LOCUS       NM_177382               1630 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily r, polypeptide 1
            (Cyp2r1), transcript variant 1, mRNA.
ACCESSION   NM_177382
VERSION     NM_177382.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Elkhwanky,M.S., Kummu,O. and Hakkola,J.
  TITLE     Streptozotocin-induced Diabetes Represses Hepatic CYP2R1 Expression
            but Induces Vitamin D 25-Hydroxylation in Male Mice
  JOURNAL   Endocrinology 163 (7) (2022)
   PUBMED   35524739
  REMARK    GeneRIF: Streptozotocin-induced Diabetes Represses Hepatic CYP2R1
            Expression but Induces Vitamin D 25-Hydroxylation in Male Mice.
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Roizen,J.D., Long,C., Casella,A., O'Lear,L., Caplan,I., Lai,M.,
            Sasson,I., Singh,R., Makowski,A.J., Simmons,R. and Levine,M.A.
  TITLE     Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum
            25-Hydroxyvitamin D
  JOURNAL   J Bone Miner Res 34 (6), 1068-1073 (2019)
   PUBMED   30790351
  REMARK    GeneRIF: Obesity Decreases Hepatic 25-Hydroxylase Activity Causing
            Low Serum 25-Hydroxyvitamin D.
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Ochiai,W., Hirose,A., Kawamura,T., Komachi,K., Yamamoto,Y.,
            Kitaoka,S., Hatogai,J., Kusunoki,Y., Kon,R., Ikarashi,N. and
            Sugiyama,K.
  TITLE     Role of the Drug-Metabolizing Enzyme CYP during Mouse Liver
            Development
  JOURNAL   Biol Pharm Bull 39 (12), 2015-2021 (2016)
   PUBMED   27904043
  REMARK    GeneRIF: These results suggest that CYP2R1 and CYP26A1 may play a
            major role in hepatoblast cell differentiation during the
            development of the liver.
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Zhu,J.G., Ochalek,J.T., Kaufmann,M., Jones,G. and Deluca,H.F.
  TITLE     CYP2R1 is a major, but not exclusive, contributor to
            25-hydroxyvitamin D production in vivo
  JOURNAL   Proc Natl Acad Sci U S A 110 (39), 15650-15655 (2013)
   PUBMED   24019477
  REMARK    GeneRIF: CYP2R1 is the major enzyme responsible for
            25-hydroxylation of vitamin D.
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Wang,Y., Marling,S.J., Zhu,J.G., Severson,K.S. and DeLuca,H.F.
  TITLE     Development of experimental autoimmune encephalomyelitis (EAE) in
            mice requires vitamin D and the vitamin D receptor
  JOURNAL   Proc Natl Acad Sci U S A 109 (22), 8501-8504 (2012)
   PUBMED   22592802
  REMARK    GeneRIF: Data show that the absence of either of the two key
            hydroxylases, vitamin D 25-hydroxylase (CYP2R1) or vitamin D
            25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)neither inhibits
            nor enhances the development of experimental autoimmune
            encephalomyelitis (EAE).
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Choudhary,D., Jansson,I., Stoilov,I., Sarfarazi,M. and
            Schenkman,J.B.
  TITLE     Expression patterns of mouse and human CYP orthologs (families 1-4)
            during development and in different adult tissues
  JOURNAL   Arch Biochem Biophys 436 (1), 50-61 (2005)
   PUBMED   15752708
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Cheng,J.B., Motola,D.L., Mangelsdorf,D.J. and Russell,D.W.
  TITLE     De-orphanization of cytochrome P450 2R1: a microsomal vitamin D
            25-hydroxilase
  JOURNAL   J Biol Chem 278 (39), 38084-38093 (2003)
   PUBMED   12867411
  REMARK    GeneRIF: CYP2R1 is a strong candidate for the microsomal vitamin D
            25-hydroxylase.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC108961.1, BB061096.1 and BB013625.1.
            
            On Jan 31, 2014 this sequence version replaced NM_177382.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY323818.1, BC108961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1571              BC108961.1         1-1571
            1572-1605           BB061096.1         203-236
            1606-1630           BB013625.1         204-228
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.79 cM"
     gene            1..1630
                     /gene="Cyp2r1"
                     /note="cytochrome P450, family 2, subfamily r, polypeptide
                     1"
                     /db_xref="GeneID:244209"
                     /db_xref="MGI:MGI:2449771"
     exon            1..240
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..382
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..1015
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1345
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1630
                     /gene="Cyp2r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagcccgg ggccgatgtt ggagctaccg ggagcccggg cgtgcgctgg ggcgctcgcg
       61 ggcgctctcc tgctgctgct cttcgtgctg gtggtccgcc agctgctgag gcagaggcga
      121 ccggcgggct tccccccggg tcctccgcgg ctgccatttg tcggcaacat ctgctccctg
      181 gccttgtcgg ccgatcttcc ccacgtctac atgaggaagc agagccgggt gtatggcgag
      241 attttcagtt tagatcttgg aggcatatca actgtcgttc taaatggcta tgatgtagta
      301 aaggaatgcc ttgttcatca aagtgaaatt tttgcagata gaccatgcct tcctttgttc
      361 atgaagatga caaaaatggg aggcttactc aattccagat atggtagagg atggattgat
      421 cacagaaggt tggctgttaa cagctttcat tattttggaa gtggccaaaa atcttttgaa
      481 tctaaaattt tagaagaaac ttggtcttta attgatgcta ttgaaacata caaaggtgga
      541 ccttttgacc tcaagcaact gataacaaat gctgtttcaa acataactaa ccttatcctt
      601 tttggagaac gattcactta tgaagacact gattttcagc acatgattga attatttagt
      661 gagaatgtgg aactagctgc cagtgctcca gtcttccttt ataatgcatt tccatggatt
      721 ggcatcttac cttttgggaa acatcaaaga ctatttagaa atgcagatgt ggtctatgat
      781 ttcctctcca gacttattga aaaagctgca gtcaatagaa agcctcattt acctcaccat
      841 tttgttgatg cctatttaga tgagatggat caaggtcaaa atgatccttt atctacattt
      901 tccaaagaga atctaatttt ttcagtgggt gaactcatca ttgctggaac tgaaactaca
      961 accaatgtgc tccgctgggc aattcttttc atggcccttt atcctaatat tcaaggacaa
     1021 gttcataaag agattgattt aattgtgggc cacaacagga gaccttcttg ggaatacaaa
     1081 tgcaaaatgc cttatactga agcagtttta catgaagttt taagattctg taatatagtt
     1141 ccactgggaa ttttccatgc aacttcggaa gatgcagttg tacgtggcta ttccattcct
     1201 aaaggcacaa cagtcattac aaatctttat tctgttcact ttgatgaaaa gtactggaaa
     1261 gatccagaca tgttctatcc tgagcgattt ctggacagca atggatattt tactaaaaag
     1321 gaagctttga ttcctttttc tctagggaga agacattgtc ttggagaaca gctggctcga
     1381 atggaaatgt tcttgttttt tacatcatta cttcagcaat ttcatttgca ttttccacat
     1441 gaactagttc caaatctgaa gcccaggttg ggcatgacat tacaacccca gccctacctc
     1501 atctgtgcag aaagacgctg aaagtgcaaa atgtattggg gaataacctt gttgaatcac
     1561 aataatggtg tttgggccaa agccacattt ttataaagcc aagtaaacac aaatacactg
     1621 tttaaaatag
//
