LOCUS       NM_177406               2422 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily a, polypeptide
            12a (Cyp4a12a), mRNA.
ACCESSION   NM_177406
VERSION     NM_177406.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2422)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   2  (bases 1 to 2422)
  AUTHORS   Creasy,K.T., Jiang,J., Ren,H., Peterson,M.L. and Spear,B.T.
  TITLE     Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic
            Cyp Gene Expression in the Adult Mouse Liver
  JOURNAL   Gene Expr 17 (1), 7-17 (2016)
   PUBMED   27197076
REFERENCE   3  (bases 1 to 2422)
  AUTHORS   Muller,D.N., Schmidt,C., Barbosa-Sicard,E., Wellner,M., Gross,V.,
            Hercule,H., Markovic,M., Honeck,H., Luft,F.C. and Schunck,W.H.
  TITLE     Mouse Cyp4a isoforms: enzymatic properties, gender- and
            strain-specific expression, and role in renal
            20-hydroxyeicosatetraenoic acid formation
  JOURNAL   Biochem J 403 (1), 109-118 (2007)
   PUBMED   17112342
  REMARK    GeneRIF: Enzyme is the predominant 20-hydroxyeicosatetraenoic
            synthase in mouse kidney.
REFERENCE   4  (bases 1 to 2422)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   5  (bases 1 to 2422)
  AUTHORS   Jeffery,B., Choudhury,A.I., Horley,N., Bruce,M., Tomlinson,S.R.,
            Roberts,R.A., Gray,T.J., Barrett,D.A., Shaw,P.N., Kendall,D. and
            Bell,D.R.
  TITLE     Peroxisome proliferator activated receptor alpha regulates a
            male-specific cytochrome P450 in mouse liver
  JOURNAL   Arch Biochem Biophys 429 (2), 231-236 (2004)
   PUBMED   15313227
REFERENCE   6  (bases 1 to 2422)
  AUTHORS   Heng,Y.M., Kuo,C.S., Jones,P.S., Savory,R., Schulz,R.M.,
            Tomlinson,S.R., Gray,T.J. and Bell,D.R.
  TITLE     A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
            and Cyp4b, but not of CYP4F, genes in mouse and humans
  JOURNAL   Biochem J 325 (Pt 3) (Pt 3), 741-749 (1997)
   PUBMED   9271096
REFERENCE   7  (bases 1 to 2422)
  AUTHORS   Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
            Acharya,S.K., Davies,M.H., Elias,E., Jenkins,N.A. et al.
  TITLE     Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning
            of partial guinea-pig, human and mouse CYP4A cDNAs
  JOURNAL   Biochem J 294 (Pt 1) (Pt 1), 173-180 (1993)
   PUBMED   8363569
REFERENCE   8  (bases 1 to 2422)
  AUTHORS   Nelson,D.R., Kamataki,T., Waxman,D.J., Guengerich,F.P.,
            Estabrook,R.W., Feyereisen,R., Gonzalez,F.J., Coon,M.J.,
            Gunsalus,I.C., Gotoh,O. et al.
  TITLE     The P450 superfamily: update on new sequences, gene mapping,
            accession numbers, early trivial names of enzymes, and nomenclature
  JOURNAL   DNA Cell Biol 12 (1), 1-51 (1993)
   PUBMED   7678494
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB955255.1, BC014721.1, CB950710.1 and AL627182.22.
