LOCUS       NM_001105159            2064 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide
            41B (Cyp3a41b), mRNA.
ACCESSION   NM_001105159 XM_001476442
VERSION     NM_001105159.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Sakuma,T., Takai,M., Endo,Y., Kuroiwa,M., Ohara,A., Jarukamjorn,K.,
            Honma,R. and Nemoto,N.
  TITLE     A novel female-specific member of the CYP3A gene subfamily in the
            mouse liver
  JOURNAL   Arch Biochem Biophys 377 (1), 153-162 (2000)
   PUBMED   10775455
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124483.4.
            
            On Sep 19, 2007 this sequence version replaced XM_001476442.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849386
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC124483.4         1709-1870
            163-256             AC124483.4         3831-3924
            257-309             AC124483.4         6335-6387
            310-409             AC124483.4         8244-8343
            410-523             AC124483.4         12695-12808
            524-612             AC124483.4         12888-12976
            613-761             AC124483.4         13248-13396
            762-889             AC124483.4         15981-16108
            890-959             AC124483.4         16999-17068
            960-1120            AC124483.4         19572-19732
            1121-1347           AC124483.4         21876-22102
            1348-1510           AC124483.4         23530-23692
            1511-2064           AC124483.4         27222-27775
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.17 cM"
     gene            1..2064
                     /gene="Cyp3a41b"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     41B"
                     /db_xref="GeneID:100041375"
                     /db_xref="MGI:MGI:3714859"
     exon            1..162
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1606
                     /gene="Cyp3a41b"
                     /EC_number="1.14.14.1"
                     /codon_start=1
                     /product="cytochrome P450 3A41"
                     /protein_id="NP_001098629.1"
                     /db_xref="CCDS:CCDS39389.1"
                     /db_xref="GeneID:100041375"
                     /db_xref="MGI:MGI:3714859"
                     /translation="MNLFSALSLDTWVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPL
                     PFLGTVLNYYKGLWKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVF
                     TNRREFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYL
                     MQEAEKGKPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDP
                     LVFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMM
                     NAHNNSKDKDSHKALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQE
                     EIDETLPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKG
                     STVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAF
                     MTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKVVPRDVVITGA"
     exon            163..256
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            257..309
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            310..409
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            410..523
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            524..612
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            613..761
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            762..889
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            890..959
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1120
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1347
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1510
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..2064
                     /gene="Cyp3a41b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2040..2045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp3a41b"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="Cyp3a41b"
                     /note="major polyA site"
ORIGIN      
        1 aggcagaaag gtagccctac agagagtcac acacacacac acatctggag ggagaacact
       61 gaggagtaaa attgctgaca gacaagcagg gatgaaccta ttttcagctc tctcactgga
      121 tacatgggtc ctcctggcaa tcatcctggt gctcctctac cgatatggga cccgtacaca
      181 tggacttttt aagaaacagg ggattcctgg acccaaacct ctgccatttt taggcactgt
      241 gctgaattat tacaagggtt tatggaaatt tgacatggag tgctatgaaa agtatggaaa
      301 aacatggggg ttgtttgatg gtcaaatgcc tctctttgtc atcacggacc cagagatgat
      361 taagaatgtt ctagtgaagg aatgtttttc tgtcttcaca aaccggcggg aatttggccc
      421 agtgggtata atgagtaaag ctatctcaat atctaaggat gaggaatgga agagatatag
      481 agctttgctg tcccccacat tcaccagtgg aaaactcaag gagatgtttc ctgtcattga
      541 acagtatgga gacattttgg taaagtactt gatgcaagag gcagagaaag gcaagcctgt
      601 tactatgaaa gatgtgttag gtgcttacag catagatgtg atcaccagca catcatttgg
      661 agtgaatgtg gattccctca acaacccaga ggatcccttt gtggagaaag ccaaagggat
      721 tttaagagtt gacttttttg atcctttggt cttctcagtt gtactttttc cattcctgac
      781 accagtatat gaaatgttaa atatctgcat gttcccaaag gattcaatag aatttttcaa
      841 aaaatttgtg aacagaatga aggaaagccg cctcgattct aagcagaagc accgagttga
      901 ttttcttcag ctgatgatga acgctcataa taattccaaa gacaaagact ctcataaagc
      961 cctttctgac atggagatca cagcccagtc aattgtcttt atttttgctg ggtatgaaac
     1021 caccagtagc acactttcct tcaccctgta ttgtttggcc actcaccctg atatccagaa
     1081 gaaactgcag gaagagatcg atgagactct gcccaataag gcacctccca cctatgatac
     1141 tgtgatggag atggaatacc tggatatggt gcttaatgaa accctcagat tatatcccat
     1201 tggtaataga cttgagagat tctgtaagaa agatgttgaa ctcaatggtg tgtatatccc
     1261 caaagggtca acagtgatga ttccatctta tgctcttcac catgacccac agcactggcc
     1321 agagcctgaa gaattccaac ctgaaaggtt cagcaaagag aacaagggca gcattgatcc
     1381 ttatttatat atgccctttg gaattggacc caggaactgc attggcatga ggtttgcttt
     1441 catgactatg aaacttgctc tcactaaagt tatgcagaac ttttccttcc agccttgtca
     1501 ggaaacacag atacctctga aattaagcag acaaggactt cttcaaccag aaaaacccat
     1561 tgttctaaag gttgtaccac gggatgtagt tataactgga gcatgagttt ccctcaagga
     1621 gttctgctga gttcttcaga aaggcagtgt ctaagaacat cagatatgtt agtttcatca
     1681 tgagtaaaat cgagatgaat aaggggctta atagattgat tttgattcat ggttaaagat
     1741 tcagtacatc cactgagctt tctcagtgtc tgtacaggtt atcatctaat taaaaagaga
     1801 tgaataaatt agtgacagca cagcaaattt gccttcactg gttctcatgg gaccatctcc
     1861 atccacatct cattgtctct gctaattcct tttgagatct tttgatagta accaagtgtt
     1921 tgtaatttga acaaaaattt ttgatgaaaa tgtgagctat tgtaacatct ctaattgtag
     1981 aattgttatc agatgcttta gttgccatat tttataataa atgctgcaca gaaaatgtaa
     2041 ataaacactt attaaaaatc ctca
//
