNAL   Mol Reprod Dev 43 (4), 428-436 (1996)
   PUBMED   9052933
REFERENCE   8  (bases 1 to 4353)
  AUTHORS   Lai,M.H. and Kirsch,D.R.
  TITLE     Nucleotide sequence of cytochrome P450 L1A1 (lanosterol 14
            alpha-demethylase) from Candida albicans
  JOURNAL   Nucleic Acids Res 17 (2), 804 (1989)
   PUBMED   2644625
REFERENCE   9  (bases 1 to 4353)
  AUTHORS   Chen,C., Turi,T.G., Sanglard,D. and Loper,J.C.
  TITLE     Isolation of the Candida tropicalis gene for P450 lanosterol
            demethylase and its expression in Saccharomyces cerevisiae
  JOURNAL   Biochem Biophys Res Commun 146 (3), 1311-1317 (1987)
   PUBMED   3304292
REFERENCE   10 (bases 1 to 4353)
  AUTHORS   Kalb,V.F., Loper,J.C., Dey,C.R., Woods,C.W. and Sutter,T.R.
  TITLE     Isolation of a cytochrome P-450 structural gene from Saccharomyces
            cerevisiae
  JOURNAL   Gene 45 (3), 237-245 (1986)
   PUBMED   3542713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB524876.1, AK028815.1, AC068609.3 and AC064793.3.
            
            On Jul 22, 2005 this sequence version replaced NM_020010.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028815.1, AK031059.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-697               CB524876.1         1-697
            698-3882            AK028815.1         455-3639
            3883-4069           AC068609.3         170221-170407
            4070-4353           AC064793.3         1-284
FEATURES             Location/Qualifiers
     source          1..4353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.3 cM"
     gene            1..4353
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /note="cytochrome P450, family 51"
                     /db_xref="GeneID:13121"
                     /db_xref="MGI:MGI:106040"
     exon            1..564
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..1902
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /EC_number="1.14.14.154"
                     /note="cytochrome P450, 51; cytochrome P450 51A1;
                     cytochrome P450LI; cytochrome P45014DM; cytochrome
                     P450-14DM; sterol 14-alpha demethylase"
                     /codon_start=1
                     /product="lanosterol 14-alpha demethylase"
                     /protein_id="NP_064394.2"
                     /db_xref="CCDS:CCDS19071.1"
                     /db_xref="GeneID:13121"
                     /db_xref="MGI:MGI:106040"
                     /translation="MVLLGLLQSGGWVLGQAMEQVTGGNLLSTLLIACAFTLSLVYLF
                     RLAVGHMVQLPAGAKSPPHIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVG
                     KTFTYLLGSDAAALLFNSKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAIFLEQKKIIK
                     SGLNIAHFKQYVPIIEKEAKEYFQSWGESGERNVFEALSELIILTASHCLHGKEIRSQ
                     LNEKVAQLYADLDGGFTHAAWLLPAWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKE
                     PAEDILQTLLDSTYKDGRPLTDEEISGMLIGLLLAGQHTSSTTSAWMGFFLAKDKPLQ
                     EKCYLEQKAVCGEDLPPLTYDQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAG
                     YTIPPGHQVCVSPTVNQRLKDSWAERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCV
                     GENFAYVQIKTIWSTMLRLYEFDLINGYFPTVNYTTMIHTPENPVIRYKRRSK"
     exon            565..663
