LOCUS       NM_133969               2898 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily v, polypeptide 3
            (Cyp4v3), mRNA.
ACCESSION   NM_133969
VERSION     NM_133969.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2898)
  AUTHORS   Shen,C., Yang,Q., Chen,K., Ma,H., Wang,X., Tong,J., Shen,Y. and
            Cui,H.
  TITLE     Uncovering the role of ferroptosis in Bietti crystalline dystrophy
            and potential therapeutic strategies
  JOURNAL   Cell Commun Signal 22 (1), 359 (2024)
   PUBMED   38992691
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2898)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2898)
  AUTHORS   Jones,M.R., Lingampally,A., Ahmadvand,N., Chong,L., Wu,J.,
            Wilhem,J., Vazquez-Armendariz,A.I., Ansari,M., Herold,S.,
            Ornitz,D.M., Schiller,H.B., Chao,C.M., Zhang,J.S., Carraro,G. and
            Bellusci,S.
  TITLE     FGFR2b signalling restricts lineage-flexible alveolar progenitors
            during mouse lung development and converges in mature alveolar type
            2 cells
  JOURNAL   Cell Mol Life Sci 79 (12), 609 (2022)
   PUBMED   36445537
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2898)
  AUTHORS   Wang,Y., Liu,Y., Liu,S., Li,X., Liu,X., Jiao,M., Yang,Y., Luo,X.,
            Wang,F., Wan,X. and Sun,X.
  TITLE     A novel and efficient murine model of Bietti crystalline dystrophy
  JOURNAL   Dis Model Mech 15 (3) (2022)
   PUBMED   35230417
REFERENCE   5  (bases 1 to 2898)
  AUTHORS   Lockhart,C.M., Nakano,M., Rettie,A.E. and Kelly,E.J.
  TITLE     Generation and characterization of a murine model of Bietti
            crystalline dystrophy
  JOURNAL   Invest Ophthalmol Vis Sci 55 (9), 5572-5581 (2014)
   PUBMED   25118264
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2898)
  AUTHORS   Safdar,H., Cleuren,A.C., Cheung,K.L., Gonzalez,F.J., Vos,H.L.,
            Inoue,Y., Reitsma,P.H. and van Vlijmen,B.J.
  TITLE     Regulation of the F11, Klkb1, Cyp4v3 gene cluster in livers of
            metabolically challenged mice
  JOURNAL   PLoS One 8 (9), e74637 (2013)
   PUBMED   24066149
  REMARK    GeneRIF: Data conclude that within the mouse F11, Klkb1, Cyp4v3
            gene cluster, F11 and Cyp4v3 frequently display striking parallel
            transcriptional responses suggesting the presence of shared
            regulatory elements.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120003.6.
            
            On Jun 15, 2018 this sequence version replaced NM_133969.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004724.1, AK150653.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               AC120003.6         143913-144311       c
            400-512             AC120003.6         139261-139373       c
            513-598             AC120003.6         132851-132936       c
            599-789             AC120003.6         131675-131865       c
            790-859             AC120003.6         131239-131308       c
            860-986             AC120003.6         128815-128941       c
            987-1172            AC120003.6         126683-126868       c
            1173-1275           AC120003.6         121331-121433       c
            1276-1410           AC120003.6         119805-119939       c
            1411-1590           AC120003.6         119528-119707       c
            1591-2898           AC120003.6         116949-118256       c
FEATURES             Location/Qualifiers
     source          1..2898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 25.17 cM"
     gene            1..2898
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /note="cytochrome P450, family 4, subfamily v, polypeptide
                     3"
                     /db_xref="GeneID:102294"
                     /db_xref="MGI:MGI:2142763"
     exon            1..399
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1763
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /EC_number="1.14.14.79"
                     /EC_number="1.14.14.80"
                     /note="cytochrome P450 4V3; docosahexaenoic acid
                     omega-hydroxylase CYP4V2; long-chain fatty acid
                     omega-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 4V2"
                     /protein_id="NP_598730.1"
                     /db_xref="CCDS:CCDS22276.1"
                     /db_xref="GeneID:102294"
                     /db_xref="MGI:MGI:2142763"
                     /translation="MLWLWLGLSGQKLLLWGAASAVSLAGATILISIFPMLVSYARKW
                     QQMRSIPSVARAYPLVGHALYMKPNNAEFFQQLIYYTEEFRHLPIIKLWIGPVPLVAL
                     YKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFHFTILE
                     NFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICETAMGKNIGAQSNNDSE
                     YVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFTNNVIAERVKER
