LOCUS       NM_010011               2096 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytochrome P450, family 4, subfamily a, polypeptide 10
            (Cyp4a10), mRNA.
ACCESSION   NM_010011 XM_204116
VERSION     NM_010011.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Van Veldhoven,P.P., de Schryver,E., Young,S.G., Zwijsen,A.,
            Fransen,M., Espeel,M., Baes,M. and Van Ael,E.
  TITLE     Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal
            Degradation of Phytanic and Pristanic Acid
  JOURNAL   Front Cell Dev Biol 8, 144 (2020)
   PUBMED   32266253
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Lu,J., Xu,Q., Ji,M., Guo,X., Xu,X., Fargo,D.C. and Li,X.
  TITLE     The phosphorylation status of T522 modulates tissue-specific
            functions of SIRT1 in energy metabolism in mice
  JOURNAL   EMBO Rep 18 (5), 841-857 (2017)
   PUBMED   28364022
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Chen,S., Lu,W., Yueh,M.F., Rettenmeier,E., Liu,M., Paszek,M.,
            Auwerx,J., Yu,R.T., Evans,R.M., Wang,K., Karin,M. and Tukey,R.H.
  TITLE     Intestinal NCoR1, a regulator of epithelial cell maturation,
            controls neonatal hyperbilirubinemia
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), E1432-E1440 (2017)
   PUBMED   28167773
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4115. doi:
            10.1073/pnas.1705671114.. Paszek, Miles [added]. PMID: 28484028]
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Palladino,E.N., Wang,W.Y., Albert,C.J., Langhi,C., Baldan,A. and
            Ford,D.A.
  TITLE     Peroxisome proliferator-activated receptor-alpha accelerates
            alpha-chlorofatty acid catabolism
  JOURNAL   J Lipid Res 58 (2), 317-324 (2017)
   PUBMED   28007964
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Creasy,K.T., Jiang,J., Ren,H., Peterson,M.L. and Spear,B.T.
  TITLE     Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic
            Cyp Gene Expression in the Adult Mouse Liver
  JOURNAL   Gene Expr 17 (1), 7-17 (2016)
   PUBMED   27197076
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Hanley-Hyde,J., Mushinski,J.F., Sadofsky,M., Huppi,K., Krall,M.,
            Kozak,C.A. and Mock,B.
  TITLE     Expression of murine cyclin B1 mRNAs and genetic mapping of related
            genomic sequences
  JOURNAL   Genomics 13 (4), 1018-1030 (1992)
   PUBMED   1387105
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Meistrich,M.L., Trostle-Weige,P.K. and Womack,J.E.
  TITLE     Mapping of the azh locus to mouse chromosome 4
  JOURNAL   J Hered 83 (1), 56-61 (1992)
   PUBMED   1552159
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Miles,J.S., Moss,J.E., Taylor,B.A., Burchell,B. and Wolf,C.R.
  TITLE     Mapping genes encoding drug-metabolizing enzymes in recombinant
            inbred mice
  JOURNAL   Genomics 11 (2), 309-316 (1991)
   PUBMED   1685137
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Bahary,N., Zorich,G., Pachter,J.E., Leibel,R.L. and Friedman,J.M.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
REFERENCE   10 (bases 1 to 2096)
  AUTHORS   Bahary,N., Leibel,R.L., Joseph,L. and Friedman,J.M.
  TITLE     Molecular mapping of the mouse db mutation
  JOURNAL   Proc Natl Acad Sci U S A 87 (21), 8642-8646 (1990)
   PUBMED   1978328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002528.1 and AI042822.1.
