LOCUS       NM_010008               3595 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus cytochrome P450, family 2, subfamily j, polypeptide 6
            (Cyp2j6), mRNA.
ACCESSION   NM_010008
VERSION     NM_010008.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3595)
  AUTHORS   Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H,
            Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt
            M, Lu R, Suo J, Zhang DD, Schafer SM, Hofmann M, Yekkirala AS, de
            Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K and Geisslinger G.
  TITLE     Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic
            pain
  JOURNAL   Proc Natl Acad Sci U S A 113 (44), 12544-12549 (2016)
   PUBMED   27791151
  REMARK    GeneRIF: Data suggest inhibition of cytochrome P-450 CYP2J6 (CYP2J)
            isoforms as a treatment option for paclitaxel-induced neuropathic
            pain.
REFERENCE   2  (bases 1 to 3595)
  AUTHORS   Nayeem MA, Zeldin DC, Boegehold MA, Morisseau C, Marowsky A,
            Ponnoth DS, Roush KP and Falck JR.
  TITLE     Modulation by salt intake of the vascular response mediated through
            adenosine A(2A) receptor: role of CYP epoxygenase and soluble
            epoxide hydrolase
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 299 (1), R325-R333 (2010)
   PUBMED   20427718
REFERENCE   3  (bases 1 to 3595)
  AUTHORS   Baragatti B, Schwartzman ML, Angeloni D, Scebba F, Ciofini E,
            Sodini D, Ottaviano V, Nencioni S, Paolicchi A, Graves JP, Zeldin
            DC, Gotlinger K, Luin S and Coceani F.
  TITLE     EDHF function in the ductus arteriosus: evidence against
            involvement of epoxyeicosatrienoic acids and
            12S-hydroxyeicosatetraenoic acid
  JOURNAL   Am J Physiol Heart Circ Physiol 297 (6), H2161-H2168 (2009)
   PUBMED   19801493
REFERENCE   4  (bases 1 to 3595)
  AUTHORS   Seubert J, Yang B, Bradbury JA, Graves J, Degraff LM, Gabel S,
            Gooch R, Foley J, Newman J, Mao L, Rockman HA, Hammock BD, Murphy E
            and Zeldin DC.
  TITLE     Enhanced postischemic functional recovery in CYP2J2 transgenic
            hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44
            MAPK pathway
  JOURNAL   Circ Res 95 (5), 506-514 (2004)
   PUBMED   15256482
REFERENCE   5  (bases 1 to 3595)
  AUTHORS   Ma J, Bradbury JA, King L, Maronpot R, Davis LS, Breyer MD and
            Zeldin DC.
  TITLE     Molecular cloning and characterization of mouse CYP2J6, an unstable
            cytochrome P450 isoform
  JOURNAL   Biochem Pharmacol 64 (10), 1447-1460 (2002)
   PUBMED   12417258
REFERENCE   6  (bases 1 to 3595)
  AUTHORS   Ma J, Qu W, Scarborough PE, Tomer KB, Moomaw CR, Maronpot R, Davis
            LS, Breyer MD and Zeldin DC.
  TITLE     Molecular cloning, enzymatic characterization, developmental
            expression, and cellular localization of a mouse cytochrome P450
            highly expressed in kidney
  JOURNAL   J Biol Chem 274 (25), 17777-17788 (1999)
   PUBMED   10364221
REFERENCE   7  (bases 1 to 3595)
  AUTHORS   Ma J, Ramachandran S, Fiedorek FT Jr and Zeldin DC.
  TITLE     Mapping of the CYP2J cytochrome P450 genes to human chromosome 1
            and mouse chromosome 4
  JOURNAL   Genomics 49 (1), 152-155 (1998)
   PUBMED   9570962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033614.1, AK045421.1 and AL683816.6.
            
            [WARNING] On May 6, 2023 this sequence was replaced by NM_010008.5.
