LOCUS       NM_001160265            4082 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily w, polypeptide 1
            (Cyp2w1), mRNA.
ACCESSION   NM_001160265 XM_001481321 XM_620268
VERSION     NM_001160265.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4082)
  AUTHORS   Choong,E., Guo,J., Persson,A., Virding,S., Johansson,I.,
            Mkrtchian,S. and Ingelman-Sundberg,M.
  TITLE     Developmental regulation and induction of cytochrome P450 2W1, an
            enzyme expressed in colon tumors
  JOURNAL   PLoS One 10 (4), e0122820 (2015)
   PUBMED   25844926
  REMARK    GeneRIF: Results show the developmental expression of CYP2W1 in the
            GI tract mediated by epigenetic modifications, its specific
            location, and regulation by anticancer drugs which can be
            considered as an adjuvant therapy of colon and hepatic cancers.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161058.2.
            
            On Jun 26, 2019 this sequence version replaced NM_001160265.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC161058.2         34351-34564         c
            215-377             AC161058.2         33178-33340         c
            378-527             AC161058.2         32791-32940         c
            528-685             AC161058.2         32563-32720         c
            686-859             AC161058.2         31453-31626         c
            860-998             AC161058.2         30992-31130         c
            999-1183            AC161058.2         30728-30912         c
            1184-1325           AC161058.2         30433-30574         c
            1326-4082           AC161058.2         27578-30334         c
FEATURES             Location/Qualifiers
     source          1..4082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.44 cM"
     gene            1..4082
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /note="cytochrome P450, family 2, subfamily w, polypeptide
                     1"
                     /db_xref="GeneID:545817"
                     /db_xref="MGI:MGI:3616076"
     exon            1..214
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1513
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /note="cytochrome P450 2W1"
                     /codon_start=1
                     /product="cytochrome P450 2W1 precursor"
                     /protein_id="NP_001153737.1"
                     /db_xref="CCDS:CCDS51683.1"
                     /db_xref="GeneID:545817"
                     /db_xref="MGI:MGI:3616076"
                     /translation="MALLLLGVWGILLLLGLWGLLQGCTRSPSLAPRWPPGPRPLPFL
                     GNLHLLGVTQQDRALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADR
                     PPIPIFQHIQRGGGIFFSSGARWRAGRQFTVRTLQSLGVQQPSMVGKVLQELACLKGQ
                     LDSYGGQPLPLALLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQ
                     LFNTFPRLGAFLRLHRPVLSKIEEVRTILRTLLETRRPPLPTGGPAQSYVEALLQQGQ
                     EDDPEDMFGEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLG
                     PGQLPQPEHQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLL
                     TSVLLDKTQWETPSQFNPNHFLDAKGRFMKRGAFLPFSAGRRVCVGKSLARTELFLLF
                     AGLLQRYRLLPPPGLSPADLDLRPAPAFTMRPPAQTLCVVPRS"
     exon            215..377
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
     exon            378..527
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
     exon            528..685
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
     exon            686..859
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
     exon            860..998
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1183
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1325
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..4082
                     /gene="Cyp2w1"
                     /gene_synonym="Gm455"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctgagg atttgccatc cagctgttca catggctctg ctgctcctgg gtgtctgggg
       61 gatcttgcta cttctggggc tgtggggact gctccagggc tgcacccgga gcccctccct
      121 ggctcctcgg tggccccctg ggcctcgccc tctgccgttc ctggggaacc tgcatttgct
      181 gggtgtgacc caacaagacc gggcactgat ggagctctca gaacgctacg ggcccatgtt
      241 cacaatccat ctgggatctc agaagaccgt ggtgctgtcg ggctatgagg tggtgaggga
      301 ggccttggtt ggaaccgggc atgagctagc cgaccggccc ccaattccca tcttccagca
      361 catccagcga ggtgggggca ttttcttttc ttctggagct cgctggaggg cgggtcgcca
      421 attcacggtg cgcacactgc agagcctggg tgtgcaacag ccatccatgg tgggcaaggt
