LOCUS       NP_031845                503 aa            linear   ROD 04-JUN-2024
DEFINITION  cytochrome P450 3A13 [Mus musculus].
ACCESSION   NP_031845
VERSION     NP_031845.1
DBSOURCE    REFSEQ: accession NM_007819.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Wang,Y., Sparidans,R.W., Li,W., Lebre,M.C., Beijnen,J.H. and
            Schinkel,A.H.
  TITLE     OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the
            NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict
            its brain accumulation
  JOURNAL   Br J Pharmacol 177 (13), 3060-3074 (2020)
   PUBMED   32087611
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Darr,J., Tomar,A., Lassi,M., Gerlini,R., Berti,L., Hering,A.,
            Scheid,F., Hrabe de Angelis,M., Witting,M. and Teperino,R.
  TITLE     iTAG-RNA Isolates Cell-Specific Transcriptional Responses to
            Environmental Stimuli and Identifies an RNA-Based Endocrine Axis
  JOURNAL   Cell Rep 30 (9), 3183-3194 (2020)
   PUBMED   32130917
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Henderson,C.J., Kapelyukh,Y., Scheer,N., Rode,A., McLaren,A.W.,
            MacLeod,A.K., Lin,D., Wright,J., Stanley,L.A. and Wolf,C.R.
  TITLE     An Extensively Humanized Mouse Model to Predict Pathways of Drug
            Disposition and Drug/Drug Interactions, and to Facilitate Design of
            Clinical Trials
  JOURNAL   Drug Metab Dispos 47 (6), 601-615 (2019)
   PUBMED   30910785
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Runtz,L., Girard,B., Toussenot,M., Espallergues,J., Fayd'Herbe De
            Maudave,A., Milman,A., deBock,F., Ghosh,C., Guerineau,N.C.,
            Pascussi,J.M., Bertaso,F. and Marchi,N.
  TITLE     Hepatic and hippocampal cytochrome P450 enzyme overexpression
            during spontaneous recurrent seizures
  JOURNAL   Epilepsia 59 (1), 123-134 (2018)
   PUBMED   29125184
  REMARK    GeneRIF: A significant increase of Cyp3a13 transcript level and
            protein expression was found in the liver and hippocampi during
            spontaneous recurrent seizures in mice.
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Takahashi,S., Fukami,T., Masuo,Y., Brocker,C.N., Xie,C.,
            Krausz,K.W., Wolf,C.R., Henderson,C.J. and Gonzalez,F.J.
  TITLE     Cyp2c70 is responsible for the species difference in bile acid
            metabolism between mice and humans
  JOURNAL   J Lipid Res 57 (12), 2130-2137 (2016)
   PUBMED   27638959
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Itoh,S., Satoh,M., Abe,Y., Hashimoto,H., Yanagimoto,T. and
            Kamataki,T.
  TITLE     A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA
            cloning and expression in fetal liver
  JOURNAL   Eur J Biochem 226 (3), 877-882 (1994)
   PUBMED   7813478
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Yanagimoto,T., Itoh,S., Sawada,M., Hashimoto,H. and Kamataki,T.
  TITLE     Molecular cloning and functional expression of a mouse cytochrome
            P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate
            aflatoxin B1 (AFB1)
  JOURNAL   Biochim Biophys Acta 1201 (3), 405-410 (1994)
   PUBMED   7803471
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Nelson,D.R., Kamataki,T., Waxman,D.J., Guengerich,F.P.,
            Estabrook,R.W., Feyereisen,R., Gonzalez,F.J., Coon,M.J.,
            Gunsalus,I.C., Gotoh,O. et al.
  TITLE     The P450 superfamily: update on new sequences, gene mapping,
            accession numbers, early trivial names of enzymes, and nomenclature
  JOURNAL   DNA Cell Biol 12 (1), 1-51 (1993)
   PUBMED   7678494
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149572.1 and AK136494.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136494.1, AK149572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.89 cM"
     Protein         1..503
                     /product="cytochrome P450 3A13"
                     /EC_number="1.14.14.1"
                     /note="CYPIIIA13; cytochrome P450, steroid inducible 3a13"
                     /calculated_mol_wt=57361
     Region          67..492
                     /region_name="CYP3A"
                     /note="cytochrome P450 family 3, subfamily A; cd20650"
                     /db_xref="CDD:410743"
     Site            order(76,105..108,119..120,210,212..213,215,220,241,301,
                     304..305,309,370..372,374,481..482)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410743"
     Site            order(105,118..119,126,130,137,302,305..306,309,370,373,
                     375,434..437,440..444,448)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410743"
     CDS             1..503
                     /gene="Cyp3a13"
                     /gene_synonym="IIIAm2"
                     /coded_by="NM_007819.4:108..1619"
                     /db_xref="CCDS:CCDS19781.1"
                     /db_xref="GeneID:13113"
                     /db_xref="MGI:MGI:88610"
ORIGIN      
        1 mdlipnfsme twmllatslv llylygthsh gifkklgipg pkplpflgti layqkgfwec
       61 diqchkkygk mwglydgrqp vlaitdpdii ktvlvkecys tftnrrrfgp vgilkkaisi
      121 seneewkrir allsptftsg rlkemfpiin qftdvlvrnm rqglgegkpt smkdifgays
      181 mdvitatsfg vnidslnnpq dpfvekikkl lkfdifdplf lsvtlfpflt pvfdalnvsl
      241 fprdvisfft tsvermkenr mkekekqrvd flqlminsqn yktkeshkal sdveivaqsv
      301 ififagyett ssalsfalyl laihpdvqkk lqdeidaalp nkapatydtl lqmeyldmvv
      361 netlrlypia grlervcktd veinglfipk gtvvmiptfa lhkdpkywpe peefrperfs
      421 kknqdsinpy mylpfgsgpr ncigmrfali nmkvalvrvl qnftvqpcke teiplklskq
      481 gllqpenpll lkvvsrdetv sde
//
