LOCUS       NM_001105160            1999 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide 59
            (Cyp3a59), mRNA.
ACCESSION   NM_001105160 XM_001476549
VERSION     NM_001105160.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1999)
  AUTHORS   Kazuki Y, Kobayashi K, Aueviriyavit S, Oshima T, Kuroiwa Y,
            Tsukazaki Y, Senda N, Kawakami H, Ohtsuki S, Abe S, Takiguchi M,
            Hoshiya H, Kajitani N, Takehara S, Kubo K, Terasaki T, Chiba K,
            Tomizuka K and Oshimura M.
  TITLE     Trans-chromosomic mice containing a human CYP3A cluster for
            prediction of xenobiotic metabolism in humans
  JOURNAL   Hum Mol Genet 22 (3), 578-592 (2013)
   PUBMED   23125282
REFERENCE   2  (bases 1 to 1999)
  AUTHORS   van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van
            Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O,
            van der Hoorn JW, Rosing H, Beijnen JH and Schinkel AH.
  TITLE     Knockout of cytochrome P450 3A yields new mouse models for
            understanding xenobiotic metabolism
  JOURNAL   J Clin Invest 117 (11), 3583-3592 (2007)
   PUBMED   17975676
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC104856.19.
            
            On Sep 19, 2007 this sequence version replaced XM_001476549.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.161757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC104856.19        133158-133305
            149-242             AC104856.19        139657-139750
            243-295             AC104856.19        141271-141323
            296-395             AC104856.19        144539-144638
            396-509             AC104856.19        148247-148360
            510-598             AC104856.19        150152-150240
            599-747             AC104856.19        150477-150625
            748-875             AC104856.19        152084-152211
            876-942             AC104856.19        153688-153754
            943-1103            AC104856.19        156684-156844
            1104-1330           AC104856.19        158574-158800
            1331-1493           AC104856.19        162943-163105
            1494-1999           AC104856.19        166680-167185
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.17 cM"
     gene            1..1999
                     /gene="Cyp3a59"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     59"
                     /db_xref="GeneID:100041449"
                     /db_xref="MGI:MGI:3769707"
     exon            1..148
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1589
                     /gene="Cyp3a59"
                     /note="cytochrome P450, subfamily 3A, polypeptide 59"
                     /codon_start=1
                     /product="cytochrome P450, family 3, subfamily a,
                     polypeptide 59"
                     /protein_id="NP_001098630.1"
                     /db_xref="CCDS:CCDS39390.1"
                     /db_xref="GeneID:100041449"
                     /db_xref="MGI:MGI:3769707"
                     /translation="MELIPNLSIETWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPL
                     PLFGTIFNYFDGMWKFDEDCYKKYGKIWGFYVGPKPILAIMDPEIIKIVLVKECYSVF
                     TNRPTLGPVGFLKKSITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNL
                     RREEEKGEPINMKDIFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDP
                     FLLSTILFPFLTPIYEMLNLSIFPRDSMNFFKKFVKRMKKERLASKQKNRVDFLQLMM
                     NTQNSKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDE
                     IDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEINGVFIPKGT
                     VVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYIYMPFGNGPRNCLDMRFALI
                     SMKLAVIGVLQNFTVQPCEETQIPLKISREPVFQPEKPIILKVVSRDKPRTAS"
     exon            149..242
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            243..295
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            296..395
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            396..509
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            510..598
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            599..747
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            748..875
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            876..942
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1103
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1330
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1493
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1999
                     /gene="Cyp3a59"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctagcag aggatccctg caagactctc agctgggagg gaaacttgga ggcctgaact
       61 gctaaaggaa agctaagatg gagctcatcc ccaacctttc tatagaaacc tgggtgctgc
      121 tggttactag cctggtgttc ttctacatat atgggaccta ttctcatggc ttgtttaaga
      181 aactaggaat tcctggacca aaacctctac ctttatttgg caccattttc aactactttg
      241 atggcatgtg gaaatttgat gaagattgct ataaaaagta tgggaaaata tgggggtttt
      301 atgtgggccc aaagcctata ttggctatca tggatccaga gatcatcaag attgtgctgg
      361 tgaaagaatg ttactcagtc ttcacaaacc gtccgactct tgggccagtg ggatttttga
      421 aaaagtccat taccatatct gaggatgaag aatggaagag acttagaaca ctcctgtctc
      481 caaccttcac cagtggcaaa ctcaaggaga tgttccccat catgagacag tatggagata
      541 tattggtgag aaacttgaga cgagaagaag agaaagggga gcccatcaac atgaaagaca
      601 tctttggagc ttatagcatg gatgtgatca ctggcacatc atttggagtg aacatcgatt
      661 ccctcaataa tccacagaat ccctttgtgc agaaaaccaa gaagatctta aaatttaaaa
      721 tttttgatcc atttcttctg tctacaattc tgtttccatt tcttactcca atatatgaga
      781 tgttaaatct ttccattttt ccaagagatt caatgaactt tttcaaaaaa tttgtaaaaa
      841 ggatgaagaa agaacgcctt gcttcaaaac agaagaaccg agtggatttt ctacaactga
      901 tgatgaatac tcagaactcc aaaggccaag agtcccagaa agctctttct gatctagaaa
      961 tggcagcaca agctgttatt tttattttcg ggggctatga tgccacaagc acttccattt
     1021 ccctcataat gtatgaactg gccactcacc ctgatgtgca aaaaaaactt caggatgaga
     1081 ttgacagaac tctgcccaac aaggcacctg tcacctatga tgccctgatg gacatggagt
     1141 acctggacat ggtggtgaat gaaagtctaa gattgtaccc aactgctatc aggctagaaa
     1201 gggtctcaaa aaaagatgtg gaaatcaatg gagtgttcat tcccaaaggg accgtagtca
     1261 tgataccaat ctatcctctt caccgaaacc ctgagtactg gccagagcct caagaattct
     1321 gccctggaag gttcagcaag gagaacgagg gcaacattga tccatatata tacatgccct
     1381 ttggaaatgg acccaggaac tgcctagaca tgaggtttgc tctcatcagc atgaaacttg
     1441 ctgtcatagg agtcctgcag aacttcactg tccagccttg tgaagagaca cagatccccc
     1501 tgaagatcag cagggaacca gttttccaac cagaaaaacc catcatccta aaggttgtgt
     1561 caagagataa acccagaact gcatcatgaa tttccctcag aaaccatgtt atattcttca
     1621 aggagactgt gtcacagaac accagagaat ttaattaacc ttagaacaac ataatatgag
     1681 cataatcaac tttccttgat gattgaatat tcagaaattc actgaacatg ctcagtggct
     1741 ctgcagtgta tcatctgttt tgtgattcaa aagaaattat taactcaatg gtagttgtgg
     1801 atgttcatct tctgattctc gtgggaatgt ctacactaat tccagttagt tccatccatt
     1861 ctgaattcta actgcagcaa caattttcta tagttctatt aatagaaact gttgtaatga
     1921 tggttagtaa atgtgtatca agttttctcc ttgttaaaat gtatgatatt aagtgtatac
     1981 atacatatat cttttaaaa
//
