LOCUS       NM_027816               2331 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily u, polypeptide 1
            (Cyp2u1), mRNA.
ACCESSION   NM_027816 XM_131188 XM_983734 XM_992136
VERSION     NM_027816.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2331)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 2331)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2331)
  AUTHORS   Pujol,C., Legrand,A., Parodi,L., Thomas,P., Mochel,F., Saracino,D.,
            Coarelli,G., Croon,M., Popovic,M., Valet,M., Villain,N.,
            Elshafie,S., Issa,M., Zuily,S., Renaud,M., Marelli-Tosi,C.,
            Legendre,M., Trimouille,A., Kemlin,I., Mathieu,S., Gleeson,J.G.,
            Lamari,F., Galatolo,D., Alkouri,R., Tse,C., Rodriguez,D.,
            Ewenczyk,C., Fellmann,F., Kuntzer,T., Blond,E., El Hachimi,K.H.,
            Darios,F., Seyer,A., Gazi,A.D., Giavalisco,P., Perin,S.,
            Boucher,J.L., Le Corre,L., Santorelli,F.M., Goizet,C., Zaki,M.S.,
            Picaud,S., Mourier,A., Steculorum,S.M., Mignot,C., Durr,A.,
            Trifunovic,A. and Stevanin,G.
  TITLE     Implication of folate deficiency in CYP2U1 loss of function
  JOURNAL   J Exp Med 218 (11) (2021)
   PUBMED   34546337
REFERENCE   4  (bases 1 to 2331)
  AUTHORS   Chikada,H., Ida,K., Ando,E., Inagaki,Y., Sakamoto,A. and Kamiya,A.
  TITLE     Establishment and analysis of a mouse model that regulates
            sex-related differences in liver drug metabolism
  JOURNAL   Lab Invest 98 (11), 1500-1511 (2018)
   PUBMED   29968852
REFERENCE   5  (bases 1 to 2331)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2331)
  AUTHORS   Choudhary,D., Jansson,I., Stoilov,I., Sarfarazi,M. and
            Schenkman,J.B.
  TITLE     Expression patterns of mouse and human CYP orthologs (families 1-4)
            during development and in different adult tissues
  JOURNAL   Arch Biochem Biophys 436 (1), 50-61 (2005)
   PUBMED   15752708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165416.12 and AC123634.10.
            
            On Jun 7, 2008 this sequence version replaced NM_027816.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142740.1, SRR7652917.264878.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-548               AC165416.12        60933-61480
            549-1184            AC123634.10        1435-2070
            1185-1346           AC123634.10        4307-4468
            1347-1514           AC123634.10        6172-6339
            1515-2331           AC123634.10        8549-9365
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 60.89 cM"
     gene            1..2331
                     /gene="Cyp2u1"
                     /gene_synonym="8430436A10Rik"
                     /note="cytochrome P450, family 2, subfamily u, polypeptide
                     1"
                     /db_xref="GeneID:71519"
                     /db_xref="MGI:MGI:1918769"
     exon            1..548
                     /gene="Cyp2u1"
                     /gene_synonym="8430436A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            549..1184
                     /gene="Cyp2u1"
                     /gene_synonym="8430436A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1346
                     /gene="Cyp2u1"
                     /gene_synonym="8430436A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1514
                     /gene="Cyp2u1"
