LOCUS       NM_001003947            3987 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily x, polypeptide 1
            (Cyp4x1), mRNA.
ACCESSION   NM_001003947 NR_002138 XM_112218 XM_144006 XM_289695
VERSION     NM_001003947.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3987)
  AUTHORS   Kharkwal,H., Batool,F., Koentgen,F., Bell,D.R., Kendall,D.A.,
            Ebling,F.J.P. and Duce,I.R.
  TITLE     Generation and phenotypic characterisation of a cytochrome P450 4x1
            knockout mouse
  JOURNAL   PLoS One 12 (12), e0187959 (2017)
   PUBMED   29227996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3987)
  AUTHORS   Al-Anizy,M., Horley,N.J., Kuo,C.W., Gillett,L.C., Laughton,C.A.,
            Kendall,D., Barrett,D.A., Parker,T. and Bell,D.R.
  TITLE     Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain
  JOURNAL   FEBS J 273 (5), 936-947 (2006)
   PUBMED   16478468
  REMARK    GeneRIF: Cyp4x RNA was expressed principally in brain, and at much
            lower levels in liver
REFERENCE   3  (bases 1 to 3987)
  AUTHORS   Choudhary,D., Jansson,I., Stoilov,I., Sarfarazi,M. and
            Schenkman,J.B.
  TITLE     Expression patterns of mouse and human CYP orthologs (families 1-4)
            during development and in different adult tissues
  JOURNAL   Arch Biochem Biophys 436 (1), 50-61 (2005)
   PUBMED   15752708
REFERENCE   4  (bases 1 to 3987)
  AUTHORS   Bylund,J., Zhang,C. and Harder,D.R.
  TITLE     Identification of a novel cytochrome P450, CYP4X1, with unique
            localization specific to the brain
  JOURNAL   Biochem Biophys Res Commun 296 (3), 677-684 (2002)
   PUBMED   12176035
REFERENCE   5  (bases 1 to 3987)
  AUTHORS   Gottgens,B., Gilbert,J.G., Barton,L.M., Grafham,D., Rogers,J.,
            Bentley,D.R. and Green,A.R.
  TITLE     Long-range comparison of human and mouse SCL loci: localized
            regions of sensitivity to restriction endonucleases correspond
            precisely with peaks of conserved noncoding sequences
  JOURNAL   Genome Res 11 (1), 87-97 (2001)
   PUBMED   11156618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645473.12.
            
            On Sep 8, 2022 this sequence version replaced NM_001003947.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038526.1, AJ786769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AL645473.12        43680-43958         c
            280-421             AL645473.12        37320-37461         c
            422-466             AL645473.12        36440-36484         c
            467-594             AL645473.12        34220-34347         c
            595-722             AL645473.12        31736-31863         c
            723-877             AL645473.12        31504-31658         c
            878-978             AL645473.12        30038-30138         c
            979-1169            AL645473.12        29318-29508         c
            1170-1303           AL645473.12        22685-22818         c
            1304-1368           AL645473.12        21497-21561         c
            1369-1451           AL645473.12        19908-19990         c
            1452-3987           AL645473.12        16200-18735         c
FEATURES             Location/Qualifiers
     source          1..3987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 52.76 cM"
     gene            1..3987
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /note="cytochrome P450, family 4, subfamily x, polypeptide
                     1"
                     /db_xref="GeneID:81906"
                     /db_xref="MGI:MGI:1932403"
     exon            1..279
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1626
