LOCUS       NM_172306               2395 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily a, polypeptide
            12B (Cyp4a12b), mRNA.
ACCESSION   NM_172306
VERSION     NM_172306.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Muller,D.N., Schmidt,C., Barbosa-Sicard,E., Wellner,M., Gross,V.,
            Hercule,H., Markovic,M., Honeck,H., Luft,F.C. and Schunck,W.H.
  TITLE     Mouse Cyp4a isoforms: enzymatic properties, gender- and
            strain-specific expression, and role in renal
            20-hydroxyeicosatetraenoic acid formation
  JOURNAL   Biochem J 403 (1), 109-118 (2007)
   PUBMED   17112342
REFERENCE   3  (bases 1 to 2395)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   4  (bases 1 to 2395)
  AUTHORS   Jeffery,B., Choudhury,A.I., Horley,N., Bruce,M., Tomlinson,S.R.,
            Roberts,R.A., Gray,T.J., Barrett,D.A., Shaw,P.N., Kendall,D. and
            Bell,D.R.
  TITLE     Peroxisome proliferator activated receptor alpha regulates a
            male-specific cytochrome P450 in mouse liver
  JOURNAL   Arch Biochem Biophys 429 (2), 231-236 (2004)
   PUBMED   15313227
REFERENCE   5  (bases 1 to 2395)
  AUTHORS   Le Bouquin,R., Lugnier,A., Frossard,N. and Pons,F.
  TITLE     Expression of cytochrome P450 4A mRNA in mouse lung: effect of
            clofibrate and interleukin-1beta
  JOURNAL   Fundam Clin Pharmacol 18 (2), 181-186 (2004)
   PUBMED   15066132
  REMARK    GeneRIF: '...Cyp4a12...is expressed in mouse lung... may be
            upregulated by...clofibrate and... cytokine IL-1Beta...IL-1Beta has
            been...associated with asthma...data raise the question...whether
            CYP4A expression could be altered in asthmatic conditions' p. 184-5
REFERENCE   6  (bases 1 to 2395)
  AUTHORS   Heng,Y.M., Kuo,C.S., Jones,P.S., Savory,R., Schulz,R.M.,
            Tomlinson,S.R., Gray,T.J. and Bell,D.R.
  TITLE     A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
            and Cyp4b, but not of CYP4F, genes in mouse and humans
  JOURNAL   Biochem J 325 (Pt 3) (Pt 3), 741-749 (1997)
   PUBMED   9271096
REFERENCE   7  (bases 1 to 2395)
  AUTHORS   Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
            Acharya,S.K., Davies,M.H., Elias,E., Jenkins,N.A. et al.
  TITLE     Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning
            of partial guinea-pig, human and mouse CYP4A cDNAs
  JOURNAL   Biochem J 294 (Pt 1) (Pt 1), 173-180 (1993)
   PUBMED   8363569
REFERENCE   8  (bases 1 to 2395)
  AUTHORS   Nelson,D.R., Kamataki,T., Waxman,D.J., Guengerich,F.P.,
            Estabrook,R.W., Feyereisen,R., Gonzalez,F.J., Coon,M.J.,
            Gunsalus,I.C., Gotoh,O. et al.
  TITLE     The P450 superfamily: update on new sequences, gene mapping,
            accession numbers, early trivial names of enzymes, and nomenclature
  JOURNAL   DNA Cell Biol 12 (1), 1-51 (1993)
   PUBMED   7678494
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB665127.1, AK098123.1 and BC060945.1.
