LOCUS       NM_001100180            2004 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide 57
            (Cyp3a57), mRNA.
ACCESSION   NM_001100180 XM_001473095
VERSION     NM_001100180.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2004)
  AUTHORS   Kazuki Y, Kobayashi K, Aueviriyavit S, Oshima T, Kuroiwa Y,
            Tsukazaki Y, Senda N, Kawakami H, Ohtsuki S, Abe S, Takiguchi M,
            Hoshiya H, Kajitani N, Takehara S, Kubo K, Terasaki T, Chiba K,
            Tomizuka K and Oshimura M.
  TITLE     Trans-chromosomic mice containing a human CYP3A cluster for
            prediction of xenobiotic metabolism in humans
  JOURNAL   Hum Mol Genet 22 (3), 578-592 (2013)
   PUBMED   23125282
REFERENCE   2  (bases 1 to 2004)
  AUTHORS   van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van
            Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O,
            van der Hoorn JW, Rosing H, Beijnen JH and Schinkel AH.
  TITLE     Knockout of cytochrome P450 3A yields new mouse models for
            understanding xenobiotic metabolism
  JOURNAL   J Clin Invest 117 (11), 3583-3592 (2007)
   PUBMED   17975676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127411.3 and AC115895.9.
            
            On Jun 24, 2019 this sequence version replaced NM_001100180.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were inferred from the orthlologous transcript, X79991.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164133,
                              SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC127411.3         12386-12534         c
            150-243             AC127411.3         8383-8476           c
            244-296             AC115895.9         54232-54284
            297-396             AC115895.9         57789-57888
            397-510             AC115895.9         61201-61314
            511-599             AC115895.9         62809-62897
            600-748             AC115895.9         63132-63280
            749-876             AC115895.9         64699-64826
            877-943             AC115895.9         66406-66472
            944-1104            AC115895.9         69416-69576
            1105-1331           AC115895.9         73412-73638
            1332-1494           AC115895.9         79133-79295
            1495-2004           AC115895.9         82592-83101
FEATURES             Location/Qualifiers
     source          1..2004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.17 cM"
     gene            1..2004
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     57"
                     /db_xref="GeneID:622127"
                     /db_xref="MGI:MGI:3646373"
     exon            1..149
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1590
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /codon_start=1
                     /product="cytochrome P450, family 3, subfamily a,
                     polypeptide 57"
                     /protein_id="NP_001093650.1"
                     /db_xref="CCDS:CCDS39388.1"
                     /db_xref="GeneID:622127"
                     /db_xref="MGI:MGI:3646373"
                     /translation="MELIPNLSIQTWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPL
                     PLFGNIINYLDGMWKFDDDCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVF
                     TNRRPFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNL
                     RREEEKEEPINMKDIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKILKFKFFDP
                     FLLSVVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKKDRLDYNQKNRVDFLQLMM
                     NTQNSKGQESLKALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDE
                     IDRALPNKAPVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGT
                     IVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALI
                     SVKLAVTGVLQNFTVQPCEETQIPVKISRQPIFRPEKPIILKFVSRDKPRTGP"
     exon            150..243
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            244..296
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            297..396
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            397..510
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            511..599
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            600..748
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            749..876
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            877..943
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1104
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1331
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1494
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..2004
                     /gene="Cyp3a57"
                     /gene_synonym="EG622127"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcctagca gagaagcgct gcaagactct cagctgggag ggaaacttgg aggcctgaac
       61 tgctaaagga aagctaagat ggagctcatc cccaaccttt ctatacaaac ctgggtgctg
      121 ctggttacta gcctggtgtt cttctacata tatgggacct attctcatgg tctctttaag
      181 aaactaggaa ttcctggacc aaaacctctg cctttatttg gcaacattat caactacctt
      241 gatggcatgt ggaaatttga tgatgattgc tataaaaaat atggaaaaat atgggggttt
      301 tatgagggcc cacagcctat attggctatc atggatccag agatcatcaa aattgtgctg
      361 gtgaaagaat gttactcagt cttcacaaac cgtcggcctt ttgggccagt gggatttttg
      421 aaaaagtcca ttaccatatc tgaggatgaa gaatggaaga gacttcgaac actcctgtct
      481 ccaaccttca ccagtagcaa actcaaggag atgttcccca tcatgagaca gtatggagat
      541 atattggtga gaaacttgag acgagaagaa gagaaagagg agcccatcaa catgaaagat
      601 atctttggag cttatagcat ggatgtgatc actggtacat catgtggagt gaacatcgat
      661 tccctcaata atccacagga tccctttgtg cagaaaatca agaagatctt aaaatttaaa
      721 ttttttgatc catttcttct ttctgtagtt ctgtttccat ttcttactcc aatatatgag
      781 atgttaaatc tttccatttt tccaagacag tcaatgaact ttttcaaaaa atttgtaaaa
      841 aagatgaaga aagatcgcct tgattacaac cagaagaacc gagtagattt tctacaactg
      901 atgatgaata ctcagaactc caaaggccaa gagtccctga aagctctttc tgatctagaa
      961 atggcagcac aaactcttat ttttattttc gggggctatg atggcacaag cacctccatt
     1021 tccttcataa tgtatgaact ggccactcac cctgatgtgc aaaagaaact tcaggatgag
     1081 attgacagag ctttgcccaa taaggcacct gtcacctatg atgccctgat ggacatggag
     1141 tacctggaca tggtggtgaa tgaaagtcta agactgtacc cagttgttag caggatagac
     1201 aggttctcaa aaaaagatgt ggaaattcat ggagtgttta ttcccaaagg gacaatagtt
     1261 atgataccaa tctatcctct tcatcgggac cccgagtact ggccagagcc tgaagacttc
     1321 tgccctgaaa ggttcagcaa ggagaacaag ggcaacattg atccatatat atacatgccc
     1381 tttgggaatg gacccaggaa ctgcataggc atgaggtttg ctctcatcag cgtgaaactt
     1441 gctgtcacag gagtcttgca gaacttcact gtccagcctt gtgaggagac acagatccct
     1501 gtgaagatca gcaggcaacc aattttccga ccagaaaaac ccatcatcct aaagtttgtg
     1561 tcaagagata aacccagaac tggaccgtga atttccttca gaaaccatgt tatattcttc
     1621 aaggggcttg tgtcacagaa caccagagaa tttaattaac cttagaacaa gaccaacata
     1681 atatgggcat aatcctcttt ccttgatgac taagtattaa gaaactcatt gaacatgctc
     1741 agtgtctctg cagtatatca tctattgtgt gattcaaagg aaattattga ctcaatgtta
     1801 gacgtggaga ttcatcttct gattctcgtg ggaccatcta cacttattcc agttagttcc
     1861 atccattctg aattctaact gcagcaacta tttatctcta gttctatcaa tagaaaccat
     1921 tgtaataact gttagtaaat gtgtatcaag ttttctctat gtaaaatata tgatattaag
     1981 aatatacata aatatatctt tcaa
//
