LOCUS       NM_007819               2955 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide 13
            (Cyp3a13), mRNA.
ACCESSION   NM_007819
VERSION     NM_007819.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2955)
  AUTHORS   Wang,Y., Sparidans,R.W., Li,W., Lebre,M.C., Beijnen,J.H. and
            Schinkel,A.H.
  TITLE     OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the
            NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict
            its brain accumulation
  JOURNAL   Br J Pharmacol 177 (13), 3060-3074 (2020)
   PUBMED   32087611
REFERENCE   2  (bases 1 to 2955)
  AUTHORS   Darr,J., Tomar,A., Lassi,M., Gerlini,R., Berti,L., Hering,A.,
            Scheid,F., Hrabe de Angelis,M., Witting,M. and Teperino,R.
  TITLE     iTAG-RNA Isolates Cell-Specific Transcriptional Responses to
            Environmental Stimuli and Identifies an RNA-Based Endocrine Axis
  JOURNAL   Cell Rep 30 (9), 3183-3194 (2020)
   PUBMED   32130917
REFERENCE   3  (bases 1 to 2955)
  AUTHORS   Henderson,C.J., Kapelyukh,Y., Scheer,N., Rode,A., McLaren,A.W.,
            MacLeod,A.K., Lin,D., Wright,J., Stanley,L.A. and Wolf,C.R.
  TITLE     An Extensively Humanized Mouse Model to Predict Pathways of Drug
            Disposition and Drug/Drug Interactions, and to Facilitate Design of
            Clinical Trials
  JOURNAL   Drug Metab Dispos 47 (6), 601-615 (2019)
   PUBMED   30910785
REFERENCE   4  (bases 1 to 2955)
  AUTHORS   Runtz,L., Girard,B., Toussenot,M., Espallergues,J., Fayd'Herbe De
            Maudave,A., Milman,A., deBock,F., Ghosh,C., Guerineau,N.C.,
            Pascussi,J.M., Bertaso,F. and Marchi,N.
  TITLE     Hepatic and hippocampal cytochrome P450 enzyme overexpression
            during spontaneous recurrent seizures
  JOURNAL   Epilepsia 59 (1), 123-134 (2018)
   PUBMED   29125184
  REMARK    GeneRIF: A significant increase of Cyp3a13 transcript level and
            protein expression was found in the liver and hippocampi during
            spontaneous recurrent seizures in mice.
REFERENCE   5  (bases 1 to 2955)
  AUTHORS   Takahashi,S., Fukami,T., Masuo,Y., Brocker,C.N., Xie,C.,
            Krausz,K.W., Wolf,C.R., Henderson,C.J. and Gonzalez,F.J.
  TITLE     Cyp2c70 is responsible for the species difference in bile acid
            metabolism between mice and humans
  JOURNAL   J Lipid Res 57 (12), 2130-2137 (2016)
   PUBMED   27638959
REFERENCE   6  (bases 1 to 2955)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   7  (bases 1 to 2955)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   8  (bases 1 to 2955)
  AUTHORS   Itoh,S., Satoh,M., Abe,Y., Hashimoto,H., Yanagimoto,T. and
            Kamataki,T.
  TITLE     A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA
            cloning and expression in fetal liver
  JOURNAL   Eur J Biochem 226 (3), 877-882 (1994)
   PUBMED   7813478
REFERENCE   9  (bases 1 to 2955)
  AUTHORS   Yanagimoto,T., Itoh,S., Sawada,M., Hashimoto,H. and Kamataki,T.
  TITLE     Molecular cloning and functional expression of a mouse cytochrome
            P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate
            aflatoxin B1 (AFB1)
  JOURNAL   Biochim Biophys Acta 1201 (3), 405-410 (1994)
   PUBMED   7803471
REFERENCE   10 (bases 1 to 2955)
  AUTHORS   Nelson,D.R., Kamataki,T., Waxman,D.J., Guengerich,F.P.,
            Estabrook,R.W., Feyereisen,R., Gonzalez,F.J., Coon,M.J.,
            Gunsalus,I.C., Gotoh,O. et al.
