LOCUS       NM_007818               2053 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus cytochrome P450, family 3, subfamily a, polypeptide 11
            (Cyp3a11), mRNA.
ACCESSION   NM_007818 XM_984479
VERSION     NM_007818.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Togao,M., Kurakawa,T., Tajima,S., Wagai,G., Ohta-Takada,Y.,
            Otsuka,J., Kurita,A. and Kawakami,K.
  TITLE     Human gut microbiota influences drug-metabolizing enzyme hepatic
            Cyp3a: A human flora-associated mice study
  JOURNAL   J Toxicol Sci 48 (6), 333-343 (2023)
   PUBMED   37258238
  REMARK    GeneRIF: Human gut microbiota influences drug-metabolizing enzyme
            hepatic Cyp3a: A human flora-associated mice study.
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Uehara,S., Iida,Y., Ida-Tanaka,M., Goto,M., Kawai,K., Yamamoto,M.,
            Higuchi,Y., Ito,S., Takahashi,R., Kamimura,H., Ito,M., Yamazaki,H.,
            Oshimura,M., Kazuki,Y. and Suemizu,H.
  TITLE     Humanized liver TK-NOG mice with functional deletion of hepatic
            murine cytochrome P450s as a model for studying human drug
            metabolism
  JOURNAL   Sci Rep 12 (1), 14907 (2022)
   PUBMED   36050438
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2053)
  AUTHORS   Lin,Y., Wang,S., Zhou,Z., Guo,L., Yu,F. and Wu,B.
  TITLE     Bmal1 regulates circadian expression of cytochrome P450 3a11 and
            drug metabolism in mice
  JOURNAL   Commun Biol 2, 378 (2019)
   PUBMED   31633069
  REMARK    GeneRIF: Here we unravel a critical role of Bmal1 for circadian
            clock-controlled Cyp3a11 expression and xenobiotic metabolism.
            Bmal1 connects circadian clock and Cyp3a11 metabolism, thereby
            impacting drug detoxification as a function of daily time.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2053)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2053)
  AUTHORS   Itoh,S., Satoh,M., Abe,Y., Hashimoto,H., Yanagimoto,T. and
            Kamataki,T.
  TITLE     A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA
            cloning and expression in fetal liver
  JOURNAL   Eur J Biochem 226 (3), 877-882 (1994)
   PUBMED   7813478
REFERENCE   7  (bases 1 to 2053)
  AUTHORS   Tolliver,B.K., Belknap,J.K., Woods,W.E. and Carney,J.M.
  TITLE     Genetic analysis of sensitization and tolerance to cocaine
  JOURNAL   J Pharmacol Exp Ther 270 (3), 1230-1238 (1994)
   PUBMED   7932176
REFERENCE   8  (bases 1 to 2053)
  AUTHORS   Yanagimoto,T., Itoh,S., Muller-Enoch,D. and Kamataki,T.
  TITLE     Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and
            inducibility by dexamethasone
  JOURNAL   Biochim Biophys Acta 1130 (3), 329-332 (1992)
   PUBMED   1339292
REFERENCE   9  (bases 1 to 2053)
  AUTHORS   Bornheim,L.M. and Correia,M.A.
  TITLE     Selective inactivation of mouse liver cytochrome P-450IIIA by
            cannabidiol
  JOURNAL   Mol Pharmacol 38 (3), 319-326 (1990)
   PUBMED   2402224
REFERENCE   10 (bases 1 to 2053)
  AUTHORS   Simmons,D.L., Lalley,P.A. and Kasper,C.B.
  TITLE     Chromosomal assignments of genes coding for components of the
            mixed-function oxidase system in mice. Genetic localization of the
            cytochrome P-450PCN and P-450PB gene families and the
            nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes
  JOURNAL   J Biol Chem 260 (1), 515-521 (1985)
   PUBMED   3917435
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC111090.20
            and AC166648.4.
