LOCUS       NM_007823               1917 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily b, polypeptide 1
            (Cyp4b1), mRNA.
ACCESSION   NM_007823
VERSION     NM_007823.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1917)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1917)
  AUTHORS   Parkinson,O.T., Liggitt,H.D., Rettie,A.E. and Kelly,E.J.
  TITLE     Generation and characterization of a Cyp4b1 null mouse and the role
            of CYP4B1 in the activation and toxicity of Ipomeanol
  JOURNAL   Toxicol Sci 134 (2), 243-250 (2013)
   PUBMED   23748241
REFERENCE   3  (bases 1 to 1917)
  AUTHORS   Ye,Z., Liu,Z., Henderson,A., Lee,K., Hostetter,J., Wannemuehler,M.
            and Hendrich,S.
  TITLE     Increased CYP4B1 mRNA is associated with the inhibition of dextran
            sulfate sodium-induced colitis by caffeic acid in mice
  JOURNAL   Exp Biol Med (Maywood) 234 (6), 605-616 (2009)
   PUBMED   19307459
  REMARK    GeneRIF: Increased CYP4B1 mRNA is associated with the inhibition of
            dextran sulfate sodium-induced colitis by caffeic acid in mice.
REFERENCE   4  (bases 1 to 1917)
  AUTHORS   Petri,A., Ahnfelt-Ronne,J., Frederiksen,K.S., Edwards,D.G.,
            Madsen,D., Serup,P., Fleckner,J. and Heller,R.S.
  TITLE     The effect of neurogenin3 deficiency on pancreatic gene expression
            in embryonic mice
  JOURNAL   J Mol Endocrinol 37 (2), 301-316 (2006)
   PUBMED   17032746
REFERENCE   5  (bases 1 to 1917)
  AUTHORS   Choudhary,D., Jansson,I., Stoilov,I., Sarfarazi,M. and
            Schenkman,J.B.
  TITLE     Expression patterns of mouse and human CYP orthologs (families 1-4)
            during development and in different adult tissues
  JOURNAL   Arch Biochem Biophys 436 (1), 50-61 (2005)
   PUBMED   15752708
REFERENCE   6  (bases 1 to 1917)
  AUTHORS   Isern,J. and Meseguer,A.
  TITLE     Hormonal regulation and characterisation of the mouse Cyp4b1 gene
            5'-flanking region
  JOURNAL   Biochem Biophys Res Commun 307 (1), 139-147 (2003)
   PUBMED   12849993
  REMARK    GeneRIF: Data show that the 5' flanking region of the Cyp4b1 gene
            exhibits promoter activity when expressed in different cell lines
            and that a 98-truncated fragment represents the minimal sequence
            required for basal transcription.
REFERENCE   7  (bases 1 to 1917)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   8  (bases 1 to 1917)
  AUTHORS   Imaoka,S., Hayashi,K., Hiroi,T., Yabusaki,Y., Kamataki,T. and
            Funae,Y.
  TITLE     A transgenic mouse expressing human CYP4B1 in the liver
  JOURNAL   Biochem Biophys Res Commun 284 (3), 757-762 (2001)
   PUBMED   11396967
REFERENCE   9  (bases 1 to 1917)
  AUTHORS   Heng,Y.M., Kuo,C.S., Jones,P.S., Savory,R., Schulz,R.M.,
            Tomlinson,S.R., Gray,T.J. and Bell,D.R.
  TITLE     A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
            and Cyp4b, but not of CYP4F, genes in mouse and humans
  JOURNAL   Biochem J 325 (Pt 3) (Pt 3), 741-749 (1997)
   PUBMED   9271096
REFERENCE   10 (bases 1 to 1917)
  AUTHORS   Imaoka,S., Hiroi,T., Tamura,Y., Yamazaki,H., Shimada,T., Komori,M.,
            Degawa,M. and Funae,Y.
  TITLE     Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal
            cytochrome P450 CYP4B1: cloning and characterization of mouse
            CYP4B1
  JOURNAL   Arch Biochem Biophys 321 (1), 255-262 (1995)
   PUBMED   7639529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626805.14.