            
            On Apr 21, 2009 this sequence version replaced NM_010011.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002528.1, BC051049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2083              AK002528.1         2-2084
            2084-2096           AI042822.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.05 cM"
     gene            1..2096
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /note="cytochrome P450, family 4, subfamily a, polypeptide
                     10"
                     /db_xref="GeneID:13117"
                     /db_xref="MGI:MGI:88611"
     exon            1..224
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1565
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /EC_number="1.14.14.80"
                     /note="CYPIVA10; cytochrome P452; cytochrome P450-LA-omega
                     1; lauric acid omega-hydroxylase; cytochrome P450, 4a10;
                     long-chain fatty acid omega-monooxygenase"
                     /codon_start=1
                     /product="cytochrome P450 4A10"
                     /protein_id="NP_034141.3"
                     /db_xref="CCDS:CCDS18492.1"
                     /db_xref="GeneID:13117"
                     /db_xref="MGI:MGI:88611"
                     /translation="MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRQWL
                     LKAFQQFPSPPFHWFFGHEKFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPD
                     YMKVILGRSDPKANGAYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKN
                     MADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYRTYLQ
                     AIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHTDGVIKLRKDQLQDE
                     GELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFY
                     ALATHPDHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVREL
                     STSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFS
                     GGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHLKKL
                     H"
     exon            225..369
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..414
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..542
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..667
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..822
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..929
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1120
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1254
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1319
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1396
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1570
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..2086
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /note="hexamer: AATAAA"
     polyA_site      2084
                     /gene="Cyp4a10"
                     /gene_synonym="Cyp4a; D4Rp1; Msp-3; RP1"
                     /note="major polyA site"
ORIGIN      
        1 gagagtgagg acagcaacag aagagtggat gaactatgag tgtctctgct ctaagcccaa
       61 cccgatttgc agacagcctc tctggcttcc tccaagtggc ctctgtgctc ggtctgctcc
      121 tgctgctggt gaaagctgtc cagttctacc tccacaggca atggctactc aaggctttcc
      181 agcagttccc atcacctcct tttcactggt tctttgggca tgagaagttc aaaggtgacc
      241 aagaactaca ggaaattgtg tcgtgcatag agaacttccc aagtgccttt cctagatggt
      301 tctggggaag caaggcctac ttaactgtct atgaccctga ctacatgaaa gtgattctgg
      361 ggcgatcaga tccaaaggct aatggtgcgt acagattgct agctccttgg attgggtatg
      421 gtttgctctt gttgaatgga cagccatggt tccagcacag gaggatgcta accccagcct
      481 tccactatga cattctgaaa ccctatgtga aaaacatggc cgactccatt cgattgatgc
      541 tagacaaatg ggaacggctg gctgatcagg actcctctat agagatcttt caacacatct
      601 ccttaatgac cctagacact gtcatgaaat gtgccttcag ccacaagggc agtgttcagg
      661 tagatggaaa ttacaggacc tacctccagg ccattgggga cttgaataac ctatttcact
      721 cccgtgtgag gaatatcttt catcagaatg ataccatcta caaactttct tccaatggcc
      781 gcttggccaa acaagcttgt caacttgccc atgatcacac agatggagtg atcaagctga
      841 gaaaggatca gctgcaggat gagggagagc tggaaaagat caagaagaag agacgtttgg
      901 attttctgga tatcctttta tttgccagaa tggagaatgg ggacagcatg tctgacaagg
      961 acctacgtgc tgaggtggac acattcatgt tcgagggcca tgacaccaca gccagtggag
     1021 tctcctggat cttctatgct ctggccacac accctgatca ccaacagaga tgcagagagg
     1081 aagttcagag cctcctgggg gatggatcct ctatcacctg ggatcaccta gaccagattc
     1141 cctataccac aatgtgcatc aaggaggccc taaggctcta cccacctgtc ccaggcattg
     1201 tcagagaact cagtacatct gtcaccttcc ctgatggacg ctctttaccc aaaggtgtcc
     1261 aggtcacact ctccatttat ggtctccacc acaacccgaa ggtgtggcca aatccagagg
     1321 tgtttgaccc ttccaggttt gcaccagact ctccccgaca cagccactca ttcctgccct
     1381 tctcaggagg agccaggaac tgcattggga aacaatttgc tatgagtgag ctgaaggtga
     1441 ttgtggccct gacactgctc cgcttcgaac tactgccaga tcctaccagg gtccccatgc
     1501 ccttagcccg acttgtgctg aagtccaaaa atgggatcta cctacatctc aagaagctcc
     1561 actgattctg ttgtggagct ccaatgtctg agaagagttt cactggagaa agctaagttg
     1621 ttggtgtgac ctaccttttt cagaagaata ctccagagag tcctctcatc ctctgttcag
     1681 tatagatcat cattccttgg cactggaata ttcccctgct tcaaagccag caccctcctc
     1741 atcccctctc ttctaatgtc cttacctttt acagatgctt atgacatcat taagatccct
     1801 aaaagctcca agatagtttt cccatctaaa tgtatcttat tcaatctaac ctactaagtt
     1861 ccttctgaat tatgaggaat cattcaatat gtaccatggt ctccaaaatc caaggcctga
     1921 acatcattgt gaagacatta ttcagcttag tatcattttc acatgacagt tacctaatgt
     1981 gttcatctaa atctaccctg catagtctct ttctacctga ttaatcctca cacgagtttc
     2041 tccatcttcc ctcctttctg caataaagtt cccagtgtca tgcacaaaaa aaaaaa
//
