LOCUS       NM_018887               3106 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 39, subfamily a, polypeptide 1
            (Cyp39a1), transcript variant 1, mRNA.
ACCESSION   NM_018887
VERSION     NM_018887.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Creasy,K.T., Jiang,J., Ren,H., Peterson,M.L. and Spear,B.T.
  TITLE     Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic
            Cyp Gene Expression in the Adult Mouse Liver
  JOURNAL   Gene Expr 17 (1), 7-17 (2016)
   PUBMED   27197076
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 3106)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   5  (bases 1 to 3106)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   6  (bases 1 to 3106)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
REFERENCE   7  (bases 1 to 3106)
  AUTHORS   Li-Hawkins,J., Lund,E.G., Bronson,A.D. and Russell,D.W.
  TITLE     Expression cloning of an oxysterol 7alpha-hydroxylase selective for
            24-hydroxycholesterol
  JOURNAL   J Biol Chem 275 (22), 16543-16549 (2000)
   PUBMED   10748047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE648427.1, AC154647.2 and AK031733.1.
            
            [WARNING] On Aug 1, 2024 this sequence was replaced by NM_018887.5.
            
            On Oct 25, 2013 this sequence version replaced NM_018887.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031733.1, AF237981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BE648427.1         497-522             c
            27-27               AC154647.2         141585-141585
            28-53               BE648427.1         470-495             c
            54-3106             AK031733.1         2-3054
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.75 cM"
     gene            1..3106
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /note="cytochrome P450, family 39, subfamily a,
                     polypeptide 1"
                     /db_xref="GeneID:56050"
                     /db_xref="MGI:MGI:1927096"
     exon            1..423
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1650
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /EC_number="1.14.14.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     24-hydroxycholesterol 7-alpha-hydroxylase; oxysterol
                     7-alpha-hydroxylase; cytochrome P450, 39a1 (oxysterol
                     7alpha-hydroxylase)"
                     /codon_start=1
                     /product="24-hydroxycholesterol 7-alpha-hydroxylase
                     isoform 1"
                     /protein_id="NP_061375.1"
                     /db_xref="CCDS:CCDS28799.1"
                     /db_xref="GeneID:56050"
                     /db_xref="MGI:MGI:1927096"
                     /translation="MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIGA
                     GLEFGKAPLEFIEKARIKYGPVFTIFAMGNRMTFVSEEEGINVLLKSEHVDFESAVQS
                     PVYHTAWIPKNVFSALHERLYALMKGKMGTFNTHHFTGPLTEELHEQLEGLGTHGTMD
                     LNDFVRYLLYPATLNTLFKKGLFLTDKRTIKEFYQQFKTYDEGFEYGSQLPEWLLRNW
                     SKSKRWLLALFEKNIGNIKAHGSAGHSGTLLQAILEVVETETRQYSPNYGLVVLWAAL
                     ANAPPIAFWTLGYILSHPDIHRTVLESISSVFGTAGKDKIKVSEDDLKKLLIIKWCIL
                     ESVRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWK
                     EANLDKYIFLDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQSSR
                     HLVGVPQPAGKCRIEYKQRA"
     exon            424..559
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..734
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..884
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..975
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1080
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1171
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1305
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1401
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1490
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1578
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..3106
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2508..2513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /note="hexamer: AATAAA"
