LOCUS       NM_028775               2623 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily s, polypeptide 1
            (Cyp2s1), mRNA.
ACCESSION   NM_028775
VERSION     NM_028775.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Fekry,M.I., Xiao,Y., Berg,J.Z. and Guengerich,F.P.
  TITLE     A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated
            Fatty Acid omega-1 Hydroxylation Using an Untargeted Metabolomic
            Approach
  JOURNAL   Drug Metab Dispos 47 (11), 1325-1332 (2019)
   PUBMED   31511258
  REMARK    GeneRIF: P450 2S1 is a fatty acid omega-1 hydroxylase, although the
            physiologic relevance of these oxidations remains to be
            established.
            Erratum:[Drug Metab Dispos. 2020 Mar;48(3):159. doi:
            10.1124/dmd.119.089086err. PMID: 32001573]
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Wu,D., Schieren,I., Qian,Y., Zhang,C., Jessell,T.M. and de
            Nooij,J.C.
  TITLE     A Role for Sensory end Organ-Derived Signals in Regulating Muscle
            Spindle Proprioceptor Phenotype
  JOURNAL   J Neurosci 39 (22), 4252-4267 (2019)
   PUBMED   30926747
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Li,L., Megaraj,V., Wei,Y. and Ding,X.
  TITLE     Identification of cytochrome P450 enzymes critical for lung
            tumorigenesis by the tobacco-specific carcinogen
            4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from
            a novel Cyp2abfgs-null mouse
  JOURNAL   Carcinogenesis 35 (11), 2584-2591 (2014)
   PUBMED   25173884
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Fromel,T., Kohlstedt,K., Popp,R., Yin,X., Awwad,K.,
            Barbosa-Sicard,E., Thomas,A.C., Lieberz,R., Mayr,M. and Fleming,I.
  TITLE     Cytochrome P4502S1: a novel monocyte/macrophage fatty acid
            epoxygenase in human atherosclerotic plaques
  JOURNAL   Basic Res Cardiol 108 (1), 319 (2013)
   PUBMED   23224081
  REMARK    GeneRIF: no Cyp2s1 protein was detected in aortae from wild-type
            mice it was expressed in aortae and macrophage foam cells from
            ApoE(-/-) mice
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Wei,Y., Li,L., Zhou,X., Zhang,Q.Y., Dunbar,A., Liu,F.,
            Kluetzman,K., Yang,W. and Ding,X.
  TITLE     Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse
            model
  JOURNAL   Drug Metab Dispos 41 (1), 132-140 (2013)
   PUBMED   23073733
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Rivera,S.P., Wang,F., Saarikoski,S.T., Taylor,R.T., Chapman,B.,
            Zhang,R. and Hankinson,O.
  TITLE     A novel promoter element containing multiple overlapping xenobiotic
            and hypoxia response elements mediates induction of cytochrome
            P4502S1 by both dioxin and hypoxia
  JOURNAL   J Biol Chem 282 (15), 10881-10893 (2007)
   PUBMED   17277313
  REMARK    GeneRIF: identify a novel regulatory cassette that mediates changes
            in Cyp2s1 expression
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Choudhary,D., Jansson,I., Stoilov,I., Sarfarazi,M. and
            Schenkman,J.B.
  TITLE     Expression patterns of mouse and human CYP orthologs (families 1-4)
            during development and in different adult tissues
  JOURNAL   Arch Biochem Biophys 436 (1), 50-61 (2005)
   PUBMED   15752708
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Wang,H., Donley,K.M., Keeney,D.S. and Hoffman,S.M.
  TITLE     Organization and evolution of the Cyp2 gene cluster on mouse
            chromosome 7, and comparison with the syntenic human cluster
  JOURNAL   Environ Health Perspect 111 (15), 1835-1842 (2003)
   PUBMED   14630516
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Choudhary,D., Jansson,I., Schenkman,J.B., Sarfarazi,M. and
            Stoilov,I.
  TITLE     Comparative expression profiling of 40 mouse cytochrome P450 genes
            in embryonic and adult tissues
  JOURNAL   Arch Biochem Biophys 414 (1), 91-100 (2003)
   PUBMED   12745259
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119211.8.