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     exon            664..840
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     exon            841..967
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1142
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1262
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1458
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1554
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1723
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..4353
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /note="hexamer: AATAAA"
     polyA_site      2489
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /note="major polyA site"
     regulatory      2891..2896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /note="hexamer: AATAAA"
     polyA_site      2913
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /note="major polyA site"
     regulatory      3856..3861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
                     /note="hexamer: ATTAAA"
     polyA_site      3888
                     /gene="Cyp51"
                     /gene_synonym="Cyp51a1; CYPLI; Ldm; P450-14DM; P450LI"
ORIGIN      
        1 gctcgtccgt gcccgctgcc ggggccgtgc tcgttaagca cgcgggacct cgtggtctgc
       61 ggttctcggg gcgcgatcat ttgtgcagcc atcactttct tcaccgagtc caagtgccac
      121 ggtagagcct gcttcctcag gtcccctcgg tggcgcaaga atccccgcac ctagacggag
      181 gcgtggccac cagaagcccc gccccgtctg tgacgtcctg gtggcgcgcg agctgtctgt
      241 gggcgtgtga agggcccggg ccagactaag ccatcaggcc ggggccgcct cccgacttct
      301 atctgccggc ttctcctgct ccatcttttc cgagaagcgg tgtgcgacct cggcccccag
      361 cctaccgggc ggatcgaagc gacggtcggg atggtacttc tgggcttgct gcagtcaggc
      421 ggctgggtgc tcggacaggc gatggagcag gtgacaggag gcaacttgct ttccacgctg
      481 ctcatcgcct gcgccttcac tctcagcctc gtctacctgt tccgtctcgc cgtgggccac
      541 atggtccagc tgcccgctgg agcgaaaagt ccaccacata tttactctcc aattccattc
      601 cttggccatg caatagcatt tgggaaaagt ccaattgagt ttctggaaaa tgcatatgag
      661 aagtatggac ctgtgtttag ctttaccatg gtgggcaaga ccttcactta ccttctgggg
      721 agtgatgcag ctgcgctgct cttcaatagt aaaaacgaag acctgaatgc agaagaagtc
      781 tacggtcggc tgacaacacc tgtgtttggg aagggagttg catatgatgt gccaaatgca
      841 attttcttgg aacagaagaa aatcataaaa agtggcctta acatagccca ctttaagcag
      901 tatgttccta tcattgaaaa agaagcaaag gaatactttc aaagttgggg agaaagcgga
      961 gaaagaaatg tgtttgaagc actgtctgag ctcataattt tgacagctag ccattgttta
     1021 catggaaagg aaattagaag tcaactcaac gagaaggtgg ctcagctgta cgcagacctg
     1081 gatggaggtt ttacccacgc tgcctggcta ttgccagctt ggctgcctct gccaagtttc
     1141 aggcgcaggg atagagccca tcgagagatc aagaatattt tctataaggc catccagaag
     1201 cgcaggctgt caaaagaacc agctgaggac attcttcaaa ctttactaga ttctacatac
     1261 aaggacgggc gtcctctaac agatgaggag atatcaggga tgctcatcgg actgctgctg
     1321 gctggacagc acacatcctc caccaccagt gcctggatgg gcttctttct ggccaaagat
     1381 aaaccacttc aagaaaaatg ctacttagaa cagaaagcag tgtgtggcga ggatctgcct
     1441 cctttaactt acgaccagtt gaaggatctg aatttacttg atagatgcat aaaagaaaca
     1501 ctaagactga ggcctccaat aatgaccatg atgagaatgg ccaagacccc tcagacggtg
     1561 gcagggtaca ccattcctcc aggacatcag gtgtgtgtct ctcctactgt caatcaaaga
     1621 ctgaaagact cctgggcaga gcgcttggac tttaatcctg accgctactt acaggataac
     1681 ccagcatcag gagagaagtt tgcctatgtg ccatttggag ctgggcgtca tcgttgtgtt
