LOCUS       NM_017396               2060 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide
            41A (Cyp3a41a), mRNA.
ACCESSION   NM_017396 XM_917375
VERSION     NM_017396.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2060)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   2  (bases 1 to 2060)
  AUTHORS   Armfield,B.A., Seifert,A.W., Zheng,Z., Merton,E.M., Rock,J.R.,
            Lopez,M.C., Baker,H.V. and Cohn,M.J.
  TITLE     Molecular Characterization of the Genital Organizer: Gene
            Expression Profile of the Mouse Urethral Plate Epithelium
  JOURNAL   J Urol 196 (4), 1295-1302 (2016)
   PUBMED   27173853
REFERENCE   3  (bases 1 to 2060)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 2060)
  AUTHORS   Bhadhprasit,W., Sakuma,T., Kawasaki,Y. and Nemoto,N.
  TITLE     Hepatocyte nuclear factor 4alpha regulates expression of the mouse
            female-specific Cyp3a41 gene in the liver
  JOURNAL   Drug Metab Dispos 39 (3), 490-497 (2011)
   PUBMED   21088200
  REMARK    GeneRIF: Data suggest that modification of histones bound to
            Cyp3a41 gene contributes to sex specificity of Cyp3a41 expression
            by controlling access of HNF4 to DNA.
REFERENCE   5  (bases 1 to 2060)
  AUTHORS   van Waterschoot,R.A., Rooswinkel,R.W., Wagenaar,E., van der
            Kruijssen,C.M., van Herwaarden,A.E. and Schinkel,A.H.
  TITLE     Intestinal cytochrome P450 3A plays an important role in the
            regulation of detoxifying systems in the liver
  JOURNAL   FASEB J 23 (1), 224-231 (2009)
   PUBMED   18794335
REFERENCE   6  (bases 1 to 2060)
  AUTHORS   Sakuma,T., Kitajima,K., Nishiyama,M., Endo,Y., Miyauchi,K.,
            Jarukamjorn,K. and Nemoto,N.
  TITLE     Collaborated regulation of female-specific murine Cyp3a41 gene
            expression by growth and glucocorticoid hormones
  JOURNAL   Biochem Biophys Res Commun 314 (2), 495-500 (2004)
   PUBMED   14733933
  REMARK    GeneRIF: Cyp3a41 gene expression is regulated by growth and
            glucocorticoid hormones
REFERENCE   7  (bases 1 to 2060)
  AUTHORS   Zaphiropoulos,P.G.
  TITLE     A map of the mouse Cyp3a locus
  JOURNAL   DNA Seq 14 (3), 155-162 (2003)
   PUBMED   14509827
REFERENCE   8  (bases 1 to 2060)
  AUTHORS   Sakuma,T., Takai,M., Endo,Y., Kuroiwa,M., Ohara,A., Jarukamjorn,K.,
            Honma,R. and Nemoto,N.
  TITLE     A novel female-specific member of the CYP3A gene subfamily in the
            mouse liver
  JOURNAL   Arch Biochem Biophys 377 (1), 153-162 (2000)
   PUBMED   10775455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166648.4.
            
            On Mar 19, 2008 this sequence version replaced NM_017396.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033414.1, SRR5189685.189634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC166648.4         144830-144987
            159-252             AC166648.4         146948-147041
            253-305             AC166648.4         149444-149496
            306-405             AC166648.4         151353-151452
            406-519             AC166648.4         155808-155921
            520-608             AC166648.4         156001-156089
            609-757             AC166648.4         156361-156509
            758-885             AC166648.4         159089-159216
            886-955             AC166648.4         160106-160175
            956-1116            AC166648.4         162678-162838
            1117-1343           AC166648.4         165014-165240
            1344-1506           AC166648.4         166667-166829
            1507-2060           AC166648.4         170365-170918
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.17 cM"
     gene            1..2060
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     41A"
                     /db_xref="GeneID:53973"
                     /db_xref="MGI:MGI:1858451"
     exon            1..158
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1602
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     41; steroid inducible; cytochrome P450, steroid inducible
                     3a41"
                     /codon_start=1
                     /product="cytochrome P450 3A41"
                     /protein_id="NP_059092.2"
                     /db_xref="CCDS:CCDS19863.1"
                     /db_xref="GeneID:53973"