            
            On Nov 22, 2007 this sequence version replaced NM_010008.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033614.1, AK045421.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AK033614.1         4-14
            12-2490             AK045421.1         2-2480
            2491-3595           AL683816.6         7147-8251           c
FEATURES             Location/Qualifiers
     source          1..3595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 44.62 cM"
     gene            1..3595
                     /gene="Cyp2j6"
                     /note="cytochrome P450, family 2, subfamily j, polypeptide
                     6"
                     /db_xref="GeneID:13110"
                     /db_xref="MGI:MGI:1270148"
     exon            1..410
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1706
                     /gene="Cyp2j6"
                     /EC_number="1.14.14.1"
                     /note="CYPIIJ6; arachidonic acid epoxygenase; cytochrome
                     P450, 2j6"
                     /codon_start=1
                     /product="cytochrome P450 2J6"
                     /protein_id="NP_034138.3"
                     /db_xref="CCDS:CCDS18369.1"
                     /db_xref="GeneID:13110"
                     /db_xref="MGI:MGI:1270148"
                     /translation="MLAATGSLLATIWAALHPRTLLVAAVTFLLLADYFKNRRPKNYP
                     PGPWGLPFVGNIFQLDFGQPHLSIQPLVKKYGNIFSLNLGDITSVVITGLPLIKEALT
                     QMEQNIMNRPLSVMQERISNKNGLIFSSGQIWKEQRRFALMTLRNFGLGKKSLEERMQ
                     EEASHLVEAIREEEGKPFNPHFSINNAVSNIICSVTFGERFDYHDSRFQEMLRLLDEV
                     MYLETTMISQLYNIFPWIMKYIPGSHQKVFRNWEKLKLFVSCMIDDHRKDWNPDEPRD
                     FIDAFLKEMTKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQE
                     KVQAEIDRVIGQKRAARLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTNLNGF
                     HLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSMGKRACLGE
                     QLARSELFIFFTSLMQKFTFNPPINEKLSPKFRNGLTLSPVSHRICAVPRQ"
     exon            411..573
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     exon            574..723
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     exon            724..884
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1061
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1200
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1388
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1527
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..3595
                     /gene="Cyp2j6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cyp2j6"
     polyA_site      3595
                     /gene="Cyp2j6"
ORIGIN      
        1 aaactactct cagaagcttt gtcacttcct gcgagagccc agctccaggg aggaaaccag
       61 aggagcaaag gggagtggac agaaagggat agggagggac tgaggggacc ggttttagaa
      121 gggtgccctt gttgttagca cctgggactt gccgcagctc agaccttcat tcctcagacg
      181 aaccagctgc agtcctagcc atgctcgctg ctaccggctc cttgttagcc acgatctggg
      241 cagcgctcca tcccaggact ctgttggtgg ctgcagtcac cttcctgctt ctggctgatt
      301 acttcaaaaa ccggcgcccc aagaactatc ccccagggcc ttggggtctg cctttcgtgg
      361 gcaacatatt ccagttggac tttgggcagc cccacctctc aatccagccg ttggtgaaga
      421 aatatgggaa tatttttagc ctgaatcttg gtgacataac ttcagtggtc ataactggac
      481 tgcccttaat caaagaagca cttactcaaa tggaacaaaa cattatgaat cgtcctctaa
      541 gtgttatgca agaacgtata tctaataaaa atggattgat cttctccagt ggccaaatat
      601 ggaaggagca aagaaggttt gccctgatga cactgaggaa ctttggactg ggaaagaaga
      661 gcttagagga gcgcatgcag gaggaggcct cccacctagt ggaagccata agagaggagg