     1741 ggagaaaatt ttgcctatgt tcaaattaag acaatttggt cgactatgct tcgtttatat
     1801 gaatttgacc tcatcaatgg atattttccc actgtgaatt atacaacaat gatccacacc
     1861 ccagaaaacc cagtaatccg ttacaaacga cgatcaaaat gagaagagga acaagaagcc
     1921 agtgtggaga gaggaccgca agccgcagct ggcaaagaat gaagcctctg agaagctctc
     1981 gtgctgtact gggttgaaga gtgtggttct gagagccagt ttatgatttt aatgttttat
     2041 taactcggtg atttttgtca gaccgaatgg catttgaaac agtttatagt agttttgata
     2101 ggatttcagg gaagccaagt ttatgttaga aatcatttgg gggggtgtgt cttggaatta
     2161 agaagatata gaatgcagca tccaggtaat taactccaca cattgccaca gggagatttg
     2221 gaactggtgt ttgaagtttc aaagccttgt caaatgctac aaaggtaatg gggtcgtgta
     2281 gttgggccac ttctgtgcgt aaagatatga aaggataaag gttaagttta ctgcgaagct
     2341 tgaggtggaa gtaaacgcta cttagatggt gtggtgtgtc ctttgaaatg ttaactggag
     2401 caccgctcct ggaagatggc agcgatcttg aaccttgcct tgataacctt aattcctaaa
     2461 agtaataaaa tctaaagagt gcttatgtat gttactggtc ccaaatggtc acagttttgt
     2521 gaaaaatcca aaatcaaatc cttgtaagac ttttttattt taatttggct taaggttttt
     2581 tgttgttgtt gggaagttta aatttaccag gcttttaaaa gtgtctgatt ttgagattag
     2641 tgagttctgg ccttgagact ggggaatggg agatggtatc attgcccgta ttctgtgctc
     2701 aggagacaac ctaacagatt gtaaccacgg acccaactct gtgacatgcc cttaatctgt
     2761 gttaggagta agaatagctc tgttgctgga gtggtgctgc acacctgtaa tgctgttatt
     2821 caggacctgc ggcaggattg agaatttgag gccaacctag gctacggagc aagactaaca
     2881 cactccccaa aataaaacct cttttctcta aaagtatgtg tactggctgg tcttaggcac
     2941 ttgacacaag ctagggtcat cagagagaaa aggaagcctc agttgaggaa atgcctccat
     3001 gagatccagc tgtaaggcat tttcttaata agtgatcaat gggagaggct ccagcccact
     3061 gtggtggttc catccctacg ctagtgatcc tatgaaaggc tgaccgtgac atgaggagca
     3121 aaacagtaag cagcactcat ttatggcctc tgcatcagct cctgcctcca ggttcctgac
     3181 ctgcttgagt tcctgtcctc acttgatgat aaacagtgat atggaagtgt aagccaaata
     3241 acccaccttc accctcggga tttgcttttt ggtcatggtg tttccttgta gcaagaggaa
     3301 ctgaaactcc gttacagttt taagaggctt ttgaagactc ccagtgaagg cctaaatctc
     3361 tgctgttaaa ggctccacat taaaattctc tgagaaagtt ttactggttt gtattcatga
     3421 atttgaactt gtgcttcagt aagtacagtt catgaaatct gggcatatgg aagcttacat
     3481 cctatttgcc tgaaataggt tccttttagt attatctttg gttatttagg taagtcactc
     3541 ttgttatcaa tgccccatga gaaatcaggt attttcataa caagttacaa aagttgctca
     3601 cctctcaaaa gtgtgcttgt ctcttactga gtggttgtta gacttttagg tcatagatgt
     3661 tacatttgac gtgttaggtt aaaaccttga ttaaagtttg aagactgttt gtttctaagt
     3721 aacagatttt ctttgccagt gtagatgttt tgtgtttatt attcctagag gggttctaga
     3781 ctttgatcaa gtccctcctt ttactgtgtg gttgttaaga cttttaagtc atagacgtgt
     3841 taggttaaaa ccttgattaa agtttgatga ttgtttctaa gtaacagatt ttctttgcca
     3901 atgtagatgt tttgtcttta ttattcctag aggggttcta gactttgatc agattggtag
     3961 attcctggca gagttgtgac ttgagtaagg ctgtcctgtt tactgtctag ttttagactt
     4021 tgacatattt tcagtgctga gatttaaaag ggctcaagca ctagaattcc agattgagat
     4081 actgaccaca gacgagctat taagttattg tgaacaacac agcagaggct gagggccata
     4141 gggtgttagt agggtagact agcagtaggg tagattggct ggcaagcacc tgtccatctg
     4201 ccttttcccg actgaactgt cttgacttgg caactgtatt agttttttaa agagtttaat
     4261 gcacaacttt cctgctcaac tagttgcttt agaatagttt tgatattttt agaaagccta
     4321 gttgaaattt gggaaataaa attagaaatt ccc
//
