LOCUS       NM_007822               2503 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily a, polypeptide 14
            (Cyp4a14), mRNA.
ACCESSION   NM_007822
VERSION     NM_007822.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2503)
  AUTHORS   Ma,R., Liu,Q., Liu,Z., Sun,X., Jiang,X., Hou,J., Zhang,Y., Wu,Y.,
            Cheng,M. and Dong,Z.
  TITLE     H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on
            liver in the treatment of Schistosoma japonicum infection
  JOURNAL   Acta Trop 247, 107012 (2023)
   PUBMED   37659685
  REMARK    GeneRIF: H19/Mir-130b-3p/Cyp4a14 potentiate the effect of
            praziquantel on liver in the treatment of Schistosoma japonicum
            infection.
REFERENCE   2  (bases 1 to 2503)
  AUTHORS   Gilani,A., Pandey,V., Garcia,V., Agostinucci,K., Singh,S.P.,
            Schragenheim,J., Bellner,L., Falck,J.R., Paudyal,M.P.,
            Capdevila,J.H., Abraham,N.G. and Laniado Schwartzman,M.
  TITLE     High-fat diet-induced obesity and insulin resistance in CYP4a14-/-
            mice is mediated by 20-HETE
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 315 (5), R934-R944 (2018)
   PUBMED   30088983
REFERENCE   3  (bases 1 to 2503)
  AUTHORS   Zhou,Y., Yu,J., Liu,J., Cao,R., Su,W., Li,S., Ye,S., Zhu,C.,
            Zhang,X., Xu,H., Chen,H., Zhang,X. and Guan,Y.
  TITLE     Induction of cytochrome P450 4A14 contributes to angiotensin
            II-induced renal fibrosis in mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (3), 860-870 (2018)
   PUBMED   29277328
  REMARK    GeneRIF: CYP4A14 may represent a useful target for the treatment of
            AngII-associated renal damage.
REFERENCE   4  (bases 1 to 2503)
  AUTHORS   Pandey,V., Garcia,V., Gilani,A., Mishra,P., Zhang,F.F.,
            Paudyal,M.P., Falck,J.R., Nasjletti,A., Wang,W.H. and
            Schwartzman,M.L.
  TITLE     The Blood Pressure-Lowering Effect of 20-HETE Blockade in
            Cyp4a14(-/-) Mice Is Associated with Natriuresis
  JOURNAL   J Pharmacol Exp Ther 363 (3), 412-418 (2017)
   PUBMED   28912346
  REMARK    GeneRIF: Hypertension in Cyp4a14(-/-) male mice was accompanied by
            decreased renal perfusion and reduced glomerular filtration rates
REFERENCE   5  (bases 1 to 2503)
  AUTHORS   Zhang,X., Li,S., Zhou,Y., Su,W., Ruan,X., Wang,B., Zheng,F.,
            Warner,M., Gustafsson,J.A. and Guan,Y.
  TITLE     Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates
            hepatic steatosis and fibrosis
  JOURNAL   Proc Natl Acad Sci U S A 114 (12), 3181-3185 (2017)
   PUBMED   28270609
  REMARK    GeneRIF: this study provides a link between CYP4A14 and NAFLD.
            Overexpression of CYP4A14 promotes, whereas gene disruption of
            CYP4A14 attenuates, HFD- and MCD-induced liver lipid accumulation.
            Ablation of CYP4A14 gene markedly attenuates liver damage,
            inflammation, and fibrosis in MCD-induced NASH.
            Erratum:[Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2315591120.
            doi: 10.1073/pnas.2315591120.. PMID: 37824533]
REFERENCE   6  (bases 1 to 2503)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   7  (bases 1 to 2503)
  AUTHORS   Cook,W.S., Jain,S., Jia,Y., Cao,W.Q., Yeldandi,A.V., Reddy,J.K. and
            Rao,M.S.
  TITLE     Peroxisome proliferator-activated receptor alpha-responsive genes
            induced in the newborn but not prenatal liver of peroxisomal fatty
            acyl-CoA oxidase null mice
  JOURNAL   Exp Cell Res 268 (1), 70-76 (2001)
   PUBMED   11461119
REFERENCE   8  (bases 1 to 2503)
  AUTHORS   Holla,V.R., Adas,F., Imig,J.D., Zhao,X., Price,E. Jr., Olsen,N.,
            Kovacs,W.J., Magnuson,M.A., Keeney,D.S., Breyer,M.D., Falck,J.R.,
            Waterman,M.R. and Capdevila,J.H.