     regulatory      2525..2530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /note="major polyA site"
     polyA_site      2565
                     /gene="Cyp39a1"
                     /gene_synonym="mCYP39A1"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt ttttttttct cataatttga aagccgtggg aaggtggaag atagccacaa
       61 tgcaaaaatc acacaaaaac tggggcgggg caaaggaacc acagttacgc aagagaattt
      121 gtttaaaaag tttctcggct cagagtttgc aaaactgggc gcattttcct cagtcggcgg
      181 gggactagga gattcccctg gagaaggacg ttttcaaacg tctgttgatt ctggaagatg
      241 ggcattatgg agttattctc accaatagca atcgccgttc tgggaagctg tgttcttttc
      301 ttattctctc ggttgaagaa tttgcttgga cccccgtgca tccaaggctg gattccctgg
      361 attggagctg gacttgagtt tgggaaagcc cctcttgaat ttatagaaaa agcaagaatc
      421 aagtatggac cggtatttac catctttgct atgggaaacc gaatgacctt tgttagtgaa
      481 gaagaaggaa tcaatgtgct tctaaaatct gaacatgtag attttgaatc agcagtacaa
      541 agtcctgtct atcacacagc atggattcca aagaatgtct tctctgcact gcatgagcga
      601 ctgtatgcct tgatgaaagg gaagatggga actttcaaca cacatcactt tactgggccg
      661 ctaactgaag aacttcatga gcaactggaa ggtttaggca ctcatggaac aatggacctg
      721 aatgactttg taaggtatct actttatcca gccacactca ataccctctt taagaaaggg
      781 ttgtttctca cagacaagag gacaatcaag gaattctacc agcagtttaa aacctatgat
      841 gagggctttg agtatggctc ccagctgcct gaatggcttc tgagaaactg gtcaaaatcc
      901 aaaagatggc tcctggcgct gtttgagaaa aatattggca acataaaagc tcacggatct
      961 gcaggtcatt ctggaaccct cttgcaggcc atattggaag tggtggagac ggaaacacgt
     1021 caatacagtc caaattatgg actggtcgta ctttgggctg ctctggccaa tgctcctcct
     1081 attgcattct ggacacttgg atatatcctg tctcatcccg atatccacag gactgtttta
     1141 gaaagcatat cttctgtgtt tggcactgca ggtaaagaca agattaaagt gtctgaagat
     1201 gacctgaaga agcttctaat aattaagtgg tgcattctgg aatctgtccg cttgagagcc
     1261 cctggtgtca ttactagaaa ggtagtgaag ccagttaaaa ttctgaatca cacagttcct
     1321 tctggtgatc tgctgatgtt gtctccattc tggctacaca gaaatccaaa atattttcct
     1381 gaacctgagt cattcaaacc tgaacgctgg aaagaggcaa atttagataa gtacattttc
     1441 ttggactact tcatggcatt tggaggcggg aagttccagt gtcctggaag gtggtttgct
     1501 ctcttagaga ttcaactatg cattatctta gtgctgtata agtacgaatg cagtcttctg
     1561 gacccattac caaagcagag ttctcgtcat ttggtgggtg tcccccagcc tgcagggaaa
     1621 tgccggattg aatataaaca aagagcttga ctttcattgg gactcaagag attcagaacc
     1681 ttctagagga gtgaagctac gtgcccagct actatcctcc cagcacctcg acctaaagac
     1741 atcctactgg ctcatggatt tcaaatctga ggaccgtgca ccagatttca ctgtcagaaa
     1801 catagacacc ccaattcaag gtttacagaa agggttcaga tgattttgaa aaagttgata
     1861 aaacgttgga atttggcttc atacatagcc atatcaaaac ttcaagtaga aatgtcactt
     1921 tcatagaaat atttgtatgt taaattcact gtgaaggcaa catacataaa aaattctctt
     1981 tttgcaaaag aactacagtg gaggacactg aaaaattaga tcaattctag atattttata
     2041 ttttcaaaat atggtactta actagacctt ggaaatctta ggcttattga tgccaaccgc
     2101 tgcagacatg cgtagtgctc agaaatgtag ataaatagtg ttttacgata ttggtggggc
     2161 tgagttccca tgccgcggtc attcctgtac tctgttatgc ccagggtagc gtcttcctgt
     2221 tggggatagc taatcagtgc acactgaccg aggcattggc ttgtatgtta gctaaggggg
     2281 aagcactctt ttgaatcaaa tgatctttgc tcgtagtttg acaaagataa catttttact
     2341 catatgtaag aacgcgcagt ctcattatgt ctggttatac catgtctttg tggtatccct
     2401 gggagacctg ctcttttcgg aaatgaaaca tgaacagtgg atctggggaa gaaggaaggt
     2461 ggggaacgga aactggggtg ggaatgtatt gtcttaagag atgaataaat aaatcaatgg
     2521 ataaaataaa tgcgcatctg gttttgtgcc aggtaaataa ctgcacatga gtctggtttt
     2581 tgagtcttag gacagaggaa catttgccat tacgttctgg agagaaaaca cagcagatcc
     2641 atgggaacat agggttttcc tgaaaaacgg caccatcatt catccgccaa aatccagtaa
     2701 gagttcatct ctgacatttc atggtggctg tatatctctt ctcaggcttc ttcccttacc
     2761 tgtcctggct ccggctcctg aagttggaaa ttgttgactc tccttttcct cactgacaag
     2821 gacacaggtc tccagaagac tgaccagtgc tttcgagagt gtccactctt cgcaatgagt
     2881 gaattgattc tggagctcaa ctggcagctc agagcttccc tcagcaggct cggtgcactg
     2941 gagaaggcag ctcccaagtc cacagcaggg tagtgttgca gcccagcctg gcaggttctg
     3001 cagtaacagc tgtttcctgt gggaagggat atgcactacc caacagccaa ggcccacagt
     3061 gaaatgctat atttgcttat atttgcataa agttgaacta aatttc
//