            
            On Apr 27, 2018 this sequence version replaced NM_007823.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143890.1, AK165445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL626805.14        110229-110442       c
            215-356             AL626805.14        104567-104708       c
            357-401             AL626805.14        104338-104382       c
            402-529             AL626805.14        103026-103153       c
            530-654             AL626805.14        98985-99109         c
            655-806             AL626805.14        98595-98746         c
            807-913             AL626805.14        98353-98459         c
            914-1104            AL626805.14        91390-91580         c
            1105-1238           AL626805.14        89528-89661         c
            1239-1303           AL626805.14        88545-88609         c
            1304-1386           AL626805.14        88367-88449         c
            1387-1917           AL626805.14        87419-87949         c
FEATURES             Location/Qualifiers
     source          1..1917
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.06 cM"
     gene            1..1917
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /note="cytochrome P450, family 4, subfamily b, polypeptide
                     1"
                     /db_xref="GeneID:13120"
                     /db_xref="MGI:MGI:103225"
     exon            1..214
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1570
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, subfamily IV B, polypeptide 1"
                     /codon_start=1
                     /product="cytochrome P450 4B1"
                     /protein_id="NP_031849.1"
                     /db_xref="CCDS:CCDS18493.1"
                     /db_xref="GeneID:13120"
                     /db_xref="MGI:MGI:103225"
                     /translation="MALSFLSPSLSRLGLWASVVILMVTVLKLLSLLFRRQKLARALD
                     SFPGPPKHWLFGHALEIQKTGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKA
                     VYSRGDPKAAYVYDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAES
                     TRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDL
                     TLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKK
                     LQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY
                     PMHQQRCREEVREILGDRDSFQWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVT
                     FVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAGP
                     RNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILRSKNGIHLYLKPLGPG
                     SGK"
     exon            215..356
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..401
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..529
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..654
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..806
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..913
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1104
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1238
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1303
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1386
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1917
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /note="hexamer: AATAAT"
     polyA_site      1890
                     /gene="Cyp4b1"
                     /gene_synonym="CYPIVB1"
                     /note="major polyA site"
ORIGIN      
        1 aggcagttgg agcctgggtc ctgcgagttt agccatggcg ctcagctttc tctctccaag
       61 cctttcccgc ctcggcctgt gggcttctgt agtgatcctg atggtaaccg tcctgaagct
      121 cctcagcctg ctgtttcgga ggcagaagct ggccagggct ttggacagct tcccagggcc
      181 ccccaagcac tggctttttg gtcatgccct tgagatccag aagacaggag gcctggacaa
      241 ggtggtaact tggaccgaac agttccccta tgcccaccca ctctggcttg gacaatttat
      301 tgttttcctg aacatctatg agcctgacta tgctaaagct gtatacagcc gaggggaccc
      361 gaaggctgca tatgtgtatg acttcttcct ccagtggatc ggaaaaggcc tactggttct
      421 ggaagggcca aaatggttcc agcaccgcaa gctgctcaca cctggcttcc attatgatgt
      481 gctgaagccc tatgtggcca tatttgctga gtccacacgg gtgatgctgg acaagtggga
      541 gaaaaaggct agtgagaata agagctttga catcttctgt gacgtgggcc acatggcact
      601 ggacaccctc atgaagtgca cctttggcaa aggagacagc ggcctaagcc acagtgacaa
      661 cagctactac ctggcagtta gtgacctcac actgctgatg cagcagcgca tcgactcctt
      721 ccagtaccat aatgacttca tttactggct cacaccacat ggccgccgtt tcttgcgggc
      781 ctgccagata gcccatgacc atacagatca tgtcatcagg cagcggaagg cagctctgca
      841 ggatgagaag gagcagaaaa agcttcagga gcggagacac ctggacttcc tcgacattct
      901 cctgggtgcc cgggatgaaa gtgggatcaa gttgtcagat gcagacctcc gggctgaagt
      961 ggacacattc atgttcgaag gccacgacac caccactagt ggtatctctt ggtttctcta
     1021 ctgcatggcc ctttatccta tgcaccagca gcgatgtagg gaggaggtcc gtgagatcct
     1081 aggggaccgg gactccttcc agtgggatga tctggcccag atgacctacc tgaccatgtg
     1141 catgaaggag tgcttccgcc tctacccacc tgtaccccaa gtgtaccgcc agctcagcaa
     1201 gccagtaacc tttgtggatg gccgctctct acctgcaggc agcctgatct ctctgcacat
     1261 ctatgccctc catcggaaca gtgctgtgtg gcctgaccca gaggtctttg acccactgcg
     1321 cttttctcct gagaatatga caggacggca tccctttgcc ttcatgcctt tttctgcagg
     1381 gcccaggaat tgcattgggc agcagtttgc tatgaacgag atgaaggtgg tcacagccct
     1441 ctgtttgctg cgctttgaat tctctccaga tccctcaaag atccccatta aggtccccca
     1501 gctgatcttg cgctccaaaa atggcatcca cctctacctg aagccactgg gccctgggtc
     1561 tggaaagtag gtcttaggag agcaaggata tggagtcatt gtggatccct gcctgtgggg
     1621 ggtttgtgag ataaaagcat gcacattgag agtatcctgg aagacattct cttgtaaaca
     1681 tgtgtgtgga atgattcaat gcctgggctt tcaaactcat tccttcactc cacaaatatt
     1741 tgctgaatgt ttccctgtct tgagaaactt catttatttc tcataactgc atttatttag
     1801 ccatctcagt gtgcattttg gatataatag acataaggaa aattgcttaa actaaatctg
     1861 tacaaaataa ataatacttt aaaaagcaaa tactcaccac tgaattcaaa gaatatg
//