                     /gene_synonym="8430436A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..2331
                     /gene="Cyp2u1"
                     /gene_synonym="8430436A10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2u1"
                     /gene_synonym="8430436A10Rik"
                     /note="hexamer: AATGAA"
     polyA_site      1943
                     /gene="Cyp2u1"
                     /gene_synonym="8430436A10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccttgccct gcctcgcggt tgaccttgag tcatgtagcc ggctactgtc gcggtgccgg
       61 cgcgtctgca gcggagctag atgcaggcgg tacctgggac atgtcctcgc tcggggacca
      121 gcgtcccgcg gcaggggagc agccgggagc tagactgcac gtgcgggcga caggaggcgc
      181 gctgctactt tgcctgctgg cggtgctgct aggctgggtt tggctgcggc ggcaacgcgc
      241 ctgcggcatc cctccggggc ccaagcctcg gccactcgtg ggtaacttcg ggcacttgct
      301 ggtgccgcgc tttctacgac cgcagttctg gctgggctcg ggcagccaga cggacacggt
      361 gggccagcat gtgtacctgg ccaggatggc ccgtgtctat ggcaacatct tcagcttctt
      421 catcggccac cgtctggtgg tggtcctcag cgacttccac agcgtgcgcg aggcgctagt
      481 gcagcaggct gaagtgttca gtgaccgccc gcggatgccg ctcatctcca tcatgaccaa
      541 ggagaaggga atcgtgtttg cacactatgg tccaatttgg aaacagcaga ggagattctc
      601 ccactcgacg cttcgtcatt tcggtctggg caagctcagc ctggagccca ggatcatcga
      661 ggagtttgca tacgtgaaag aagccatgca gaagcacggg gaggccccct tcagcccctt
      721 cccaatcatc agcaatgccg tctccaacat catctgctcc ctgtgcttcg gccagcgctt
      781 cgattacacc aacaaggagt ttaaaaaggt gttggatttc atgtcccggg ggttggaaat
      841 ctgcctgcac agccagctct tcctgatcaa catatgcccc tggttttact acctcccctt
      901 tggtccattt aaggagctaa ggcaaatcga aagggacata tcctgcttcc tgaaaaacat
      961 catccgagag catcaagagt ctctggatgc cagcaaccct caggacttca tagacatgta
     1021 ccttctgcac atggaggaag agcagggagc cagcaggcgc agcagcttcg acgaggacta
     1081 cctgttctac atcattgggg acctcttcat cgccggcact gacaccacga ccaactctct
     1141 gctctggtgc ctgctgtaca tgtcactgaa ccccgacgtg caaaaaaagg ttcatgaaga
     1201 aattgaaagg gtcattggct gtgaccgtgc accttccctc acggacaagg cccagatgcc
     1261 atacacagag gccaccatca tggaggtgca gcggctgtcc atggtggtgc cgctcgccat
     1321 tcctcacatg acctcggaga aaacagtcct ccaagggttc accattccca aaggcacagt
     1381 ggtcctaatc aacctgtggt cagtacacag agacccagcc atctgggaga agccagacga
     1441 cttctgtcct catcgatttc tggatgacca aggacaactt ttgaaaagag aaacttttat
     1501 tccttttggg atagggaagc gggtgtgtat gggagagcag ctggccaaga tggagttatt
     1561 cctgatgttc gtgagcctga tgcagacttt cacctttgcg ttacctgagg gttccgagaa
     1621 gcctgtcatg actgggagat ttggtctaac actggccccg caccctttta atgtaaccat
     1681 ctcaaagaga tgaagaagcc ccgagaagag aggcgcgggc agactccatg tactggtcgg
     1741 tcctagacag ccttcctatt gctgctgagc atgggcctcg cagttcggca cagccaggag
     1801 aggctgagtg gtgcccactg gccacgggga agcatggaca ctcggtttag ttgtgtggat
     1861 tccatcagaa agcagtgctt ctcatctctc agcctccgtc atcccatggt aaaatgaggt
     1921 aatgaaacgt ctctcaactc tgagaggaac tggatgcttc atgaagtctg tgctggtggc
     1981 agatgctggg caaatcagta gatctgcctt cggacctccc aaggcccctc cctgcaacat
     2041 ctagtgtcag cacggacact cggtcagaga gggatgtagg tctaggttat attgaagtag
     2101 accttttttt tcccccatac tttttttttc ttttgtattt tttttttctg gcatagattc
     2161 aatgtcagtt tctttgggtt tgtcttatga gtgttgttgt tggttttttt tgtttgtttg
     2221 tttttttttg ttgttttttt tgtttttttt ttttagggat gtgtcccttt tatagagcta
     2281 ggatgaaatg tccccttgcc cagtatgttg agaaaatgaa aagcatcctc t
//