                     KAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTT
                     AAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKKLKYLDCVIKETLRVF
                     PSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQ
                     GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILR
                     PNNGIWIKLKRRHEDDP"
     exon            400..512
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..598
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..789
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..859
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..986
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1172
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1275
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1410
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1590
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2898
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1864
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /note="hexamer: AATAAA"
     polyA_site      2898
                     /gene="Cyp4v3"
                     /gene_synonym="Cyp4v2"
                     /note="major polyA site"
ORIGIN      
        1 acagattttc ccagctccag agctggaaga tctgagagga cctggtgtgc cccgggggtt
       61 ctttttcctg agccctgagc cgggagcttg gagttcccga atttgtccct ccctcctctg
      121 cacccggcag cgactggtcg ccaccttctc actggcaatc cagagggaag aggggaatca
      181 gagagatgtt gtggctgtgg ttagggctca gtgggcagaa actattgctt tggggcgcag
      241 cgagcgcggt ctccctggcc ggcgccacta tcctgatcag catctttccg atgctggtaa
      301 gctacgcgcg gaaatggcag cagatgcggt caatcccgtc ggtggcccgc gcctacccct
      361 tggtgggaca cgcgctttat atgaagccca acaacgcaga attttttcag cagctaattt
      421 attacacaga agaatttcga cacctgccga tcattaaact ttggattgga cccgtgcccc
      481 tggtggcact ttataaggca gagaatgtgg aggtgatttt gaccagttct aagcaaattg
      541 ataaatcgtt tttgtacaag ttcctacagc catggctggg actaggactt cttacaagta
      601 cggggagcaa atggcgcacc aggaggaaga tgctaacgcc cactttccat tttaccattc
      661 tggagaactt cttggatgtc atgaatgagc aagcaaatat attggttaat aagcttgaaa
      721 aacacgtcaa ccaagaagcc tttaattgtt ttttttacat cactctttgt gctctggata
      781 taatctgtga aacggctatg gggaagaaca tcggagctca aagcaataat gattccgagt
      841 atgtccgtac agtgtatagg atgagtgata tgatatatag aagaatgaag atgccctggc
      901 tttggtttga cctttggtac cttgtgttta aagaaggacg ggaccacaaa aggggactca
      961 aatgcctaca tactttcacc aacaatgtca ttgctgaacg agtcaaagaa aggaaggcag
     1021 aggaagactg gacgggtgct ggcaggggtc ctatcccctc caaaaataag cgcaaggctt
     1081 tccttgactt gcttttgagt gtgactgatg aggaaggaaa cagattaagc caggaagaca
     1141 tccgagagga agttgacacc ttcatgtttg agggtcacga tacaactgct gctgcaatca
     1201 actggtcctt atacctattg ggcacgaatc cagaagtcca gaggaaagtg gatcaggagc
     1261 tggatgaagt gtttggaaga tcccatcgtc ctgtcacctt ggaagacctg aagaaactta
     1321 aatatttgga ttgcgtcatt aaggagactc tccgagtttt cccatctgtc cctttatttg
     1381 cccggagtct tagcgaggac tgtgaagtgg gcggttacaa agtcacaaaa ggaacggaag
     1441 caatcatcat tccctacgca ctacaccgag accccagata cttcccagat ccagaggaat
     1501 tccgaccaga gcggttcttt cctgaaaatt cccaaggacg ccatccctat gcctatgtgc
     1561 cattttctgc tggacctcga aactgtattg gtcaaaagtt tgctgtcatg gaggagaaga
     1621 ccattcttgc ctgtatcctg aggcagtttt gggtagaatc caaccagaag agagaagaac
     1681 tcggcctggc tggagatttg attcttaggc caaataatgg catctggatc aagctgaaga
     1741 ggagacatga agatgacccc taactccatc ctcaagctgt gactttatta atgaagatca
     1801 ttccatagga aacatggtat ctgtaaattt ttagattatg aattgaaaac tatgaatctt
     1861 caaacctagt gtttttcctt tcttgtcccc cccactcctg caccccagat cttgggacac
     1921 agtctatcac tgagaatttt ggtgtgtttc ttaccaacat gggtgccaca tcacacttgg
     1981 tctctctctc gagggcacag ttagctagct ggagcagcac tgacataaac atgcaggaaa
     2041 aattataaca gagggaccat cggcctgccc aaagatcatc atttaaatga aatctcagaa
     2101 ttaagaaaat gttctcattg acttggaaat tcatatatca tttgaaaatg ttgggtcact
     2161 aagccctcag gataatgggc ttaagttttt atgatgtcat cagagatatc agttatgatg
     2221 ggagtagttg ttaaaacact ttcagatttt ataatgaaaa gcaggcccct tgcatgcccc
     2281 tgtcaaggta cagtcacctc gtggactgtg tgctagaatc ttctttctgt tctcagtcga
     2341 cacaataacg ttagacatct tattactgga agatatccct ctccagcaca tctaacctct
     2401 cacagaagct tagttagtgg cttttgaagt tcaagtggcc acagaaactt cctggttatg
     2461 tgccattcta ttaagaatag gggtatggag tagaggagac atcaaatttc tgccatggct
     2521 aaaagtagct aaaatgtcta cactgaggcc tctccacttc cattctgatt tactctctcc
     2581 cacaatatat tttggtgttg tggaagtcaa gaccgtgatt ggatgagtta gaactcagga
     2641 tttatgtcct tgatgtggcc atgtctttct tgtaattcct ctacttttag tagaaagaat
     2701 ctttccttct atatttagtt acactgtatg atcgcacttg gttcagcccg agacatctaa
     2761 ttaacccagc cccatggagt attctcccca agctgtcaac tgaattccat tccttgcatt
     2821 ttaatttggc acacaaggct actattcctc acacaatgac ttttagaaac ttctcttaat
     2881 aaatcatttt taacagca
//