            
            On Jan 31, 2006 this sequence version replaced NM_172306.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098123.1, BC060945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BB665127.1         3-21
            20-552              AK098123.1         1-533
            553-906             BC060945.1         534-887
            907-2395            AK098123.1         888-2376
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 52.99 cM"
     gene            1..2395
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /note="cytochrome P450, family 4, subfamily a, polypeptide
                     12B"
                     /db_xref="GeneID:13118"
                     /db_xref="MGI:MGI:3611747"
     exon            1..248
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1586
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, family 4, subfamily a family;
                     cytochrome P450, family 4, subfamily a, polypeptide 12;
                     cytochrome P450 4A12B"
                     /codon_start=1
                     /product="cytochrome P450 4A12B precursor"
                     /protein_id="NP_758510.2"
                     /db_xref="CCDS:CCDS18490.1"
                     /db_xref="GeneID:13118"
                     /db_xref="MGI:MGI:3611747"
                     /translation="MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWL
                     LSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDY
                     MKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIM
                     ADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQA
                     VEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEE
                     ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
                     LATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELS
                     SPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSG
                     GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ
                     "
     exon            249..390
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            391..435
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            436..563
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            564..688
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            689..843
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            844..950
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1141
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1275
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1340
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1417
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..2395
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1933..1938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /note="hexamer: ATTAAA"
     polyA_site      1965
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /note="major polyA site"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
                     /note="hexamer: AATGAA"
     polyA_site      2025
                     /gene="Cyp4a12b"
                     /gene_synonym="Cyp4a12"
ORIGIN      
        1 agacaggagg gtgttcattg aaagtgaagg agagttggtg atccagaagc tgttgtatca
       61 tgagtgcctc tgctctgagc tccatcagat tcccaggaag catctctgag taccttcaag
      121 tagcctctgt gctcagcctg ctcctgctgc tcttcaagac agcccagctc tacctgcaca
      181 ggcaatggct actcagcagt actcagcagt tcccatcccc accttctcac tggctctttg
      241 gacacaagat cttaaaggac caggaccttc aagatattct aactaggatt aagaatttcc
      301 caagtgcctg tccacagtgg ctctggggaa gcaaagtgcg cattcaagtg tatgaccctg
      361 actacatgaa gctgattctg gggagatcag acccaaaagc tcatggttcc tacagatttc
      421 tagctccctg gattgggcgt ggtttgcttc tgctggatgg acagacatgg tttcagcacc
      481 gacgaatgtt gaccccagct ttccactatg acattctgaa gccttacacg gaaatcatgg
      541 cagactctgt tcatgtcatg ctggataaat gggaacagat tgttggccag gattccaccc
      601 tggagatctt ccaacacatc accttgatga ccttggacac catcatgaag tgtgccttca
      661 gccatgaggg cagtgtccag ttggacagaa aatacaagtc ctatatccag gcagttgagg
      721 acctgaacaa tctctttttt ctccgtgtgc ggaacatctt tcaccagaat gacatcatct
      781 acagagtgtc ctctaatggc tgcttggcca acagtgcctg ccaacttgcc catgatcaca
      841 cagaccaagt gatcaaatca aggaggagtc aacttcagga tgaggaagag ttggaaaagc
      901 ttaagaagaa aaggcgattg gatttcctgg acatcctcct atttgccaga atggaaaatg
      961 gaaaaagctt atctgataag gaccttcgtg ctgaagtgga tactttcatg ttcgagggcc
     1021 atgacaccac agctagtggt atctcctgga tcttctatgc tttggccaca aatcctgaac
     1081 atcaacagag atgcaggaag gagatccaaa gtctcttagg agatggggct tctatcacct
     1141 ggaacgacct ggacaagatg ccctatacta ccatgtgcat caaggaggcc ctgaggatct
     1201 acccccctgt accaagtgtg agcagagagc tcagctcacc tgtcaccttt cctgatggac
     1261 gttctttacc caaaggtatc catgtcatgc tctcctttta tggccttcat cacaacccaa
     1321 ctgtgtggcc aaatccagag gtgtttgatc cttctcgatt tgcaccaggg tcttcccggc
     1381 acagccactc attcctgccc ttctcaggag gagcaaggaa ctgcattggg aaacagtttg
     1441 cgatgaatga gctgaaggtg gctgtggccc tgaccctgct ccgctttgag ctgctgccag
     1501 atcccaccag agtcccaatc cccataccaa gaattgtgtt gaagtccaag aatgggatcc
     1561 acttgcatct caaaaagctc caataatctt cacagaacaa gacagctcaa atggcctgct
     1621 gcctgccatt ctgtctttct gtcactcact cttttcccca atccttctgc tcacatctca
     1681 ttctttcttc tcaccttgtt cacctccacc caccttctgc tgggcttcca gtctccttgc
     1741 ctgtcagtct ttttcaactt cttctgagat ccctacttgc ttttctctct acctgtccct
     1801 aaccagactg catgtttgac ctttgacttt aatgatctcc ctaacttgca ccctgccttt
     1861 cttttctgtg tatttccttc tcttctactg cttgtctatc cttaaattgg gcttattctg
     1921 atgtcataat taattaaaag ataagtgtgt gctcttatga ttctagatat cgagtgtttt
     1981 tgatgatttc actggaatga agctgagttc attgcaatgc catcactcct tgggtatcgc
     2041 tgtgcctctt tttacctttc cgtcacctat agctgcattc cttggtttca agagccctcc
     2101 taagtgttaa aatccaacac cattgttaag catctcttct gtctccagat catttctcca
     2161 tctttccaat gtgtatgctt gttttgtgcc taaaagggta atactggtcc tgttcttagt
     2221 tctatcaaga ttaggacatg catatctgaa agagccaatt ttcaaccaac ctaactgaga
     2281 ccttccctga ctgtcacctc atctatccat ataaatctcc ccttcaaact ctccaccttt
     2341 cagcttacat ttaagagtct tgccatcttc cccacaataa agttcataat gtggc
//