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /EC_number="1.14.14.1"
                     /codon_start=1
                     /product="cytochrome P450 4X1"
                     /protein_id="NP_001003947.1"
                     /db_xref="CCDS:CCDS18488.1"
                     /db_xref="GeneID:81906"
                     /db_xref="MGI:MGI:1932403"
                     /translation="MEASWLETRWARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLS
                     PFPGPPAHWLLGHQKFLQEDNMETLDEIVKKHPCAFPCWVGPFQAFFYIYDPDYAKIF
                     LSRTDPKMQYLHQLLTPCIGRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSV
                     KVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQINGTYESYVKATFE
                     LGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYTEKIIQDRKKILKNQVKQD
                     DTQTSQIFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHDASAASISWLLYCLALNP
                     EHQDRCRTEIRSILGDGSSITWEQLDEMSYTTMCIKETLRLIPPVPSISRELSKPLTL
                     PDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQRHPCAFLPFSSGPR
                     NCIGQQFAMLELKVAIALILLHFQVAPDLTRPPAFSSHTVLRPKHGIYLHLKKLLEC"
     exon            280..421
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            422..466
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            467..594
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            595..722
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            723..877
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            878..978
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1169
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1303
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1368
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1451
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..3987
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3961..3966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /note="hexamer: ATTAAA"
     polyA_site      3987
                     /gene="Cyp4x1"
                     /gene_synonym="A230025G20; Cyp4a28-ps; CYPIVX1; CYP_a"
                     /note="major polyA site"
ORIGIN      
        1 gtggttcacg ccagctccgg gctggagaaa gctaagagct tcccaccacc actaccatat
       61 cctccaccca cccactgccc gccgaaaagc gagctcagag tgatggaggc ctcctggctg
      121 gagactcgtt gggcgcggcc cttgcacctg gctttggtgt tctgcctggc gctggtgctg
      181 atgcaggcca tgaagctcta cctgcggaga cagcgactgc tgcgcgacct gagccccttc
      241 ccggggcctc ccgcccactg gctcctggga caccagaagt ttcttcagga ggataatatg
      301 gagacgcttg atgagattgt caaaaagcac ccttgtgcct tcccctgctg ggtagggccc
      361 ttccaggcat ttttctacat ctatgaccca gactatgcga agatatttct gagcagaaca
      421 gacccaaaga tgcagtatct gcaccagctc ctgactccat gcattggacg aggactcctg
      481 aatttagatg ggcccaggtg gttccaacac cgctgcctcc taactcctgc attccatcag
      541 gacatcctaa aaccatgtgt ggacacgatg gcccactctg tgaaagtgat gctggataaa
      601 tgggagaaga tgtggaccac tcaggaaaca accatcgagg tttttgaaca catcaacttg
      661 atgaccctgg acataataat gaaatgtgct tttggccagg agaccaactg ccagataaac
      721 ggcacctatg agtcttacgt gaaggcaaca tttgaacttg gtgaaatcat atcttctcgc
      781 ttgtacaatt tctggcatca tcatgacata attttcaaac tcagtcctaa gggccactgc
      841 ttccaggagt taggcaaagt gatacatcaa tacacagaaa agataatcca ggacagaaag
      901 aaaatcctca agaatcaagt aaagcaggat gacactcaga cgtctcaaat ttttctggat
      961 attgttcttt ctgcacaggc tgaagatgaa cgagccttct cagatgctga ccttcgggct
     1021 gaggtgaaca ccttcatgtg ggcaggacat gatgcctctg cagctagcat ctcctggctc
     1081 ctttactgcc tggctctaaa tcccgagcat caggacagat gccggacaga gatcaggagc