      481 gctgcaggag ctggcctgtc ttaaaggaca gctggatagc tatggaggcc agcccctccc
      541 cctggcgctg ctgggttggg caccctgcaa catcaccttc acacttctct tcggccagcg
      601 ctttgactac caggatcctg tgtttgtgtc cctgctgagt ctcattgacc aggtcatggt
      661 cctgttgggg tcacctggca tacagctatt caacacgttc ccccggctgg gggccttcct
      721 gcggttgcac aggccggtct tgagcaagat cgaggaggtg cgcaccatcc tgagaaccct
      781 gctggaaacg cggagaccac ccttgccaac gggcggtccc gcgcagagtt atgtagaagc
      841 tctgcttcag cagggccagg aagatgaccc tgaggacatg tttggcgagg ccaatgtcct
      901 ggcctgtaca ctggacatgg tcatggctgg aacagagacc acggcggcca cgctgcagtg
      961 ggccgtcttc ctgatggtta agcacccaca tgtgcagggt cgcgtgcagg aggaactgga
     1021 ccgagtgctg ggtcctgggc agctgcctca accagagcac cagcgagcac tgccctacac
     1081 cagtgctgtg ttgcatgagg tccagcggta catcacactc ctgccccatg tgccccgctg
     1141 cacagctgct gacatccagc tgggtggcta cctgctcccc aagggcactc ctgtgattcc
     1201 tttgctcact tcagtcctcc tggacaagac gcagtgggag accccaagcc agttcaaccc
     1261 aaaccacttt ctggacgcga aggggcgctt tatgaagcgg ggggccttcc tgccattctc
     1321 cgctggtcgc cgggtctgcg ttgggaagag cctggccagg acagagctct tcctgctgtt
     1381 cgctggcctc cttcagcggt accgcctcct gcccccaccc ggcctcagcc ctgcagacct
     1441 ggatttacgg cctgccccag ctttcaccat gcggcctcct gcccagacct tgtgtgtggt
     1501 gccgagatct tagggtgcac acattctgga aaactaccag agcctagcct acctctcctc
     1561 cagggtgcac tgcaggtttt ggggtggttg tagcattcct agcaatgaat gataggcaga
     1621 cagtcccaca ctgtccctct ggaccaccac agctcttatg actcagtgta cagtggtgcc
     1681 aaggctgctt acccgtatgt ggaggttgga agctggcctt tcatctggca tcatggggca
     1741 gagggcgtat cggcccagtg cagcggccct accctgtcct gatatggtgc ttacaggaac
     1801 cctaactcac cttccaggct tttacacccc ggacactaca gacacttttc tattctggtc
     1861 cccaaggcag ccaaatcctc agagtagaga ctacaatccc ttcattgttc tcccccccac
     1921 acacacactg caccccccgc ccaccctatc tttggctata cccaggcttc ccaccaggtc
     1981 acagggttcc cccatcccca gaagcctggt ctatagccct tccatagccc ccccgtatac
     2041 cccatctccc tacctaggca gattctgccc aaagttcggg attgctccac ctttgactgg
     2101 taccaagggg acccaggggc tgctgagctt gaccacaggc gacatttttg ttcctttctt
     2161 ttgctgtgac aactggcatt ctgccatgtg gctacttgga acaggaatgg ctggagggaa
     2221 agagcttcgc ccagctgatg ccccgggaac cttcgcctgg ttcctgatgc cagttctcac
     2281 caacagcgag gaacctacca catttcctgt ttcgacttgg ctaccaggaa acccttagct
     2341 atggtccttg ttccttccat ctcctccccc tgccccacct cctcttctca gtggtgtttg
     2401 tattccttgt ttctctgtgc gctcactcaa ggctttgaaa tgcgcgggtg ataaccttgt
     2461 tgcgtatgtc tgttgtgacg tgccaactcc agctgtgcct tctccagaag cattcctgtg
     2521 gccacggata tggccaccgt cagtacaggg cttccccaag tgcggaaggg caggcctaga
     2581 tgccaccatg agtggcaaga gccagttgga gtacatgtga gacccagatc atacaacact
     2641 tgggtccctt ctggcaccaa gagtctggtg gttggtggtg acaggtcgct gttgactaaa
     2701 gagacatgag taagtccccc ttgggctctg gtggtgtact gtgttggtgc tggccccagc
     2761 cagtgcttta aagtaactaa acatgaagtg acagagtgtc taaatgacat aggacaaggt
     2821 cgaggacagg gtttgtagcc agattgtctg agaccccaag acccaggaag gggttcatgc
     2881 tttggctggc cgcctgtctc cccacattaa tgcagtattt ggctactgtg cccaagtgct
     2941 agggaccgga gacaagccta tcccatttgt tttttgaaac agggtttttc tgtgtagccc
     3001 tggctgtcct agaactcact ctgtggacca ggctggcctt gaactcagag ttctgcctgt
     3061 ctctgcctcc cgagtgctgg gactaaaggc gtgcgccact gttgtcaatc tcatcacttt
     3121 tactagacct ggggtcagct cagctctgct ccactcaagt gagctggcag gttagaagtc
     3181 tagaggctgc cccagtgtgt cctctctcct gccatgtggc aactgccagg caggaaggca
     3241 gaggacaaca tgcttaaggt ttgggagtgt ggggtctgcc ctctagtggc agttggatct
     3301 gagtggactg ctcatgaagg actatggctg ctctcacagg ctcaggatag tgggcctcca
     3361 ggcagctgag ggcacctggc tttagcccag ctggcccagg atgcccacct cctccctgtg
     3421 acacatgtcc tgatcactgg gagctgcgag tgggaggtgg actgtgtcct ctgtccttgg
     3481 atcagagcag ctgtcatcac ctgaacaaga ccctggagag actcggccta ttaacattcc
     3541 tgtaggaaag ggataggtgg gtgggatgac tgcctgacct accagagatc ccagccaccg
     3601 tcccccctgc ctcttccact gtggattgca accttgcttg ggcacaaaat atttggcaag
     3661 tcagacgtat ctgtgtaatg atcaaaaatt agaagtaaaa tgtgtacctg gtggtggtag
     3721 ggcttgggtg acagaggcag gtgggtctct gtgagtttaa ggccagtcca gtctacagat
     3781 ccagttccag gatagccagg gtcacacaca caaaccttgc ctagaaaaaa accaaagcca
     3841 accaaccagg caagcaaaag caactgtgtg aggcatcctc acgggcaccg cacgtgccct
     3901 ggtgtaagta agctgtaccc tggctcttgg ccagatgtta tcagtctcag gtcacaggtc
     3961 atgtgatgtt ccacctagcc atggtggaac tcactctgta gaccaggctg acctcgaact
     4021 caagagactg gcctgcttct gcctcctaag cgctgggaat aaagagtctc atggttttaa
     4081 aa
//