            
            On Jun 5, 2018 this sequence version replaced NM_028775.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064733.1, AK004699.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC119211.8         124118-124320       c
            204-369             AC119211.8         122680-122845       c
            370-519             AC119211.8         119397-119546       c
            520-680             AC119211.8         117233-117393       c
            681-860             AC119211.8         116974-117153       c
            861-1002            AC119211.8         115839-115980       c
            1003-1190           AC119211.8         113666-113853       c
            1191-1332           AC119211.8         111711-111852       c
            1333-2623           AC119211.8         110264-111554       c
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 14.05 cM"
     gene            1..2623
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /note="cytochrome P450, family 2, subfamily s, polypeptide
                     1"
                     /db_xref="GeneID:74134"
                     /db_xref="MGI:MGI:1921384"
     exon            1..203
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..369
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..519
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..680
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..860
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1002
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1190
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1332
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2623
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2595..2600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /note="hexamer: AATAAA"
     polyA_site      2619
                     /gene="Cyp2s1"
                     /gene_synonym="1200011C15Rik; CYPIIS1"
                     /note="major polyA site"
ORIGIN      
        1 acagacccag ccgacctgca gagatggagg cagccagcac ctgggcgctg ctgctggccc
       61 tgctgctgct gctgctgctg ctgtctctga cgctattcag gaccccggcc cgaggctacc
      121 tacccccggg gcccacgccg ctgccgttgc tggggaacct cctgcagctg cgtcccgggg
      181 ctctgtactc ggggcttttg cggctaagta agaagtatgg gcctgtgttc acggtatacc
      241 tgggcccctg gcgccgcgtg gtggtcctgg ttggacatga tgctgtaaga gaagccttgg
      301 gaggtcaggc tgaggaattc agcgggcgtg gaacattggc aacgctggac aagacctttg
      361 atggtcacgg agttttcttt gccaatgggg agcggtggaa acagctgagg aaattcaccc
      421 tgctcgctct acgggacctg ggcatgggca agcgagaagg cgaggagctg atccaggcgg
      481 aggtgcagag tctggtggag gctttccaga agacagaagg acgtccattc aacccttcca
      541 tgctgctggc ccaggccacc tctaatgtcg tctgttccct tgtctttggc atccgtttgc
      601 cctatgacga taaagagttc caggctgtga tccaggcagc aagtggtacc ttgttaggga
      661 tcagctctcc atggggccag gcctacgaga tgttctcctg gctactgcag cccctgccag
      721 gcccccacac acagctccag caccacttgg gcaccctggc tgccttcact atccagcagg
      781 tacagaaaca ccagggacgc ttccaaacct caggtcctgc acgtgatgtc gttgacgcct
      841 tcctgctaaa gatggcacag gagaaacaag acccaggtac agaattcacc gagaagaact
      901 tgctgatgac ggtcacatac ctgctgtttg ctgggaccat gaccatcggt gccaccatcc
      961 gctatgccct cctgctcctg ctgagatacc ctcaagtcca gcagcgcgtc cgggaggagc
     1021 tcatacagga gctgggtcct ggcagggctc caagtctcag cgatcgagtt cgcctccctt
     1081 acacggatgc cgttttacac gaggcacagc ggctcctggc actggtaccc atgggcatgc
     1141 cccacaccat cacgaggacc acttgcttcc gagggtacac tctgcccaag ggcactgagg
     1201 tcttccctct gattggctcc atactgcatg accctgcggt tttccagaac ccaggagagt
     1261 tccatccagg ccgcttcctg gacgaagatg gtcggttgag aaaacacgaa gccttcctgc
     1321 cctactcctt aggtaagcga gtctgcctgg gagaaggcct ggctcgggcg gagttgtggc
     1381 ttttcttcac ttccatcttg caagccttct ccctggagac cccgtgcccg ccgggtgacc
     1441 tgagcctgaa gccagccatc agtggacttt tcaacatccc cccggacttc cagctgcggg
     1501 tctggcccac tggcgaccag tccagatgaa ggaaggagtt tggaaggtgg gagccctctg
     1561 ggctgaaaga gccttactca gggtgtgtgt gaagcaggtg tctcagaagc aacatcacac
     1621 tacacaccac gtatcaaggc agctgtggag accagggacc acaccactac acaaccgcac
     1681 agcaactgat gcataggctt ctttttggag agggctgtct gaaacgggga tcttgttatg
     1741 tggtgacaca agccgaactc aaacttgtga tcctcccgcc tcggtgtcct gctcgctgga
     1801 attacaggta tgcgccacca tgagctgcat aggctttcag cctacatcat gtaatatagg
     1861 ccatctggaa ttgcaagcat atagctagat accccgctgt ccaccacacg actctgtatg
     1921 ctcacaactc taatccagcg actgcctaca caaacacaca aacaacccaa ccgtattcag
     1981 gactcttaac tctgtctaac acgctcagca ccgctgttgc tgggtccccg ccatagaaaa
     2041 cagcaagccc cagctggggt catgtcacag ccagaacgat gttctgtcta ctcccatgga
     2101 tgacctcacc accatccagg ctcatgagtg gctctatcaa cggccaccag ccagtaatcc
     2161 acacagccaa accgtatgtg acaagatctt ggcccttcca aacttcttcc cactgaggca
     2221 caccgtgacg acatactatt ccccagtcac gtccacaccc atgcccctcc agcacgctcc
     2281 ttccaacaaa tgttcccaaa tataaaggtt tcctggtctg tgattgtgca cacagacctt
     2341 ctacaaatga ggaccagcga cccaaagaaa aagggtttcc cagtcatgtt atcaggggcc
     2401 tgctctcaaa cgcattctga tctctgagct gcctgcaagt cctcatgaga gtgctggaaa
     2461 tgtatcctcc tcctggaagg actaactggc ctcacaggga tgatgcaggg gagtgctgtt
     2521 agctgtttcc agccctcctt atcaggacag aagccatagc tgacctcttt gtgacttgaa
     2581 ggttcccgtt ttgcaataaa agtttgtttc tggcccgaac gga
//