     1141 atcctgggag atgggtcttc catcacctgg gaacagctgg atgagatgtc atacaccaca
     1201 atgtgcatca aggagacact ccgcttgatt cctcctgtcc catccatctc cagggagctc
     1261 agcaaacccc ttaccctccc agatggacac tcactgcctg caggtatgac tgtggttctt
     1321 agtatttggg gtctccacca caaccctgct gtctggaacg acccaaaggt ctttgacccc
     1381 ttgagattca ctaaggagaa ttctgatcag agacacccct gtgccttcct accattctcc
     1441 agtggtccaa ggaactgcat cgggcagcag tttgccatgc tggagctaaa ggtggccatt
     1501 gccttgattc tgctccactt tcaagtagct ccagacctca ccaggcctcc tgccttctcc
     1561 agccacactg tcctcagacc caagcatgga atctatttgc acctgaagaa actccttgag
     1621 tgttagatac taggagaaat ggcgaaattt atgtttgttg ttaagttaaa tttacagccc
     1681 atggtccagg caagtggaaa agaatctaag attgatagaa gccttggagg actgtgggtt
     1741 ggagcatttc tacagctgca cattacccaa agttattttc aggtaacaca tgtgaccctg
     1801 ataagtataa cttggagaga ttgtcaaatt attttctaat ggttattacc aatcttatct
     1861 gaagtgggaa tttctgagtt cactggagac tcagttgtgc catgtgatgt tcttctggaa
     1921 gctgtcttat gagaggatgt tttgctgaag aagacacatg agaggttgtt ttgctgaagc
     1981 agacacatga gaggatgttt tgctgaagaa gacacatgag aggttgtttt gctgaagaag
     2041 acacatgaga ggatgttttg ctgaagaaga cacatgagag gttgttttgc tgaagaagac
     2101 acataagagg ttgttttgct gaagaagaca catgggagga tgttttgctg aagcagacac
     2161 atggtgttct tctggaagct gcctggtgaa agggcatggg gtgtttcgct gaaagtgatg
     2221 cttaagagga tacatgatgt ttgaaaagag tgtacgtata acccaacaga cagtgagcaa
     2281 ctctggcatt ggttcacctt gctttcctca ctgatcttta tttgtcagga ctccgtagag
     2341 agaaactcag ccaagagctt caagaggtgt tccagctgct tcttgctgct tcaggggact
     2401 ccattcagtt tcttctggat caagctgctg cttgttcatg tttggtgttt tgctagtgga
     2461 ctggtatgct aacgattaag attggaatca cctcaaagaa ctacttcttt ttttatgatt
     2521 ttttttgtta ggtattttcc tcatttacat ttccaatgct ataccaaaag tcccccatac
     2581 cctaccaccc actcccactt tttggccctg gcgttcccct gtactggggc atataaaatt
     2641 tgcaagtcca atgggcctct ctttccagtg atggccaact aagccatctt ctgatacata
     2701 tgcagctaga gtcaagagct caggggtact ggttagttca tgatgttgtt ctacctatag
     2761 ggttgcagat ccctttagct ccttgggtat tttctctagc ttctccatcg ggggccctgt
     2821 gatccatcca atagctgact gtgagcatcc acttctgtgt ttgctaggcc ccagcatagt
     2881 ctcacaagag acagctatat cagggtcctt tcagcaaaat cttgctactg tgtgcaatgg
     2941 tgtcagcgtt tggaagctga ttatgggatg gatccccaga tatggcagtc tctagatggt
     3001 ccatcctttc gtcacagctc caaacattgt ctctgtaact cctttccatg ggtgttttgt
     3061 tcccaattct aagaagggga aaagtgtcca cactttggtc ttcgttcttc ttgagtttca
     3121 tgcctttagc aaattgtatc ttatatcttg agtatcctaa gtttctgggc taatatccac
     3181 ttatcagtga gtacatattt tgtgagttcc tttgtggtgg ggttacctca ctcaggatga
     3241 tgccctccag gtccatccaa ctaggtccat gtcctccttg tcctattaac catcttcctt
     3301 ccccaccttt ggtctgtggg gtataaagga ggttgaagca ttaagaatct ttattagggg
     3361 ctggtgagat ggctcagtgg gtaagagcac ccgactgctc ttccgaaggt ccagagttca
     3421 aatcccagca accacatggt ggctcacaac cacccgaaat gagatctgat gccctcttct
     3481 ggtgtgtctg acgacagcta cagtgtactt gcatataata aataaataaa tctttaaaaa
     3541 aaaaaaaaga aagaaaggct acactcgggg ctacactggg atcttgaaca cctatggttg
     3601 tcaatgactg gttaataaag actttctgtt ggcttaaaaa aaaaacaaaa aaaaagaatc
     3661 tttattaaag taggcttaat gaaaaatcta agcctacacc tagtgatgat tttctgtttg
     3721 ttttttattg tttttggaat tatacaaata acaggatttg tattggatga aaaacatttc
     3781 cagcaatagg aggtgttcat aaaatcccac ctcaccaggg ctactgccct gacagagtct
     3841 actgctttct ctaaaaacag aattgtatgc attcttcctg actctttcct gcataaataa
     3901 tgtgtgtgtg cactcttaga catgtgatca tatttgtatt cttcttgttt ttctcacata
     3961 attaaaaaat tgccctaatc cacctta
//
