LOCUS       NM_024444               1702 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily f, polypeptide 18
            (Cyp4f18), mRNA.
ACCESSION   NM_024444 XM_904310
VERSION     NM_024444.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1702)
  AUTHORS   Yoshida,M., Ishihara,T., Isobe,Y. and Arita,M.
  TITLE     Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation
            pathway and results in psoriasis-like dermatitis
  JOURNAL   FASEB J 36 (12), e22648 (2022)
   PUBMED   36374250
  REMARK    GeneRIF: Genetic deletion of Cyp4f18 disrupts the omega-3
            epoxidation pathway and results in psoriasis-like dermatitis.
REFERENCE   3  (bases 1 to 1702)
  AUTHORS   Wu,J., Lai,G., Chen,F., Zhang,B. and Zhao,Y.
  TITLE     Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and
            High-Fat Diet in CYP4F2 Transgenic Mice
  JOURNAL   Kidney Blood Press Res 46 (5), 601-612 (2021)
   PUBMED   34320496
  REMARK    GeneRIF: Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE
            and High-Fat Diet in CYP4F2 Transgenic Mice.
REFERENCE   4  (bases 1 to 1702)
  AUTHORS   Vaivoda,R., Vaine,C., Boerstler,C., Galloway,K. and Christmas,P.
  TITLE     CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to
            Complement Component C5a
  JOURNAL   J Immunol Res 2015, 250456 (2015)
   PUBMED   26613087
  REMARK    GeneRIF: CYP4F18-deficient neutrophils exhibit increased chemotaxis
            to complement component C5a.
REFERENCE   5  (bases 1 to 1702)
  AUTHORS   Winslow,V., Vaivoda,R., Vasilyev,A., Dombkowski,D., Douaidy,K.,
            Stark,C., Drake,J., Guilliams,E., Choudhary,D., Preffer,F.,
            Stoilov,I. and Christmas,P.
  TITLE     Altered leukotriene B4 metabolism in CYP4F18-deficient mice does
            not impact inflammation following renal ischemia
  JOURNAL   Biochim Biophys Acta 1841 (6), 868-879 (2014)
   PUBMED   24632148
  REMARK    GeneRIF: It is concluded that CYP4F18 is necessary for omega
            oxidation of leukotriene B4 in neutrophils, and is not compensated
            by other CYP enzymes
REFERENCE   6  (bases 1 to 1702)
  AUTHORS   Stoilov,I., Krueger,W., Mankowski,D., Guernsey,L., Kaur,A.,
            Glynn,J. and Thrall,R.S.
  TITLE     The cytochromes P450 (CYP) response to allergic inflammation of the
            lung
  JOURNAL   Arch Biochem Biophys 456 (1), 30-38 (2006)
   PUBMED   17081494
  REMARK    GeneRIF: The mRNA levels of Cyp4f18 increase with the development
            of allergic inflammation in the lung.
REFERENCE   7  (bases 1 to 1702)
  AUTHORS   Christmas,P., Tolentino,K., Primo,V., Berry,K.Z., Murphy,R.C.,
            Chen,M., Lee,D.M. and Soberman,R.J.
  TITLE     Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2
            hydroxylase in mouse polymorphonuclear leukocytes: identification
            as the functional orthologue of human polymorphonuclear leukocyte
            CYP4F3A in the down-regulation of responses to LTB4
  JOURNAL   J Biol Chem 281 (11), 7189-7196 (2006)
   PUBMED   16380383
  REMARK    GeneRIF: CYP4F18 is a critical protein in the regulation of LTB(4)
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007863.1, AC162522.6 and BB804325.1.