  TITLE     The P450 superfamily: update on new sequences, gene mapping,
            accession numbers, early trivial names of enzymes, and nomenclature
  JOURNAL   DNA Cell Biol 12 (1), 1-51 (1993)
   PUBMED   7678494
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149572.1 and AK136494.1.
            
            On Jan 9, 2008 this sequence version replaced NM_007819.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136494.1, AK149572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1919              AK149572.1         2-1920
            1920-2208           AK136494.1         1919-2207
            2209-2955           AK136494.1         2209-2955
FEATURES             Location/Qualifiers
     source          1..2955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.89 cM"
     gene            1..2955
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     13"
                     /db_xref="GeneID:13113"
                     /db_xref="MGI:MGI:88610"
     exon            1..178
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1619
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /EC_number="1.14.14.1"
                     /note="CYPIIIA13; cytochrome P450, steroid inducible 3a13"
                     /codon_start=1
                     /product="cytochrome P450 3A13"
                     /protein_id="NP_031845.1"
                     /db_xref="CCDS:CCDS19781.1"
                     /db_xref="GeneID:13113"
                     /db_xref="MGI:MGI:88610"
                     /translation="MDLIPNFSMETWMLLATSLVLLYLYGTHSHGIFKKLGIPGPKPL
                     PFLGTILAYQKGFWECDIQCHKKYGKMWGLYDGRQPVLAITDPDIIKTVLVKECYSTF
                     TNRRRFGPVGILKKAISISENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNM
                     RQGLGEGKPTSMKDIFGAYSMDVITATSFGVNIDSLNNPQDPFVEKIKKLLKFDIFDP
                     LFLSVTLFPFLTPVFDALNVSLFPRDVISFFTTSVERMKENRMKEKEKQRVDFLQLMI
                     NSQNYKTKESHKALSDVEIVAQSVIFIFAGYETTSSALSFALYLLAIHPDVQKKLQDE
                     IDAALPNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGLFIPKGT
                     VVMIPTFALHKDPKYWPEPEEFRPERFSKKNQDSINPYMYLPFGSGPRNCIGMRFALI
                     NMKVALVRVLQNFTVQPCKETEIPLKLSKQGLLQPENPLLLKVVSRDETVSDE"
     exon            179..272
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..325
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..425
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..539
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..628
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..777
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..905
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..972
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1133
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1360
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1523
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..2955
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1687..1692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /note="hexamer: GATAAA"
     polyA_site      1712
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /note="major polyA site"
     regulatory      1892..1897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /note="hexamer: AATAAA"
     polyA_site      1925
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /note="major polyA site"
     regulatory      2016..2021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /note="hexamer: AATAAA"
     polyA_site      2044
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
ORIGIN      
        1 acaaacagct gggcagggaa gggagctcag caggctcagc cctgaaaggt gcagcacaca
