LOCUS       NM_024442               2258 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily f, polypeptide 16
            (Cyp4f16), transcript variant 1, mRNA.
ACCESSION   NM_024442
VERSION     NM_024442.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 2258)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2258)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB581939.1, AK078557.1 and BP758307.1.
            
            On Sep 28, 2017 this sequence version replaced NM_024442.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078557.1, AF233646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BB581939.1         2-13
            13-2233             AK078557.1         2-2222
            2234-2258           BP758307.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.59 cM"
     gene            1..2258
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /note="cytochrome P450, family 4, subfamily f, polypeptide
                     16"
                     /db_xref="GeneID:70101"
                     /db_xref="MGI:MGI:1917351"
     exon            1..99
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            100..298
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1675
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cytochrome P450, family 4, subfamily f,
                     polypeptide 16 isoform 1"
                     /protein_id="NP_077762.1"
                     /db_xref="CCDS:CCDS28619.1"
                     /db_xref="GeneID:70101"
                     /db_xref="MGI:MGI:1917351"
                     /translation="MLRLSVSGLDLGSVVTSSWHLLLLGVASWILARILAWTYSFYEN
                     CSRLSCFPQPPKKNWFSGHLGMIQSNEEGMQLVTEMGQTFQDVHLFWLGPVIPVLRIV
                     DPAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGLFLSSGDKWSRHRRLLTPAFHFDIL
                     KPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQESP
                     SEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIRERRH
                     TLSSQNHDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTA
                     SALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEWDDLAQLPFLTMCIKESLRLH
                     SPVIDLLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENP
                     QKRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPEIILRA
                     EGGLWLRVEPLSKGAQ"
     exon            299..443
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            444..497
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            498..625
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..747
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1018
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1085
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1215
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1349
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1414
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1497
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..2240
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2239
                     /gene="Cyp4f16"
                     /gene_synonym="2310021J05Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcctcccac acagcttcct gaagttagga agcaggggat aaatgctttt cacaggactg
       61 gggagaaggt cttagaggac cagcagctcc tgagataagg atgctgcggc taagtgtgtc
      121 tgggctggac ctgggctctg tggtgacctc gtcatggcat cttctgctgc ttggagtggc
      181 ttcctggatt ttggccagaa tccttgcctg gacttactca ttctatgaga actgctcccg
      241 cctcagttgt ttccctcagc ctcctaaaaa aaactggttt tcaggtcact tgggcatgat
      301 ccagagcaat gaggaaggca tgcagctggt taccgaaatg ggccagactt tccaagatgt
      361 ccatctcttt tggctgggac cagtgatccc tgtgctgagg attgttgacc ctgcatttgt
      421 tgcccccctg ctccaggccc cagctttggt ggccccaaag gacatgacat ttttacgctt
      481 cctgaagccc tggctggggg atgggctctt cctgagttca ggtgacaagt ggagccgcca
      541 tcgtcgactg ctgacacctg ccttccactt tgatatcctg aagccctatg tgaagatttt
      601 taaccagagt gtgaacatca tgcacgccaa gtggaagcac ctatcctcgg aaggcagtgc
      661 acgtctggaa atgtttgagc acatcagcct catgaccttg gacagtctgc agaaatgcct
      721 ctttggcttt gacagcaact gtcaggagtc tcccagtgaa tacatttctg ccatcttgga
      781 actcagttcc ctcataataa aaaggtcact tcagctcttc ttgttcgttg acttcctgta
      841 ttaccacact gctgatgggc ggcgcttccg caaggcctgt gacctggtgc acaacttcac
      901 agatgctgtc attagggaga gacggcacac tctctccagc caaaaccatg atgagttctt
      961 gaagtccaag actaagtcta agactctgga tttcattgat gttctcttgt tggccaagga
     1021 tgaacatgga aaggagctgt cagatgagga catccgggca gaggctgaca cctttatgtt
     1081 tggaggccat gacaccacag ccagtgcact ctcctggatc ctgtacaacc tggcgaggca
     1141 ccccgaatac caggagcgct gccggcagga ggttcaggag ctgctgaggg accgagagcc
     1201 tgaggagatt gaatgggacg acctggccca gctacccttc ctgaccatgt gcatcaagga
     1261 gagtctgcgg ctacattccc cagtcataga cctcctccgc cgctgcaccc gggacattgt
     1321 gctacctgat ggccgggtca tccctaaagg gaacatctgt gtcatcagca tctttggtat
     1381 tcatcacaat ccatcagtct ggccagaccc tgaggtctat gaccccttcc gctttgaccc
     1441 agaaaaccca cagaagaggt cccctctggc ttttattccc ttttctgccg ggcccaggaa
     1501 ctgcatagga cagactttcg ccatgagcga gatgaaggtg gcactggcgc tgactctgct
     1561 gcgcttccgc atcctgcctg atgacaagga gccgcgccgg aagccagaga taatcctgcg
     1621 ggcggagggc gggttgtggc tgcgggtgga gcctctgagc aagggcgctc agtgaccagg
     1681 tctactactg tctcagtcac tttcctttgc caatcccaga ataagcggag tttcacccag
     1741 agccatcaga gggcgctgca ggataacaga gactgtctgg aagcctggct gagaaaagtc
     1801 tggggctgct ttctgagtcc aagggccttt ctgggtagcc cacagggcct gcagactgat
     1861 gaagagttgc atgcacccca gctcaagaac ggcctttatt cttttagcga tagggaggca
     1921 ccatagatgt ttgagcagga gagttacaag gtttactggc atgtaacctc ccacaagtct
     1981 gaagcaggct gagccagacc ttgactttgc tgacactaag gagattacct agggtgtagc
     2041 cttcctccct agattactct agtgttcagc cattttccct gttcctcttc aagatactgc
     2101 tacggtgctg agaggcccca gagctattca ggagactatg cctgcagctg gctccaggct
     2161 ccaaattgaa ttggtgggaa tgggcttccc ctccttttta taagcgcatt ctccattaaa
     2221 catttgaacc ttgaacagac aaaaaaaaaa aaaaaaaa
//
