LOCUS       NM_019792               2002 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide 25
            (Cyp3a25), transcript variant 1, mRNA.
ACCESSION   NM_019792 XM_001004890 XM_972785 XM_972825 XM_972859 XM_972905
VERSION     NM_019792.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Creasy,K.T., Jiang,J., Ren,H., Peterson,M.L. and Spear,B.T.
  TITLE     Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic
            Cyp Gene Expression in the Adult Mouse Liver
  JOURNAL   Gene Expr 17 (1), 7-17 (2016)
   PUBMED   27197076
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Zaphiropoulos,P.G.
  TITLE     A map of the mouse Cyp3a locus
  JOURNAL   DNA Seq 14 (3), 155-162 (2003)
   PUBMED   14509827
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Dai,D., Bai,R., Hodgson,E. and Rose,R.L.
  TITLE     Cloning, sequencing, heterologous expression, and characterization
            of murine cytochrome P450 3a25*(Cyp3a25), a testosterone
            6beta-hydroxylase
  JOURNAL   J Biochem Mol Toxicol 15 (2), 90-99 (2001)
   PUBMED   11284050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY099368.1, Y11995.1 and AK149541.1.
            
            On Nov 21, 2009 this sequence version replaced NM_019792.1.
            
            Transcript Variant: This variant (1) encodes a functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028855.1, AF204959.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY099368.1         3-20
            19-1270             Y11995.1           21-1272
            1271-2002           AK149541.1         1184-1915
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.17 cM"
     gene            1..2002
                     /gene="Cyp3a25"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     25"
                     /db_xref="GeneID:56388"
                     /db_xref="MGI:MGI:1930638"
     exon            1..148
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1589
                     /gene="Cyp3a25"
                     /EC_number="1.14.14.1"
                     /note="cytochrome P450, 3a25; CYPIIIA25"
                     /codon_start=1
                     /product="cytochrome P450 3A25"
                     /protein_id="NP_062766.2"
                     /db_xref="CCDS:CCDS19866.1"
                     /db_xref="GeneID:56388"
                     /db_xref="MGI:MGI:1930638"
                     /translation="MELIPNLSIETWVLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPL
                     PLLGTIFNYYDGMWKFDEDCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVF
                     TNRRFFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNL
                     RREEEKGEPISMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKIFDP
                     FLLSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQKNRVDFLQLMM
                     NTQNSKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDE
                     IDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGT
                     VVMIPIYPLHRNPEYWPEPQEFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALI
                     SIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQPEKPIILKVVSRDKPRTGS"
     exon            149..242
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            243..295
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            296..395
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            396..509
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            510..598
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            599..747
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            748..875
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            876..942
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1103
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1330
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1493
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..2002
                     /gene="Cyp3a25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1985..1990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp3a25"
                     /note="hexamer: AATATA"
     polyA_site      2000
                     /gene="Cyp3a25"
                     /note="major polyA site"
ORIGIN      
        1 ggcctagcag aggatccctg caagactctc agctgggagg gaaacttgga ggcctgaact
       61 gctaaaggaa agctaagatg gagctcatcc ccaacctttc tatagaaacc tgggtgctgc
      121 tggttactag cctggtgctc ttctacatat atgggaccta ttctcatggc ttgtttaaga
      181 aactaggaat tcctggacca aaacctctac cgttacttgg caccattttc aactactatg
      241 atggcatgtg gaaatttgat gaagattgct ataaaaagta tgggaaaata tgggggtttt
      301 atgagggccc acagcctata ttggctatca tggatccaga gatcatcaag attgtgctgg
      361 tgaaagaatg ttactcagtc ttcacaaacc gtcggttttt tgggccagtg ggattcatga
      421 aaaaggccat taccatatct gaggatgaag aatggaagag acttagaaca ctcctgtctc
      481 caaccttcac cagtggcaaa ctcaaggaga tgttccccat catgagacag tatggagata
      541 tattggtgag aaacttgaga cgagaagaag agaaagggga gcccatcagt atgaaagaca
      601 tctttggagc ttatagcatg gatgtgatca ctggcacatc atttggcgtg aacgtcgatt
      661 ccctcaataa tccacaggat ccctttgtgc agaaagccaa gaagatctta aaatttaaaa
      721 tttttgatcc atttcttctg tctataattc tgtttccatt tcttactcca atatatgaga
      781 tgttaaactt ttccattttt ccaagagatt caatgaactt tttcaaaaaa tttgtaaaaa
      841 ggatgaagaa agaacgcctt gcttcaaacc agaagaaccg agtggatttt ctacaactga
      901 tgatgaatac tcagaactcc aaaggccaag agtcacagaa agctctttct gatctagaaa
      961 tggcagcaca agctgttatt tttatcttcg ggggctatga tgccacaagc acttccattt
     1021 ccctcataat gtatgaactg gccactcacc ctgatgtgca aaaaaaactt caggatgaga
     1081 ttgacagaac tctgcccaat aaggcacctg tcacctatga cgccctgatg gacatggagt
     1141 acctggacat ggtggtgaat gaaagtctaa gattgtaccc aattgctatc aggctagaaa
     1201 gggtctcaaa aaaagatgtg gaaatcaatg gagtgttcat tcccaaaggg accgtagtta
     1261 tgataccaat ctatcctctt caccgaaatc ctgagtactg gccagagcct caggaattct
     1321 gccctgaaag gttcagcaag gagaacaagg gcaacattga tccatatata tacatgccct
     1381 ttggaaatgg acccaggaac tgcataggca tgaggtttgc tctcatcagc atcaaacttg
     1441 ctgtcatagg agtcctgcag aacttcactg tccagccttg tgaagagaca cagatccccc
     1501 tgaagatcag cagggaacca attttccaac cagaaaaacc catcatccta aaggttgtgt
     1561 caagagataa acccagaact ggatcatgaa tttccctcag aaaacatgtt atattcttca
     1621 aggagactgt gtcatagaac acaagagaat ttaattaact ttagaacaac ataatatggg
     1681 catactcaac tttccttgat gattgaatat tcagaaattc actgaacatg ctcagtgact
     1741 atgcagtgta tcatctattt tgtgattcaa aggaaattat taactcaatg gtagttgtgg
     1801 atgttcacct tctgattctt gtgggaatgt ctacactaat tccagttagt tacatccatt
     1861 ctgaattcta actgcagcaa ctatttctct atcattttat taatagaaac ccttgtaatg
     1921 atggttagta aatgtgtatc aagttttctc tttgttaaaa tgtatgatat taagtgtata
     1981 cataaatata tcttttaaaa tg
//