            
            On Nov 17, 2006 this sequence version replaced NM_007818.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010528.1, AK149433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC111090.20        104036-104184
            150-243             AC111090.20        106159-106252
            244-296             AC111090.20        108416-108468
            297-396             AC111090.20        110359-110458
            397-510             AC111090.20        114653-114766
            511-599             AC111090.20        114846-114934
            600-748             AC111090.20        115206-115354
            749-876             AC111090.20        117879-118006
            877-905             AC111090.20        118896-118924
            906-946             AC166648.4         1-41
            947-1107            AC166648.4         2459-2619
            1108-1334           AC166648.4         4428-4654
            1335-1497           AC166648.4         6083-6245
            1498-2053           AC166648.4         9804-10359
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.17 cM"
     gene            1..2053
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /note="cytochrome P450, family 3, subfamily a, polypeptide
                     11"
                     /db_xref="GeneID:13112"
                     /db_xref="MGI:MGI:88609"
     exon            1..149
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1593
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /EC_number="1.14.14.1"
                     /note="CYPIIIA11; cytochrome P-450UT; cytochrome
                     P-450IIIAM1; steroid inducible; cytochrome P450, steroid
                     inducible 3a11"
                     /codon_start=1
                     /product="cytochrome P450 3A11"
                     /protein_id="NP_031844.1"
                     /db_xref="CCDS:CCDS19865.1"
                     /db_xref="GeneID:13112"
                     /db_xref="MGI:MGI:88609"
                     /translation="MDLVSALSLETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPL
                     PFLGTVLNYYKGLWKFDMECYKKYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVF
                     TNRRDFGPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYL
                     RQKAKKGKPVTMKDVLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDP
                     LLFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQKHRVDFLQLMM
                     NSHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQD
                     EIDEALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKG
                     STVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCLGMRFAL
                     MNMKLALTKIMQNFSFQPCKETQIPLKLSRQGLLQPEKPIVLKVVPRDAVITGA"
     exon            150..243
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            244..296
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            297..396
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            397..510
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            511..599
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            600..748
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            749..876
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            877..946
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1107
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1334
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1497
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..2053
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2028..2033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /note="hexamer: AATAAA"
     polyA_site      2053
                     /gene="Cyp3a11"
                     /gene_synonym="Cyp3a; IIIAm1; Pcn"
                     /note="major polyA site"
ORIGIN      
        1 gagggaagca ttgaggagga tcacacacac agttgtaggg agaacacaga gaagtaaatt
       61 gctgacaaac aagcagggat ggacctggtt tcagctctct cactggaaac ctgggtgctc
      121 ctagcaatca gcttggtgct cctctaccga tatgggactc gtaaacatga actttttaag
      181 aaacagggaa ttcctgggcc caaacctctg ccatttttag gcactgtgct gaattattac
      241 aagggtttat ggaaattcga catggagtgc tataaaaagt atggaaaaac atgggggttg
      301 tttgatggtc aaacgcctct ccttgctgtc acagacccag agacgattaa gaatgtgcta
      361 gtgaaggaat gtttttctgt cttcacaaac cggcgggatt ttggcccagt ggggataatg
      421 agtaaagcta tctcaatatc taaggatgat gaatggaaga gatatagagc tttgctgtcc
      481 cccacattca ccagtggaaa actcaaggag atgttccctg tcattgaaca gtatggagac
      541 attttggtaa agtacttgag gcagaaggca aagaaaggca agcctgttac tatgaaagat
      601 gtgttaggtg cttacagcat ggatgtgatc accagcacat catttggagt gaacgtggat
      661 tccctcaaca acccagagga tccttttgtg gagaaagcca aaaagctttt aagatttgat
      721 ttttttgatc ctttgctctt ctcagtagta ctttttccat tcctgacacc agtatatgag
      781 atgttaaata tctgcatgtt cccaaaggat tcaatagaat ttttcaaaaa atttgtggac
      841 agaatgaagg aaagccgcct ggattctaag cagaagcacc gagtggattt tcttcagctg
      901 atgatgaatt ctcataataa ttccaaagac aaagtctctc ataaagccct ttctgacatg
      961 gagatcacag cccagtcaat tatctttatt tttgctgggt atgaaaccac cagtagcaca
     1021 ctttccttca ccctgcattc cttggccact caccctgata tccagaaaaa actgcaggat
     1081 gagatcgatg aggctctgcc caacaaggca cctcccacgt atgatactgt gatggagatg
     1141 gaatacctgg atatggtgct taatgaaacc ctcagattat atcccattgc taatagactt
     1201 gagagagtct gtaagaaaga tgttgaactc aatggtgtgt atatccccaa agggtcaaca
     1261 gtgatgattc catcttatgc tcttcaccat gacccacagc actggtcaga gcctgaagaa
     1321 ttccaacctg aaaggttcag caaggagaac aagggcagca ttgatcctta tgtatatctg
     1381 ccctttggga atggacccag gaactgcctt ggcatgaggt ttgctctcat gaatatgaaa
     1441 cttgctctca ctaaaattat gcagaacttc tccttccagc cttgtaagga aacacagata
     1501 cctctgaaat taagcagaca aggacttctt caaccagaaa aacccattgt tctaaaggtt
     1561 gtgccacggg atgcagtcat aactggagca tgagtctccc tcaaggagtt cttctgagtt
     1621 cttcagaaag gcagtgtcta agaacatcgg acattttagt ttcatcatga gtaaaattga
     1681 gatgaataag gggcttaata gattggtttt gatgcctggt taaagattca gtacatccac
     1741 tgaactttct cagtgtctgt acaagttacc atctaataaa aaagagatga ataaattagt
     1801 gacagcacag gaaatttgcc ttcactggtt ctcatgggat catctccatc catatctcgt
     1861 tttctctgct aattcctttt gagatctttc gatagtaacc acgtttttgt aatttgaaca
     1921 aaaatttttg atgaaaaatg tgagctcttg taacaactct agttgtagaa ttgttatcag
     1981 atgctttagt tgccatatat tataataaat gctgcacaga aaatgtaaat aaacacttag
     2041 ttaaaaatcc tca
//