                     /db_xref="MGI:MGI:1858451"
                     /translation="MNLFSALSLDTWVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPL
                     PFLGTVLNYYKGLWKFDMECYEKYGKTWGLFDGQMPLFVITDPEMIKNVLVKECFSVF
                     TNRREFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYL
                     MQEAEKGKPVTMKDVLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDP
                     LVFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQKHRVDFLQLMM
                     NAHNNSKDKDSHKALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQE
                     EIDETLPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKG
                     STVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAF
                     MTMKLALTKVMQNFSFQPCQETQIPLKLSRQGLLQPEKPIVLKVVPRDVVITGA"
     exon            159..252
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            253..305
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            306..405
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            406..519
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            520..608
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            609..757
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            758..885
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            886..955
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1116
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1343
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1506
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..2060
                     /gene="Cyp3a41a"
                     /gene_synonym="Cyp3a41"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagaaag gtagccctac agagagtcac acacacacat ctggagggag aacactgagg
       61 agtaaaattg ctgacagaca agcagggatg aacctatttt cagctctctc actggataca
      121 tgggtcctcc tggcaatcat cctggtgctc ctctaccgat atgggacccg tacacatgga
      181 ctttttaaga aacaggggat tcctgggccc aaacctctgc catttttagg cactgtgctg
      241 aattattaca agggtttatg gaaatttgac atggagtgct atgaaaagta tggaaaaaca
      301 tgggggttgt ttgatggtca aatgcctctc tttgtcatca cggacccaga gatgattaag
      361 aatgttctag tgaaggaatg tttttctgtc ttcacaaacc ggcgggaatt tggcccagtg
      421 gggataatga gtaaagctat ctcaatatct aaggatgagg aatggaagag atatagagct
      481 ttgctgtccc ccacattcac cagtggaaaa ctcaaggaga tgtttcctgt cattgaacag
      541 tatggagaca ttttggtaaa gtacttgatg caagaggcag agaaaggcaa gcctgttact
      601 atgaaagatg tgttaggtgc ttacagcata gatgtgatca ccagcacatc atttggagtg
      661 aatgtggatt ccctcaacaa cccagaggat ccctttgtgg agaaagccaa agggatttta
      721 agagttgact tttttgatcc tttggtcttc tcagttgtac tttttccatt cctgacacca
      781 gtatatgaaa tgttaaatat ctgcatgttc ccaaaggatt caatagaatt tttcaaaaaa
      841 tttgtgaaca gaatgaagga aagccgcctc gattctaagc agaagcaccg agttgatttt
      901 cttcagctga tgatgaacgc tcataataat tccaaagaca aagactctca taaagccctt
      961 tctgacatgg agatcacagc ccagtcaatt gtctttattt ttgctgggta tgaaaccacc
     1021 agtagcacac tttccttcac cctgtattgt ttggccactc accctgatat ccagaagaaa
     1081 ctgcaggaag agatcgatga gactctgccc aataaggcac ctcccaccta tgatactgtg
     1141 atggagatgg aatacctgga tatggtgctt aatgaaaccc tcagattata tcccattggt
     1201 aatagacttg agagattctg taagaaagat gttgaactca atggtgtgta tatccccaaa
     1261 gggtcaacag tgatgattcc atcttatgct cttcaccatg acccacagca ctggccagag
     1321 cctgaagaat tccaacctga aaggttcagc aaagagaaca agggcagcat tgatccttat
     1381 ttatatatgc cctttggaat tggacccagg aactgcattg gcatgaggtt tgctttcatg
     1441 actatgaaac ttgctctcac taaagttatg cagaactttt ccttccagcc ttgtcaggaa
     1501 acacagatac ctctgaaatt aagcagacaa ggacttcttc aaccagaaaa acccattgtt
     1561 ctaaaggttg taccacggga tgtagttata actggagcat gagtttccct caaggagttc
     1621 tgctgagttc ttcagaaagg cagtgtctaa gaacatcaga tatgttagtt tcatcatgag
     1681 taaaatcgag atgaataagg ggcttaatag attgattttg attcatggtt aaagattcag
     1741 tacatccact gagctttctc agtgtctgta caggttatca tctaattaaa aagagatgaa
     1801 taaattagtg acagcacagc aaatttgcct tcactggttc tcatgggacc atctccatcc
     1861 acatctcatt gtctctgcta attccttttg agatcttttg atagtaacca agtgtttgta
     1921 atttgaacaa aaatttttga tgaaaatgtg agctattgta acatctctaa ttgtagaatt
     1981 gttatcagat gctttagttg ccatatttta taataaatgc tgcacagaaa atgtaaataa
     2041 acacttatta aaaatcctca
//