  TITLE     Alterations in the regulation of androgen-sensitive Cyp 4a
            monooxygenases cause hypertension
  JOURNAL   Proc Natl Acad Sci U S A 98 (9), 5211-5216 (2001)
   PUBMED   11320253
REFERENCE   9  (bases 1 to 2503)
  AUTHORS   Enriquez,A., Leclercq,I., Farrell,G.C. and Robertson,G.
  TITLE     Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic
            ob/ob mice, and fa/fa Zucker rats
  JOURNAL   Biochem Biophys Res Commun 255 (2), 300-306 (1999)
   PUBMED   10049703
REFERENCE   10 (bases 1 to 2503)
  AUTHORS   Heng,Y.M., Kuo,C.S., Jones,P.S., Savory,R., Schulz,R.M.,
            Tomlinson,S.R., Gray,T.J. and Bell,D.R.
  TITLE     A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
            and Cyp4b, but not of CYP4F, genes in mouse and humans
  JOURNAL   Biochem J 325 (Pt 3) (Pt 3), 741-749 (1997)
   PUBMED   9271096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089609.1, AK165452.1 and BF322553.1.
            
            On Jan 9, 2008 this sequence version replaced NM_007822.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089609.1, AK098088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               BC089609.1         1-342
            343-2179            AK165452.1         341-2177
            2180-2503           BF322553.1         1-324               c
FEATURES             Location/Qualifiers
     source          1..2503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.04 cM"
     gene            1..2503
                     /gene="Cyp4a14"
                     /note="cytochrome P450, family 4, subfamily a, polypeptide
                     14"
                     /db_xref="GeneID:13119"
                     /db_xref="MGI:MGI:1096550"
     exon            1..223
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1552
                     /gene="Cyp4a14"
                     /EC_number="1.14.14.80"
                     /note="CYPIVA14; cytochrome P450-LA-omega 3; lauric acid
                     omega-hydroxylase 3; cytochrome P450, 4a14; long-chain
                     fatty acid omega-monooxygenase; lauric acid hydroxylase"
                     /codon_start=1
                     /product="cytochrome P450 4A14"
                     /protein_id="NP_031848.1"
                     /db_xref="CCDS:CCDS18491.1"
                     /db_xref="GeneID:13119"
                     /db_xref="MGI:MGI:1096550"
                     /translation="MGFFLFSPTRYLDGISGFFQWAFLLSLFLVLFKAVQFYLRRQWL
                     LKTLQHFPCMPSHWLWGHHLKDKELQQILIWVEKFPSACLQCLSGSNIRVLLYDPDYV
                     KVVLGRSDPKASGIYQFFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMA
                     DSVNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLDENSKLYTKAV
                     EDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHTDGVIKMRKSQLQNEEE
                     LQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYAL
                     ATHPEHQQRCREEVQSILGDGTSVTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSS
                     PVTFPDGRSIPKGITATISIYGLHHNPRFWPNPKVFDPSRFAPDSSHHSHAYLPFSGG
                     SRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHLCLKKLR"
     exon            224..356
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            357..401
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            402..529
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            530..654
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            655..809
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            810..916
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1107
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1241
