LOCUS       NM_177380               1962 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide 44
            (Cyp3a44), mRNA.
ACCESSION   NM_177380 XM_982854
VERSION     NM_177380.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Chang,M.M., Lin,C.N., Fang,C.C., Chen,M., Liang,P.I., Li,W.M.,
            Yeh,B.W., Cheng,H.C., Huang,B.M., Wu,W.J. and Chen,Y.A.
  TITLE     Glycine N-methyltransferase inhibits aristolochic acid nephropathy
            by increasing CYP3A44 and decreasing NQO1 expression in female
            mouse hepatocytes
  JOURNAL   Sci Rep 8 (1), 6960 (2018)
   PUBMED   29725048
  REMARK    GeneRIF: Hepatic GNMT protected mice from aristolochic acids
            induced nephropathy by enhancing CAR/PXR/CYP3A44/3A41
            transcriptions and reducing Nrf2/NQO1 transcriptions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Zaphiropoulos,P.G.
  TITLE     A map of the mouse Cyp3a locus
  JOURNAL   DNA Seq 14 (3), 155-162 (2003)
   PUBMED   14509827
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   Sakuma,T., Endo,Y., Mashino,M., Kuroiwa,M., Ohara,A.,
            Jarukamjorn,K. and Nemoto,N.
  TITLE     Regulation of the expression of two female-predominant CYP3A mRNAs
            (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones
  JOURNAL   Arch Biochem Biophys 404 (2), 234-242 (2002)
   PUBMED   12147261
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC166648.4.
            
            On Nov 17, 2006 this sequence version replaced NM_177380.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039380.1, BC125522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC166648.4         59092-59247
            157-250             AC166648.4         61209-61302
            251-303             AC166648.4         63638-63690
            304-403             AC166648.4         65546-65645
            404-517             AC166648.4         69950-70063
            518-606             AC166648.4         70143-70231
            607-755             AC166648.4         70499-70647
            756-883             AC166648.4         73224-73351
            884-953             AC166648.4         74247-74316
            954-1114            AC166648.4         76445-76605
            1115-1341           AC166648.4         85217-85443
            1342-1504           AC166648.4         86883-87045
            1505-1962           AC166648.4         90526-90983
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.17 cM"
     gene            1..1962
                     /gene="Cyp3a44"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     44"
                     /db_xref="GeneID:337924"
                     /db_xref="MGI:MGI:2449818"
     exon            1..156
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1600
                     /gene="Cyp3a44"
                     /note="cytochrome P450, 3a44"
                     /codon_start=1
                     /product="cytochrome P450, family 3, subfamily a,
                     polypeptide 44"
                     /protein_id="NP_796354.1"
                     /db_xref="CCDS:CCDS19864.1"
                     /db_xref="GeneID:337924"
                     /db_xref="MGI:MGI:2449818"
                     /translation="MNLFSALSLDTLVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPL
                     PFLGTVLNYYTGIWKFDMECYEKYGKTWGLFDGQTPLLVITDPETIKNVLVKDCLSVF
                     TNRREFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYL
                     RQEAEKGMPVAMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDP
                     LLFSVVLFPLLTPVYEMLNICMFPNDSIEFFKKFVDRMQESRLDSNQKHRVDFLQLMM
                     NSHNNSKDKDSHKAFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQA
                     EIDKALPNKATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKG
                     SMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFAL
                     MNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKVVPRDAVITGA"
     exon            157..250
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            251..303
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            304..403
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            404..517
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            518..606
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            607..755
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            756..883
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            884..953
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1114
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1341
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1504
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1962
                     /gene="Cyp3a44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp3a44"
                     /note="hexamer: AATAAA"
     polyA_site      1821
                     /gene="Cyp3a44"
                     /note="major polyA site"
ORIGIN      
        1 aggcagaaag gaagccctac agagagtcac acatacatct ggagggggaa cactgaggag
       61 taaaattgca gacagacaag cagggatgaa cctattttca gctctctcac tggatacatt
      121 ggtcctgctg gcaatcatcc tggtgctcct ctaccgatat gggacccgta cacatggact
      181 ttttaagaaa caggggattc ctgggcccaa acctctgcca tttttaggca ctgtgctgaa
      241 ttattacacg ggtatatgga aatttgacat ggagtgctat gaaaagtatg gaaaaacatg
      301 ggggttgttt gatggtcaaa cacctctcct tgtcatcacg gacccagaga cgattaagaa
      361 tgtgctagtg aaggattgtt tatctgtctt cacaaaccgg cgggaatttg gcccagtggg
      421 gataatgagt aaagctatct caatatctaa ggatgaggaa tggaagagat atagagcttt
      481 gctgtccccc acattcacca gtggaagact caaggagatg ttccctgtca ttgaacagta
      541 tggagacatt ttggtaaagt acttgaggca agaggcagag aaaggcatgc ctgttgctat
      601 gaaagatgtg ttaggtgctt acagcatgga tgtgatcacc agcacatcat ttggagtgaa
      661 cgtggattcc ctcaacaacc cagaggatcc ttttgtggag gaagccaaaa agtttttaag
      721 agttgacttt tttgatcctt tgctcttctc agtagtactt tttccattac tgacaccagt
      781 atatgagatg ttaaatatct gcatgttccc aaatgattca atagaatttt tcaaaaaatt
      841 tgtggacaga atgcaggaaa gccgcctgga ttctaatcag aagcaccgag tggattttct
      901 tcagctgatg atgaattctc ataataattc caaagacaaa gactctcata aagccttttc
      961 taacatggag atcacagtcc agtcaattat ctttatttct gctgggtatg aaaccaccag
     1021 tagcacactt tccttcacct tgtattgttt ggccactcac cctgatatcc agaagaaact
     1081 gcaggcagag atcgataagg ctctgcccaa taaggcaact cccacctgtg atactgtgat
     1141 ggagatggaa tacctggata tggtgcttaa tgaaaccctc agattatatc ccattgttac
     1201 tagacttgag agagtctgta agaaagatgt tgaactcaat ggtgtgtata tccccaaagg
     1261 gtcaatggtg atgattccat cttatgctct tcaccatgac ccacagcact ggccagaccc
     1321 tgaagaattc caacctgaaa ggttcagcaa ggagaacaag ggcagcattg atccttacgt
     1381 atatctgccc tttggaattg gacccaggaa ctgcattggc atgaggtttg ctctcatgaa
     1441 tatgaaactt gctgtcacta aagttctgca gaacttttcc ttccagcctt gtcaggaaac
     1501 acagatacct ctgaaattaa gcagacaagg aattcttcaa ccagaaaaac ccattgttct
     1561 aaaagttgtg ccacgggatg cagttataac tggagcatga cattccctca aggagttctt
     1621 ctgagttctt caggaaggca gtgtctaaga acatcagaca ctttagtttc atcatgagta
     1681 aaatccagat gaataatgga cttaatagat tgattttgat tcatggttaa agattcagta
     1741 catccactga gctttctcag tgtctgtgca agttaacata taatacgaaa gagatgaata
     1801 aatcagtgac agcaaaggaa atttgccttc accgtttctc atgggatcat ctctatccac
     1861 atctcattgt ctctgctaat tccttttgag atctttagat agtaaccacg tgtttgtaat
     1921 ttgatcaaga atttttgatg aaaatgagag ctattgtaac aa
//