      721 aaggaaaacc tttcaaccct cacttcagta tcaacaatgc agtttccaat atcatttgct
      781 ctgtcacctt tggggagcgc tttgactacc atgacagtag atttcaggag atgctgaggt
      841 tactggacga ggttatgtat ttggagacaa caatgattag tcagctgtat aatatttttc
      901 catggataat gaaatacatc cctggatcac atcaaaaagt tttcagaaac tgggaaaaac
      961 tgaaattgtt tgtctcttgt atgattgatg atcaccggaa agactggaac cccgatgaac
     1021 caagagactt cattgatgct ttcctcaagg aaatgacaaa gtacccagag aagactacaa
     1081 gtttcaatga agaaaacctt atctgcagca ctttggacct cttctttgct ggaacagaga
     1141 caacatcaac tacattacgc tgggctctgc tctacatggc cctctaccca gaagtccaag
     1201 aaaaagtaca ggcagagatt gatagggtga ttggccagaa gagggcagca agacttgctg
     1261 atagagaatc catgccctat accaatgctg tcatccacga ggtgcagagg atgggcaata
     1321 tcatcccctt gaatgttccc agggaagtag caatggatac caatttgaat ggatttcatc
     1381 tgccaaaggg tacaatggtt ctaacaaacc taactgcact gcacagagac ccaaaagagt
     1441 gggccactcc agatgtgttc aatccagagc actttttgga gaatggacag tttaagaaga
     1501 gagaatcctt tctgcccttc tcaatgggaa agcgagcttg cctgggagaa caactggcca
     1561 ggtctgagct gttcattttc ttcactagcc ttatgcaaaa attcaccttc aatcccccaa
     1621 tcaatgagaa gctgagccca aagttcagaa atggcctcac actttctcca gtcagccacc
     1681 gcatctgtgc tgtccctaga cagtgatgct ggagaagcaa tgagaaaagg aagataagat
     1741 gtaaggcctg aagcttctgg gttgctcaca cgagagaaga aagatgtcag aaaaggaagg
     1801 tgattcaaga agtactgaag aaatgtggct tagaaaattg aagcaatctc ctagaatagt
     1861 agccccttga tttggtggtg ggcacatcat ttatgagctc agtggcatgc cttttcatct
     1921 aaatgttttg aggataatgg tgattcttcc aaacaaagtg cattaaattg aattgaaaat
     1981 gaattaaaca tcaaaattaa aactgtaatt gttatttaaa aagtaaattt tctaagttca
     2041 ccctgaatca tatcttgact ggtgtactat cagtttgcct ctttcctcct ttcatgcatc
     2101 tgtatttgtt tcttgcccat tgaaatgtta gcctaaagcg gtacaaagaa agaataagaa
     2161 tcagatccga gcttctgatt gcatctacag aaacaggctt tttttgagac tttcccagat
     2221 gacagatctg tcactaactt ctgtagatct aaatctaaat agacctagaa accaataaag
     2281 caggaatgtt tccctactca caggctggca aataagtgct ataaaaccat ttgcctcttt
     2341 ttaaagtttt tattgtttta ttgagaattt catatcatgt acccccattc aacttatgtc
     2401 ccccaaccct ttacctcata tccacctcat atcctccatc cttgtaacct ctggcaaaat
     2461 gtagactaaa atatatcatt gtggatgctg gagtgtgtca cagtttgtcc aacagtttac
     2521 tgctttggaa ctgctccatt gtcaatactg aaaaagattt cagtatttta tttcttattg
     2581 ggactcctca aggatattct tttgttgtgc ggtatcttgt atattccgtg gttttgaatg
     2641 agtaggactg gcccctttat atactacatg gatgagatag atgtgagaca ggacagttca
     2701 aagtcccaga tctgggcctg agaggtattt gagctctcag gaatctacac cttctgtgca
     2761 aaccctcctg ccttgcccta gcttgaccaa tgtcactgcc agcaaggggc agagcctact
     2821 cccatgcctt tgggctggtt catatgtacc cataccatca agtataactc ttctgtgctt
     2881 ccaaggggag ctcgcccaag tgttacagaa ggagagaggc aggggcattc tccaataact
     2941 ttgaatccca gggtcagctc tctcatgtat gatcagtacc aaaattagat tctttttata
     3001 tattgtagtt tgacaaaaac ctaggctaag taatcatatc acttgaagga ggttagccaa
     3061 tgtggtcaat gttaatatca ttttaaatga gtcctgctaa cttgtactcc attttcaaga
     3121 ttctgttctg agataatcac aaatcctctg tctctatatg atttgattgt gtaccttagc
     3181 aggttttgtg gggacaccaa acagtagaag tcaaggtgtc tcttttaact gatcttagaa
     3241 tcttttgcct cctactgact aggctccatc cagcattgat tggaggactt gtgcttagtc
     3301 ttagtgtaat gtcctaatgc catgttcagt tgatagctct ggaggccagc tcttttcagg
     3361 aagcaaattg aggagaggta gatctgagga agaacaaaga tgaggaagag actgtgacaa
     3421 taggagggag gggaaactat ggtcagaatg taatgtataa gagaataata agtcataaat
     3481 tcactagtta attaatttac taaataatga aaacctcttc tacaaaaata cacaatgcct
     3541 ttcttgtact gagacatgat attacaggtt ttaataaaga aaacctcacc tgtga
//
