LOCUS       NM_007820               1730 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide 16
            (Cyp3a16), mRNA.
ACCESSION   NM_007820
VERSION     NM_007820.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Creasy,K.T., Jiang,J., Ren,H., Peterson,M.L. and Spear,B.T.
  TITLE     Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic
            Cyp Gene Expression in the Adult Mouse Liver
  JOURNAL   Gene Expr 17 (1), 7-17 (2016)
   PUBMED   27197076
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Casey,S.C. and Blumberg,B.
  TITLE     The steroid and xenobiotic receptor negatively regulates B-1 cell
            development in the fetal liver
  JOURNAL   Mol Endocrinol 26 (6), 916-925 (2012)
   PUBMED   22496360
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Li,Y., Cui,Y., Hart,S.N., Klaassen,C.D. and Zhong,X.B.
  TITLE     Dynamic patterns of histone methylation are associated with
            ontogenic expression of the Cyp3a genes during mouse liver
            maturation
  JOURNAL   Mol Pharmacol 75 (5), 1171-1179 (2009)
   PUBMED   19188337
  REMARK    GeneRIF: Dynamic patterns of histone methylation are associated
            with ontogenic expression of the Cyp3a genes during mouse liver
            maturation.
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Zaphiropoulos,P.G.
  TITLE     A map of the mouse Cyp3a locus
  JOURNAL   DNA Seq 14 (3), 155-162 (2003)
   PUBMED   14509827
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Itoh,S., Abe,Y., Kubo,A., Okuda,M., Shimoji,M., Nakayama,K. and
            Kamataki,T.
  TITLE     Isolation of a promoter region in mouse cytochrome P450 3A
            (Cyp3A16) gene and its transcriptional control
  JOURNAL   Biochim Biophys Acta 1350 (2), 155-158 (1997)
   PUBMED   9048885
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   Itoh,S., Satoh,M., Abe,Y., Hashimoto,H., Yanagimoto,T. and
            Kamataki,T.
  TITLE     A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA
            cloning and expression in fetal liver
  JOURNAL   Eur J Biochem 226 (3), 877-882 (1994)
   PUBMED   7813478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY772732.1, BC113143.1 and AC115895.9.
            
            On Apr 22, 2009 this sequence version replaced NM_007820.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26137.1, BC113143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BY772732.1         2-36
            36-433              BC113143.1         1-398
            434-434             AC115895.9         148318-148318       c
            435-887             BC113143.1         400-852
            888-888             AC115895.9         144036-144036       c
            889-1726            BC113143.1         854-1691
            1727-1730           AC115895.9         128484-128487       c
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.17 cM"
     gene            1..1730
                     /gene="Cyp3a16"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     16"
                     /db_xref="GeneID:13114"
                     /db_xref="MGI:MGI:106099"
     exon            1..154
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1598
                     /gene="Cyp3a16"
                     /EC_number="1.14.14.1"
                     /note="CYPIIIA16; cytochrome P450, 3a16"
                     /codon_start=1
                     /product="cytochrome P450 3A16"
                     /protein_id="NP_031846.2"
                     /db_xref="CCDS:CCDS19862.1"
                     /db_xref="GeneID:13114"
                     /db_xref="MGI:MGI:106099"
                     /translation="MNLFSALSLDTLVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPL
                     PFLGTVLNYYKGLWKFDMECYEKYGKTWGLFDGQIPLFVITDPETIKNVLVKECFSVF
                     TNRQDFFPVGIMSKSISLAKDEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYL
                     RQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNIDSLNNPEDPFVENAKKVLRFDYFDP
                     LSLSVALFPFLTPIYEMLNICMFPKDSIEFFKKFVDRMTENRLDSKQKHRVDFIYLMM
                     EAYNKSKDKDSHKALSEIEITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQE
                     EIDEALPNKAPPTYDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKDVEINGIYIPKG
                     STVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFAL
                     MNMKLALIKVLQNFSFQPCKETQIPLKLSRELLLQPVKPIVLKVVPRDAVITGA"
     exon            155..248
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            249..301
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            302..401
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            402..515
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            516..604
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            605..753
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            754..881
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            882..951
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1112
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1339
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1502
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1730
                     /gene="Cyp3a16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp3a16"
                     /note="hexamer: AATAAA"
     polyA_site      1703
                     /gene="Cyp3a16"
                     /note="major polyA site"
ORIGIN      
        1 agaaaggaag ccctacagag agtcacacac acacatctgg agggagaaca ctgaggagta
       61 aaattgcaga cagacaagca gagatgaacc tattttcagc gctctcactg gatacattgg
      121 tcctcctggc aatcatcctg gtgctcctct accgatatgg gacctgtaca catggacttt
      181 ttaagaaaca gggaattcct gggcccaaac ctctgccatt tttaggcact gtcctgaatt
      241 attacaaggg tttatggaaa tttgacatgg agtgctatga aaagtatgga aaaacgtggg
      301 ggttgtttga tggtcaaata cctctctttg tcatcacgga cccagagacg attaagaatg
      361 tgctagtgaa ggaatgtttt tctgtcttca caaaccggca ggattttttc ccagtgggga
      421 taatgagtaa atccatctct ctagctaaag atgaggaatg gaagagatat agagctttgc
      481 tgtcccccac attcaccagt ggaaatctca aggagatgtt tcctgtcatt gaacagtatg
      541 gagacatttt ggtaaagtac ttgaggcaag aggcagagaa aggcaagcct gttgctgtga
      601 aagatgtgtt aggtgcctac agcatggatg tgatcatcag cacaacattt ggagtgaaca
      661 tagattccct caacaaccca gaggatcctt ttgtggagaa tgccaagaag gttttaagat
      721 ttgattattt tgatcctttg tccttgtcag tagcactctt tccattcctc acaccaatat
      781 atgagatgtt aaatatctgc atgttcccaa aggattcaat agaatttttc aaaaaatttg
      841 tggatagaat gacagaaaac cgcctggatt ctaagcagaa gcaccgcgtg gactttattt
      901 atctgatgat ggaagcttat aataagtcaa aagacaaaga ctctcataaa gccctttctg
      961 aaatcgagat cacagcccag tcaattattt ttatttttgc tgggtatgaa accaccagca
     1021 gcatactttc cttcaccgtg tattccttgg ccactcaccc tgatatccag aagaaactgc
     1081 aggaggagat cgatgaggct ctgcccaata aggcacctcc cacctatgat accgtgatgg
     1141 cgatggaata cctggatatg gtgctgaatg aaaccctcag attatatccc attactaata
     1201 gacttcagag agtctgtaaa aaggatgttg aaatcaatgg tatttatatc ccgaaagggt
     1261 caacagtgat aattccatct tatgttcttc accatgaccc acagcactgg ccagagcctg
     1321 aagaattcca acctgaaagg ttcagcaagg agaacaaggg cagcattgat ccttatgtat
     1381 atctgccctt tgggaatgga cccaggaact gcattggcat gaggtttgct ctcatgaata
     1441 tgaaacttgc tctcattaaa gttctgcaga acttctcctt ccagccttgt aaggaaacac
     1501 agatacctct gaaattaagc agagaactac ttcttcaacc agtaaaaccc attgttctaa
     1561 aggttgtgcc acgggatgca gtcataactg gagcgtgatt ttcccttgag gagttctgct
     1621 gagttcttca gaaagttaga gtctaagaac attgaacact ttagtctcat catgaataaa
     1681 aatcaagatg aaatggtgct taactgattg attttgatgc ctggttaaag
//