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1306
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1383
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..2495
                     /gene="Cyp4a14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2475..2480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4a14"
                     /note="hexamer: ATTAAA"
     polyA_site      2495
                     /gene="Cyp4a14"
                     /note="major polyA site"
ORIGIN      
        1 gacactagtg atccagaaac tactaaccat gggttttttt ttatttagcc ctacaaggta
       61 cttggatggt atctctgggt tcttccaatg ggccttcttg ctcagtctat ttctggtgct
      121 gttcaaggca gtccaattct acttacgaag gcagtggctg ctcaagaccc tccagcattt
      181 cccatgcatg ccttcccact ggctttgggg gcaccatctg aaggacaagg agctccagca
      241 gattcttata tgggtagaga aattcccaag tgcctgctta cagtgtctct cggggagcaa
      301 tatacgagtc ctgctttatg accctgacta tgtgaaggtg gttctgggga gatcagatcc
      361 aaaggcttct ggaatttatc aattctttgc tccctggatt ggttatggtt tgctcctgtt
      421 gaatgggaag aagtggttcc agcatcggcg gatgttgact ccagccttcc actatgatat
      481 cctcaaaccc tatgtcaaaa tcatggcgga ctctgtcaat ataatgctag ataaatggga
      541 gaagcttgat ggccaggacc accctctgga gatcttccac tgtgtttcat tgatgacact
      601 ggacactgtt atgaagtgtg ctttcagcta ccaaggcagt gttcagttgg atgaaaattc
      661 caagttgtat actaaggctg tcgaggatct aaacaacctg actttctttc gcctgcggaa
      721 tgccttttat aagtacaaca tcatctacaa tatgtcctct gatggacgtt tgtcccacca
      781 tgcctgccag attgctcacg agcacacaga tggagtgatc aagatgagga agtctcagct
      841 gcagaatgag gaagagctgc agaaggccag gaagaagaga cacttggatt tcttggacat
      901 cctcttgttt gccagaatgg aggataggaa cagcttgtct gatgaggacc tgcgtgcaga
      961 ggtggacaca ttcatgtttg agggtcatga cactacagcc agtggaattt cctggatttt
     1021 ctatgctctg gccacccacc ctgagcacca acagagatgc agagaggagg tgcagagcat
     1081 tctgggtgat ggaacctctg tcacatggga ccatctgggc cagatgccct acaccaccat
     1141 gtgcatcaag gaggccctga ggctctatcc accagtaata tctgtgagtc gagagctcag
     1201 ctcacctgtc accttcccag atggacgctc catacccaaa ggtatcacag ccacaatttc
     1261 catttatggc ctacatcata acccacgttt ctggccaaac ccaaaggtgt ttgacccctc
     1321 tagatttgca ccagattctt ctcaccatag ccatgcttat ctgccattct caggaggatc
     1381 aaggaactgc attgggaaac agtttgctat gaacgagctg aaggtggctg tggccctgac
     1441 cctgctccgc tttgaattgc tgccagatcc caccaggatc ccagtcccca ttgcaagact
     1501 tgtgttgaag tccaagaatg ggatccacct gtgtctcaag aagctaagat aattctgatg
     1561 gagtcagggc agctccagag gtctgctgcc tgcaatacct gcttttgtct ctggcttttc
     1621 tgtactttgc tttctctttg attcccattc ttctgctctc tgcaatgtgt cctgtcatct
     1681 catctttctg ccctcatttc tgtagctttt cctctagaca ccttcccaac ctgtgcatgt
     1741 acctgtttcc catctcgctt taactctgac cagccactga acctgcagcc agcagcctgt
     1801 cccccagcct gttcacccct cataaccatt gcactgacag aggaagatat attttagagg
     1861 gagacacttg tacctttctc tcccttcagt tattagactc ttgggacaat ggacatcatg
     1921 aattaaaacg ttcttagaaa tcacatgctg ggagaaaatt aacactaaaa tctggtacca
     1981 gccagaggaa ggaacttgac tcaaaataag agatttttag atatttctgt ctgtctcata
     2041 gttaaaatta atgttttcct gctttctggc atatgcctca tcttttctat gaagtagtaa
     2101 tactgataca gaaaggtaga gagaaatgaa tagtttttgc tactttgggc caaactgtga
     2161 aaaaatccat tttatttcat caatttctgt ttcccaattt catttaagac acaggaaaac
     2221 tactcagcat gaactttggg gagccagagc agttttggca atccagggaa gcatgttgcc
     2281 atctggtccc tactgttaga atgtggtaga attctcagct cctgagaggt tgttctctgc
     2341 ttttgactcc tgagctggtt gtgtagaaat gcaggttggc gttttttgtg aagctaagga
     2401 gttttctgac tttaacccgg tcttatttgt ttagagtact ctgattattc actttagtga
     2461 tttggagaat tcctattaaa atcacatgac atggaaaaaa aaa
//