            
            On Jan 31, 2006 this sequence version replaced NM_177406.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014721.1, BC026582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-690               CB955255.1         3-692
            691-1314            BC014721.1         637-1260
            1315-1662           CB950710.1         272-619
            1663-2422           AL627182.22        34339-35098
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 52.91 cM"
     gene            1..2422
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /note="cytochrome P450, family 4, subfamily a, polypeptide
                     12a"
                     /db_xref="GeneID:277753"
                     /db_xref="MGI:MGI:88612"
     exon            1..271
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1609
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450 4A12A; cytochrome P450, family 4,
                     subfamily a, polypeptide 12; CYPIVA12"
                     /codon_start=1
                     /product="cytochrome P450 4A12A precursor"
                     /protein_id="NP_803125.2"
                     /db_xref="CCDS:CCDS18489.1"
                     /db_xref="GeneID:277753"
                     /db_xref="MGI:MGI:88612"
                     /translation="MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWL
                     LSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDY
                     MKLILGRSDPKANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIM
                     ADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQA
                     VEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEE
                     ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
                     LATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELS
                     SPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSG
                     GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ
                     "
     exon            272..413
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            414..458
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            459..586
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            587..711
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            712..866
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            867..973
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1164
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1298
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1363
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1440
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..2422
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /note="hexamer: ATTAAA"
     polyA_site      1987
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /note="major polyA site"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
                     /note="hexamer: AATAAA"
     polyA_site      2422
                     /gene="Cyp4a12a"
                     /gene_synonym="Cyp4a12"
ORIGIN      
        1 ggggcaaccc tcctggggtt tgcagacagg agggtgttca ttgaaagtga aggagagttg
       61 gtgatccaga agctgttgta tcatgagtgc ctctgctctg agctccatca gattcccagg
      121 aagcatctct gagtaccttc aagtagcctc tgtgctcagc ctgctcctgc tgctcttcaa
      181 gacagcccag ctctacctgc acaggcaatg gctactcagc agtactcagc agttcccatc
      241 cccaccttct cactggctct ttggacacaa gatcttaaag gaccaggacc ttcaagatat
      301 tctaactagg attaagaatt tcccaagtgc ctgtccacag tggctctggg gaagcaaagt
      361 gcgcattcaa gtgtatgacc ctgactacat gaagctgatt ctggggagat cagacccaaa
      421 agctaatggt tcctacagat ttctagctcc ctggattggg cgtggtttgc ttatgctgga
      481 tggacagaca tggtttcagc accgacgaat gttgacccca gctttccact atgacattct
      541 gaagccttat acggaaatca tggcagactc tgttcgtgta atgctggata aatgggaaca
      601 gattgttggc caggattcca ccctggagat ctttcgacac atcaccttga tgaccttgga
      661 caccatcatg aagtgtgcct tcagccacga gggcagtgtc cagttggaca gaaaatacaa
      721 gtcctatatc caggcagttg aggacctgaa cgatctcgtt ttttcccgtg tgcggaacat
      781 ctttcaccag aatgacatca tctacagagt gtcctctaat ggctgcaagg ctaacagtgc
      841 ctgcaaactt gcccatgatc acacagacca agtgatcaaa tcaaggagga ttcaacttca
      901 ggatgaggaa gagttggaaa agcttaagaa gaaaaggcga ttggatttcc tggacatcct
      961 cctatttgcc agaatggaaa atggaaaaag cttatctgat aaggaccttc gtgctgaagt
     1021 ggatactttc atgttcgagg gccatgacac cacagctagt ggtatctcct ggatcttcta
     1081 tgctttggcc acaaatcctg aacatcaaca gagatgcagg aaggagatcc aaagtctcct
     1141 aggagatggg acttctatca cctggaatga cctggacaag atgccctata ctaccatgtg
     1201 catcaaggag gccctgagga tctaccctcc tgtaccaagt gtgagcagag agctcagctc
     1261 acctgtcacc tttccagatg gacgttcttt acccaaaggt atccatgtta tgctctcctt
     1321 ttatggcctt catcacaacc caactgtgtg gccaaatcca gaggtgtttg atccttctcg
     1381 atttgcacca gggtcttccc ggcacagcca ctcattcctg cccttctcag gaggagcaag
     1441 gaactgcatt gggaaacagt ttgcgatgaa tgagctgaag gtggctgtgg ccctgaccct
     1501 gctccgcttt gagctgctgc cagatcccac cagagtccca atccccatac caagaattgt
     1561 gttgaagtcc aagaatggga tccacttgca tctcaaaaag ctccaataat cttcacagga
     1621 caagacagct caaatggcat gctgcctgcc attctgtctt tctgtcactt actcttttcc
     1681 ccaatccttc tgctcacatc tcattctttc ttctcacctt gttcacctcc acccaccttc
     1741 tgctgggctt ccagtctcct tgcctgtcag tctttttcaa cttcttctga gatccctact
     1801 tgcttttctc tctacctgtc cctaacctga ctgcatgttt gacctttgac cttaatgatc
     1861 tccctaacct gcaccctgcc tttctcttct gtgtatttcc ttctcttcta ccgcttgtct
     1921 atccttaaat tgggcttatt ctgatgtcat aattaattaa aagataatgt gtgctcttgt
     1981 gattctagat atcgagtgtt tttcatgatt tcactggaat gaagctgagg tcattgcagt
     2041 gccatcactc cttgggtatc gctgtgcctc tttttacctt tctatcacct atagctgcat
     2101 tccttggttt caagagccct cctaagtgtt aaaatccaac accattgtta agcatctctt
     2161 ctgtctccag atcatttctc catctttcca atgtgtatgc ttgttttgtg cctaaaaggg
     2221 taatactggt cctgttctta gttctatcaa gattaggaca tgcatatctg aaagagccaa
     2281 ttttcaacca acctaacaga gaccttccct gactgtcacc tcatctatcc atataaatct
     2341 ccccttcaaa ttctccacct atcagcttac gtttaagagt cttgccatct tccccacaat
     2401 aaagttcata atgtggcatg ta
//