            
            On Jul 8, 2009 this sequence version replaced NM_024444.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007863.1, AF233647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               AK007863.1         3-475
            474-474             AC162522.6         86078-86078         c
            475-1627            AK007863.1         477-1629
            1628-1628           BB804325.1         328-328
            1629-1702           AK007863.1         1631-1704
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.67 cM"
     gene            1..1702
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /note="cytochrome P450, family 4, subfamily f, polypeptide
                     18"
                     /db_xref="GeneID:72054"
                     /db_xref="MGI:MGI:1919304"
     exon            1..48
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            49..247
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1624
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /EC_number="1.14.14.94"
                     /note="cytochrome P450, 4f18; cytochrome P450 CYP4F18;
                     leukotriene-B(4) omega-hydroxylase 2; cytochrome
                     P450-LTB-omega; leukotriene-B(4) 20-monooxygenase 2;
                     leukotriene-B(4) omega-1/omega-2 hydroxylase"
                     /codon_start=1
                     /product="cytochrome P450 4F3"
                     /protein_id="NP_077764.2"
                     /db_xref="CCDS:CCDS22406.1"
                     /db_xref="GeneID:72054"
                     /db_xref="MGI:MGI:1919304"
                     /translation="MSQLSMSWMGLGHTAASPWLLLLLAGASCLLAYILTPIYGVFEN
                     SLRLRCFPQPPKRNWILGHLGLIQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIF
                     HPAFIKPVVLAPALVAPKDTVFYRFLKPWLGDGLLMSTGDKWSRHRRMLTPAFHFNIL
                     KPYVKVFNDSTNIMHAKWQRLASKGSAYLNMFEHISLMTLDSLQKCVFSFDSNCQEKP
                     SEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTDAVIRERRR
                     TLLDQGGVDVLKAKAKAKTLDFIDVLLLSKDEHGKALSDEDIRAEADTFMFGGHDTTA
                     SGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLH
                     PPVTAISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVWPDPEVYDPFRFDADNV
                     KGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRA
                     EGGLWLKVEPLSAGAQ"
     exon            248..392
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..446
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            447..574
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..696
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            697..967
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1034
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1164
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1298
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1363
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1446
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1702
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /note="hexamer: AATAAA"
     polyA_site      1702
                     /gene="Cyp4f18"
                     /gene_synonym="1810054N16Rik; Cyp4f3; Cypf18; CYPIVF3"
                     /note="major polyA site"
ORIGIN      
        1 agagaagggg agagacagac ctgggaaaca cagtgctcct gagagaagga tgtcacagct
       61 gagcatgtcc tggatgggcc tgggccacac agcagcctct ccatggctgt tgctgttgct
      121 ggctggggcc tcctgccttc tggcttacat ccttacaccg atttatggtg tttttgagaa
      181 ctctcttcgc ctccgctgtt tcccacagcc tcccaaacga aactggatct tgggacacct
      241 aggcctgatc cagagctcag aggaaggact cctgtacatc cagagcctgg tgcgaacctt
      301 cagggatgca tgctgctggt gggtggggcc gttgcaccca gtcatccgta tattccaccc
      361 tgctttcatc aagcctgtgg tcttggctcc agctttagtt gcccccaagg acacagtctt
      421 ctaccgtttc ctgaagccgt ggctagggga tggcctcttg atgagtactg gtgacaagtg
      481 gagccgccac cgtcgcatgc tgacacctgc cttccatttc aacatcctga agccctatgt
      541 gaaggttttt aatgacagca ccaacatcat gcacgccaag tggcagcgcc tggcctccaa
      601 gggcagtgcc tatttgaaca tgtttgaaca catcagcctc atgaccctgg acagtctgca
      661 gaagtgtgtt ttcagctttg acagcaattg ccaggagaag cctagtgaat acatcactgc
      721 catcttagaa cttagtacct tagtggccag aaggcaccag aggctgcttc tgcacgtgga
      781 cctgttttat tacctcaccc atgatgggat gcgcttccgg aaggcctgcc gtctagtgca
      841 tgacttcact gatgctgtca tccgggagcg gcgccgcacc ctccttgatc agggtggtgt
      901 tgatgtcctc aaggccaagg ccaaggccaa gactttggac ttcattgacg tgctgctgct
      961 gagcaaggat gaacatggaa aggctctgtc tgatgaggac atccgagcgg aggctgacac
     1021 cttcatgttt ggaggccatg acaccacggc cagtggactt tcctggatcc tgtacaacct
     1081 ggcaagacac ccagaatacc aggagcgctg ccggcaggag gtgcgggagc tcctgaggga
     1141 ccgcgagcct gaggagattg aatgggacga cctggcccag ctgccattcc tcaccatgtg
     1201 cattaaggag agcctacggc tgcatcctcc cgtcactgca atctcccgat gctgcactca
     1261 ggacattgtg ctcccagatg gtcgggtcat ccctaaaggt gtcataagcc gaataagtat
     1321 tttcgggaca catcacaatc cagctgtgtg gccagacccg gaggtctatg accccttccg
     1381 ctttgatgcc gacaacgtca agggcaggtc acccctggct tttattccct tctcggctgg
     1441 gcccaggaac tgcataggac agactttcgc catgagcgag atgaaagtag ctctggcgct
     1501 gactctgctg cgcttccgcg ttctgccgga tgacaaggag ccccgcagga agccggagct
     1561 gatcctgcgc gcagaaggcg ggctgtggct gaaagtggag ccgctcagcg caggcgcgca
     1621 gtgatctctg agctggcgtg ggactctcct atccatccac ccacctgtgc ctttccagga
     1681 ataaaatttt cttgtcacct tg
//