       61 aaattgagag tacaacttgg agagagactt gtttaaagaa aacagcaatg gacctgatcc
      121 caaacttttc catggaaacc tggatgctcc tggctaccag cctggtcctt ctctacttat
      181 atggaactca ttcacatgga atttttaaaa agttgggaat tcctgggcca aaacctctgc
      241 ctttcttggg gacgattctt gcttaccaga agggcttctg ggaatgtgac atacaatgtc
      301 ataaaaaata tgggaaaatg tgggggttgt atgacggtcg acagcctgtg ctggctatca
      361 cagatccaga cataatcaaa acagtgctgg tgaaggaatg ttactctacc ttcacaaacc
      421 ggcggcgctt tggtccagtg ggtattttga aaaaggccat ctctatctct gagaatgaag
      481 aatggaagag aatccgagcc ctgctgtctc caaccttcac cagtgggagg ctcaaggaga
      541 tgttccccat cattaaccag tttacagatg tgttggtgag aaacatgagg cagggattag
      601 gagaaggaaa gcccaccagc atgaaagaca tctttggggc ctacagcatg gatgtgatca
      661 cagccacctc atttggagtg aatattgatt ccctcaacaa cccacaggat ccttttgtgg
      721 agaaaatcaa gaagctctta aaatttgata tctttgatcc actgttcctc tcagtgacac
      781 tctttccatt ccttacccca gtatttgatg cactaaatgt ctccttgttt ccaagagatg
      841 tcataagctt ttttacaact tcagtagaac gaatgaaaga gaatcgcatg aaagagaaag
      901 aaaagcaaag agtggatttt cttcagctga tgataaactc ccagaattac aaaaccaaag
      961 aatctcataa agcattatct gatgtggaga ttgtggctca gtcagttatc tttatttttg
     1021 ctggctatga gaccacaagc agtgctcttt cctttgcatt gtatttgctg gccattcacc
     1081 ctgatgtaca gaagaaactt caggatgaaa ttgatgcggc tctgcccaat aaggcacctg
     1141 ccacctatga taccctgcta cagatggagt atctagacat ggtggtgaat gaaactctca
     1201 gattatatcc aatcgctgga agacttgaga gggtctgtaa gacagatgtt gaaatcaatg
     1261 ggctattcat tcccaaaggg actgtggtga tgataccaac ctttgctctt cacaaagacc
     1321 cgaagtactg gccagagcct gaggaattcc gccctgaaag gttcagcaag aagaatcagg
     1381 acagcatcaa tccttacatg tacctgccct ttgggagtgg accaaggaac tgcattggca
     1441 tgaggtttgc tctcataaac atgaaagttg ctcttgtcag agtcctgcag aacttcactg
     1501 tccagccttg taaggaaact gagatccctt taaaattaag caaacaagga cttcttcaac
     1561 cagaaaaccc actccttcta aaagttgtgt ccagagatga gactgtaagt gatgaatgaa
     1621 taatggtctg ttatgatgtt gtatcctgtg gaccagaaac caattcatat tgtgaatgaa
     1681 tccagagata aagattgcaa taatttcgtg cactcctgaa ggattccggg tgttctttga
     1741 acttgctcag tctctgtgaa agttatcttc tgtggaacat aagggtgtaa cgacacaaat
     1801 ccaagataaa tatatccaac tccctggttc ttgtggggct gccgatgttc acttcattgt
     1861 tactactaaa tacccagatt tctgatgaga aaataaacac caattactag ttttatttct
     1921 gaaaataagc atttttgtac tcatgctaat gaccaaattt ttaccaaacc ttttgatttg
     1981 cagcacacta caatgatgta ctaagctgag aagtcaataa acatggtgat attgactttt
     2041 cctagagagt tctggaagga caactattta cttcagttat ggcactaatg agataccaaa
     2101 ggaatgattc tacccaagtc tagcttagtg aaccagtgcc tttcaagggt acttacagag
     2161 tcatgggtga gtggttgctt acatatgtat gagtgatcca acttgaagtt ccctgaaatt
     2221 gttactgttt atgtaacctg ggagctggga gctgggagct tatgacttgt gtaagtttca
     2281 ggaacttcct gagacttgtg aactttgttt atatcctgag tctggttaag attcatttac
     2341 ttctgaattt tatgtttctc tcttacatta catcctcacc agtttccctc tgtccactct
     2401 tgttacccct tgctactttc tttatccacc cctcttctgc ttccctttag aaaagggtct
     2461 ctcacctgtc tctccccaca cctgatcgtg acctcccatt cctctcccca tcccctcttc
     2521 caccaagttt cttcctcctt ctgccttcca tgactgtttt gcctccttct aagtggattc
     2581 aagcatcctt acttgtgcct tccttcttgc taaacttctc agtatcatgg gtattctgtt
     2641 cttcatggtt aatacccacg tatcagggaa tacataccat gcatgtcctt cacagttgca
     2701 ggtaactcca gttccatgat ctattgccct ctgctggcct ctgtgaacac ctgcatgtgg
     2761 gtggtctggg ttaccttatt gaggatattt tctagttcca cccatttacc tgcaaaattc
     2821 atgatgtcct tgcttttaat agctaaatag tatttcattg tgtaaatgga caacattttc
     2881 tgtatccatt ctttgggtga ggggtgtctt ttttttttcc attttctggc tattatgaat
     2941 aaagctgcta tgaac
//
